Cyclin E2
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| cyclin E2 | |
|---|---|
| Identifiers | |
| Symbol | CCNE2 |
| Entrez | 9134 |
| HUGO | 1590 |
| OMIM | 603775 |
| RefSeq | NM_057749 |
| UniProt | O96020 |
| Other data | |
| Locus | Chr. 8 q22.1 |
Cyclin E2 is a protein that in humans is encoded by the CCNE2 gene. It is a G1 cyclin that binds Cdk2 and is inhibited by p27(Kip1) and p21(Cip1).[1] It plays a role in the G1/S portion of the cell cycle and also has putative interactions with proteins CDKN1A, CDKN1B, and CDK3. Aberrant expression can lead to cancer.[1]
References
- ↑ 1.0 1.1 Gudas JM, Payton M, Thukral S, Chen E, Bass M, Robinson MO, Coats S (January 1999). "Cyclin E2, a novel G1 cyclin that binds Cdk2 and is aberrantly expressed in human cancers". Molecular and Cellular Biology. 19 (1): 612–22. doi:10.1128/mcb.19.1.612. PMC 83919. PMID 9858585.