SLC10A2
| Solute carrier family 10 (sodium/bile acid cotransporter family), member 2 | |||||||||||
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| Identifiers | |||||||||||
| Symbols | SLC10A2 ; ASBT; ISBT; NTCP2 | ||||||||||
| External IDs | Template:OMIM5 Template:MGI HomoloGene: 390 | ||||||||||
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| RNA expression pattern | |||||||||||
| File:PBB GE SLC10A2 207095 at tn.png | |||||||||||
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| Template:GNF Ortholog box | |||||||||||
| Species | Human | Mouse | |||||||||
| Entrez | n/a | n/a | |||||||||
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| RefSeq (mRNA) | n/a | n/a | |||||||||
| RefSeq (protein) | n/a | n/a | |||||||||
| Location (UCSC) | n/a | n/a | |||||||||
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Solute carrier family 10 (sodium/bile acid cotransporter family), member 2, also known as SLC10A2, is a human gene.[1]
See also
References
Further reading
- Shneider BL (2001). "Intestinal bile acid transport: biology, physiology, and pathophysiology". J. Pediatr. Gastroenterol. Nutr. 32 (4): 407–17. PMID 11396803.
- Balakrishnan A, Polli JE (2006). "Apical sodium dependent bile acid transporter (ASBT, SLC10A2): a potential prodrug target". Mol. Pharm. 3 (3): 223–30. doi:10.1021/mp060022d. PMID 16749855.
- Wong MH, Oelkers P, Dawson PA (1995). "Identification of a mutation in the ileal sodium-dependent bile acid transporter gene that abolishes transport activity". J. Biol. Chem. 270 (45): 27228–34. PMID 7592981.
- Wong MH, Rao PN, Pettenati MJ, Dawson PA (1996). "Localization of the ileal sodium-bile acid cotransporter gene (SLC10A2) to human chromosome 13q33". Genomics. 33 (3): 538–40. doi:10.1006/geno.1996.0233. PMID 8661017.
- Oelkers P, Kirby LC, Heubi JE, Dawson PA (1997). "Primary bile acid malabsorption caused by mutations in the ileal sodium-dependent bile acid transporter gene (SLC10A2)". J. Clin. Invest. 99 (8): 1880–7. PMID 9109432.
- Craddock AL, Love MW, Daniel RW; et al. (1998). "Expression and transport properties of the human ileal and renal sodium-dependent bile acid transporter". Am. J. Physiol. 274 (1 Pt 1): G157–69. PMID 9458785.
- Montagnani M, Love MW, Rössel P; et al. (2002). "Absence of dysfunctional ileal sodium-bile acid cotransporter gene mutations in patients with adult-onset idiopathic bile acid malabsorption". Scand. J. Gastroenterol. 36 (10): 1077–80. PMID 11589382.
- Love MW, Craddock AL, Angelin B; et al. (2002). "Analysis of the ileal bile acid transporter gene, SLC10A2, in subjects with familial hypertriglyceridemia". Arterioscler. Thromb. Vasc. Biol. 21 (12): 2039–45. PMID 11742882.
- Jung D, Fried M, Kullak-Ublick GA (2002). "Human apical sodium-dependent bile salt transporter gene (SLC10A2) is regulated by the peroxisome proliferator-activated receptor alpha". J. Biol. Chem. 277 (34): 30559–66. doi:10.1074/jbc.M203511200. PMID 12055195.
- Zelcer N, Saeki T, Bot I; et al. (2003). "Transport of bile acids in multidrug-resistance-protein 3-overexpressing cells co-transfected with the ileal Na+-dependent bile-acid transporter". Biochem. J. 369 (Pt 1): 23–30. doi:10.1042/BJ20021081. PMID 12220224.
- Chumakov I, Blumenfeld M, Guerassimenko O; et al. (2002). "Genetic and physiological data implicating the new human gene G72 and the gene for D-amino acid oxidase in schizophrenia". Proc. Natl. Acad. Sci. U.S.A. 99 (21): 13675–80. doi:10.1073/pnas.182412499. PMID 12364586.
- Dunham A, Matthews LH, Burton J; et al. (2004). "The DNA sequence and analysis of human chromosome 13". Nature. 428 (6982): 522–8. doi:10.1038/nature02379. PMID 15057823.
- Neimark E, Chen F, Li X, Shneider BL (2004). "Bile acid-induced negative feedback regulation of the human ileal bile acid transporter". Hepatology. 40 (1): 149–56. doi:10.1002/hep.20295. PMID 15239098.
- Xia X, Roundtree M, Merikhi A; et al. (2004). "Degradation of the apical sodium-dependent bile acid transporter by the ubiquitin-proteasome pathway in cholangiocytes". J. Biol. Chem. 279 (43): 44931–7. doi:10.1074/jbc.M400969200. PMID 15304498.
- Zhang EY, Phelps MA, Banerjee A; et al. (2004). "Topology scanning and putative three-dimensional structure of the extracellular binding domains of the apical sodium-dependent bile acid transporter (SLC10A2)". Biochemistry. 43 (36): 11380–92. doi:10.1021/bi049270a. PMID 15350125.
- Banerjee A, Ray A, Chang C, Swaan PW (2005). "Site-directed mutagenesis and use of bile acid-MTS conjugates to probe the role of cysteines in the human apical sodium-dependent bile acid transporter (SLC10A2)". Biochemistry. 44 (24): 8908–17. doi:10.1021/bi050553s. PMID 15952798.
- Nakahara M, Furuya N, Takagaki K; et al. (2006). "Ileal bile acid-binding protein, functionally associated with the farnesoid X receptor or the ileal bile acid transporter, regulates bile acid activity in the small intestine". J. Biol. Chem. 280 (51): 42283–9. doi:10.1074/jbc.M507454200. PMID 16230354.
- Bergheim I, Harsch S, Mueller O; et al. (2006). "Apical sodium bile acid transporter and ileal lipid binding protein in gallstone carriers". J. Lipid Res. 47 (1): 42–50. doi:10.1194/jlr.M500215-JLR200. PMID 16237211.
- Banerjee A, Swaan PW (2006). "Membrane topology of human ASBT (SLC10A2) determined by dual label epitope insertion scanning mutagenesis. New evidence for seven transmembrane domains". Biochemistry. 45 (3): 943–53. doi:10.1021/bi052202j. PMID 16411770.
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