Atopic dermatitis laboratory findings
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Shalinder Singh, M.B.B.S.[2]
Overview
There diagnosis of atopic dermatitis remains clinical as there is no reliable bio-marker that can differentiate the atopic dermatitis from other skin diseases.
Laboratory Findings
- There are no reliable diagnostic laboratory findings associated with atopic dermatitis.
- The most common laborotory finding in atopic dermatitis is an elevated total and/or allergen-specific serum IgE level, which is not present in about 20% of affected individuals.[1]
- Monitoring of IgE levels is not recommended for the assessment of atopic dermatitis severity.
- Some of new biomarkers using the SCORing Atopic Dermatitis (SCORAD) index and other severity scales[2][3]
- Serum levels of CD30
- Macrophage-derived chemoattractant (MDC)
- Interleukins (IL)-12
- Interleukins (IL)-16
- Interleukins (IL)-18
- Interleukins (IL)-31
- Thymus and activation-regulated chemokine (TARC)
References
- ↑ Kabashima K (April 2013). "New concept of the pathogenesis of atopic dermatitis: interplay among the barrier, allergy, and pruritus as a trinity". J. Dermatol. Sci. 70 (1): 3–11. doi:10.1016/j.jdermsci.2013.02.001. PMID 23473856.
- ↑ Aral M, Arican O, Gul M, Sasmaz S, Kocturk SA, Kastal U, Ekerbicer HC (2006). "The relationship between serum levels of total IgE, IL-18, IL-12, IFN-gamma and disease severity in children with atopic dermatitis". Mediators Inflamm. 2006 (4): 73098. doi:10.1155/MI/2006/73098. PMC 1618943. PMID 17047294.
- ↑ Di Lorenzo G, Gangemi S, Merendino RA, Minciullo PL, Cannavò SP, Martinelli N, Mansueto P, Rini GB, Corrocher R, Pacor ML (April 2003). "Serum levels of soluble CD30 in adult patients affected by atopic dermatitis and its relation to age, duration of disease and Scoring Atopic Dermatitis index". Mediators Inflamm. 12 (2): 123–5. doi:10.1080/0962935031000097736. PMC 1781600. PMID 12775363.