Putative tyrosine-protein phosphatase TPTE is an enzyme that in humans is encoded by the TPTEgene.[1][2]
Function
TPTE is a member of a large class of membrane-associated phosphatases with substrate specificity for the 3-position phosphate of inositolphospholipids.[2] TPTE is a primate-specific duplicate of the TPTE2 (TPIP) inositol phospholipd phosphatase;[3] TPTE itself is predicted to lack phosphatase activity.[4] TPTE and TPTE2 are the mammalian homologues to the subfamily of voltage sensitive phosphatases.
References
↑Tapparel C, Reymond A, Girardet C, Guillou L, Lyle R, Lamon C, Hutter P, Antonarakis SE (Dec 2003). "The TPTE gene family: cellular expression, subcellular localization and alternative splicing". Gene. 323: 189–99. doi:10.1016/j.gene.2003.09.038. PMID14659893.
Antonarakis SE (1998). "10 years of Genomics, chromosome 21, and Down syndrome". Genomics. 51 (1): 1–16. doi:10.1006/geno.1998.5335. PMID9693027.
Chen H, Rossier C, Morris MA, et al. (2000). "A testis-specific gene, TPTE, encodes a putative transmembrane tyrosine phosphatase and maps to the pericentromeric region of human chromosomes 21 and 13, and to chromosomes 15, 22, and Y.". Hum. Genet. 105 (5): 399–409. doi:10.1007/s004390051122. PMID10598804.
Guipponi M, Yaspo ML, Riesselman L, et al. (2000). "Genomic structure of a copy of the human TPTE gene which encompasses 87 kb on the short arm of chromosome 21". Hum. Genet. 107 (2): 127–31. doi:10.1007/s004390000343. PMID11030409.
Wu Y, Dowbenko D, Pisabarro MT, et al. (2001). "PTEN 2, a Golgi-associated testis-specific homologue of the PTEN tumor suppressor lipid phosphatase". J. Biol. Chem. 276 (24): 21745–53. doi:10.1074/jbc.M101480200. PMID11279206.
Guipponi M, Tapparel C, Jousson O, et al. (2002). "The murine orthologue of the Golgi-localized TPTE protein provides clues to the evolutionary history of the human TPTE gene family". Hum. Genet. 109 (6): 569–75. doi:10.1007/s004390100607. PMID11810268.
