SLC12A6

Solute carrier family 12 (potassium/chloride transporters), member 6
Identifiers
Symbols	SLC12A6 ; ACCPN; DKFZP434D2135; KCC3; KCC3A; KCC3B
External IDs	Template:OMIM5 Template:MGI HomoloGene: 21069
Gene ontology Molecular function Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Biological process Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO
RNA expression pattern
File:PBB GE SLC12A6 220740 s at tn.png
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Solute carrier family 12 (potassium/chloride transporters), member 6, also known as SLC12A6, is a human gene.

This gene is a member of the K-Cl cotransporter (KCC) family. K-Cl cotransporters are integral membrane proteins that lower intracellular chloride concentrations below the electrochemical equilibrium potential. The proteins encoded by this gene are activated by cell swelling induced by hypotonic conditions. Alternate splicing results in multiple transcript variants encoding different isoforms. Mutations in this gene are associated with agenesis of the corpus callosum with peripheral neuropathy.

See also

• Solute carrier family

Further reading

• Hiki K, D'Andrea RJ, Furze J; et al. (1999). "Cloning, characterization, and chromosomal location of a novel human K+-Cl- cotransporter". J. Biol. Chem. 274 (15): 10661–7. PMID 10187864.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Mount DB, Mercado A, Song L; et al. (1999). "Cloning and characterization of KCC3 and KCC4, new members of the cation-chloride cotransporter gene family". J. Biol. Chem. 274 (23): 16355–62. PMID 10347194.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Race JE, Makhlouf FN, Logue PJ; et al. (2000). "Molecular cloning and functional characterization of KCC3, a new K-Cl cotransporter". Am. J. Physiol. 277 (6 Pt 1): C1210–9. PMID 10600773.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Casula S, Shmukler BE, Wilhelm S; et al. (2001). "A dominant negative mutant of the KCC1 K-Cl cotransporter: both N- and C-terminal cytoplasmic domains are required for K-Cl cotransport activity". J. Biol. Chem. 276 (45): 41870–8. doi:10.1074/jbc.M107155200. PMID 11551954.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Howard HC, Mount DB, Rochefort D; et al. (2002). "The K-Cl cotransporter KCC3 is mutant in a severe peripheral neuropathy associated with agenesis of the corpus callosum". Nat. Genet. 32 (3): 384–92. doi:10.1038/ng1002. PMID 12368912.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Bräuer M, Frei E, Claes L; et al. (2003). "Influence of K-Cl cotransporter activity on activation of volume-sensitive Cl- channels in human osteoblasts". Am. J. Physiol., Cell Physiol. 285 (1): C22–30. doi:10.1152/ajpcell.00289.2002. PMID 12637262.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Bergeron MJ, Gagnon E, Wallendorff B; et al. (2003). "Ammonium transport and pH regulation by K(+)-Cl(-) cotransporters". Am. J. Physiol. Renal Physiol. 285 (1): F68–78. doi:10.1152/ajprenal.00032.2003. PMID 12657561.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Shen MR, Lin AC, Hsu YM; et al. (2004). "Insulin-like growth factor 1 stimulates KCl cotransport, which is necessary for invasion and proliferation of cervical cancer and ovarian cancer cells". J. Biol. Chem. 279 (38): 40017–25. doi:10.1074/jbc.M406706200. PMID 15262997.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Mercado A, Vázquez N, Song L; et al. (2005). "NH2-terminal heterogeneity in the KCC3 K+-Cl- cotransporter". Am. J. Physiol. Renal Physiol. 289 (6): F1246–61. doi:10.1152/ajprenal.00464.2004. PMID 16048901.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Uyanik G, Elcioglu N, Penzien J; et al. (2006). "Novel truncating and missense mutations of the KCC3 gene associated with Andermann syndrome". Neurology. 66 (7): 1044–8. doi:10.1212/01.wnl.0000204181.31175.8b. PMID 16606917.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Hsu YM, Chou CY, Chen HH; et al. (2007). "IGF-1 upregulates electroneutral K-Cl cotransporter KCC3 and KCC4 which are differentially required for breast cancer cell proliferation and invasiveness". J. Cell. Physiol. 210 (3): 626–36. doi:10.1002/jcp.20859. PMID 17133354.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Salin-Cantegrel A, Rivière JB, Dupré N; et al. (2007). "Distal truncation of KCC3 in non-French Canadian HMSN/ACC families". Neurology. 69 (13): 1350–5. doi:10.1212/01.wnl.0000291779.35643.15. PMID 17893295.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Hsu YM, Chen YF, Chou CY; et al. (2007). "KCl cotransporter-3 down-regulates E-cadherin/beta-catenin complex to promote epithelial-mesenchymal transition". Cancer Res. 67 (22): 11064–73. doi:10.1158/0008-5472.CAN-07-2443. PMID 18006853.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.