Autoimmune retinopathy causes
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-In-Chief: M. Hassan, M.B.B.S
Overview
Causes
As with all autoimmune diseases, autoimmune retinopathy is caused by antibodies cross reacting against the retinal, and retinal like antigens. [1]
Main antibodies against retinal proteins associated with AIR include: Anti-recoverin, anti-alpha-enolase, anti-transducin, anti-CAII, anti-arrestin, anti-rhodopsin, anti-Muller glial cells, anti-mitofilin, anti-tintin, anti-COX. However, seronegative disease is also common.
Anti-recoverin is associated with rapid onset and visual decline as compared to anti-alpha-enolase. [2]
References
- ↑ Dutta Majumder P, Marchese A, Pichi F, Garg I, Agarwal A (2020). "An update on autoimmune retinopathy". Indian J Ophthalmol. 68 (9): 1829–1837. doi:10.4103/ijo.IJO_786_20. PMC 7690499 Check
|pmc=value (help). PMID 32823399 Check|pmid=value (help). - ↑ Canamary AM, Takahashi WY, Sallum JMF (2018). "Autoimmune retinopathy: A Review". Int J Retina Vitreous. 4: 1. doi:10.1186/s40942-017-0104-9. PMC 5759752. PMID 29340169.