Autoimmune retinopathy historical perspective
|
Autoimmune retinopathy Microchapters |
|
Diagnosis |
|---|
|
Treatment |
|
Case Studies |
|
Autoimmune retinopathy historical perspective On the Web |
|
American Roentgen Ray Society Images of Autoimmune retinopathy historical perspective |
|
Risk calculators and risk factors for Autoimmune retinopathy historical perspective |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-In-Chief: M. Hassan, M.B.B.S
Overview
Historical Perspective
- In 1976, the first cases of cancer associated retinopathy (CAR) were observed in three female patients with bronchial carcinoma who developed vision loss with photoreceptor (rods and cones) degeneration.
- In 1987, 23-kDa retinal antigen, recoverin, targeted by antibodies in the serum of CAR patients was identified by Thirkill and colleague.
- In 1997, the first case of autoimmune retinopathy (AIR) was reported in the absence of malignancy with clinical features similar to CAR. Since then, hundreds of cases of paraneoplastic AIR, and non-paraneoplastic AIR have been reported. [1]