TAP2

Transporter 2, ATP-binding cassette, sub-family B (MDR/TAP)
Identifiers
Symbols	TAP2 ; ABC18; ABCB3; APT2; D6S217E; PSF2; RING11
External IDs	Template:OMIM5 Template:MGI HomoloGene: 37323
Gene ontology Molecular function Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Biological process Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO
RNA expression pattern
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Overview

Transporter 2, ATP-binding cassette, sub-family B (MDR/TAP), also known as TAP2, is a human gene. The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance. This gene is located 7 kb telomeric to gene family member ABCB2. The protein encoded by this gene is involved in antigen presentation. This protein forms a heterodimer with ABCB2 in order to transport peptides from the cytoplasm to the endoplasmic reticulum. Mutations in this gene may be associated with ankylosing spondylitis, insulin-dependent diabetes mellitus, and celiac disease. Alternative splicing of this gene produces two products which differ in peptide selectivity and level of restoration of surface expression of MHC class I molecules.

See also

• ATP-binding cassette transporter

Further reading

• Townsend A, Trowsdale J (1993). "The transporters associated with antigen presentation". Semin. Cell Biol. 4 (1): 53–61. PMID 8453065.
• Beck S, Kelly A, Radley E; et al. (1992). "DNA sequence analysis of 66 kb of the human MHC class II region encoding a cluster of genes for antigen processing". J. Mol. Biol. 228 (2): 433–41. PMID 1453454.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Bodmer JG, Marsh SG, Albert ED; et al. (1992). "Nomenclature for factors of the HLA system, 1991. WHO Nomenclature Committee for factors of the HLA system". Tissue Antigens. 39 (4): 161–73. PMID 1529427.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Kelly A, Powis SH, Kerr LA; et al. (1992). "Assembly and function of the two ABC transporter proteins encoded in the human major histocompatibility complex". Nature. 355 (6361): 641–4. doi:10.1038/355641a0. PMID 1538751.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Colonna M, Bresnahan M, Bahram S; et al. (1992). "Allelic variants of the human putative peptide transporter involved in antigen processing". Proc. Natl. Acad. Sci. U.S.A. 89 (9): 3932–6. PMID 1570316.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Powis SH, Mockridge I, Kelly A; et al. (1992). "Polymorphism in a second ABC transporter gene located within the class II region of the human major histocompatibility complex". Proc. Natl. Acad. Sci. U.S.A. 89 (4): 1463–7. PMID 1741401.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Bahram S, Arnold D, Bresnahan M; et al. (1991). "Two putative subunits of a peptide pump encoded in the human major histocompatibility complex class II region". Proc. Natl. Acad. Sci. U.S.A. 88 (22): 10094–8. PMID 1946428.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Trowsdale J, Hanson I, Mockridge I; et al. (1991). "Sequences encoded in the class II region of the MHC related to the 'ABC' superfamily of transporters". Nature. 348 (6303): 741–4. doi:10.1038/348741a0. PMID 2259383.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• de la Salle H, Hanau D, Fricker D; et al. (1994). "Homozygous human TAP peptide transporter mutation in HLA class I deficiency". Science. 265 (5169): 237–41. PMID 7517574.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Cano P, Baxter-Lowe LA (1995). "Novel human TAP2*103 allele shows further polymorphism in the ATP-binding domain". Tissue Antigens. 45 (2): 139–42. PMID 7792761.
• Roby KF, Fei K, Yang Y, Hunt JS (1995). "Expression of HLA class II-associated peptide transporter and proteasome genes in human placentas and trophoblast cell lines". Immunology. 83 (3): 444–8. PMID 7835969.CS1 maint: Multiple names: authors list (link)
• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. PMID 8125298.
• Singal DP, Ye M, Qiu X, D'Souza M (1994). "Polymorphisms in the TAP2 gene and their association with rheumatoid arthritis". Clin. Exp. Rheumatol. 12 (1): 29–33. PMID 8162639.CS1 maint: Multiple names: authors list (link)
• Powis SH, Tonks S, Mockridge I; et al. (1993). "Alleles and haplotypes of the MHC-encoded ABC transporters TAP1 and TAP2". Immunogenetics. 37 (5): 373–80. PMID 8428770.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Glynne R, Kerr LA, Mockridge I; et al. (1993). "The major histocompatibility complex-encoded proteasome component LMP7: alternative first exons and post-translational processing". Eur. J. Immunol. 23 (4): 860–6. PMID 8458375.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Beck S, Abdulla S, Alderton RP; et al. (1996). "Evolutionary dynamics of non-coding sequences within the class II region of the human MHC". J. Mol. Biol. 255 (1): 1–13. doi:10.1006/jmbi.1996.0001. PMID 8568858.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Ahn K, Meyer TH, Uebel S; et al. (1996). "Molecular mechanism and species specificity of TAP inhibition by herpes simplex virus ICP47". EMBO J. 15 (13): 3247–55. PMID 8670825.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Pattanakitsakul S, Takeuchi F, Nabeta H; et al. (1996). "A novel TAP 2 gene RFLP observed in a Japanese". Tissue Antigens. 47 (4): 353–5. PMID 8773329.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Lewis JW, Neisig A, Neefjes J, Elliott T (1997). "Point mutations in the alpha 2 domain of HLA-A2.1 define a functionally relevant interaction with TAP". Curr. Biol. 6 (7): 873–83. PMID 8805302.CS1 maint: Multiple names: authors list (link)

External links

• TAP2+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.