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{{Infobox_gene}}
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'''Protein phosphatase Slingshot homolog 1''' is an [[enzyme]] that in humans is encoded by the ''SSH1'' [[gene]].<ref name="pmid10718198">{{cite journal | vauthors = Nagase T, Kikuno R, Ishikawa KI, Hirosawa M, Ohara O | title = Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro | journal = DNA Res | volume = 7 | issue = 1 | pages = 65–73 |date=Apr 2000 | pmid = 10718198 | pmc =  | doi =10.1093/dnares/7.1.65 }}</ref><ref name="pmid11832213">{{cite journal | vauthors = Niwa R, Nagata-Ohashi K, Takeichi M, Mizuno K, Uemura T | title = Control of actin reorganization by Slingshot, a family of phosphatases that dephosphorylate ADF/cofilin | journal = Cell | volume = 108 | issue = 2 | pages = 233–46 |date=Feb 2002 | pmid = 11832213 | pmc = | doi =10.1016/S0092-8674(01)00638-9 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: SSH1 slingshot homolog 1 (Drosophila)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=54434| accessdate = }}</ref>
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Slingshot homolog 1 (Drosophila)
| HGNCid = 30579
| Symbol = SSH1
| AltSymbols =; FLJ38102; KIAA1298; SSH-1
| OMIM = 606778
| ECnumber =
| Homologene = 41299
| MGIid = 2686240
  | GeneAtlas_image1 = PBB_GE_SSH1_221753_at_tn.png
| Function = {{GNF_GO|id=GO:0003779 |text = actin binding}} {{GNF_GO|id=GO:0004725 |text = protein tyrosine phosphatase activity}} {{GNF_GO|id=GO:0008138 |text = protein tyrosine/serine/threonine phosphatase activity}} {{GNF_GO|id=GO:0016787 |text = hydrolase activity}}
| Component = {{GNF_GO|id=GO:0005737 |text = cytoplasm}} {{GNF_GO|id=GO:0005856 |text = cytoskeleton}} {{GNF_GO|id=GO:0005886 |text = plasma membrane}}
  | Process = {{GNF_GO|id=GO:0000902 |text = cell morphogenesis}} {{GNF_GO|id=GO:0006470 |text = protein amino acid dephosphorylation}} {{GNF_GO|id=GO:0030036 |text = actin cytoskeleton organization and biogenesis}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 54434
    | Hs_Ensembl = ENSG00000084112
    | Hs_RefseqProtein = NP_061857
    | Hs_RefseqmRNA = NM_018984
    | Hs_GenLoc_db =
    | Hs_GenLoc_chr = 12
    | Hs_GenLoc_start = 107705100
    | Hs_GenLoc_end = 107775480
    | Hs_Uniprot = Q8WYL5
    | Mm_EntrezGene = 231637
    | Mm_Ensembl = ENSMUSG00000042121
    | Mm_RefseqmRNA = NM_198109
    | Mm_RefseqProtein = NP_932777
    | Mm_GenLoc_db =   
    | Mm_GenLoc_chr = 5
    | Mm_GenLoc_start = 114202650
    | Mm_GenLoc_end = 114254758
    | Mm_Uniprot = Q76I79
  }}
}}
'''Slingshot homolog 1 (Drosophila)''', also known as '''SSH1''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: SSH1 slingshot homolog 1 (Drosophila)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=54434| accessdate = }}</ref>


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{{PBB_Summary
{{PBB_Summary
| section_title =  
| section_title =  
| summary_text = The ADF (actin-depolymerizing factor)/cofilin family (see MIM 601442) is composed of stimulus-responsive mediators of actin dynamics. ADF/cofilin proteins are inactivated by kinases such as LIM domain kinase-1 (LIMK1; MIM 601329). The SSH family appears to play a role in actin dynamics by reactivating ADF/cofilin proteins in vivo (Niwa et al., 2002).[supplied by OMIM]<ref name="entrez">{{cite web | title = Entrez Gene: SSH1 slingshot homolog 1 (Drosophila)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=54434| accessdate = }}</ref>
| summary_text = The ADF (actin-depolymerizing factor)/cofilin family (see MIM 601442) is composed of stimulus-responsive mediators of actin dynamics. ADF/cofilin proteins are inactivated by kinases such as LIM domain kinase-1 (LIMK1; MIM 601329). The SSH family appears to play a role in actin dynamics by reactivating ADF/cofilin proteins in vivo (Niwa et al., 2002).[supplied by OMIM]<ref name="entrez"/>
}}
}}


==References==
==References==
{{reflist|2}}
{{reflist}}
 
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading  
{{PBB_Further_reading  
| citations =  
| citations =  
*{{cite journal | author=Nagase T, Kikuno R, Ishikawa KI, ''et al.'' |title=Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro. |journal=DNA Res. |volume=7 |issue= 1 |pages= 65-73 |year= 2000 |pmid= 10718198 |doi=  }}
*{{cite journal   |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 }}
*{{cite journal  | author=Niwa R, Nagata-Ohashi K, Takeichi M, ''et al.'' |title=Control of actin reorganization by Slingshot, a family of phosphatases that dephosphorylate ADF/cofilin. |journal=Cell |volume=108 |issue= 2 |pages= 233-46 |year= 2002 |pmid= 11832213 |doi=  }}
*{{cite journal   |vauthors=Endo M, Ohashi K, Sasaki Y, etal |title=Control of growth cone motility and morphology by LIM kinase and Slingshot via phosphorylation and dephosphorylation of cofilin. |journal=J. Neurosci. |volume=23 |issue= 7 |pages= 2527–37 |year= 2003 |pmid= 12684437 |doi=  }}
*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal   |vauthors=Kaji N, Ohashi K, Shuin M, etal |title=Cell cycle-associated changes in Slingshot phosphatase activity and roles in cytokinesis in animal cells. |journal=J. Biol. Chem. |volume=278 |issue= 35 |pages= 33450–5 |year= 2003 |pmid= 12807904 |doi= 10.1074/jbc.M305802200 }}
*{{cite journal | author=Endo M, Ohashi K, Sasaki Y, ''et al.'' |title=Control of growth cone motility and morphology by LIM kinase and Slingshot via phosphorylation and dephosphorylation of cofilin. |journal=J. Neurosci. |volume=23 |issue= 7 |pages= 2527-37 |year= 2003 |pmid= 12684437 |doi=  }}
*{{cite journal   |vauthors=Ohta Y, Kousaka K, Nagata-Ohashi K, etal |title=Differential activities, subcellular distribution and tissue expression patterns of three members of Slingshot family phosphatases that dephosphorylate cofilin. |journal=Genes Cells |volume=8 |issue= 10 |pages= 811–24 |year= 2004 |pmid= 14531860 |doi=10.1046/j.1365-2443.2003.00678.x }}
*{{cite journal | author=Kaji N, Ohashi K, Shuin M, ''et al.'' |title=Cell cycle-associated changes in Slingshot phosphatase activity and roles in cytokinesis in animal cells. |journal=J. Biol. Chem. |volume=278 |issue= 35 |pages= 33450-5 |year= 2003 |pmid= 12807904 |doi= 10.1074/jbc.M305802200 }}
*{{cite journal   |vauthors=Nishita M, Wang Y, Tomizawa C, etal |title=Phosphoinositide 3-kinase-mediated activation of cofilin phosphatase Slingshot and its role for insulin-induced membrane protrusion. |journal=J. Biol. Chem. |volume=279 |issue= 8 |pages= 7193–8 |year= 2004 |pmid= 14645219 |doi= 10.1074/jbc.M312591200 }}
*{{cite journal | author=Ohta Y, Kousaka K, Nagata-Ohashi K, ''et al.'' |title=Differential activities, subcellular distribution and tissue expression patterns of three members of Slingshot family phosphatases that dephosphorylate cofilin. |journal=Genes Cells |volume=8 |issue= 10 |pages= 811-24 |year= 2004 |pmid= 14531860 |doi=  }}
*{{cite journal   |vauthors=Ota T, Suzuki Y, Nishikawa T, etal |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
*{{cite journal | author=Nishita M, Wang Y, Tomizawa C, ''et al.'' |title=Phosphoinositide 3-kinase-mediated activation of cofilin phosphatase Slingshot and its role for insulin-induced membrane protrusion. |journal=J. Biol. Chem. |volume=279 |issue= 8 |pages= 7193-8 |year= 2004 |pmid= 14645219 |doi= 10.1074/jbc.M312591200 }}
*{{cite journal   |vauthors=Dai S, Sarmiere PD, Wiggan O, etal |title=Efficient Salmonella entry requires activity cycles of host ADF and cofilin. |journal=Cell. Microbiol. |volume=6 |issue= 5 |pages= 459–71 |year= 2004 |pmid= 15056216 |doi= 10.1111/j.1462-5822.2004.00375.x }}
*{{cite journal | author=Ota T, Suzuki Y, Nishikawa T, ''et al.'' |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40-5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
*{{cite journal   |vauthors=Nagata-Ohashi K, Ohta Y, Goto K, etal |title=A pathway of neuregulin-induced activation of cofilin-phosphatase Slingshot and cofilin in lamellipodia. |journal=J. Cell Biol. |volume=165 |issue= 4 |pages= 465–71 |year= 2004 |pmid= 15159416 |doi= 10.1083/jcb.200401136 | pmc=2172350 }}
*{{cite journal | author=Dai S, Sarmiere PD, Wiggan O, ''et al.'' |title=Efficient Salmonella entry requires activity cycles of host ADF and cofilin. |journal=Cell. Microbiol. |volume=6 |issue= 5 |pages= 459-71 |year= 2004 |pmid= 15056216 |doi= 10.1111/j.1462-5822.2004.00375.x }}
*{{cite journal   |vauthors=Beausoleil SA, Jedrychowski M, Schwartz D, etal |title=Large-scale characterization of HeLa cell nuclear phosphoproteins. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=101 |issue= 33 |pages= 12130–5 |year= 2004 |pmid= 15302935 |doi= 10.1073/pnas.0404720101 | pmc=514446 }}
*{{cite journal | author=Nagata-Ohashi K, Ohta Y, Goto K, ''et al.'' |title=A pathway of neuregulin-induced activation of cofilin-phosphatase Slingshot and cofilin in lamellipodia. |journal=J. Cell Biol. |volume=165 |issue= 4 |pages= 465-71 |year= 2004 |pmid= 15159416 |doi= 10.1083/jcb.200401136 }}
*{{cite journal   |vauthors=Zhang Z, Niu Z, Yuan W, etal |title=Fine mapping and identification of a candidate gene SSH1 in disseminated superficial actinic porokeratosis. |journal=Hum. Mutat. |volume=24 |issue= 5 |pages= 438 |year= 2005 |pmid= 15459975 |doi= 10.1002/humu.9283 }}
*{{cite journal | author=Beausoleil SA, Jedrychowski M, Schwartz D, ''et al.'' |title=Large-scale characterization of HeLa cell nuclear phosphoproteins. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=101 |issue= 33 |pages= 12130-5 |year= 2004 |pmid= 15302935 |doi= 10.1073/pnas.0404720101 }}
*{{cite journal   |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 }}
*{{cite journal | author=Zhang Z, Niu Z, Yuan W, ''et al.'' |title=Fine mapping and identification of a candidate gene SSH1 in disseminated superficial actinic porokeratosis. |journal=Hum. Mutat. |volume=24 |issue= 5 |pages= 438 |year= 2005 |pmid= 15459975 |doi= 10.1002/humu.9283 }}
*{{cite journal   |vauthors=Soosairajah J, Maiti S, Wiggan O, etal |title=Interplay between components of a novel LIM kinase-slingshot phosphatase complex regulates cofilin. |journal=EMBO J. |volume=24 |issue= 3 |pages= 473–86 |year= 2005 |pmid= 15660133 |doi= 10.1038/sj.emboj.7600543 | pmc=548651 }}
*{{cite journal | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal  | vauthors=Wang Y, Shibasaki F, Mizuno K |title=Calcium signal-induced cofilin dephosphorylation is mediated by Slingshot via calcineurin. |journal=J. Biol. Chem. |volume=280 |issue= 13 |pages= 12683–9 |year= 2005 |pmid= 15671020 |doi= 10.1074/jbc.M411494200 }}
*{{cite journal | author=Soosairajah J, Maiti S, Wiggan O, ''et al.'' |title=Interplay between components of a novel LIM kinase-slingshot phosphatase complex regulates cofilin. |journal=EMBO J. |volume=24 |issue= 3 |pages= 473-86 |year= 2005 |pmid= 15660133 |doi= 10.1038/sj.emboj.7600543 }}
*{{cite journal   |vauthors=Nishita M, Tomizawa C, Yamamoto M, etal |title=Spatial and temporal regulation of cofilin activity by LIM kinase and Slingshot is critical for directional cell migration. |journal=J. Cell Biol. |volume=171 |issue= 2 |pages= 349–59 |year= 2006 |pmid= 16230460 |doi= 10.1083/jcb.200504029 | pmc=2171197 }}
*{{cite journal  | author=Wang Y, Shibasaki F, Mizuno K |title=Calcium signal-induced cofilin dephosphorylation is mediated by Slingshot via calcineurin. |journal=J. Biol. Chem. |volume=280 |issue= 13 |pages= 12683-9 |year= 2005 |pmid= 15671020 |doi= 10.1074/jbc.M411494200 }}
*{{cite journal   |vauthors=Yamamoto M, Nagata-Ohashi K, Ohta Y, etal |title=Identification of multiple actin-binding sites in cofilin-phosphatase Slingshot-1L. |journal=FEBS Lett. |volume=580 |issue= 7 |pages= 1789–94 |year= 2006 |pmid= 16513117 |doi= 10.1016/j.febslet.2006.02.034 }}
*{{cite journal | author=Nishita M, Tomizawa C, Yamamoto M, ''et al.'' |title=Spatial and temporal regulation of cofilin activity by LIM kinase and Slingshot is critical for directional cell migration. |journal=J. Cell Biol. |volume=171 |issue= 2 |pages= 349-59 |year= 2006 |pmid= 16230460 |doi= 10.1083/jcb.200504029 }}
*{{cite journal   |vauthors=Cai L, Marshall TW, Uetrecht AC, etal |title=Coronin 1B coordinates Arp2/3 complex and cofilin activities at the leading edge. |journal=Cell |volume=128 |issue= 5 |pages= 915–29 |year= 2007 |pmid= 17350576 |doi= 10.1016/j.cell.2007.01.031 | pmc=2630706 }}
*{{cite journal | author=Yamamoto M, Nagata-Ohashi K, Ohta Y, ''et al.'' |title=Identification of multiple actin-binding sites in cofilin-phosphatase Slingshot-1L. |journal=FEBS Lett. |volume=580 |issue= 7 |pages= 1789-94 |year= 2006 |pmid= 16513117 |doi= 10.1016/j.febslet.2006.02.034 }}
*{{cite journal   |vauthors=Kligys K, Claiborne JN, DeBiase PJ, etal |title=The slingshot family of phosphatases mediates Rac1 regulation of cofilin phosphorylation, laminin-332 organization, and motility behavior of keratinocytes. |journal=J. Biol. Chem. |volume=282 |issue= 44 |pages= 32520–8 |year= 2007 |pmid= 17848544 |doi= 10.1074/jbc.M707041200 | pmc=2754063 }}
*{{cite journal | author=Cai L, Marshall TW, Uetrecht AC, ''et al.'' |title=Coronin 1B coordinates Arp2/3 complex and cofilin activities at the leading edge. |journal=Cell |volume=128 |issue= 5 |pages= 915-29 |year= 2007 |pmid= 17350576 |doi= 10.1016/j.cell.2007.01.031 }}
*{{cite journal | author=Kligys K, Claiborne JN, DeBiase PJ, ''et al.'' |title=The slingshot family of phosphatases mediates Rac1 regulation of cofilin phosphorylation, laminin-332 organization, and motility behavior of keratinocytes. |journal=J. Biol. Chem. |volume=282 |issue= 44 |pages= 32520-8 |year= 2007 |pmid= 17848544 |doi= 10.1074/jbc.M707041200 }}
}}
}}
{{refend}}
{{refend}}


{{protein-stub}}
{{Protein tyrosine phosphatases}}
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{{gene-12-stub}}

Latest revision as of 07:06, 11 September 2017

VALUE_ERROR (nil)
Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

For the SSH-1 protocol, see Secure Shell#Version 1.x

Protein phosphatase Slingshot homolog 1 is an enzyme that in humans is encoded by the SSH1 gene.[1][2][3]

The ADF (actin-depolymerizing factor)/cofilin family (see MIM 601442) is composed of stimulus-responsive mediators of actin dynamics. ADF/cofilin proteins are inactivated by kinases such as LIM domain kinase-1 (LIMK1; MIM 601329). The SSH family appears to play a role in actin dynamics by reactivating ADF/cofilin proteins in vivo (Niwa et al., 2002).[supplied by OMIM][3]

References

  1. ↑ Nagase T, Kikuno R, Ishikawa KI, Hirosawa M, Ohara O (Apr 2000). "Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 7 (1): 65–73. doi:10.1093/dnares/7.1.65. PMID 10718198.
  2. ↑ Niwa R, Nagata-Ohashi K, Takeichi M, Mizuno K, Uemura T (Feb 2002). "Control of actin reorganization by Slingshot, a family of phosphatases that dephosphorylate ADF/cofilin". Cell. 108 (2): 233–46. doi:10.1016/S0092-8674(01)00638-9. PMID 11832213.
  3. ↑ 3.0 3.1 "Entrez Gene: SSH1 slingshot homolog 1 (Drosophila)".

Further reading



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