MAP2K6

Main article: Mitogen-activated protein kinase kinase

Mitogen-activated protein kinase kinase 6
Identifiers
Symbols	MAP2K6 ; MAPKK6; MEK6; MKK6; PRKMK6; SAPKK3
External IDs	Template:OMIM5 Template:MGI HomoloGene: 55686
Gene ontology Molecular function Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Biological process Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO
RNA expression pattern
File:PBB GE MAP2K6 205698 s at tn.png
File:PBB GE MAP2K6 205699 at tn.png
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Mitogen-activated protein kinase kinase 6, also known as MAP2K6, is a human gene.

This gene encodes a member of the dual specificity protein kinase family, which functions as a mitogen-activated protein (MAP) kinase kinase. MAP kinases, also known as extracellular signal-regulated kinases (ERKs), act as an integration point for multiple biochemical signals. This protein phosphorylates and activates p38 MAP kinase in response to inflammatory cytokines or environmental stress. As an essential component of p38 MAP kinase mediated signal transduction pathway, this gene is involved in many cellular processes such as stress induced cell cycle arrest, transcription activation and apoptosis.

Further reading

• Ben-Levy R, Hooper S, Wilson R; et al. (1999). "Nuclear export of the stress-activated protein kinase p38 mediated by its substrate MAPKAP kinase-2". Curr. Biol. 8 (19): 1049–57. PMID 9768359.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Tanaka S, Nakamura K, Takahasi N, Suda T (2006). "Role of RANKL in physiological and pathological bone resorption and therapeutics targeting the RANKL-RANK signaling system". Immunol. Rev. 208: 30–49. doi:10.1111/j.0105-2896.2005.00327.x. PMID 16313339.CS1 maint: Multiple names: authors list (link)
• Doza YN, Cuenda A, Thomas GM; et al. (1995). "Activation of the MAP kinase homologue RK requires the phosphorylation of Thr-180 and Tyr-182 and both residues are phosphorylated in chemically stressed KB cells". FEBS Lett. 364 (2): 223–8. PMID 7750576.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. PMID 8125298.
• Han J, Lee JD, Jiang Y; et al. (1996). "Characterization of the structure and function of a novel MAP kinase kinase (MKK6)". J. Biol. Chem. 271 (6): 2886–91. PMID 8621675.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Raingeaud J, Whitmarsh AJ, Barrett T; et al. (1996). "MKK3- and MKK6-regulated gene expression is mediated by the p38 mitogen-activated protein kinase signal transduction pathway". Mol. Cell. Biol. 16 (3): 1247–55. PMID 8622669.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Stein B, Brady H, Yang MX; et al. (1996). "Cloning and characterization of MEK6, a novel member of the mitogen-activated protein kinase kinase cascade". J. Biol. Chem. 271 (19): 11427–33. PMID 8626699.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Moriguchi T, Kuroyanagi N, Yamaguchi K; et al. (1996). "A novel kinase cascade mediated by mitogen-activated protein kinase kinase 6 and MKK3". J. Biol. Chem. 271 (23): 13675–9. PMID 8663074.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Cuenda A, Alonso G, Morrice N; et al. (1996). "Purification and cDNA cloning of SAPKK3, the major activator of RK/p38 in stress- and cytokine-stimulated monocytes and epithelial cells". EMBO J. 15 (16): 4156–64. PMID 8861944.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Goedert M, Cuenda A, Craxton M; et al. (1997). "Activation of the novel stress-activated protein kinase SAPK4 by cytokines and cellular stresses is mediated by SKK3 (MKK6); comparison of its substrate specificity with that of other SAP kinases". EMBO J. 16 (12): 3563–71. doi:10.1093/emboj/16.12.3563. PMID 9218798.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K; et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. PMID 9373149.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Enslen H, Raingeaud J, Davis RJ (1998). "Selective activation of p38 mitogen-activated protein (MAP) kinase isoforms by the MAP kinase kinases MKK3 and MKK6". J. Biol. Chem. 273 (3): 1741–8. PMID 9430721.CS1 maint: Multiple names: authors list (link)
• Chan-Hui PY, Weaver R (1999). "Human mitogen-activated protein kinase kinase kinase mediates the stress-induced activation of mitogen-activated protein kinase cascades". Biochem. J. 336 ( Pt 3): 599–609. PMID 9841871.
• Chen Z, Hutchison M, Cobb MH (1999). "Isolation of the protein kinase TAO2 and identification of its mitogen-activated protein kinase/extracellular signal-regulated kinase kinase binding domain". J. Biol. Chem. 274 (40): 28803–7. PMID 10497253.CS1 maint: Multiple names: authors list (link)
• Cong F, Goff SP (2000). "c-Abl-induced apoptosis, but not cell cycle arrest, requires mitogen-activated protein kinase kinase 6 activation". Proc. Natl. Acad. Sci. U.S.A. 96 (24): 13819–24. PMID 10570156.
• Wang X, McGowan CH, Zhao M; et al. (2000). "Involvement of the MKK6-p38gamma cascade in gamma-radiation-induced cell cycle arrest". Mol. Cell. Biol. 20 (13): 4543–52. PMID 10848581.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Visconti R, Gadina M, Chiariello M; et al. (2000). "Importance of the MKK6/p38 pathway for interleukin-12-induced STAT4 serine phosphorylation and transcriptional activity". Blood. 96 (5): 1844–52. PMID 10961885.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Fleming Y, Armstrong CG, Morrice N; et al. (2001). "Synergistic activation of stress-activated protein kinase 1/c-Jun N-terminal kinase (SAPK1/JNK) isoforms by mitogen-activated protein kinase kinase 4 (MKK4) and MKK7". Biochem. J. 352 Pt 1: 145–54. PMID 11062067.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Vitale G, Bernardi L, Napolitani G; et al. (2001). "Susceptibility of mitogen-activated protein kinase kinase family members to proteolysis by anthrax lethal factor". Biochem. J. 352 Pt 3: 739–45. PMID 11104681.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)