Spina bifida pathophysiology
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Mohamadmostafa Jahansouz M.D.[2]
Overview
Pathophysiology
- Spina bifida is a congenital malformation in which the spinal column is split (bifid) as a result of failed closure of the embryonic neural tube, during the fourth week post-fertilization.[1]
- In normal infants, the neural tube closes by the end of the 4 week of conception, but in patients with spina bifida, some parts of the neural tube fails to develop or close that causes defects in the spinal cord and in the vertebral bones.
- Spina bifida also may be classified according to the tyoe of the vertebrate defect into 2 subtypes:
- Spina bifida occulta: In this type of spina bifida, the defect of vertebrate is covered by skin ("Occulta" means "hidden"). The spinal cord does not stick out through the skin, although the skin over the lower spine may have a patch of hair, a birthmark, or a dimple above the groove between the buttocks.[1]
- Spina ifida aperta: In this type of spina bifida , the defect is widely open and is sub classified into 2 types: Meningocele and Myelomeningocele.[1]
Pathogenesis
- Spina bifida may be caused by the increase of cerebrospinal fluid (CSF) volume in the central nervous system during the first weeks of embryogenesis.[2]
- Venous insufficiency is the main cause of the increase of cerebrospinal fluid and it may be caused by any disease that reduces space for venous volume.[2]
Genetics
he candidate genes studied include. Many and maintain planar cell polarity have also been tested as candidates.
[Disease name] is transmitted in [mode of genetic transmission] pattern.
OR
The development of spina bifida may be the result of multiple genetically defect in the genes important in the metabolism of:
Other genes which may be contributed in the development of the spina bifida include:
- Genes important in apoptosis
- Genes that regulate transcription in early embryogenesis
Associated Conditions
Conditions associated with [disease name] include:
- [Condition 1]
- [Condition 2]
- [Condition 3]
Gross Pathology
On gross pathology, [feature1], [feature2], and [feature3] are characteristic findings of [disease name].
Microscopic Pathology
On microscopic histopathological analysis, [feature1], [feature2], and [feature3] are characteristic findings of [disease name].
References
- ↑ 1.0 1.1 1.2 Kenworthy ME (July 1966). "Introducing the American Orthopsychiatric Association's president for 1966-67: Norman V. Lourie". Am J Orthopsychiatry. 36 (4): 587–9. PMID 5327787.
- ↑ 2.0 2.1 Williams H (April 2008). "A unifying hypothesis for hydrocephalus, Chiari malformation, syringomyelia, anencephaly and spina bifida". Cerebrospinal Fluid Res. 5: 7. doi:10.1186/1743-8454-5-7. PMC 2365936. PMID 18405364.