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{{Infobox_gene}}
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'''K<sub>v</sub> channel-interacting protein 1''' also known as '''KChIP1''' is a [[protein]] that in humans is encoded by the ''KCNIP1'' [[gene]].<ref name="pmid10676964">{{cite journal |vauthors=An WF, Bowlby MR, Betty M, Cao J, Ling HP, Mendoza G, Hinson JW, Mattsson KI, Strassle BW, Trimmer JS, Rhodes KJ | title = Modulation of A-type potassium channels by a family of calcium sensors | journal = Nature | volume = 403 | issue = 6769 | pages = 553–556 |date=Feb 2000 | pmid = 10676964 | pmc = | doi = 10.1038/35000592 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: KCNIP1 Kv channel interacting protein 1| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=30820| accessdate = }}</ref>
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| require_manual_inspection = no
== Function ==
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
This gene encodes a member of the family of voltage-gated potassium ([[voltage-gated potassium channel|K<sub>v</sub>]]) channel-interacting proteins (KCNIPs, also frequently called "KChIP"), which belong to the [[recoverin]] branch of the [[EF hand|EF-hand]] superfamily.<ref name="pmid17311005">{{cite journal | author = Burgoyne RD| title = Neuronal calcium sensor proteins: generating diversity in neuronal Ca2+ signalling| journal = Nat. Rev. Neurosci. | volume = 8 | issue = 3 |pages = 182–193 | year = 2007 | pmid = 17311005 | pmc = 1887812 | doi = 10.1038/nrn2093 }}</ref> Members of the KCNIP family are small calcium binding proteins. They all have EF-hand-like domains, and differ from each other in the [[N-terminus]]. They are integral subunit components of native K<sub>v</sub>4 channel complexes. They may regulate A-type currents, and hence neuronal excitability, in response to changes in intracellular calcium. Alternative splicing results in multiple transcript variant encoding different isoforms.<ref name="entrez" />
{{GNF_Protein_box
| image = PBB_Protein_KCNIP1_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1s1e.
| PDB = {{PDB2|1s1e}}, {{PDB2|1s6c}}, {{PDB2|2i2r}}, {{PDB2|2nz0}}
| Name = Kv channel interacting protein 1
| HGNCid = 15521
| Symbol = KCNIP1
| AltSymbols =; KCHIP1; MGC95; VABP
| OMIM = 604660
| ECnumber = 
| Homologene = 22824
| MGIid = 1917607
| GeneAtlas_image1 = PBB_GE_KCNIP1_221307_at_tn.png
| Function = {{GNF_GO|id=GO:0005216 |text = ion channel activity}} {{GNF_GO|id=GO:0005244 |text = voltage-gated ion channel activity}} {{GNF_GO|id=GO:0005267 |text = potassium channel activity}} {{GNF_GO|id=GO:0005509 |text = calcium ion binding}} {{GNF_GO|id=GO:0030955 |text = potassium ion binding}}
| Component =
| Process = {{GNF_GO|id=GO:0005513 |text = detection of calcium ion}} {{GNF_GO|id=GO:0006811 |text = ion transport}} {{GNF_GO|id=GO:0006813 |text = potassium ion transport}} {{GNF_GO|id=GO:0007165 |text = signal transduction}} {{GNF_GO|id=GO:0007268 |text = synaptic transmission}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 30820
    | Hs_Ensembl = ENSG00000182132
    | Hs_RefseqProtein = NP_001030009
    | Hs_RefseqmRNA = NM_001034837
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 5
    | Hs_GenLoc_start = 169713459
    | Hs_GenLoc_end = 170095388
    | Hs_Uniprot = Q9NZI2
    | Mm_EntrezGene = 70357
    | Mm_Ensembl = ENSMUSG00000053519
    | Mm_RefseqmRNA = NM_027398
    | Mm_RefseqProtein = NP_081674
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 11
    | Mm_GenLoc_start = 33529343
    | Mm_GenLoc_end = 33892836
    | Mm_Uniprot = Q3YAB4
  }}
}}
'''Kv channel interacting protein 1''', also known as '''KCNIP1''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: KCNIP1 Kv channel interacting protein 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=30820| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
==See also==
{{PBB_Summary
* [[Voltage-gated potassium channel]]
| section_title =  
| summary_text = This gene encodes a member of the family of voltage-gated potassium (Kv) channel-interacting proteins (KCNIPs), which belong to the recoverin branch of the EF-hand superfamily. Members of the KCNIP family are small calcium binding proteins. They all have EF-hand-like domains, and differ from each other in the N-terminus. They are integral subunit components of native Kv4 channel complexes. They may regulate A-type currents, and hence neuronal excitability, in response to changes in intracellular calcium. Alternative splicing results in multiple transcript variant encoding different isoforms.<ref name="entrez">{{cite web | title = Entrez Gene: KCNIP1 Kv channel interacting protein 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=30820| accessdate = }}</ref>
}}


==References==
==References==
{{reflist|2}}
{{reflist}}
 
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading  
{{PBB_Further_reading  
| citations =  
| citations =  
*{{cite journal  | author=An WF, Bowlby MR, Betty M, ''et al.'' |title=Modulation of A-type potassium channels by a family of calcium sensors. |journal=Nature |volume=403 |issue= 6769 |pages= 553-6 |year= 2000 |pmid= 10676964 |doi= 10.1038/35000592 }}
*{{cite journal  | author=Bähring R |title=Conserved Kv4 N-terminal domain critical for effects of Kv channel-interacting protein 2.2 on channel expression and gating |journal=J. Biol. Chem. |volume=276 |issue= 26 |pages= 23888–23894 |year= 2001 |pmid= 11287421 |doi= 10.1074/jbc.M101320200 |name-list-format=vanc| author2=Dannenberg J  | author3=Peters HC  | display-authors=3  | last4=Leicher  | first4=T  | last5=Pongs  | first5=O  | last6=Isbrandt  | first6=D }}
*{{cite journal  | author=Bähring R, Dannenberg J, Peters HC, ''et al.'' |title=Conserved Kv4 N-terminal domain critical for effects of Kv channel-interacting protein 2.2 on channel expression and gating. |journal=J. Biol. Chem. |volume=276 |issue= 26 |pages= 23888-94 |year= 2001 |pmid= 11287421 |doi= 10.1074/jbc.M101320200 }}
*{{cite journal  | author=Nakamura TY |title=Different effects of the Ca(2+)-binding protein, KChIP1, on two Kv4 subfamily members, Kv4.1 and Kv4.2 |journal=FEBS Lett. |volume=499 |issue= 3 |pages= 205–209 |year= 2001 |pmid= 11423117 |doi=10.1016/S0014-5793(01)02560-1  |name-list-format=vanc| author2=Nandi S  | author3=Pountney DJ  | display-authors=3  | last4=Artman  | first4=M  | last5=Rudy  | first5=B  | last6=Coetzee  | first6=WA }}
*{{cite journal  | author=Nakamura TY, Nandi S, Pountney DJ, ''et al.'' |title=Different effects of the Ca(2+)-binding protein, KChIP1, on two Kv4 subfamily members, Kv4.1 and Kv4.2. |journal=FEBS Lett. |volume=499 |issue= 3 |pages= 205-9 |year= 2001 |pmid= 11423117 |doi=  }}
*{{cite journal  | author=Kutsenko AS |title=NotI flanking sequences: a tool for gene discovery and verification of the human genome |journal=Nucleic Acids Res. |volume=30 |issue= 14 |pages= 3163–3170 |year= 2002 |pmid= 12136098 |doi=10.1093/nar/gkf428  | pmc=135748  |name-list-format=vanc| author2=Gizatullin RZ  | author3=Al-Amin AN  | display-authors=3  | last4=Wang  | first4=F  | last5=Kvasha  | first5=SM  | last6=Podowski  | first6=RM  | last7=Matushkin  | first7=YG  | last8=Gyanchandani  | first8=A  | last9=Muravenko  | first9=OV }}
*{{cite journal  | author=Kutsenko AS, Gizatullin RZ, Al-Amin AN, ''et al.'' |title=NotI flanking sequences: a tool for gene discovery and verification of the human genome. |journal=Nucleic Acids Res. |volume=30 |issue= 14 |pages= 3163-70 |year= 2002 |pmid= 12136098 |doi=  }}
*{{cite journal  | author=Strausberg RL |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–16903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241  |name-list-format=vanc| author2=Feingold EA  | author3=Grouse LH  | display-authors=3  | last4=Derge  | first4=JG  | last5=Klausner  | first5=RD  | last6=Collins  | first6=FS  | last7=Wagner  | first7=L  | last8=Shenmen  | first8=CM  | last9=Schuler  | first9=GD }}
*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal  | author=Shibata R |title=A fundamental role for KChIPs in determining the molecular properties and trafficking of Kv4.2 potassium channels |journal=J. Biol. Chem. |volume=278 |issue= 38 |pages= 36445–36454 |year= 2003 |pmid= 12829703 |doi= 10.1074/jbc.M306142200 |name-list-format=vanc| author2=Misonou H  | author3=Campomanes CR  | display-authors=3  | last4=Anderson  | first4=AE  | last5=Schrader  | first5=LA  | last6=Doliveira  | first6=LC  | last7=Carroll  | first7=KI  | last8=Sweatt  | first8=JD  | last9=Rhodes  | first9=KJ }}
*{{cite journal  | author=Shibata R, Misonou H, Campomanes CR, ''et al.'' |title=A fundamental role for KChIPs in determining the molecular properties and trafficking of Kv4.2 potassium channels. |journal=J. Biol. Chem. |volume=278 |issue= 38 |pages= 36445-54 |year= 2003 |pmid= 12829703 |doi= 10.1074/jbc.M306142200 }}
*{{cite journal  | author=Van Hoorick D |title=Differential modulation of Kv4 kinetics by KCHIP1 splice variants |journal=Mol. Cell. Neurosci. |volume=24 |issue= 2 |pages= 357–366 |year= 2004 |pmid= 14572458 |doi=10.1016/S1044-7431(03)00174-X  |name-list-format=vanc| author2=Raes A  | author3=Keysers W  | display-authors=3  | last4=Mayeur  | first4=E  | last5=Snyders  | first5=DJ }}
*{{cite journal  | author=Van Hoorick D, Raes A, Keysers W, ''et al.'' |title=Differential modulation of Kv4 kinetics by KCHIP1 splice variants. |journal=Mol. Cell. Neurosci. |volume=24 |issue= 2 |pages= 357-66 |year= 2004 |pmid= 14572458 |doi=  }}
*{{cite journal  | author=Scannevin RH |title=Two N-terminal domains of Kv4 K(+) channels regulate binding to and modulation by KChIP1 |journal=Neuron |volume=41 |issue= 4 |pages= 587–598 |year= 2004 |pmid= 14980207 |doi=10.1016/S0896-6273(04)00049-2  |name-list-format=vanc| author2=Wang K  | author3=Jow F  | display-authors=3  | last4=Megules  | first4=Jennifer  | last5=Kopsco  | first5=David C  | last6=Edris  | first6=Wade  | last7=Carroll  | first7=Karen C  | last8=Lü  | first8=Qiang  | last9=Xu  | first9=Weixin }}
*{{cite journal  | author=Scannevin RH, Wang K, Jow F, ''et al.'' |title=Two N-terminal domains of Kv4 K(+) channels regulate binding to and modulation by KChIP1. |journal=Neuron |volume=41 |issue= 4 |pages= 587-98 |year= 2004 |pmid= 14980207 |doi=  }}
*{{cite journal  |vauthors=Lin YL, Lin SR, Wu TT, Chang LS |title=Evidence showing an intermolecular interaction between KChIP proteins and Taiwan cobra cardiotoxins |journal=Biochem. Biophys. Res. Commun. |volume=319 |issue= 3 |pages= 720–724 |year= 2004 |pmid= 15184042 |doi= 10.1016/j.bbrc.2004.05.064 }}
*{{cite journal  | author=Lin YL, Lin SR, Wu TT, Chang LS |title=Evidence showing an intermolecular interaction between KChIP proteins and Taiwan cobra cardiotoxins. |journal=Biochem. Biophys. Res. Commun. |volume=319 |issue= 3 |pages= 720-4 |year= 2004 |pmid= 15184042 |doi= 10.1016/j.bbrc.2004.05.064 }}
*{{cite journal  |vauthors=Lin YL, Chen CY, Cheng CP, Chang LS |title=Protein-protein interactions of KChIP proteins and Kv4.2 |journal=Biochem. Biophys. Res. Commun. |volume=321 |issue= 3 |pages= 606–610 |year= 2004 |pmid= 15358149 |doi= 10.1016/j.bbrc.2004.07.006 }}
*{{cite journal  | author=Lin YL, Chen CY, Cheng CP, Chang LS |title=Protein-protein interactions of KChIP proteins and Kv4.2. |journal=Biochem. Biophys. Res. Commun. |volume=321 |issue= 3 |pages= 606-10 |year= 2004 |pmid= 15358149 |doi= 10.1016/j.bbrc.2004.07.006 }}
*{{cite journal  | author=Gerhard DS |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–2127 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928  |name-list-format=vanc| author2=Wagner L  | author3=Feingold EA  | display-authors=3  | last4=Shenmen  | first4=CM  | last5=Grouse  | first5=LH  | last6=Schuler  | first6=G  | last7=Klein  | first7=SL  | last8=Old  | first8=S  | last9=Rasooly  | first9=R }}
*{{cite journal  | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal  |vauthors=Pruunsild P, Timmusk T |title=Structure, alternative splicing, and expression of the human and mouse KCNIP gene family |journal=Genomics |volume=86 |issue= 5 |pages= 581–593 |year= 2005 |pmid= 16112838 |doi= 10.1016/j.ygeno.2005.07.001 }}
*{{cite journal  | author=Pruunsild P, Timmusk T |title=Structure, alternative splicing, and expression of the human and mouse KCNIP gene family. |journal=Genomics |volume=86 |issue= 5 |pages= 581-93 |year= 2005 |pmid= 16112838 |doi= 10.1016/j.ygeno.2005.07.001 }}
*{{cite journal  | author=Pioletti M, Findeisen F, Hura GL, Minor DL |title=Three-dimensional structure of the KChIP1-Kv4.3 T1 complex reveals a cross-shaped octamer |journal=Nat. Struct. Mol. Biol. |volume=13 |issue= 11 |pages= 987–995 |year= 2007 |pmid= 17057713 |doi= 10.1038/nsmb1164 | last4=Minor  | pmc=3018330 }}
*{{cite journal  | author=Pioletti M, Findeisen F, Hura GL, Minor DL |title=Three-dimensional structure of the KChIP1-Kv4.3 T1 complex reveals a cross-shaped octamer. |journal=Nat. Struct. Mol. Biol. |volume=13 |issue= 11 |pages= 987-95 |year= 2007 |pmid= 17057713 |doi= 10.1038/nsmb1164 }}
*{{cite journal  | doi= 10.1083/jcb.200506005  |vauthors=Hasdemir B, Fitzgerald DJ, Prior IA, Tepikin AV, Burgoyne  RD |title= Traffic of Kv4 K+ channels mediated by KChIP1 is via a novel post-ER vesicular pathway |journal=J. Cell Biol. |volume=171  | issue= 3 |pages= 459–469 |year= 2005 |pmid= 16260497  | pmc= 2171252 }}
*{{cite journal  | doi= 10.1042/BJ20080441  |vauthors=Venn N, Haynes LP, Burgoyne  RD |title= Specific effects of KChIP3/calsenilin/DREAM but not KChIPs1, 2 and 4 on calcium signalling and regulated secretion in PC12 cells |journal= Biochem. J. |volume=413  | issue= 1 |pages= 71–80 |year= 2008 |pmid= 18393943  | pmc= 2474559 }}
}}
}}
{{refend}}
{{refend}}


{{protein-stub}}
== External links ==
{{WikiDoc Sources}}
* {{MeshName|KCNIP1+protein,+human}}
 
{{NLM content}}
{{PDB Gallery|geneid=30820}}
{{Ion channels|g3}}
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{{PBB_Controls
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[[Category:Ion channels]]
[[Category:EF-hand-containing proteins]]
 
 
{{gene-5-stub}}

Latest revision as of 06:14, 2 September 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Kv channel-interacting protein 1 also known as KChIP1 is a protein that in humans is encoded by the KCNIP1 gene.[1][2]

Function

This gene encodes a member of the family of voltage-gated potassium (Kv) channel-interacting proteins (KCNIPs, also frequently called "KChIP"), which belong to the recoverin branch of the EF-hand superfamily.[3] Members of the KCNIP family are small calcium binding proteins. They all have EF-hand-like domains, and differ from each other in the N-terminus. They are integral subunit components of native Kv4 channel complexes. They may regulate A-type currents, and hence neuronal excitability, in response to changes in intracellular calcium. Alternative splicing results in multiple transcript variant encoding different isoforms.[2]

See also

References

  1. ↑ An WF, Bowlby MR, Betty M, Cao J, Ling HP, Mendoza G, Hinson JW, Mattsson KI, Strassle BW, Trimmer JS, Rhodes KJ (Feb 2000). "Modulation of A-type potassium channels by a family of calcium sensors". Nature. 403 (6769): 553–556. doi:10.1038/35000592. PMID 10676964.
  2. ↑ 2.0 2.1 "Entrez Gene: KCNIP1 Kv channel interacting protein 1".
  3. ↑ Burgoyne RD (2007). "Neuronal calcium sensor proteins: generating diversity in neuronal Ca2+ signalling". Nat. Rev. Neurosci. 8 (3): 182–193. doi:10.1038/nrn2093. PMC 1887812. PMID 17311005.

Further reading

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


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