Chondrosarcoma classification
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Rohan A. Bhimani, M.B.B.S., D.N.B., M.Ch.[2]
Overview
Chondrosarcoma may be classified based on histological findings and location.
Classification
- Chondrosarcoma be classified based on histological findings, location and imaging findings.
Histological Classification
Primary Chondrosarcoma
- Chondrosarcoma that arises denovo and comprises of following subtypes:
- Conventional chondrosarcoma - Low-grade, high-grade, and dedifferentiated chondrosarcoma (90% of all chondrosarcomas)
- Clear cell chondrosarcoma (1% of all chondrosarcomas)
- Mesenchymal chondrosarcoma (2% of all chondrosarcomas)
Secondary Chondrosarcoma
- Chondrosarcoma that arises from benign cartilage lesions includes (7% of all chondrosarcomas):
- Osteochondroma (<1% risk of malignant transfomation)
- Multiple hereditary exostosis (1-10% risk of malignant transformation)
- Enchondromas (1% risk of malignant transformation)
- Ollier's disease (25-40% risk of malignant transformation)
- Maffucci's disease(100% risk of malignant transformation)
Based on Location
- Chondrosarcoma may be classified based on location into following groups:[3][4]
- Centrally located within the medullary cavity. (central chondrosarcoma) (70% of all chondrosarcomas)
- Peripherally located on the surface of bone as a result of malignant transformation within the cartilaginous cap. (Peripheral chondrosarcoma) (15% of all chondrosarcomas)
References
- ↑ Raymond E, L'Her P, Jeanbourquin D, Schill H, Jancovici R, Daly JP; et al. (1993). "[Chondrosarcoma of the thoracic wall. Review of the literature apropos of 4 cases]". Rev Pneumol Clin. 49 (1): 19–25. PMID 8378694.
- ↑ Lex JR, Evans S, Stevenson JD, Parry M, Jeys LM, Grimer RJ (2018). "Dedifferentiated chondrosarcoma of the pelvis: clinical outcomes and current treatment". Clin Sarcoma Res. 8: 23. doi:10.1186/s13569-018-0110-1. PMC 6293503. PMID 30559960.
- ↑ Giuffrida AY, Burgueno JE, Koniaris LG, Gutierrez JC, Duncan R, Scully SP (2009). "Chondrosarcoma in the United States (1973 to 2003): an analysis of 2890 cases from the SEER database". J Bone Joint Surg Am. 91 (5): 1063–72. doi:10.2106/JBJS.H.00416. PMID 19411454.
- ↑ Skeletal Lesions Interobserver Correlation among Expert Diagnosticians (SLICED) Study Group (2007). "Reliability of histopathologic and radiologic grading of cartilaginous neoplasms in long bones". J Bone Joint Surg Am. 89 (10): 2113–23. doi:10.2106/JBJS.F.01530. PMID 17908885.