Low molecular weight phosphotyrosine protein phosphatase is an enzyme that in humans is encoded by the ACP1gene.
The product of this gene belongs to the phosphotyrosine protein phosphatase family of proteins. It functions as an acid phosphatase and a protein tyrosine phosphatase by hydrolyzing protein tyrosine phosphate to protein tyrosine and orthophosphate. This enzyme also hydrolyzes orthophosphoric monoesters to alcohol and orthophosphate. This gene is genetically polymorphic, and three common alleles segregating at the corresponding locus give rise to six phenotypes. Each allele appears to encode at least two electrophoretically different isozymes, Bf and Bs, which are produced in allele-specific ratios. Three transcript variants encoding distinct isoforms have been identified for this gene.[1]
↑Kikawa, Keith D; Vidale Derika R; Van Etten Robert L; Kinch Michael S (October 2002). "Regulation of the EphA2 kinase by the low molecular weight tyrosine phosphatase induces transformation". J. Biol. Chem. United States. 277 (42): 39274–9. doi:10.1074/jbc.M207127200. ISSN0021-9258. PMID12167657.
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Tailor P, Gilman J, Williams S, et al. (1997). "Regulation of the low molecular weight phosphotyrosine phosphatase by phosphorylation at tyrosines 131 and 132". J. Biol. Chem. 272 (9): 5371–4. doi:10.1074/jbc.272.9.5371. PMID9038134.
Modesti A, Marzocchini R, Raugei G, et al. (1998). "Cloning, expression and characterisation of a new human low Mr phosphotyrosine protein phosphatase originating by alternative splicing". FEBS Lett. 431 (1): 111–5. doi:10.1016/S0014-5793(98)00732-7. PMID9684876.
Zhang M, Stauffacher CV, Lin D, Van Etten RL (1998). "Crystal structure of a human low molecular weight phosphotyrosyl phosphatase. Implications for substrate specificity". J. Biol. Chem. 273 (34): 21714–20. doi:10.1074/jbc.273.34.21714. PMID9705307.
Tailor P, Gilman J, Williams S, Mustelin T (1999). "A novel isoform of the low molecular weight phosphotyrosine phosphatase, LMPTP-C, arising from alternative mRNA splicing". Eur. J. Biochem. 262 (2): 277–82. doi:10.1046/j.1432-1327.1999.00353.x. PMID10336608.
Huang L, Sankar S, Lin C, et al. (2000). "HCPTPA, a protein tyrosine phosphatase that regulates vascular endothelial growth factor receptor-mediated signal transduction and biological activity". J. Biol. Chem. 274 (53): 38183–8. doi:10.1074/jbc.274.53.38183. PMID10608891.
Bottini N, Stefanini L, Williams S, et al. (2002). "Activation of ZAP-70 through specific dephosphorylation at the inhibitory Tyr-292 by the low molecular weight phosphotyrosine phosphatase (LMPTP)". J. Biol. Chem. 277 (27): 24220–4. doi:10.1074/jbc.M202885200. PMID11976341.
Kikawa KD, Vidale DR, Van Etten RL, Kinch MS (2002). "Regulation of the EphA2 kinase by the low molecular weight tyrosine phosphatase induces transformation". J. Biol. Chem. 277 (42): 39274–9. doi:10.1074/jbc.M207127200. PMID12167657.