Dual specificity protein phosphatase 15 is an enzyme that in humans is encoded by the DUSP15gene.[1][2]
The protein encoded by this gene belongs to the non-receptor class of the protein-tyrosine phosphatase family. The encoded protein has both protein-tyrosine phosphatase activity and serine/threonine-specific phosphatase activity, and therefore is known as a dual specificity phosphatase. Three transcript variants, encoding two different isoforms have been found for this gene.[2]
References
↑Alonso A, Narisawa S, Bogetz J, Tautz L, Hadzic R, Huynh H, Williams S, Gjorloff-Wingren A, Bremer MC, Holsinger LJ, Millan JL, Mustelin T (Jul 2004). "VHY, a novel myristoylated testis-restricted dual specificity protein phosphatase related to VHX". J Biol Chem. 279 (31): 32586–91. doi:10.1074/jbc.M403442200. PMID15138252.
Yoon TS, Jeong DG, Kim JH, et al. (2006). "Crystal structure of the catalytic domain of human VHY, a dual-specificity protein phosphatase". Proteins. 61 (3): 694–7. doi:10.1002/prot.20642. PMID16170801.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID14702039.
Deloukas P, Matthews LH, Ashurst J, et al. (2002). "The DNA sequence and comparative analysis of human chromosome 20". Nature. 414 (6866): 865–71. doi:10.1038/414865a. PMID11780052.
