The WikiDoc Living Textbook of Infectious Disease

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Click Here For A Complete Listing Of All Chapters/Microchapters In The Living Textbook Of Infectious Disease In Alphabetical Order

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Physiology

Immunology: lymphocytic adaptive immune system and complement

Lymphoid

Antigens	Antigen Superantigen Allergen Hapten Epitope Linear Conformational Mimotope Antigen presentation/Professional APCs: Dendritic cell Macrophage B cell Immunogen
Antibodies	Antibody Monoclonal antibodies Polyclonal antibodies Autoantibody Microantibody Polyclonal B cell response Allotype Isotype Idiotype Immune complex Paratope
Immunity vs. tolerance	action: Immunity Autoimmunity Alloimmunity Allergy Hypersensitivity Inflammation Cross-reactivity inaction: Tolerance Central Peripheral Clonal anergy Clonal deletion Tolerance in pregnancy Immunodeficiency
Immunogenetics	Affinity maturation Somatic hypermutation Clonal selection V(D)J recombination Junctional diversity Immunoglobulin class switching MHC/HLA

Substances

Disease States

Template:Bacterial diseases Template:Protozoal diseases Template:Viral diseases

Pharmacotherapy

Template:Antibiotics Template:Agents against amoebiasis and other protozoal diseases Template:Agents against leishmaniasis and trypanosomiasis Template:AminoglycosideAntiBiotics Template:Amphenicols Template:Antidiarrheals, intestinal anti-inflammatory/anti-infective agents

v t e Antifungals (D01 and J02)
Antibiotics	Griseofulvin • polyene antimycotics (Natamycin, Nystatin)
Topical azoles	imidazoles (Bifonazole, Clomidazole, Clotrimazole, Econazole, Fenticonazole, Ketoconazole, Isoconazole, Miconazole, Oxiconazole, Sertaconazole, Sulconazole, Tioconazole) • triazoles (Fluconazole) • benzimidazole (Thiabendazole)
Other topicals	Ciclopirox • Ethylparaben • Flucytosine • Salicylic acid • Selenium sulfide • Tolnaftate • Undecylenic acid • allylamines (Amorolfine, Butenafine, Naftifine, Terbinafine)
For systemic use	Griseofulvin • allylamine (Terbinafine) • polyene antimycotic (Amphotericin B) • triazoles (Itraconazole, Posaconazole, Voriconazole) • echinocandins (Anidulafungin, Caspofungin, Micafungin)
Other	Tea tree oil • citronella oil • lemon grass • orange oil • patchouli • lemon myrtle

Template:Anthelmintics Template:Antimalarials

v t e Antimycobacterials (J04)
Tuberculosis/ tuberculosis treatment	Aminosalicylic acid (Calcium aminosalicylate, Sodium aminosalicylate) Antibiotics (Amikacin, Capreomycin, Cycloserine, Kanamycin, Rifabutin, Rifampicin, Rifamycin, Rifapentin, Streptomycin) hydrazides (Isoniazid) thiocarbamides (Ethionamide, Protionamide, Tiocarlide) Others (Ethambutol, Morinamide, Pyrazinamide, Terizidone)
Leprosy	Aldesulfone sodium • Clofazimine • Dapsone • Rifampicin

Template:Antiseptics and disinfectants

v t e Antivirals, other than for HIV (primarily J05, also S01AD and D06BB)
Anti-herpesvirus (DNA, I)	guanine analogues (Aciclovir, Famciclovir, Ganciclovir, Penciclovir, Valaciclovir, Valganciclovir) • nucleoside analogues (Idoxuridine, Trifluridine, Vidarabine) • Cidofovir • Docosanol • Fomivirsen • Foscarnet • Tromantadine
HPV/MC (DNA, I)	Imiquimod • Podophyllotoxin
Hepatitis B (DNA, VII)	Adefovir • Interferon alfa-2b • Pegylated interferon alfa-2a • Entecavir • Lamivudine • Telbivudine • Tenofovir^†
Hepatitis C (RNA, IV)	Pegylated interferon alpha • Ribavirin • Taribavirin^† • Boceprevir^†
Picornavirus (RNA, IV)	Pleconaril^†
Anti-influenza agents (RNA, V)	Arbidol adamantane derivatives/M2 inhibitors (Amantadine, Rimantadine) neuraminidase inhibitors (Oseltamivir, Zanamivir, Peramivir^†)
HIV (Reverse, VI)	See HIV pharm
Other antiviral agents	general (Inosine, Interferon)
^†Undergoing clinical trials, not FDA approved.

v t e Antibacterials: cell wall disruption (J01C-J01D)
Internal to membrane/ (inhibit peptidoglycan subunit synthesis and transport)	Template:Navbox subgroup
Glycopeptide/ (inhibit PG chain elongation)	Vancomycin # (Oritavancin, Telavancin) · Teicoplanin (Dalbavancin) · Ramoplanin
Beta-lactams/ (inhibit cross-links with PBP)	Template:Navbox subgroup
Other	Template:Navbox subgroup
# = WHO-EM

Template:Ectoparasiticides

v t e Antivirals used against HIV (HAART) (primarily J05)
Nucleoside & Nucleotide Reverse Transcriptase Inhibitors (NRTI)	Abacavir (ABC)° • Emtricitabine° • Lamivudine (3TC)° • Tenofovir° • Didanosine • Zidovudine (AZT) • Apricitabine^† • Stampidine^† • Elvucitabine^† • Racivir^† • Amdoxovir^† • Stavudine^‡ • Zalcitabine^‡
Non-Nucleoside Reverse Transcriptase Inhibitors (NNRTI)	Efavirenz° • Nevirapine • Etravirine • Rilpivirine^† • Loviride^‡ • Delavirdine^‡
Protease Inhibitors (PI)	Atazanavir° • Fosamprenavir° • Lopinavir° • Darunavir • Nelfinavir • Ritonavir • Saquinavir • Tipranavir • Amprenavir^‡ • Indinavir^‡
Entry/fusion inhibitors	Enfuvirtide • Maraviroc • Vicriviroc^† • PRO 140^† • Ibalizumab^†
Integrase inhibitors	Raltegravir • Elvitegravir^†
Maturation inhibitors	Bevirimat^† • Vivecon™^†
Combined formulations	Combivir • Atripla • Trizivir • Truvada • Kaletra • Epzicom
Other & experimental agents	Foscarnet • Hydroxyurea • Synergistic enhancers • Epigallocatechin gallate • Portmanteau inhibitors • Globoidnan A • Griffithsin • Diarylpyrimidines • Calanolide A • Cyanovirin-N • Miltefosine
°DHHS preferred first-line agent. ^†Undergoing clinical trials, not FDA approved. ^‡Formerly or rarely used agent.

v t e Antibacterials for systemic use: macrolides, lincosamides and streptogramins (J01F)
Macrolides	Erythromycin - Spiramycin - Midecamycin - Oleandomycin - Roxithromycin - Josamycin - Troleandomycin - Clarithromycin - Azithromycin - Miocamycin - Rokitamycin - Dirithromycin - Flurithromycin - Telithromycin - Cethromycin
Lincosamides	Clindamycin - Lincomycin
Streptogramins	Pristinamycin - Quinupristin/dalfopristin

Template:NNRTI Template:NRTI Template:Other antibacterials Template:OtherAntiBiotics Template:Other antiviral agents

v t e Antibacterials for systemic use: beta-lactam antibiotics - penicillins (J01C)
Antibiotics	Amoxicillin • Ampicillin • Azlocillin • Carbenicillin • Cloxacillin • Dicloxacillin • Flucloxacillin • Mezlocillin • Nafcillin • Piperacillin • Pivampicillin • Ticarcillin
Beta-lactamase inhibitors	Sulbactam • Tazobactam • Clavulanic acid
Combinations	Ampicillin/sulbactam (Sultamicillin) • Co-amoxiclav

Template:PI Template:QuinoloneAntiBiotics Template:Racetams Template:Sulfonamides and trimethoprim

v t e Antibacterials for systemic use: tetracycline antibiotics (J01A)
Tetracyclines	Chlortetracycline • Clomocycline • Demeclocycline • Doxycycline • Lymecycline • Metacycline • Minocycline • Oxytetracycline • Penimepicycline • Rolitetracycline • Tetracycline
Glycylcyclines	Tigecycline

Template:Vaccines

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