CCRL2: Difference between revisions

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{{Infobox_gene}}
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'''C-C chemokine receptor-like 2''' is a [[protein]] that in humans is encoded by the ''CCRL2'' [[gene]].<ref name="pmid9473515">{{cite journal | vauthors = Fan P, Kyaw H, Su K, Zeng Z, Augustus M, Carter KC, Li Y | title = Cloning and characterization of a novel human chemokine receptor | journal = Biochem Biophys Res Commun | volume = 243 | issue = 1 | pages = 264–8 |date=Mar 1998 | pmid = 9473515 | pmc =  | doi = 10.1006/bbrc.1997.7981 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: CCRL2 chemokine (C-C motif) receptor-like 2| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9034| accessdate = }}</ref> Recently it was found that CCRL2 also acts as  a receptor for the chemokine [[chemerin]].<ref name="pmid18794339">{{cite journal | vauthors = Zabel BA, Nakae S, Zúñiga L, Kim JY, Ohyama T, Alt C, Pan J, Suto H, Soler D, Allen SJ, Handel TM, Song CH, Galli SJ, Butcher EC | title = Mast cell-expressed orphan receptor CCRL2 binds chemerin and is required for optimal induction of IgE-mediated passive cutaneous anaphylaxis | journal = J. Exp. Med. | volume = 205 | issue = 10 | pages = 2207–20 |date=September 2008 | pmid = 18794339 | pmc = 2556791 | doi = 10.1084/jem.20080300 | url = | issn = }}</ref>
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== Function==
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This gene encodes a chemokine receptor like protein, which is predicted to be a seven transmembrane protein and most closely related to CCR1. Chemokines and their receptors mediated signal transduction are critical for the recruitment of effector immune cells to the site of inflammation. This gene is expressed at high levels in primary neutrophils and primary monocytes, and is further upregulated on neutrophil activation and during monocyte to macrophage differentiation. The function of this gene is unknown. This gene is mapped to the region where the chemokine receptor gene cluster is located.<ref name="entrez"/>
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== References ==
{{GNF_Protein_box
{{reflist}}
| image = 
| image_source = 
| PDB =
| Name = Chemokine (C-C motif) receptor-like 2
| HGNCid = 1612
| Symbol = CCRL2
| AltSymbols =; CKRX; CRAM-A; CRAM-B; HCR; MGC116710
| OMIM = 608379
| ECnumber = 
| Homologene = 2948
| MGIid = 1920904
| Function = {{GNF_GO|id=GO:0001584 |text = rhodopsin-like receptor activity}} {{GNF_GO|id=GO:0004872 |text = receptor activity}} {{GNF_GO|id=GO:0016493 |text = C-C chemokine receptor activity}}
| Component = {{GNF_GO|id=GO:0005887 |text = integral to plasma membrane}} {{GNF_GO|id=GO:0016020 |text = membrane}}
| Process = {{GNF_GO|id=GO:0006935 |text = chemotaxis}} {{GNF_GO|id=GO:0007165 |text = signal transduction}} {{GNF_GO|id=GO:0007186 |text = G-protein coupled receptor protein signaling pathway}} {{GNF_GO|id=GO:0019735 |text = antimicrobial humoral response}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 9034
    | Hs_Ensembl = 
    | Hs_RefseqProtein = NP_003956
    | Hs_RefseqmRNA = NM_003965
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 
    | Hs_GenLoc_start = 
    | Hs_GenLoc_end = 
    | Hs_Uniprot = 
    | Mm_EntrezGene = 54199
    | Mm_Ensembl = ENSMUSG00000043953
    | Mm_RefseqmRNA = XM_979714
    | Mm_RefseqProtein = XP_984808
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 9
    | Mm_GenLoc_start = 110899651
    | Mm_GenLoc_end = 110902322
    | Mm_Uniprot = O35457
  }}
}}
'''Chemokine (C-C motif) receptor-like 2''', also known as '''CCRL2''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: CCRL2 chemokine (C-C motif) receptor-like 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9034| accessdate = }}</ref>


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==External links==
{{PBB_Summary
* {{UCSC gene info|CCRL2}}
| section_title =  
| summary_text = This gene encodes a chemokine receptor like protein, which is predicted to be a seven transmembrane protein and most closely related to CCR1. Chemokines and their receptors mediated signal transduction are critical for the recruitment of effector immune cells to the site of inflammation. This gene is expressed at high levels in primary neutrophils and primary monocytes, and is further upregulated on neutrophil activation and during monocyte to macrophage differentiation. The function of this gene is unknown. This gene is mapped to the region where the chemokine receptor gene cluster is located.<ref name="entrez">{{cite web | title = Entrez Gene: CCRL2 chemokine (C-C motif) receptor-like 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9034| accessdate = }}</ref>
}}


==References==
== Further reading ==
{{reflist|2}}
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading  
{{PBB_Further_reading  
| citations =  
| citations =  
*{{cite journal  | author=Daugherty BL, Springer MS |title=The beta-chemokine receptor genes CCR1 (CMKBR1), CCR2 (CMKBR2), and CCR3 (CMKBR3) cluster within 285 kb on human chromosome 3p21. |journal=Genomics |volume=41 |issue= 2 |pages= 294-5 |year= 1997 |pmid= 9143512 |doi= 10.1006/geno.1997.4626 }}
*{{cite journal  | vauthors=Daugherty BL, Springer MS |title=The beta-chemokine receptor genes CCR1 (CMKBR1), CCR2 (CMKBR2), and CCR3 (CMKBR3) cluster within 285 kb on human chromosome 3p21. |journal=Genomics |volume=41 |issue= 2 |pages= 294–5 |year= 1997 |pmid= 9143512 |doi= 10.1006/geno.1997.4626 }}
*{{cite journal  | author=Fan P, Kyaw H, Su K, ''et al.'' |title=Cloning and characterization of a novel human chemokine receptor. |journal=Biochem. Biophys. Res. Commun. |volume=243 |issue= 1 |pages= 264-8 |year= 1998 |pmid= 9473515 |doi= 10.1006/bbrc.1997.7981 }}
*{{cite journal  | author=Strausberg RL |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241  |name-list-format=vanc| author2=Feingold EA  | author3=Grouse LH  | display-authors=3  | last4=Derge  | first4=JG  | last5=Klausner  | first5=RD  | last6=Collins  | first6=FS  | last7=Wagner  | first7=L  | last8=Shenmen  | first8=CM  | last9=Schuler  | first9=GD }}
*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal  | author=Galligan CL |title=Up-regulated expression and activation of the orphan chemokine receptor, CCRL2, in rheumatoid arthritis |journal=Arthritis Rheum. |volume=50 |issue= 6 |pages= 1806–14 |year= 2004 |pmid= 15188357 |doi= 10.1002/art.20275 |name-list-format=vanc| author2=Matsuyama W  | author3=Matsukawa A  | display-authors=3  | last4=Mizuta  | first4=Hiroshi  | last5=Hodge  | first5=David R.  | last6=Howard  | first6=O. M. Zack  | last7=Yoshimura  | first7=Teizo }}
*{{cite journal  | author=Galligan CL, Matsuyama W, Matsukawa A, ''et al.'' |title=Up-regulated expression and activation of the orphan chemokine receptor, CCRL2, in rheumatoid arthritis. |journal=Arthritis Rheum. |volume=50 |issue= 6 |pages= 1806-14 |year= 2004 |pmid= 15188357 |doi= 10.1002/art.20275 }}
*{{cite journal  | author=Gerhard DS |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928  |name-list-format=vanc| author2=Wagner L  | author3=Feingold EA  | display-authors=3  | last4=Shenmen  | first4=CM  | last5=Grouse  | first5=LH  | last6=Schuler  | first6=G  | last7=Klein  | first7=SL  | last8=Old  | first8=S  | last9=Rasooly  | first9=R }}
*{{cite journal  | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal  | author=Muzny DM |title=The DNA sequence, annotation and analysis of human chromosome 3 |journal=Nature |volume=440 |issue= 7088 |pages= 1194–8 |year= 2006 |pmid= 16641997 |doi= 10.1038/nature04728 |name-list-format=vanc| author2=Scherer SE  | author3=Kaul R  | display-authors=3  | last4=Wang  | first4=Jing  | last5=Yu  | first5=Jun  | last6=Sudbrak  | first6=Ralf  | last7=Buhay  | first7=Christian J.  | last8=Chen  | first8=Rui  | last9=Cree  | first9=Andrew }}
*{{cite journal  | author=Muzny DM, Scherer SE, Kaul R, ''et al.'' |title=The DNA sequence, annotation and analysis of human chromosome 3. |journal=Nature |volume=440 |issue= 7088 |pages= 1194-8 |year= 2006 |pmid= 16641997 |doi= 10.1038/nature04728 }}
}}
}}
{{refend}}
{{refend}}


{{NLM content}}
{{NLM content}}
{{membrane-protein-stub}}
 
{{Chemokine receptors}}
{{Chemokine receptors}}
{{Cytokine receptor modulators}}
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[[Category:Chemokine receptors]]
[[Category:Chemokine receptors]]
{{WikiDoc Sources}}
 
 
{{transmembranereceptor-stub}}

Latest revision as of 09:19, 30 August 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

C-C chemokine receptor-like 2 is a protein that in humans is encoded by the CCRL2 gene.[1][2] Recently it was found that CCRL2 also acts as a receptor for the chemokine chemerin.[3]

Function

This gene encodes a chemokine receptor like protein, which is predicted to be a seven transmembrane protein and most closely related to CCR1. Chemokines and their receptors mediated signal transduction are critical for the recruitment of effector immune cells to the site of inflammation. This gene is expressed at high levels in primary neutrophils and primary monocytes, and is further upregulated on neutrophil activation and during monocyte to macrophage differentiation. The function of this gene is unknown. This gene is mapped to the region where the chemokine receptor gene cluster is located.[2]

References

  1. ↑ Fan P, Kyaw H, Su K, Zeng Z, Augustus M, Carter KC, Li Y (Mar 1998). "Cloning and characterization of a novel human chemokine receptor". Biochem Biophys Res Commun. 243 (1): 264–8. doi:10.1006/bbrc.1997.7981. PMID 9473515.
  2. ↑ 2.0 2.1 "Entrez Gene: CCRL2 chemokine (C-C motif) receptor-like 2".
  3. ↑ Zabel BA, Nakae S, Zúñiga L, Kim JY, Ohyama T, Alt C, Pan J, Suto H, Soler D, Allen SJ, Handel TM, Song CH, Galli SJ, Butcher EC (September 2008). "Mast cell-expressed orphan receptor CCRL2 binds chemerin and is required for optimal induction of IgE-mediated passive cutaneous anaphylaxis". J. Exp. Med. 205 (10): 2207–20. doi:10.1084/jem.20080300. PMC 2556791. PMID 18794339.

External links

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.



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