Peutz-Jeghers syndrome causes

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Overview

Peutz-Jeghers, also known as Hereditary Intestinal Polyposis Syndrome, is an autosomal dominant genetic disease characterized by the development of benign hamartomatous polyps in the gastrointestinal tract.

Causes

Genetics

In 1998, a gene was found to be associated with the mutation. On chromosome 19, the gene known as STK11 (LKB1) is a possible tumor suppressor gene. It is inherited in an Autosomal Dominant pattern (see Mendelian inheritance) which means that anyone who has PJS has a 50% chance of passing it onto their children.

References

de:Peutz-Jeghers-Syndrom it:Sindrome di Peutz-Jeghers nl:Syndroom van Peutz-Jeghers