SLC22A7
| Solute carrier family 22 (organic anion transporter), member 7 | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||||
| Symbols | SLC22A7 ; MGC24091; MGC45202; NLT; OAT2 | ||||||||||
| External IDs | Template:OMIM5 Template:MGI HomoloGene: 21328 | ||||||||||
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| RNA expression pattern | |||||||||||
| File:PBB GE SLC22A7 220554 at tn.png | |||||||||||
| File:PBB GE SLC22A7 221661 at tn.png | |||||||||||
| File:PBB GE SLC22A7 221662 s at tn.png | |||||||||||
| More reference expression data | |||||||||||
| Orthologs | |||||||||||
| Template:GNF Ortholog box | |||||||||||
| Species | Human | Mouse | |||||||||
| Entrez | n/a | n/a | |||||||||
| Ensembl | n/a | n/a | |||||||||
| UniProt | n/a | n/a | |||||||||
| RefSeq (mRNA) | n/a | n/a | |||||||||
| RefSeq (protein) | n/a | n/a | |||||||||
| Location (UCSC) | n/a | n/a | |||||||||
| PubMed search | n/a | n/a | |||||||||
Solute carrier family 22 (organic anion transporter), member 7, also known as SLC22A7, is a human gene.[1]
The protein encoded by this gene is involved in the sodium-independent transport and excretion of organic anions, some of which are potentially toxic. The encoded protein is an integral membrane protein and appears to be localized to the basolateral membrane of the kidney. Alternatively spliced transcript variants encoding different isoforms have been described.[1]
See also
- SLC22A7+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)
References
Further reading
- Cropp CD, Komori T, Shima JE; et al. (2008). "Organic anion transporter 2 (SLC22A7) is a facilitative transporter of cGMP". Mol. Pharmacol. 73 (4): 1151–8. doi:10.1124/mol.107.043117. PMID 18216183.
- Kimura K, Wakamatsu A, Suzuki Y; et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMID 16344560.
- Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
- Enomoto A, Takeda M, Shimoda M; et al. (2002). "Interaction of human organic anion transporters 2 and 4 with organic anion transport inhibitors". J. Pharmacol. Exp. Ther. 301 (3): 797–802. PMID 12023506.
- Kimura H, Takeda M, Narikawa S; et al. (2002). "Human organic anion transporters and human organic cation transporters mediate renal transport of prostaglandins". J. Pharmacol. Exp. Ther. 301 (1): 293–8. PMID 11907186.
- Babu E, Takeda M, Narikawa S; et al. (2002). "Human organic anion transporters mediate the transport of tetracycline". Jpn. J. Pharmacol. 88 (1): 69–76. PMID 11855680.
- Sun W, Wu RR, van Poelje PD, Erion MD (2001). "Isolation of a family of organic anion transporters from human liver and kidney". Biochem. Biophys. Res. Commun. 283 (2): 417–22. doi:10.1006/bbrc.2001.4774. PMID 11327718.
- Kok LD, Siu SS, Fung KP; et al. (2000). "Assignment of liver-specific organic anion transporter (SLC22A7) to human chromosome 6 bands p21.2-->p21.1 using radiation hybrids". Cytogenet. Cell Genet. 88 (1–2): 76–7. PMID 10773670.
- Sekine T, Cha SH, Tsuda M; et al. (1998). "Identification of multispecific organic anion transporter 2 expressed predominantly in the liver". FEBS Lett. 429 (2): 179–82. PMID 9650585.
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This article incorporates text from the United States National Library of Medicine, which is in the public domain.