Tandem pore domain potassium channel
(Redirected from Leak channel)
Overview
Two-pore-domain potassium channels: This family of 15 members form what is known as "leak channels" which possess Goldman-Hodgkin-Katz (open) rectification.[1] These channels are regulated by several mechanisms including oxygen tension, pH, mechanical stretch, and G-proteins. Their name is derived from the fact that the α subunits consist of four transmembrane segments, each containing two pore loops. As such, they structurally correspond to two inward-rectifier α subunits and thus form dimers in the membrane.
Below is a list of the 15 known two-pore-domain human potassium channels:[1]
| Gene | Name |
| KCNK1 | K2p01.1 |
| KCNK2 | K2p02.1 |
| KCNK3 | K2p03.1 |
| KCNK4 | K2p04.1 |
| KCNK5 | K2p05.1 |
| KCNK6 | K2p06.1 |
| KCNK7 | K2p07.1 |
| KCNK9 | K2p09.1 |
| KCNK10 | K2p10.1 |
| KCNK12 | K2p12.1 |
| KCNK13 | K2p13.1 |
| KCNK15 | K2p15.1 |
| KCNK16 | K2p16.1 |
| KCNK17 | K2p17.1 |
| KCNK18 | K2p18.1 |
See also
External links
- Tandem+Pore+Domain+Potassium+Channel at the US National Library of Medicine Medical Subject Headings (MeSH)