Sodium-hydrogen antiporter 3 regulator 1

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Solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 1
File:PBB Protein SLC9A3R1 image.jpg
PDB rendering based on 1g9o.
Available structures
PDB Ortholog search: Template:Homologene2PDBe PDBe, Template:Homologene2uniprot RCSB
Identifiers
Symbols SLC9A3R1 ; EBP50; NHERF
External IDs Template:OMIM5 Template:MGI HomoloGene: 3137
RNA expression pattern
File:PBB GE SLC9A3R1 201349 at tn.png
More reference expression data
Orthologs
Template:GNF Ortholog box
Species Human Mouse
Entrez n/a n/a
Ensembl n/a n/a
UniProt n/a n/a
RefSeq (mRNA) n/a n/a
RefSeq (protein) n/a n/a
Location (UCSC) n/a n/a
PubMed search n/a n/a

Sodium-hydrogen antiporter 3 regulator 1 is a regulator of Sodium-hydrogen antiporter 3. It is encoded by the gene SLC9A3R1.

Mechanism

Members of the ezrin (VIL2; MIM 123900)-radixin (RDX; MIM 179410)-moesin (MSN; MIM 309845) (ERM) protein family are highly concentrated in the apical aspect of polarized epithelial cells. These cells are studded with microvilli containing bundles of actin filaments, which must attach to the membrane to assemble and maintain the microvilli. The ERM proteins, together with merlin, the NF2 (MIM 607379) gene product, are thought to be linkers between integral membrane and cytoskeletal proteins, and they bind directly to actin in vitro. Actin cytoskeleton reorganization requires the activation of a sodium/hydrogen exchanger (SLC9A3; MIM 182307). SLC9A3R1 is an ERM-binding protein.[supplied by OMIM][1]


See also

References

  1. ↑ "Entrez Gene: SLC9A3R1 solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 1".

Further reading

  • Weinman EJ, Steplock D, Wang Y, Shenolikar S (1995). "Characterization of a protein cofactor that mediates protein kinase A regulation of the renal brush border membrane Na(+)-H+ exchanger". J. Clin. Invest. 95 (5): 2143–9. PMID 7738182.
  • Yun CH, Oh S, Zizak M; et al. (1997). "cAMP-mediated inhibition of the epithelial brush border Na+/H+ exchanger, NHE3, requires an associated regulatory protein". Proc. Natl. Acad. Sci. U.S.A. 94 (7): 3010–5. PMID 9096337.
  • Reczek D, Berryman M, Bretscher A (1998). "Identification of EBP50: A PDZ-containing phosphoprotein that associates with members of the ezrin-radixin-moesin family". J. Cell Biol. 139 (1): 169–79. PMID 9314537.
  • Murthy A, Gonzalez-Agosti C, Cordero E; et al. (1998). "NHE-RF, a regulatory cofactor for Na(+)-H+ exchange, is a common interactor for merlin and ERM (MERM) proteins". J. Biol. Chem. 273 (3): 1273–6. PMID 9430655.
  • Hall RA, Premont RT, Chow CW; et al. (1998). "The beta2-adrenergic receptor interacts with the Na+/H+-exchanger regulatory factor to control Na+/H+ exchange". Nature. 392 (6676): 626–30. doi:10.1038/33458. PMID 9560162.
  • Wang S, Raab RW, Schatz PJ; et al. (1998). "Peptide binding consensus of the NHE-RF-PDZ1 domain matches the C-terminal sequence of cystic fibrosis transmembrane conductance regulator (CFTR)". FEBS Lett. 427 (1): 103–8. PMID 9613608.
  • Hall RA, Ostedgaard LS, Premont RT; et al. (1998). "A C-terminal motif found in the beta2-adrenergic receptor, P2Y1 receptor and cystic fibrosis transmembrane conductance regulator determines binding to the Na+/H+ exchanger regulatory factor family of PDZ proteins". Proc. Natl. Acad. Sci. U.S.A. 95 (15): 8496–501. PMID 9671706.
  • Short DB, Trotter KW, Reczek D; et al. (1998). "An apical PDZ protein anchors the cystic fibrosis transmembrane conductance regulator to the cytoskeleton". J. Biol. Chem. 273 (31): 19797–801. PMID 9677412.
  • Hall RA, Spurney RF, Premont RT; et al. (1999). "G protein-coupled receptor kinase 6A phosphorylates the Na(+)/H(+) exchanger regulatory factor via a PDZ domain-mediated interaction". J. Biol. Chem. 274 (34): 24328–34. PMID 10446210.
  • Cao TT, Deacon HW, Reczek D; et al. (1999). "A kinase-regulated PDZ-domain interaction controls endocytic sorting of the beta2-adrenergic receptor". Nature. 401 (6750): 286–90. doi:10.1038/45816. PMID 10499588.
  • Mohler PJ, Kreda SM, Boucher RC; et al. (1999). "Yes-associated protein 65 localizes p62(c-Yes) to the apical compartment of airway epithelia by association with EBP50". J. Cell Biol. 147 (4): 879–90. PMID 10562288.
  • Breton S, Wiederhold T, Marshansky V; et al. (2000). "The B1 subunit of the H+ATPase is a PDZ domain-binding protein. Colocalization with NHE-RF in renal B-intercalated cells". J. Biol. Chem. 275 (24): 18219–24. doi:10.1074/jbc.M909857199. PMID 10748165.
  • Moyer BD, Duhaime M, Shaw C; et al. (2000). "The PDZ-interacting domain of cystic fibrosis transmembrane conductance regulator is required for functional expression in the apical plasma membrane". J. Biol. Chem. 275 (35): 27069–74. doi:10.1074/jbc.M004951200. PMID 10852925.
  • Tang Y, Tang J, Chen Z; et al. (2001). "Association of mammalian trp4 and phospholipase C isozymes with a PDZ domain-containing protein, NHERF". J. Biol. Chem. 275 (48): 37559–64. doi:10.1074/jbc.M006635200. PMID 10980202.
  • Maudsley S, Zamah AM, Rahman N; et al. (2000). "Platelet-derived growth factor receptor association with Na(+)/H(+) exchanger regulatory factor potentiates receptor activity". Mol. Cell. Biol. 20 (22): 8352–63. PMID 11046132.
  • Gisler SM, Stagljar I, Traebert M; et al. (2001). "Interaction of the type IIa Na/Pi cotransporter with PDZ proteins". J. Biol. Chem. 276 (12): 9206–13. doi:10.1074/jbc.M008745200. PMID 11099500.
  • Reczek D, Bretscher A (2001). "Identification of EPI64, a TBC/rabGAP domain-containing microvillar protein that binds to the first PDZ domain of EBP50 and E3KARP". J. Cell Biol. 153 (1): 191–206. PMID 11285285.
  • Karthikeyan S, Leung T, Ladias JA (2001). "Structural basis of the Na+/H+ exchanger regulatory factor PDZ1 interaction with the carboxyl-terminal region of the cystic fibrosis transmembrane conductance regulator". J. Biol. Chem. 276 (23): 19683–6. doi:10.1074/jbc.C100154200. PMID 11304524.
  • Karthikeyan S, Leung T, Birrane G; et al. (2001). "Crystal structure of the PDZ1 domain of human Na(+)/H(+) exchanger regulatory factor provides insights into the mechanism of carboxyl-terminal leucine recognition by class I PDZ domains". J. Mol. Biol. 308 (5): 963–73. doi:10.1006/jmbi.2001.4634. PMID 11352585.
  • Brdicková N, Brdicka T, Andera L; et al. (2001). "Interaction between two adapter proteins, PAG and EBP50: a possible link between membrane rafts and actin cytoskeleton". FEBS Lett. 507 (2): 133–6. PMID 11684085.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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