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<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{Infobox_gene}}
{{PBB_Controls
'''Voltage-gated potassium channel subunit beta-2''' is a [[protein]] that in humans is encoded by the ''KCNAB2'' [[gene]].<ref name="pmid8838324">{{cite journal | vauthors = Schultz D, Litt M, Smith L, Thayer M, McCormack K | title = Localization of two potassium channel beta subunit genes, KCNA1B and KCNA2B | journal = Genomics | volume = 31 | issue = 3 | pages = 389–91 | date = Mar 1997 | pmid = 8838324 | pmc = | doi = 10.1006/geno.1996.0065 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: KCNAB2 potassium voltage-gated channel, shaker-related subfamily, beta member 2| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8514| accessdate = }}</ref>
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}


<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Function ==
{{GNF_Protein_box
| image = PBB_Protein_KCNAB2_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1exb.
| PDB = {{PDB2|1exb}}, {{PDB2|1qrq}}, {{PDB2|1zsx}}, {{PDB2|2a79}}
| Name = Potassium voltage-gated channel, shaker-related subfamily, beta member 2
| HGNCid = 6229
| Symbol = KCNAB2
| AltSymbols =; AKR6A5; HKvbeta2; HKvbeta2.1; HKvbeta2.2; KCNA2B; KV-BETA-2; MGC117289
| OMIM = 601142
| ECnumber = 
| Homologene = 56492
| MGIid = 109239
| GeneAtlas_image1 = PBB_GE_KCNAB2_211791_s_at_tn.png
| GeneAtlas_image2 = PBB_GE_KCNAB2_203402_at_tn.png
| Function = {{GNF_GO|id=GO:0005216 |text = ion channel activity}} {{GNF_GO|id=GO:0005249 |text = voltage-gated potassium channel activity}} {{GNF_GO|id=GO:0015459 |text = potassium channel regulator activity}} {{GNF_GO|id=GO:0016491 |text = oxidoreductase activity}} {{GNF_GO|id=GO:0030955 |text = potassium ion binding}}
| Component = {{GNF_GO|id=GO:0005737 |text = cytoplasm}} {{GNF_GO|id=GO:0016021 |text = integral to membrane}}
| Process = {{GNF_GO|id=GO:0006811 |text = ion transport}} {{GNF_GO|id=GO:0006813 |text = potassium ion transport}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 8514
    | Hs_Ensembl = ENSG00000069424
    | Hs_RefseqProtein = NP_003627
    | Hs_RefseqmRNA = NM_003636
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 1
    | Hs_GenLoc_start = 5974113
    | Hs_GenLoc_end = 6083840
    | Hs_Uniprot = Q13303
    | Mm_EntrezGene = 16498
    | Mm_Ensembl = ENSMUSG00000028931
    | Mm_RefseqmRNA = NM_010598
    | Mm_RefseqProtein = NP_034728
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 4
    | Mm_GenLoc_start = 151234544
    | Mm_GenLoc_end = 151321280
    | Mm_Uniprot = Q3U0B0
  }}
}}
'''Potassium voltage-gated channel, shaker-related subfamily, beta member 2''', also known as '''KCNAB2''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: KCNAB2 potassium voltage-gated channel, shaker-related subfamily, beta member 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8514| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. Four sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in Drosophila, and each has been shown to have human homolog(s). This gene encodes a member of the potassium channel, voltage-gated, shaker-related subfamily. This member is one of the beta subunits, which are auxiliary proteins associating with functional Kv-alpha subunits. This member alters functional properties of the KCNA4 gene product. Alternative splicing of this gene results in two transcript variants encoding distinct isoforms.<ref name="entrez"/>
{{PBB_Summary
| section_title =
| summary_text = Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. Four sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in Drosophila, and each has been shown to have human homolog(s). This gene encodes a member of the potassium channel, voltage-gated, shaker-related subfamily. This member is one of the beta subunits, which are auxiliary proteins associating with functional Kv-alpha subunits. This member alters functional properties of the KCNA4 gene product. Alternative splicing of this gene results in two transcript variants encoding distinct isoforms.<ref name="entrez">{{cite web | title = Entrez Gene: KCNAB2 potassium voltage-gated channel, shaker-related subfamily, beta member 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8514| accessdate = }}</ref>
}}


==See also==
In melanocytic cells KCNAB2 gene expression may be regulated by [[Microphthalmia-associated transcription factor|MITF]].<ref name="pmid19067971">{{cite journal | vauthors = Hoek KS, Schlegel NC, Eichhoff OM, Widmer DS, Praetorius C, Einarsson SO, Valgeirsdottir S, Bergsteinsdottir K, Schepsky A, Dummer R, Steingrimsson E | title = Novel MITF targets identified using a two-step DNA microarray strategy | journal = Pigment Cell Melanoma Res. | volume = 21 | issue = 6 | pages = 665–76 | year = 2008 | pmid = 19067971 | doi = 10.1111/j.1755-148X.2008.00505.x }}</ref>
 
== Interactions ==
 
KCNAB2 has been shown to [[Protein-protein interaction|interact]] with [[KCNA2]].<ref name=pmid10428084>{{cite journal | vauthors = Coleman SK, Newcombe J, Pryke J, Dolly JO | title = Subunit composition of Kv1 channels in human CNS | journal = J. Neurochem. | volume = 73 | issue = 2 | pages = 849–58 | date = Aug 1999 | pmid = 10428084 | doi = 10.1046/j.1471-4159.1999.0730849.x }}</ref><ref name=pmid8636142>{{cite journal | vauthors = Nakahira K, Shi G, Rhodes KJ, Trimmer JS | title = Selective interaction of voltage-gated K+ channel beta-subunits with alpha-subunits | journal = J. Biol. Chem. | volume = 271 | issue = 12 | pages = 7084–9 | date = Mar 1996 | pmid = 8636142 | doi = 10.1074/jbc.271.12.7084 }}</ref>
 
== See also ==
* [[Voltage-gated potassium channel]]
* [[Voltage-gated potassium channel]]


==References==
== References ==
{{reflist|2}}
{{reflist}}


==Further reading==
== Further reading ==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
* {{cite journal | vauthors = McCormack K, McCormack T, Tanouye M, Rudy B, Stühmer W | title = Alternative splicing of the human Shaker K+ channel beta 1 gene and functional expression of the beta 2 gene product. | journal = FEBS Lett. | volume = 370 | issue = 1-2 | pages = 32–6 | year = 1995 | pmid = 7649300 | doi = 10.1016/0014-5793(95)00785-8 }}
| citations =
* {{cite journal | vauthors = McCormack T, McCormack K | title = Shaker K+ channel beta subunits belong to an NAD(P)H-dependent oxidoreductase superfamily. | journal = Cell | volume = 79 | issue = 7 | pages = 1133–5 | year = 1995 | pmid = 8001150 | doi = 10.1016/0092-8674(94)90004-3 }}
*{{cite journal | author=McCormack K, McCormack T, Tanouye M, ''et al.'' |title=Alternative splicing of the human Shaker K+ channel beta 1 gene and functional expression of the beta 2 gene product. |journal=FEBS Lett. |volume=370 |issue= 1-2 |pages= 32-6 |year= 1995 |pmid= 7649300 |doi= }}
* {{cite journal | vauthors = Nakahira K, Shi G, Rhodes KJ, Trimmer JS | title = Selective interaction of voltage-gated K+ channel beta-subunits with alpha-subunits. | journal = J. Biol. Chem. | volume = 271 | issue = 12 | pages = 7084–9 | year = 1996 | pmid = 8636142 | doi = 10.1074/jbc.271.12.7084 }}
*{{cite journal | author=McCormack T, McCormack K |title=Shaker K+ channel beta subunits belong to an NAD(P)H-dependent oxidoreductase superfamily. |journal=Cell |volume=79 |issue= 7 |pages= 1133-5 |year= 1995 |pmid= 8001150 |doi= }}
* {{cite journal | vauthors = Kääb S, Dixon J, Duc J, Ashen D, Näbauer M, Beuckelmann DJ, Steinbeck G, McKinnon D, Tomaselli GF | title = Molecular basis of transient outward potassium current downregulation in human heart failure: a decrease in Kv4.3 mRNA correlates with a reduction in current density. | journal = Circulation | volume = 98 | issue = 14 | pages = 1383–93 | year = 1998 | pmid = 9760292 | doi = 10.1161/01.cir.98.14.1383 }}
*{{cite journal | author=Nakahira K, Shi G, Rhodes KJ, Trimmer JS |title=Selective interaction of voltage-gated K+ channel beta-subunits with alpha-subunits. |journal=J. Biol. Chem. |volume=271 |issue= 12 |pages= 7084-9 |year= 1996 |pmid= 8636142 |doi=  }}
* {{cite journal | vauthors = Coleman SK, Newcombe J, Pryke J, Dolly JO | title = Subunit composition of Kv1 channels in human CNS. | journal = J. Neurochem. | volume = 73 | issue = 2 | pages = 849–58 | year = 1999 | pmid = 10428084 | doi = 10.1046/j.1471-4159.1999.0730849.x }}
*{{cite journal  | author=Schultz D, Litt M, Smith L, ''et al.'' |title=Localization of two potassium channel beta subunit genes, KCNA1B and KCNA2B. |journal=Genomics |volume=31 |issue= 3 |pages= 389-91 |year= 1997 |pmid= 8838324 |doi= 10.1006/geno.1996.0065 }}
* {{cite journal | vauthors = Poliak S, Gollan L, Martinez R, Custer A, Einheber S, Salzer JL, Trimmer JS, Shrager P, Peles E | title = Caspr2, a new member of the neurexin superfamily, is localized at the juxtaparanodes of myelinated axons and associates with K+ channels. | journal = Neuron | volume = 24 | issue = 4 | pages = 1037–47 | year = 2000 | pmid = 10624965 | doi = 10.1016/S0896-6273(00)81049-1 }}
*{{cite journal | author=Kääb S, Dixon J, Duc J, ''et al.'' |title=Molecular basis of transient outward potassium current downregulation in human heart failure: a decrease in Kv4.3 mRNA correlates with a reduction in current density. |journal=Circulation |volume=98 |issue= 14 |pages= 1383-93 |year= 1998 |pmid= 9760292 |doi= }}
* {{cite journal | vauthors = Croci C, Brändstatter JH, Enz R | title = ZIP3, a new splice variant of the PKC-zeta-interacting protein family, binds to GABAC receptors, PKC-zeta, and Kv beta 2. | journal = J. Biol. Chem. | volume = 278 | issue = 8 | pages = 6128–35 | year = 2003 | pmid = 12431995 | doi = 10.1074/jbc.M205162200 }}
*{{cite journal | author=Coleman SK, Newcombe J, Pryke J, Dolly JO |title=Subunit composition of Kv1 channels in human CNS. |journal=J. Neurochem. |volume=73 |issue= 2 |pages= 849-58 |year= 1999 |pmid= 10428084 |doi= }}
* {{cite journal | vauthors = Gu C, Jan YN, Jan LY | title = A conserved domain in axonal targeting of Kv1 (Shaker) voltage-gated potassium channels. | journal = Science | volume = 301 | issue = 5633 | pages = 646–9 | year = 2003 | pmid = 12893943 | doi = 10.1126/science.1086998 }}
*{{cite journal | author=Poliak S, Gollan L, Martinez R, ''et al.'' |title=Caspr2, a new member of the neurexin superfamily, is localized at the juxtaparanodes of myelinated axons and associates with K+ channels. |journal=Neuron |volume=24 |issue= 4 |pages= 1037-47 |year= 2000 |pmid= 10624965 |doi= }}
* {{cite journal | vauthors = Rush J, Moritz A, Lee KA, Guo A, Goss VL, Spek EJ, Zhang H, Zha XM, Polakiewicz RD, Comb MJ | title = Immunoaffinity profiling of tyrosine phosphorylation in cancer cells. | journal = Nat. Biotechnol. | volume = 23 | issue = 1 | pages = 94–101 | year = 2005 | pmid = 15592455 | doi = 10.1038/nbt1046 }}
*{{cite journal | author=Croci C, Brändstatter JH, Enz R |title=ZIP3, a new splice variant of the PKC-zeta-interacting protein family, binds to GABAC receptors, PKC-zeta, and Kv beta 2. |journal=J. Biol. Chem. |volume=278 |issue= 8 |pages= 6128-35 |year= 2003 |pmid= 12431995 |doi= 10.1074/jbc.M205162200 }}
* {{cite journal|authorlink13=Huda Zoghbi | vauthors = Lim J, Hao T, Shaw C, Patel AJ, Szabó G, Rual JF, Fisk CJ, Li N, Smolyar A, Hill DE, Barabási AL, Vidal M, Zoghbi HY | title = A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration. | journal = Cell | volume = 125 | issue = 4 | pages = 801–14 | year = 2006 | pmid = 16713569 | doi = 10.1016/j.cell.2006.03.032 }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal  | author=Gu C, Jan YN, Jan LY |title=A conserved domain in axonal targeting of Kv1 (Shaker) voltage-gated potassium channels. |journal=Science |volume=301 |issue= 5633 |pages= 646-9 |year= 2003 |pmid= 12893943 |doi= 10.1126/science.1086998 }}
*{{cite journal | author=Ota T, Suzuki Y, Nishikawa T, ''et al.'' |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40-5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
*{{cite journal  | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal  | author=Rush J, Moritz A, Lee KA, ''et al.'' |title=Immunoaffinity profiling of tyrosine phosphorylation in cancer cells. |journal=Nat. Biotechnol. |volume=23 |issue= 1 |pages= 94-101 |year= 2005 |pmid= 15592455 |doi= 10.1038/nbt1046 }}
*{{cite journal | author=Gregory SG, Barlow KF, McLay KE, ''et al.'' |title=The DNA sequence and biological annotation of human chromosome 1. |journal=Nature |volume=441 |issue= 7091 |pages= 315-21 |year= 2006 |pmid= 16710414 |doi= 10.1038/nature04727 }}
*{{cite journal  | author=Lim J, Hao T, Shaw C, ''et al.'' |title=A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration. |journal=Cell |volume=125 |issue= 4 |pages= 801-14 |year= 2006 |pmid= 16713569 |doi= 10.1016/j.cell.2006.03.032 }}
}}
{{refend}}
{{refend}}


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* {{MeshName|KCNAB2+protein,+human}}
* {{MeshName|KCNAB2+protein,+human}}


{{membrane-protein-stub}}
{{PDB Gallery|geneid=8514}}
{{Ion channels|g3}}
 
{{NLM content}}
{{NLM content}}
{{Ion channels}}
 
[[Category:Ion channels]]
[[Category:Ion channels]]
{{WikiDoc Sources}}
 
 
{{membrane-protein-stub}}

Latest revision as of 02:27, 27 October 2017

VALUE_ERROR (nil)
Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

n/a

n/a

Ensembl

n/a

n/a

UniProt

n/a

n/a

RefSeq (mRNA)

n/a

n/a

RefSeq (protein)

n/a

n/a

Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Voltage-gated potassium channel subunit beta-2 is a protein that in humans is encoded by the KCNAB2 gene.[1][2]

Function

Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. Four sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in Drosophila, and each has been shown to have human homolog(s). This gene encodes a member of the potassium channel, voltage-gated, shaker-related subfamily. This member is one of the beta subunits, which are auxiliary proteins associating with functional Kv-alpha subunits. This member alters functional properties of the KCNA4 gene product. Alternative splicing of this gene results in two transcript variants encoding distinct isoforms.[2]

In melanocytic cells KCNAB2 gene expression may be regulated by MITF.[3]

Interactions

KCNAB2 has been shown to interact with KCNA2.[4][5]

See also

References

  1. ↑ Schultz D, Litt M, Smith L, Thayer M, McCormack K (Mar 1997). "Localization of two potassium channel beta subunit genes, KCNA1B and KCNA2B". Genomics. 31 (3): 389–91. doi:10.1006/geno.1996.0065. PMID 8838324.
  2. ↑ 2.0 2.1 "Entrez Gene: KCNAB2 potassium voltage-gated channel, shaker-related subfamily, beta member 2".
  3. ↑ Hoek KS, Schlegel NC, Eichhoff OM, Widmer DS, Praetorius C, Einarsson SO, Valgeirsdottir S, Bergsteinsdottir K, Schepsky A, Dummer R, Steingrimsson E (2008). "Novel MITF targets identified using a two-step DNA microarray strategy". Pigment Cell Melanoma Res. 21 (6): 665–76. doi:10.1111/j.1755-148X.2008.00505.x. PMID 19067971.
  4. ↑ Coleman SK, Newcombe J, Pryke J, Dolly JO (Aug 1999). "Subunit composition of Kv1 channels in human CNS". J. Neurochem. 73 (2): 849–58. doi:10.1046/j.1471-4159.1999.0730849.x. PMID 10428084.
  5. ↑ Nakahira K, Shi G, Rhodes KJ, Trimmer JS (Mar 1996). "Selective interaction of voltage-gated K+ channel beta-subunits with alpha-subunits". J. Biol. Chem. 271 (12): 7084–9. doi:10.1074/jbc.271.12.7084. PMID 8636142.

Further reading

  • McCormack K, McCormack T, Tanouye M, Rudy B, Stühmer W (1995). "Alternative splicing of the human Shaker K+ channel beta 1 gene and functional expression of the beta 2 gene product". FEBS Lett. 370 (1–2): 32–6. doi:10.1016/0014-5793(95)00785-8. PMID 7649300.
  • McCormack T, McCormack K (1995). "Shaker K+ channel beta subunits belong to an NAD(P)H-dependent oxidoreductase superfamily". Cell. 79 (7): 1133–5. doi:10.1016/0092-8674(94)90004-3. PMID 8001150.
  • Nakahira K, Shi G, Rhodes KJ, Trimmer JS (1996). "Selective interaction of voltage-gated K+ channel beta-subunits with alpha-subunits". J. Biol. Chem. 271 (12): 7084–9. doi:10.1074/jbc.271.12.7084. PMID 8636142.
  • Kääb S, Dixon J, Duc J, Ashen D, Näbauer M, Beuckelmann DJ, Steinbeck G, McKinnon D, Tomaselli GF (1998). "Molecular basis of transient outward potassium current downregulation in human heart failure: a decrease in Kv4.3 mRNA correlates with a reduction in current density". Circulation. 98 (14): 1383–93. doi:10.1161/01.cir.98.14.1383. PMID 9760292.
  • Coleman SK, Newcombe J, Pryke J, Dolly JO (1999). "Subunit composition of Kv1 channels in human CNS". J. Neurochem. 73 (2): 849–58. doi:10.1046/j.1471-4159.1999.0730849.x. PMID 10428084.
  • Poliak S, Gollan L, Martinez R, Custer A, Einheber S, Salzer JL, Trimmer JS, Shrager P, Peles E (2000). "Caspr2, a new member of the neurexin superfamily, is localized at the juxtaparanodes of myelinated axons and associates with K+ channels". Neuron. 24 (4): 1037–47. doi:10.1016/S0896-6273(00)81049-1. PMID 10624965.
  • Croci C, Brändstatter JH, Enz R (2003). "ZIP3, a new splice variant of the PKC-zeta-interacting protein family, binds to GABAC receptors, PKC-zeta, and Kv beta 2". J. Biol. Chem. 278 (8): 6128–35. doi:10.1074/jbc.M205162200. PMID 12431995.
  • Gu C, Jan YN, Jan LY (2003). "A conserved domain in axonal targeting of Kv1 (Shaker) voltage-gated potassium channels". Science. 301 (5633): 646–9. doi:10.1126/science.1086998. PMID 12893943.
  • Rush J, Moritz A, Lee KA, Guo A, Goss VL, Spek EJ, Zhang H, Zha XM, Polakiewicz RD, Comb MJ (2005). "Immunoaffinity profiling of tyrosine phosphorylation in cancer cells". Nat. Biotechnol. 23 (1): 94–101. doi:10.1038/nbt1046. PMID 15592455.
  • Lim J, Hao T, Shaw C, Patel AJ, Szabó G, Rual JF, Fisk CJ, Li N, Smolyar A, Hill DE, Barabási AL, Vidal M, Zoghbi HY (2006). "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration". Cell. 125 (4): 801–14. doi:10.1016/j.cell.2006.03.032. PMID 16713569.

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


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