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{{Infobox_gene}}
{{PBB_Controls
'''Calcium-activated potassium channel subunit beta-3''' is a [[protein]] that in humans is encoded by the ''KCNMB3'' [[gene]].<ref name="pmid10585773">{{cite journal |vauthors=Riazi MA, Brinkman-Mills P, Johnson A, Naylor SL, Minoshima S, Shimizu N, Baldini A, McDermid HE | title = Identification of a putative regulatory subunit of a calcium-activated potassium channel in the dup(3q) syndrome region and a related sequence on 22q11.2 | journal = Genomics | volume = 62 | issue = 1 | pages = 90–4 |date=Feb 2000 | pmid = 10585773 | pmc =  | doi = 10.1006/geno.1999.5975 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: KCNMB3 potassium large conductance calcium-activated channel, subfamily M beta member 3| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=27094| accessdate = }}</ref>
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{{GNF_Protein_box
| image =
| image_source = 
| PDB =
| Name = Potassium large conductance calcium-activated channel, subfamily M beta member 3
| HGNCid = 6287
| Symbol = KCNMB3
| AltSymbols =; KCNMB2; KCNMBL
| OMIM = 605222
| ECnumber = 
| Homologene = 18141
| MGIid = 3612244
| GeneAtlas_image1 = PBB_GE_KCNMB3_221125_s_at_tn.png
| Function = {{GNF_GO|id=GO:0005216 |text = ion channel activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0015269 |text = calcium-activated potassium channel activity}} {{GNF_GO|id=GO:0015459 |text = potassium channel regulator activity}}
| Component = {{GNF_GO|id=GO:0008076 |text = voltage-gated potassium channel complex}} {{GNF_GO|id=GO:0016020 |text = membrane}}
| Process = {{GNF_GO|id=GO:0001508 |text = regulation of action potential}} {{GNF_GO|id=GO:0005513 |text = detection of calcium ion}} {{GNF_GO|id=GO:0006811 |text = ion transport}} {{GNF_GO|id=GO:0006813 |text = potassium ion transport}} {{GNF_GO|id=GO:0019228 |text = generation of action potential}}
  | Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 27094
    | Hs_Ensembl = ENSG00000171121
    | Hs_RefseqProtein = NP_055222
    | Hs_RefseqmRNA = NM_014407
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 3
    | Hs_GenLoc_start = 180443259
    | Hs_GenLoc_end = 180467532
    | Hs_Uniprot = Q9NPA1
    | Mm_EntrezGene = 435726
    | Mm_Ensembl = ENSMUSG00000037574
    | Mm_RefseqmRNA = XM_912348
    | Mm_RefseqProtein = XP_917441
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 3
    | Mm_GenLoc_start = 32663870
    | Mm_GenLoc_end = 32674027
    | Mm_Uniprot = 
  }}
}}
'''Potassium large conductance calcium-activated channel, subfamily M beta member 3''', also known as '''KCNMB3''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: KCNMB3 potassium large conductance calcium-activated channel, subfamily M beta member 3| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=27094| accessdate = }}</ref>


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{{PBB_Summary
{{PBB_Summary
| section_title =  
| section_title =  
| summary_text = MaxiK channels are large conductance, voltage and calcium-sensitive potassium channels which are fundamental to the control of smooth muscle tone and neuronal excitability. MaxiK channels can be formed by 2 subunits: the pore-forming alpha subunit and the modulatory beta subunit. The protein encoded by this gene is an auxiliary beta subunit which may partially inactivate or slightly decrease the activation time of MaxiK alpha subunit currents. At least four transcript variants encoding four different isoforms have been found for this gene.<ref name="entrez">{{cite web | title = Entrez Gene: KCNMB3 potassium large conductance calcium-activated channel, subfamily M beta member 3| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=27094| accessdate = }}</ref>
| summary_text = MaxiK channels are large conductance, voltage and calcium-sensitive potassium channels which are fundamental to the control of smooth muscle tone and neuronal excitability. MaxiK channels can be formed by 2 subunits: the pore-forming alpha subunit and the modulatory beta subunit. The protein encoded by this gene is an auxiliary beta subunit which may partially inactivate or slightly decrease the activation time of MaxiK alpha subunit currents. At least four transcript variants encoding four different isoforms have been found for this gene.<ref name="entrez">{{cite web | title = Entrez Gene: KCNMB3 potassium large conductance calcium-activated channel, subfamily M beta member 3| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=27094| accessdate = }}</ref>
}}
}}


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==References==
==References==
{{reflist|2}}
{{reflist}}


==Further reading==
==Further reading==
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{{PBB_Further_reading  
| citations =  
| citations =  
*{{cite journal  | author=Orio P, Rojas P, Ferreira G, Latorre R |title=New disguises for an old channel: MaxiK channel beta-subunits. |journal=News Physiol. Sci. |volume=17 |issue=  |pages= 156-61 |year= 2002 |pmid= 12136044 |doi=  }}
*{{cite journal  |vauthors=Orio P, Rojas P, Ferreira G, Latorre R |title=New disguises for an old channel: MaxiK channel beta-subunits. |journal=News Physiol. Sci. |volume=17 |issue=  |pages= 156–61 |year= 2002 |pmid= 12136044 |doi=  10.1152/nips.01387.2002}}
*{{cite journal  | author=Riazi MA, Brinkman-Mills P, Johnson A, ''et al.'' |title=Identification of a putative regulatory subunit of a calcium-activated potassium channel in the dup(3q) syndrome region and a related sequence on 22q11.2. |journal=Genomics |volume=62 |issue= 1 |pages= 90-4 |year= 2000 |pmid= 10585773 |doi= 10.1006/geno.1999.5975 }}
*{{cite journal   |vauthors=Brenner R, Jegla TJ, Wickenden A, etal |title=Cloning and functional characterization of novel large conductance calcium-activated potassium channel beta subunits, hKCNMB3 and hKCNMB4. |journal=J. Biol. Chem. |volume=275 |issue= 9 |pages= 6453–61 |year= 2000 |pmid= 10692449 |doi=10.1074/jbc.275.9.6453 }}
*{{cite journal | author=Brenner R, Jegla TJ, Wickenden A, ''et al.'' |title=Cloning and functional characterization of novel large conductance calcium-activated potassium channel beta subunits, hKCNMB3 and hKCNMB4. |journal=J. Biol. Chem. |volume=275 |issue= 9 |pages= 6453-61 |year= 2000 |pmid= 10692449 |doi=  }}
*{{cite journal   |vauthors=Liu QH, Williams DA, McManus C, etal |title=HIV-1 gp120 and chemokines activate ion channels in primary macrophages through CCR5 and CXCR4 stimulation. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=97 |issue= 9 |pages= 4832–7 |year= 2000 |pmid= 10758170 |doi= 10.1073/pnas.090521697 | pmc=18318 }}
*{{cite journal | author=Liu QH, Williams DA, McManus C, ''et al.'' |title=HIV-1 gp120 and chemokines activate ion channels in primary macrophages through CCR5 and CXCR4 stimulation. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=97 |issue= 9 |pages= 4832-7 |year= 2000 |pmid= 10758170 |doi= 10.1073/pnas.090521697 }}
*{{cite journal   |vauthors=Uebele VN, Lagrutta A, Wade T, etal |title=Cloning and functional expression of two families of beta-subunits of the large conductance calcium-activated K+ channel. |journal=J. Biol. Chem. |volume=275 |issue= 30 |pages= 23211–8 |year= 2000 |pmid= 10766764 |doi= 10.1074/jbc.M910187199 }}
*{{cite journal | author=Uebele VN, Lagrutta A, Wade T, ''et al.'' |title=Cloning and functional expression of two families of beta-subunits of the large conductance calcium-activated K+ channel. |journal=J. Biol. Chem. |volume=275 |issue= 30 |pages= 23211-8 |year= 2000 |pmid= 10766764 |doi= 10.1074/jbc.M910187199 }}
*{{cite journal  |vauthors=Meera P, Wallner M, Toro L |title=A neuronal beta subunit (KCNMB4) makes the large conductance, voltage- and Ca2+-activated K+ channel resistant to charybdotoxin and iberiotoxin. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=97 |issue= 10 |pages= 5562–7 |year= 2000 |pmid= 10792058 |doi= 10.1073/pnas.100118597 | pmc=25868 }}
*{{cite journal  | author=Meera P, Wallner M, Toro L |title=A neuronal beta subunit (KCNMB4) makes the large conductance, voltage- and Ca2+-activated K+ channel resistant to charybdotoxin and iberiotoxin. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=97 |issue= 10 |pages= 5562-7 |year= 2000 |pmid= 10792058 |doi= 10.1073/pnas.100118597 }}
*{{cite journal   |vauthors=Behrens R, Nolting A, Reimann F, etal |title=hKCNMB3 and hKCNMB4, cloning and characterization of two members of the large-conductance calcium-activated potassium channel beta subunit family. |journal=FEBS Lett. |volume=474 |issue= 1 |pages= 99–106 |year= 2000 |pmid= 10828459 |doi=10.1016/S0014-5793(00)01584-2 }}
*{{cite journal | author=Behrens R, Nolting A, Reimann F, ''et al.'' |title=hKCNMB3 and hKCNMB4, cloning and characterization of two members of the large-conductance calcium-activated potassium channel beta subunit family. |journal=FEBS Lett. |volume=474 |issue= 1 |pages= 99-106 |year= 2000 |pmid= 10828459 |doi=  }}
*{{cite journal   |vauthors=Xia XM, Ding JP, Zeng XH, etal |title=Rectification and rapid activation at low Ca2+ of Ca2+-activated, voltage-dependent BK currents: consequences of rapid inactivation by a novel beta subunit. |journal=J. Neurosci. |volume=20 |issue= 13 |pages= 4890–903 |year= 2000 |pmid= 10864947 |doi=  }}
*{{cite journal | author=Xia XM, Ding JP, Zeng XH, ''et al.'' |title=Rectification and rapid activation at low Ca2+ of Ca2+-activated, voltage-dependent BK currents: consequences of rapid inactivation by a novel beta subunit. |journal=J. Neurosci. |volume=20 |issue= 13 |pages= 4890-903 |year= 2000 |pmid= 10864947 |doi=  }}
*{{cite journal  |vauthors=Lingle CJ, Zeng XH, Ding JP, Xia XM |title=Inactivation of BK channels mediated by the NH(2) terminus of the beta3b auxiliary subunit involves a two-step mechanism: possible separation of binding and blockade. |journal=J. Gen. Physiol. |volume=117 |issue= 6 |pages= 583–606 |year= 2001 |pmid= 11382808 |doi=10.1085/jgp.117.6.583  | pmc=2232400 }}
*{{cite journal  | author=Lingle CJ, Zeng XH, Ding JP, Xia XM |title=Inactivation of BK channels mediated by the NH(2) terminus of the beta3b auxiliary subunit involves a two-step mechanism: possible separation of binding and blockade. |journal=J. Gen. Physiol. |volume=117 |issue= 6 |pages= 583-606 |year= 2001 |pmid= 11382808 |doi=  }}
*{{cite journal  |vauthors=Zeng XH, Ding JP, Xia XM, Lingle CJ |title=Gating properties conferred on BK channels by the beta3b auxiliary subunit in the absence of its NH(2)- and COOH termini. |journal=J. Gen. Physiol. |volume=117 |issue= 6 |pages= 607–28 |year= 2001 |pmid= 11382809 |doi=10.1085/jgp.117.6.607  | pmc=2232397 }}
*{{cite journal  | author=Zeng XH, Ding JP, Xia XM, Lingle CJ |title=Gating properties conferred on BK channels by the beta3b auxiliary subunit in the absence of its NH(2)- and COOH termini. |journal=J. Gen. Physiol. |volume=117 |issue= 6 |pages= 607-28 |year= 2001 |pmid= 11382809 |doi=  }}
*{{cite journal   |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal  |vauthors=Zeng XH, Xia XM, Lingle CJ |title=Redox-sensitive extracellular gates formed by auxiliary beta subunits of calcium-activated potassium channels. |journal=Nat. Struct. Biol. |volume=10 |issue= 6 |pages= 448–54 |year= 2003 |pmid= 12740608 |doi= 10.1038/nsb932 }}
*{{cite journal  | author=Zeng XH, Xia XM, Lingle CJ |title=Redox-sensitive extracellular gates formed by auxiliary beta subunits of calcium-activated potassium channels. |journal=Nat. Struct. Biol. |volume=10 |issue= 6 |pages= 448-54 |year= 2003 |pmid= 12740608 |doi= 10.1038/nsb932 }}
*{{cite journal   |vauthors=Hu S, Labuda MZ, Pandolfo M, etal |title=Variants of the KCNMB3 regulatory subunit of maxi BK channels affect channel inactivation. |journal=Physiol. Genomics |volume=15 |issue= 3 |pages= 191–8 |year= 2003 |pmid= 14612589 |doi= 10.1152/physiolgenomics.00110.2003 }}
*{{cite journal | author=Hu S, Labuda MZ, Pandolfo M, ''et al.'' |title=Variants of the KCNMB3 regulatory subunit of maxi BK channels affect channel inactivation. |journal=Physiol. Genomics |volume=15 |issue= 3 |pages= 191-8 |year= 2003 |pmid= 14612589 |doi= 10.1152/physiolgenomics.00110.2003 }}
*{{cite journal  |vauthors=Lorenz S, Heils A, Kasper JM, Sander T |title=Allelic association of a truncation mutation of the KCNMB3 gene with idiopathic generalized epilepsy. |journal=Am. J. Med. Genet. B Neuropsychiatr. Genet. |volume=144 |issue= 1 |pages= 10–3 |year= 2007 |pmid= 16958040 |doi= 10.1002/ajmg.b.30369 }}
*{{cite journal  | author=Lorenz S, Heils A, Kasper JM, Sander T |title=Allelic association of a truncation mutation of the KCNMB3 gene with idiopathic generalized epilepsy. |journal=Am. J. Med. Genet. B Neuropsychiatr. Genet. |volume=144 |issue= 1 |pages= 10-3 |year= 2007 |pmid= 16958040 |doi= 10.1002/ajmg.b.30369 }}
}}
}}
{{refend}}
{{refend}}


{{membrane-protein-stub}}
{{NLM content}}
{{NLM content}}
{{Ion channels}}
{{Ion channels|g3}}
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[[Category:Ion channels]]
[[Category:Ion channels]]
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{{membrane-protein-stub}}

Latest revision as of 06:16, 2 September 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Calcium-activated potassium channel subunit beta-3 is a protein that in humans is encoded by the KCNMB3 gene.[1][2]

MaxiK channels are large conductance, voltage and calcium-sensitive potassium channels which are fundamental to the control of smooth muscle tone and neuronal excitability. MaxiK channels can be formed by 2 subunits: the pore-forming alpha subunit and the modulatory beta subunit. The protein encoded by this gene is an auxiliary beta subunit which may partially inactivate or slightly decrease the activation time of MaxiK alpha subunit currents. At least four transcript variants encoding four different isoforms have been found for this gene.[2]

See also

References

  1. ↑ Riazi MA, Brinkman-Mills P, Johnson A, Naylor SL, Minoshima S, Shimizu N, Baldini A, McDermid HE (Feb 2000). "Identification of a putative regulatory subunit of a calcium-activated potassium channel in the dup(3q) syndrome region and a related sequence on 22q11.2". Genomics. 62 (1): 90–4. doi:10.1006/geno.1999.5975. PMID 10585773.
  2. ↑ 2.0 2.1 "Entrez Gene: KCNMB3 potassium large conductance calcium-activated channel, subfamily M beta member 3".

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


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