SLC22A4
| Solute carrier family 22 (organic cation transporter), member 4 | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||||
| Symbols | SLC22A4 ; MGC34546; MGC40524; OCTN1 | ||||||||||
| External IDs | Template:OMIM5 Template:MGI HomoloGene: 81701 | ||||||||||
| |||||||||||
| RNA expression pattern | |||||||||||
| File:PBB GE SLC22A4 205896 at tn.png | |||||||||||
| More reference expression data | |||||||||||
| Orthologs | |||||||||||
| Template:GNF Ortholog box | |||||||||||
| Species | Human | Mouse | |||||||||
| Entrez | n/a | n/a | |||||||||
| Ensembl | n/a | n/a | |||||||||
| UniProt | n/a | n/a | |||||||||
| RefSeq (mRNA) | n/a | n/a | |||||||||
| RefSeq (protein) | n/a | n/a | |||||||||
| Location (UCSC) | n/a | n/a | |||||||||
| PubMed search | n/a | n/a | |||||||||
Solute carrier family 22 (organic cation transporter), member 4, also known as SLC22A4, is a human gene.[1]
Polyspecific organic cation transporters in the liver, kidney, intestine, and other organs are critical for elimination of many endogenous small organic cations as well as a wide array of drugs and environmental toxins. The encoded protein is an organic cation transporter and plasma integral membrane protein containing eleven putative transmembrane domains as well as a nucleotide-binding site motif. Transport by this protein is at least partially ATP-dependent.[1]
See also
References
Further reading
- Xuan W, Lamhonwah AM, Librach C; et al. (2003). "Characterization of organic cation/carnitine transporter family in human sperm". Biochem. Biophys. Res. Commun. 306 (1): 121–8. PMID 12788076.
- Yamada R, Tokuhiro S, Chang X, Yamamoto K (2005). "SLC22A4 and RUNX1: identification of RA susceptible genes". J. Mol. Med. 82 (9): 558–64. doi:10.1007/s00109-004-0547-y. PMID 15184985.
- Silverberg MS (2006). "OCTNs: will the real IBD5 gene please stand up?". World J. Gastroenterol. 12 (23): 3678–81. PMID 16773684.
- Tamai I, Yabuuchi H, Nezu J; et al. (1998). "Cloning and characterization of a novel human pH-dependent organic cation transporter, OCTN1". FEBS Lett. 419 (1): 107–11. PMID 9426230.
- Meyer-Wentrup F, Karbach U, Gorboulev V; et al. (1998). "Membrane localization of the electrogenic cation transporter rOCT1 in rat liver". Biochem. Biophys. Res. Commun. 248 (3): 673–8. doi:10.1006/bbrc.1998.9034. PMID 9703985.
- Urakami Y, Okuda M, Masuda S; et al. (1998). "Functional characteristics and membrane localization of rat multispecific organic cation transporters, OCT1 and OCT2, mediating tubular secretion of cationic drugs". J. Pharmacol. Exp. Ther. 287 (2): 800–5. PMID 9808712.
- Yabuuchi H, Tamai I, Nezu J; et al. (1999). "Novel membrane transporter OCTN1 mediates multispecific, bidirectional, and pH-dependent transport of organic cations". J. Pharmacol. Exp. Ther. 289 (2): 768–73. PMID 10215651.
- Alcorn J, Lu X, Moscow JA, McNamara PJ (2002). "Transporter gene expression in lactating and nonlactating human mammary epithelial cells using real-time reverse transcription-polymerase chain reaction". J. Pharmacol. Exp. Ther. 303 (2): 487–96. doi:10.1124/jpet.102.038315. PMID 12388627.
- Saito S, Iida A, Sekine A; et al. (2003). "Catalog of 238 variations among six human genes encoding solute carriers ( hSLCs) in the Japanese population". J. Hum. Genet. 47 (11): 576–84. doi:10.1007/s100380200088. PMID 12436193.
- Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
- Eraly SA, Hamilton BA, Nigam SK (2003). "Organic anion and cation transporters occur in pairs of similar and similarly expressed genes". Biochem. Biophys. Res. Commun. 300 (2): 333–42. PMID 12504088.
- Gisler SM, Pribanic S, Bacic D; et al. (2004). "PDZK1: I. a major scaffolder in brush borders of proximal tubular cells". Kidney Int. 64 (5): 1733–45. doi:10.1046/j.1523-1755.2003.00266.x. PMID 14531806.
- Tokuhiro S, Yamada R, Chang X; et al. (2004). "An intronic SNP in a RUNX1 binding site of SLC22A4, encoding an organic cation transporter, is associated with rheumatoid arthritis". Nat. Genet. 35 (4): 341–8. doi:10.1038/ng1267. PMID 14608356.
- Peltekova VD, Wintle RF, Rubin LA; et al. (2004). "Functional variants of OCTN cation transporter genes are associated with Crohn disease". Nat. Genet. 36 (5): 471–5. doi:10.1038/ng1339. PMID 15107849.
- Kawasaki Y, Kato Y, Sai Y, Tsuji A (2005). "Functional characterization of human organic cation transporter OCTN1 single nucleotide polymorphisms in the Japanese population". Journal of pharmaceutical sciences. 93 (12): 2920–6. doi:10.1002/jps.20190. PMID 15459889.
- Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
- Newman B, Gu X, Wintle R; et al. (2005). "A risk haplotype in the Solute Carrier Family 22A4/22A5 gene cluster influences phenotypic expression of Crohn's disease". Gastroenterology. 128 (2): 260–9. PMID 15685536.
- Gründemann D, Harlfinger S, Golz S; et al. (2005). "Discovery of the ergothioneine transporter". Proc. Natl. Acad. Sci. U.S.A. 102 (14): 5256–61. doi:10.1073/pnas.0408624102. PMID 15795384.
| Stub icon | This membrane protein–related article is a stub. You can help Wikipedia by expanding it. |
This article incorporates text from the United States National Library of Medicine, which is in the public domain.