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{{Infobox_gene}}
{{PBB_Controls
'''Receptor-type tyrosine-protein phosphatase-like N''' is an [[enzyme]] that in humans is encoded by the ''PTPRN'' [[gene]].<ref name="pmid8024693">{{cite journal | vauthors = Lan MS, Lu J, Goto Y, Notkins AL | title = Molecular cloning and identification of a receptor-type protein tyrosine phosphatase, IA-2, from human insulinoma | journal = DNA Cell Biol | volume = 13 | issue = 5 | pages = 505–14 | date = August 1994 | pmid = 8024693 | pmc =  | doi = 10.1089/dna.1994.13.505 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: PTPRN protein tyrosine phosphatase, receptor type, N| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5798| accessdate = }}</ref>
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}


<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Function ==
{{GNF_Protein_box
| image = PBB_Protein_PTPRN_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 2i1y.
| PDB = {{PDB2|2i1y}}
| Name = Protein tyrosine phosphatase, receptor type, N
| HGNCid = 9676
| Symbol = PTPRN
| AltSymbols =; FLJ16131; IA-2; IA-2/PTP; IA2; ICA512; R-PTP-N
| OMIM = 601773
| ECnumber = 
| Homologene = 48142
| MGIid = 102765
| GeneAtlas_image1 = PBB_GE_PTPRN_204945_at_tn.png
| Function = {{GNF_GO|id=GO:0004872 |text = receptor activity}} {{GNF_GO|id=GO:0005001 |text = transmembrane receptor protein tyrosine phosphatase activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}}
| Component = {{GNF_GO|id=GO:0005887 |text = integral to plasma membrane}} {{GNF_GO|id=GO:0016020 |text = membrane}}
| Process = {{GNF_GO|id=GO:0006470 |text = protein amino acid dephosphorylation}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 5798
    | Hs_Ensembl = ENSG00000054356
    | Hs_RefseqProtein = NP_002837
    | Hs_RefseqmRNA = NM_002846
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 2
    | Hs_GenLoc_start = 219862591
    | Hs_GenLoc_end = 219882387
    | Hs_Uniprot = Q16849
    | Mm_EntrezGene = 19275
    | Mm_Ensembl = ENSMUSG00000026204
    | Mm_RefseqmRNA = NM_008985
    | Mm_RefseqProtein = NP_033011
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 1
    | Mm_GenLoc_start = 75130198
    | Mm_GenLoc_end = 75147299
    | Mm_Uniprot = Q3UTI6
  }}
}}
'''Protein tyrosine phosphatase, receptor type, N''', also known as '''PTPRN''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: PTPRN protein tyrosine phosphatase, receptor type, N| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5798| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
The protein encoded by this gene is a member of the [[protein tyrosine phosphatase]] (PTP) family and [http://phosphatome.net/wiki/index.php/Phosphatase_Subfamily_PTPRN PTPRN] subfamily. PTPs are known to be [[signaling molecules]] that [[Regulation of gene expression|regulate]] a variety of cellular processes including [[cell growth]], [[Cell differentiation|differentiation]], [[mitosis|mitotic cycle]], and [[oncogenic]] [[transformation (genetics)|transformation]]. This PTP possesses an [[extracellular]] region, a single [[transmembrane region]], and a single [[catalytic domain]], and thus represents a [[receptor (biochemistry)|receptor]]-type PTP. This PTP was found to be an [[autoantigen]] that is reactive with [[insulin-dependent diabetes mellitus]] (IDDM) patient [[Serum (blood)|sera]], and thus may be a potential target of [[autoimmunity]] in diabetes mellitus.<ref name="entrez" />
{{PBB_Summary
| section_title =
| summary_text = The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and a single catalytic domain, and thus represents a receptor-type PTP. This PTP was found to be an autoantigen that is reactive with insulin-dependent diabetes mellitus (IDDM) patient sera, and thus may be a potential target of autoimmunity in diabetes mellitus.<ref name="entrez">{{cite web | title = Entrez Gene: PTPRN protein tyrosine phosphatase, receptor type, N| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5798| accessdate = }}</ref>
}}


==References==
== Interactions ==
{{reflist|2}}
 
==Further reading==
PTPRN has been shown to [[Protein-protein interaction|interact]] with [[SPTBN4]].<ref name=pmid11086001>{{cite journal | vauthors = Berghs S, Aggujaro D, Dirkx R, Maksimova E, Stabach P, Hermel JM, Zhang JP, Philbrick W, Slepnev V, Ort T, Solimena M | title = βiv Spectrin, a New Spectrin Localized at Axon Initial Segments and Nodes of Ranvier in the Central and Peripheral Nervous System | journal = J. Cell Biol. | volume = 151 | issue = 5 | pages = 985–1002 | date = November 2000 | pmid = 11086001 | pmc = 2174349 | doi = 10.1083/jcb.151.5.985 }}</ref>
 
== References ==
{{reflist}}
 
== Further reading ==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
* {{cite journal | vauthors = Rabin DU, Pleasic SM, Shapiro JA, Yoo-Warren H, Oles J, Hicks JM, Goldstein DE, Rae PM | title = Islet cell antigen 512 is a diabetes-specific islet autoantigen related to protein tyrosine phosphatases | journal = J. Immunol. | volume = 152 | issue = 6 | pages = 3183–8 | year = 1994 | pmid = 8144912 | doi =  }}
| citations =
* {{cite journal | vauthors = Solimena M, Dirkx R, Hermel JM, Pleasic-Williams S, Shapiro JA, Caron L, Rabin DU | title = ICA 512, an autoantigen of type I diabetes, is an intrinsic membrane protein of neurosecretory granules | journal = EMBO J. | volume = 15 | issue = 9 | pages = 2102–14 | year = 1996 | pmid = 8641276 | pmc = 450132 | doi =  }}
*{{cite journal | author=Lan MS, Lu J, Goto Y, Notkins AL |title=Molecular cloning and identification of a receptor-type protein tyrosine phosphatase, IA-2, from human insulinoma. |journal=DNA Cell Biol. |volume=13 |issue= 5 |pages= 505-14 |year= 1994 |pmid= 8024693 |doi=  }}
* {{cite journal | vauthors = van den Maagdenberg AM, Olde Weghuis D, Rijss J, van de Wetering RA, Wieringa B, Geurts van Kessel A, Hendriks WJ | title = Assignment of the human gene for receptor-type protein tyrosine phosphatase IA-2 (PTPRN) to chromosome region 2q35 --> q36.1 and identification of an intragenic genetic marker | journal = Cytogenet. Cell Genet. | volume = 73 | issue = 1–2 | pages = 145–8 | year = 1996 | pmid = 8646884 | doi = 10.1159/000134327 }}
*{{cite journal | author=Rabin DU, Pleasic SM, Shapiro JA, ''et al.'' |title=Islet cell antigen 512 is a diabetes-specific islet autoantigen related to protein tyrosine phosphatases. |journal=J. Immunol. |volume=152 |issue= 6 |pages= 3183-8 |year= 1994 |pmid= 8144912 |doi=  }}
* {{cite journal | vauthors = Cui L, Yu WP, DeAizpurua HJ, Schmidli RS, Pallen CJ | title = Cloning and characterization of islet cell antigen-related protein-tyrosine phosphatase (PTP), a novel receptor-like PTP and autoantigen in insulin-dependent diabetes | journal = J. Biol. Chem. | volume = 271 | issue = 40 | pages = 24817–23 | year = 1996 | pmid = 8798755 | doi = 10.1074/jbc.271.40.24817 }}
*{{cite journal | author=Solimena M, Dirkx R, Hermel JM, ''et al.'' |title=ICA 512, an autoantigen of type I diabetes, is an intrinsic membrane protein of neurosecretory granules. |journal=EMBO J. |volume=15 |issue= 9 |pages= 2102-14 |year= 1996 |pmid= 8641276 |doi= }}
* {{cite journal | vauthors = Xie J, Zhang B, Lan MS, Notkins AL | title = Genomic structure and promoter sequence of the insulin-dependent diabetes mellitus autoantigen, IA-2 (PTPRN) | journal = Genomics | volume = 54 | issue = 2 | pages = 338–43 | year = 1999 | pmid = 9828138 | doi = 10.1006/geno.1998.5583 }}
*{{cite journal | author=van den Maagdenberg AM, Olde Weghuis D, Rijss J, ''et al.'' |title=Assignment of the human gene for receptor-type protein tyrosine phosphatase IA-2 (PTPRN) to chromosome region 2q35 --> q36.1 and identification of an intragenic genetic marker. |journal=Cytogenet. Cell Genet. |volume=73 |issue= 1-2 |pages= 145-8 |year= 1996 |pmid= 8646884 |doi= }}
* {{cite journal | vauthors = Ort T, Maksimova E, Dirkx R, Kachinsky AM, Berghs S, Froehner SC, Solimena M | title = The receptor tyrosine phosphatase-like protein ICA512 binds the PDZ domains of beta2-syntrophin and nNOS in pancreatic beta-cells | journal = Eur. J. Cell Biol. | volume = 79 | issue = 9 | pages = 621–30 | year = 2001 | pmid = 11043403 | doi = 10.1078/0171-9335-00095 }}
*{{cite journal | author=Cui L, Yu WP, DeAizpurua HJ, ''et al.'' |title=Cloning and characterization of islet cell antigen-related protein-tyrosine phosphatase (PTP), a novel receptor-like PTP and autoantigen in insulin-dependent diabetes. |journal=J. Biol. Chem. |volume=271 |issue= 40 |pages= 24817-23 |year= 1996 |pmid= 8798755 |doi= }}
* {{cite journal | vauthors = Park YS, Kawasaki E, Kelemen K, Yu L, Schiller MR, Rewers M, Mizuta M, Eisenbarth GS, Hutton JC | title = Humoral autoreactivity to an alternatively spliced variant of ICA512/IA-2 in Type I diabetes | journal = Diabetologia | volume = 43 | issue = 10 | pages = 1293–301 | year = 2001 | pmid = 11079748 | doi = 10.1007/s001250051525 }}
*{{cite journal | author=Xie J, Zhang B, Lan MS, Notkins AL |title=Genomic structure and promoter sequence of the insulin-dependent diabetes mellitus autoantigen, IA-2 (PTPRN). |journal=Genomics |volume=54 |issue= 2 |pages= 338-43 |year= 1999 |pmid= 9828138 |doi= 10.1006/geno.1998.5583 }}
* {{cite journal | vauthors = Berghs S, Aggujaro D, Dirkx R, Maksimova E, Stabach P, Hermel JM, Zhang JP, Philbrick W, Slepnev V, Ort T, Solimena M | title = βiv Spectrin, a New Spectrin Localized at Axon Initial Segments and Nodes of Ranvier in the Central and Peripheral Nervous System | journal = J. Cell Biol. | volume = 151 | issue = 5 | pages = 985–1002 | year = 2001 | pmid = 11086001 | pmc = 2174349 | doi = 10.1083/jcb.151.5.985 }}
*{{cite journal | author=Ort T, Maksimova E, Dirkx R, ''et al.'' |title=The receptor tyrosine phosphatase-like protein ICA512 binds the PDZ domains of beta2-syntrophin and nNOS in pancreatic beta-cells. |journal=Eur. J. Cell Biol. |volume=79 |issue= 9 |pages= 621-30 |year= 2001 |pmid= 11043403 |doi= }}
* {{cite journal | vauthors = Diez J, Park Y, Zeller M, Brown D, Garza D, Ricordi C, Hutton J, Eisenbarth GS, Pugliese A | title = Differential splicing of the IA-2 mRNA in pancreas and lymphoid organs as a permissive genetic mechanism for autoimmunity against the IA-2 type 1 diabetes autoantigen | journal = Diabetes | volume = 50 | issue = 4 | pages = 895–900 | year = 2001 | pmid = 11289059 | doi = 10.2337/diabetes.50.4.895 }}
*{{cite journal | author=Park YS, Kawasaki E, Kelemen K, ''et al.'' |title=Humoral autoreactivity to an alternatively spliced variant of ICA512/IA-2 in Type I diabetes. |journal=Diabetologia |volume=43 |issue= 10 |pages= 1293-301 |year= 2001 |pmid= 11079748 |doi= }}
* {{cite journal | vauthors = Ort T, Voronov S, Guo J, Zawalich K, Froehner SC, Zawalich W, Solimena M | title = Dephosphorylation of β2-syntrophin and Ca2+/µ-calpain-mediated cleavage of ICA512 upon stimulation of insulin secretion | journal = EMBO J. | volume = 20 | issue = 15 | pages = 4013–23 | year = 2001 | pmid = 11483505 | pmc = 149140 | doi = 10.1093/emboj/20.15.4013 }}
*{{cite journal | author=Berghs S, Aggujaro D, Dirkx R, ''et al.'' |title=betaIV spectrin, a new spectrin localized at axon initial segments and nodes of ranvier in the central and peripheral nervous system. |journal=J. Cell Biol. |volume=151 |issue= 5 |pages= 985-1002 |year= 2001 |pmid= 11086001 |doi= }}
* {{cite journal | vauthors = Mikulecký M, Michalková D | title = Secular and seasonal cycling of IA2-ab autoantibody in Slovak diabetic children | journal = Biomed. Pharmacother. | volume = 55 Suppl 1 | issue = | pages = 106s–109s | year = 2002 | pmid = 11774856 | doi = }}
*{{cite journal | author=Diez J, Park Y, Zeller M, ''et al.'' |title=Differential splicing of the IA-2 mRNA in pancreas and lymphoid organs as a permissive genetic mechanism for autoimmunity against the IA-2 type 1 diabetes autoantigen. |journal=Diabetes |volume=50 |issue= 4 |pages= 895-900 |year= 2001 |pmid= 11289059 |doi= }}
* {{cite journal | vauthors = Miao D, Yu L, Tiberti C, Cuthbertson DD, Rewers M, di Mario U, Eisenbarth GS, Dotta F | title = ICA512(IA-2) epitope specific assays distinguish transient from diabetes associated autoantibodies | journal = J. Autoimmun. | volume = 18 | issue = 2 | pages = 191–6 | year = 2002 | pmid = 11908951 | doi = 10.1006/jaut.2001.0577 }}
*{{cite journal | author=Ort T, Voronov S, Guo J, ''et al.'' |title=Dephosphorylation of beta2-syntrophin and Ca2+/mu-calpain-mediated cleavage of ICA512 upon stimulation of insulin secretion. |journal=EMBO J. |volume=20 |issue= 15 |pages= 4013-23 |year= 2001 |pmid= 11483505 |doi= 10.1093/emboj/20.15.4013 }}
* {{cite journal | vauthors = Kawasaki E, Yamaguchi H, Hattori H, Egashira T, Eguchi K | title = Autoantibodies to IA-2 in type 1 diabetes: measurements with a new enzyme-linked immunosorbent assay | journal = Ann. N. Y. Acad. Sci. | volume = 958 | issue = | pages = 241–6 | year = 2002 | pmid = 12021115 | doi = 10.1111/j.1749-6632.2002.tb02978.x }}
*{{cite journal | author=Mikulecký M, Michalková D |title=Secular and seasonal cycling of IA2-ab autoantibody in Slovak diabetic children. |journal=Biomed. Pharmacother. |volume=55 Suppl 1 |issue= |pages= 106s-109s |year= 2002 |pmid= 11774856 |doi= }}
* {{cite journal | vauthors = Sanjeevi CB, Das AK, Shtauvere-Brameus A | title = BCG vaccination and GAD65 and IA-2 autoantibodies in autoimmune diabetes in southern India | journal = Ann. N. Y. Acad. Sci. | volume = 958 | issue =  | pages = 293–6 | year = 2002 | pmid = 12021127 | doi = 10.1111/j.1749-6632.2002.tb02990.x }}
*{{cite journal | author=Miao D, Yu L, Tiberti C, ''et al.'' |title=ICA512(IA-2) epitope specific assays distinguish transient from diabetes associated autoantibodies. |journal=J. Autoimmun. |volume=18 |issue= 2 |pages= 191-6 |year= 2002 |pmid= 11908951 |doi= 10.1006/jaut.2001.0577 }}
* {{cite journal | vauthors = Bearzatto M, Lampasona V, Belloni C, Bonifacio E | title = Fine mapping of diabetes-associated IA-2 specific autoantibodies | journal = J. Autoimmun. | volume = 21 | issue = 4 | pages = 377–82 | year = 2004 | pmid = 14624760 | doi = 10.1016/j.jaut.2003.08.002 }}
*{{cite journal | author=Kawasaki E, Yamaguchi H, Hattori H, ''et al.'' |title=Autoantibodies to IA-2 in type 1 diabetes: measurements with a new enzyme-linked immunosorbent assay. |journal=Ann. N. Y. Acad. Sci. |volume=958 |issue=  |pages= 241-6 |year= 2002 |pmid= 12021115 |doi= }}
* {{cite journal | vauthors = Trajkovski M, Mziaut H, Altkrüger A, Ouwendijk J, Knoch KP, Müller S, Solimena M | title = Nuclear translocation of an ICA512 cytosolic fragment couples granule exocytosis and insulin expression in {beta}-cells. | journal = J. Cell Biol. | volume = 167 | issue = 6 | pages = 1063–74 | year = 2005 | pmid = 15596545 | pmc = 2172607 | doi = 10.1083/jcb.200408172 }}
*{{cite journal | author=Sanjeevi CB, Das AK, Shtauvere-Brameus A |title=BCG vaccination and GAD65 and IA-2 autoantibodies in autoimmune diabetes in southern India. |journal=Ann. N. Y. Acad. Sci. |volume=958 |issue= |pages= 293-6 |year= 2002 |pmid= 12021127 |doi= }}
* {{cite journal | vauthors = Ota T, Takamura T, Nagai Y, Bando Y, Usuda R | title = Significance of IA-2 antibody in Japanese type 1 diabetes: its association with GAD antibody | journal = Diabetes Res. Clin. Pract. | volume = 67 | issue = 1 | pages = 63–9 | year = 2005 | pmid = 15620435 | doi = 10.1016/j.diabres.2004.05.004 }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal | author=Bearzatto M, Lampasona V, Belloni C, Bonifacio E |title=Fine mapping of diabetes-associated IA-2 specific autoantibodies. |journal=J. Autoimmun. |volume=21 |issue= 4 |pages= 377-82 |year= 2004 |pmid= 14624760 |doi=  }}
*{{cite journal  | author=Ota T, Suzuki Y, Nishikawa T, ''et al.'' |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40-5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
*{{cite journal  | author=Trajkovski M, Mziaut H, Altkrüger A, ''et al.'' |title=Nuclear translocation of an ICA512 cytosolic fragment couples granule exocytosis and insulin expression in {beta}-cells. |journal=J. Cell Biol. |volume=167 |issue= 6 |pages= 1063-74 |year= 2005 |pmid= 15596545 |doi= 10.1083/jcb.200408172 }}
*{{cite journal  | author=Ota T, Takamura T, Nagai Y, ''et al.'' |title=Significance of IA-2 antibody in Japanese type 1 diabetes: its association with GAD antibody. |journal=Diabetes Res. Clin. Pract. |volume=67 |issue= 1 |pages= 63-9 |year= 2005 |pmid= 15620435 |doi= 10.1016/j.diabres.2004.05.004 }}
}}
{{refend}}
{{refend}}


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Latest revision as of 02:02, 27 October 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Wikidata
View/Edit Human

Receptor-type tyrosine-protein phosphatase-like N is an enzyme that in humans is encoded by the PTPRN gene.[1][2]

Function

The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family and PTPRN subfamily. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and a single catalytic domain, and thus represents a receptor-type PTP. This PTP was found to be an autoantigen that is reactive with insulin-dependent diabetes mellitus (IDDM) patient sera, and thus may be a potential target of autoimmunity in diabetes mellitus.[2]

Interactions

PTPRN has been shown to interact with SPTBN4.[3]

References

  1. ↑ Lan MS, Lu J, Goto Y, Notkins AL (August 1994). "Molecular cloning and identification of a receptor-type protein tyrosine phosphatase, IA-2, from human insulinoma". DNA Cell Biol. 13 (5): 505–14. doi:10.1089/dna.1994.13.505. PMID 8024693.
  2. ↑ 2.0 2.1 "Entrez Gene: PTPRN protein tyrosine phosphatase, receptor type, N".
  3. ↑ Berghs S, Aggujaro D, Dirkx R, Maksimova E, Stabach P, Hermel JM, Zhang JP, Philbrick W, Slepnev V, Ort T, Solimena M (November 2000). "βiv Spectrin, a New Spectrin Localized at Axon Initial Segments and Nodes of Ranvier in the Central and Peripheral Nervous System". J. Cell Biol. 151 (5): 985–1002. doi:10.1083/jcb.151.5.985. PMC 2174349. PMID 11086001.

Further reading


Retrieved from "https://www.wikidoc.org/index.php?title=PTPRN&oldid=1412741"