CatSper1

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Identifiers
Aliases
External IDs	GeneCards: [1]
Orthologs
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a
Wikidata
View/Edit Human

CatSper1, is a protein which in humans is encoded by the CATSPER1 gene. CatSper1 is a member of the cation channels of sperm family of protein. The four proteins in this family together form a Ca²⁺-permeant ion channel specific essential for the correct function of sperm cells.

Function

Calcium ions play a primary role in the regulation of sperm motility. This gene belongs to a family of putative cation channels that are specific to spermatozoa and localize to the flagellum. The protein family features a single repeat with six membrane-spanning segments and a predicted calcium-selective pore region.

Further reading

• Li HG, Liao AH, Ding XF, et al. (2006). "The expression and significance of CATSPER1 in human testis and ejaculated spermatozoa". Asian J. Androl. 8 (3): 301–6. doi:10.1111/j.1745-7262.2006.00132.x. PMID 16625279.
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
• Zhang D, Chen J, Saraf A, et al. (2006). "Association of Catsper1 or -2 with Ca(v)3.3 leads to suppression of T-type calcium channel activity". J. Biol. Chem. 281 (31): 22332–41. doi:10.1074/jbc.M511288200. PMID 16740636.
• Avenarius MR, Hildebrand MS, Zhang Y, et al. (2009). "Human Male Infertility Caused by Mutations in the CATSPER1 Channel Protein". Am. J. Hum. Genet. 84 (4): 505–10. doi:10.1016/j.ajhg.2009.03.004. PMC 2667975. PMID 19344877.
• Garbers DL (2001). "Ion channels. Swimming with sperm". Nature. 413 (6856): 579, 581–2. doi:10.1038/35098164. PMID 11595929.
• Quill TA, Ren D, Clapham DE, Garbers DL (2001). "A voltage-gated ion channel expressed specifically in spermatozoa". Proc. Natl. Acad. Sci. U.S.A. 98 (22): 12527–31. doi:10.1073/pnas.221454998. PMC 60087. PMID 11675491.
• Clapham DE, Garbers DL (2005). "International Union of Pharmacology. L. Nomenclature and structure-function relationships of CatSper and two-pore channels". Pharmacol. Rev. 57 (4): 451–4. doi:10.1124/pr.57.4.7. PMID 16382101.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Nikpoor P, Mowla SJ, Movahedin M, et al. (2004). "CatSper gene expression in postnatal development of mouse testis and in subfertile men with deficient sperm motility". Hum. Reprod. 19 (1): 124–8. doi:10.1093/humrep/deh043. PMID 14688170.
• Ren D, Navarro B, Perez G, et al. (2001). "A sperm ion channel required for sperm motility and male fertility". Nature. 413 (6856): 603–9. doi:10.1038/35098027. PMID 11595941.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.