KCNJ5: Difference between revisions

Jump to navigation Jump to search
VisualWikitext
m (Robot: Automated text replacement (-{{WikiDoc Cardiology Network Infobox}} +, -<references /> +{{reflist|2}}, -{{reflist}} +{{reflist|2}}))
 
imported>SoledadMirandaRottmann
m (Added tissue expression in humans)
 
(One intermediate revision by one other user not shown)
Line 1: Line 1:
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{Infobox_gene}}
{{PBB_Controls
'''G protein-activated inward rectifier potassium channel 4''' is a [[protein]] that in humans is encoded by the ''KCNJ5'' [[gene]] and is a type of [[G protein-gated ion channel]].<ref name="pmid16382105">{{cite journal | vauthors = Kubo Y, Adelman JP, Clapham DE, Jan LY, Karschin A, Kurachi Y, Lazdunski M, Nichols CG, Seino S, Vandenberg CA | title = International Union of Pharmacology. LIV. Nomenclature and molecular relationships of inwardly rectifying potassium channels | journal = Pharmacological Reviews | volume = 57 | issue = 4 | pages = 509–26 | date = December 2005 | pmid = 16382105 | pmc = | doi = 10.1124/pr.57.4.11 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: KCNJ5 potassium inwardly-rectifying channel, subfamily J, member 5| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3762 }}</ref>
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}


<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Function ==
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Potassium inwardly-rectifying channel, subfamily J, member 5
| HGNCid = 6266
| Symbol = KCNJ5
| AltSymbols =; CIR; GIRK4; KATP1; KIR3.4
| OMIM = 600734
| ECnumber = 
| Homologene = 20248
| MGIid = 104755
| Function = {{GNF_GO|id=GO:0005244 |text = voltage-gated ion channel activity}} {{GNF_GO|id=GO:0015273 |text = G-protein enhanced inward rectifier potassium channel activity}} {{GNF_GO|id=GO:0015467 |text = G-protein activated inward rectifier potassium channel activity}} {{GNF_GO|id=GO:0030955 |text = potassium ion binding}}
| Component = {{GNF_GO|id=GO:0008076 |text = voltage-gated potassium channel complex}} {{GNF_GO|id=GO:0016020 |text = membrane}} {{GNF_GO|id=GO:0016021 |text = integral to membrane}}
| Process = {{GNF_GO|id=GO:0006811 |text = ion transport}} {{GNF_GO|id=GO:0006813 |text = potassium ion transport}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 3762
    | Hs_Ensembl = ENSG00000120457
    | Hs_RefseqProtein = NP_000881
    | Hs_RefseqmRNA = NM_000890
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 11
    | Hs_GenLoc_start = 128266517
    | Hs_GenLoc_end = 128293159
    | Hs_Uniprot = P48544
    | Mm_EntrezGene = 16521
    | Mm_Ensembl = ENSMUSG00000032034
    | Mm_RefseqmRNA = NM_010605
    | Mm_RefseqProtein = NP_034735
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 9
    | Mm_GenLoc_start = 32064348
    | Mm_GenLoc_end = 32093802
    | Mm_Uniprot = Q3MI15
  }}
}}
'''Potassium inwardly-rectifying channel, subfamily J, member 5''', also known as '''KCNJ5''' or '''K<sub>ir</sub>3.4''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: KCNJ5 potassium inwardly-rectifying channel, subfamily J, member 5| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3762| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
Potassium channels are present in most mammalian cells, where they participate in a wide range of physiologic responses. The protein encoded by this gene is an integral membrane protein and inward-rectifier type potassium channel. The encoded protein, which has a greater tendency to allow potassium to flow into a cell rather than out of a cell, is controlled by G-proteins. It may associate with other G-protein-activated potassium channel subunits to form a heterotetrameric pore-forming complex.<ref name="entrez" />
{{PBB_Summary
| section_title =
| summary_text = Potassium channels are present in most mammalian cells, where they participate in a wide range of physiologic responses. The protein encoded by this gene is an integral membrane protein and inward-rectifier type potassium channel. The encoded protein, which has a greater tendency to allow potassium to flow into a cell rather than out of a cell, is controlled by G-proteins. It may associate with two other G-protein-activated potassium channels to form a heteromultimeric pore-forming complex.<ref name="entrez">{{cite web | title = Entrez Gene: KCNJ5 potassium inwardly-rectifying channel, subfamily J, member 5| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3762| accessdate = }}</ref>
}}


==See also==
In humans KCNJ5 is mainly expressed in [[adrenal gland]] and [[Pituitary gland|pituitary]], although it is also detected at low levels in [[pancreas]], [[spleen]], [[lung]], [[heart]] and [[brain]] <ref>{{Cite web|url=https://gtexportal.org/home/gene/KCNJ5|title=Gtexportal|last=|first=|date=|website=GETEX portal|archive-url=|archive-date=|dead-url=|access-date=}}</ref>. Consistent with this expression pattern, mutations in KCNJ5/Kir3.4 can cause [[familial hyperaldosteronism]] type III and a type of [[long QT syndrome]].<ref>{{OMIM|600734|potassium channel, inwardly rectifying, subfamily j, member 5; KCNJ5}}</ref>
 
== Interactions ==
 
KCNJ5 has been shown to [[Protein-protein interaction|interact]] with [[KCNJ3]].<ref name=pmid9108307>{{cite journal | vauthors = Huang CL, Jan YN, Jan LY | title = Binding of the G protein betagamma subunit to multiple regions of G protein-gated inward-rectifying K+ channels | journal = FEBS Letters | volume = 405 | issue = 3 | pages = 291–8 | date = April 1997 | pmid = 9108307 | doi = 10.1016/S0014-5793(97)00197-X }}</ref><ref name=pmid11741896>{{cite journal | vauthors = He C, Yan X, Zhang H, Mirshahi T, Jin T, Huang A, Logothetis DE | title = Identification of critical residues controlling G protein-gated inwardly rectifying K(+) channel activity through interactions with the beta gamma subunits of G proteins | journal = The Journal of Biological Chemistry | volume = 277 | issue = 8 | pages = 6088–96 | date = February 2002 | pmid = 11741896 | doi = 10.1074/jbc.M104851200 }}</ref>
 
== See also ==
* [[G protein-coupled inwardly-rectifying potassium channel]]
* [[G protein-coupled inwardly-rectifying potassium channel]]
* [[Inward-rectifier potassium ion channel]]
* [[Inward-rectifier potassium ion channel]]


==References==
== References ==
{{reflist|2}}
{{Reflist}}


==Further reading==
== Further reading ==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
* {{cite journal | vauthors = Zhuo ML, Huang Y, Liu DP, Liang CC | title = KATP channel: relation with cell metabolism and role in the cardiovascular system | journal = The International Journal of Biochemistry & Cell Biology | volume = 37 | issue = 4 | pages = 751–64 | date = April 2005 | pmid = 15694835 | doi = 10.1016/j.biocel.2004.10.008 }}
| citations =
* {{cite journal | vauthors = Tucker SJ, James MR, Adelman JP | title = Assignment of KATP-1, the cardiac ATP-sensitive potassium channel gene (KCNJ5), to human chromosome 11q24 | journal = Genomics | volume = 28 | issue = 1 | pages = 127–8 | date = July 1995 | pmid = 7590741 | doi = 10.1006/geno.1995.1121 }}
*{{cite journal | author=Zhuo ML, Huang Y, Liu DP, Liang CC |title=KATP channel: relation with cell metabolism and role in the cardiovascular system. |journal=Int. J. Biochem. Cell Biol. |volume=37 |issue= 4 |pages= 751-64 |year= 2005 |pmid= 15694835 |doi= 10.1016/j.biocel.2004.10.008 }}
* {{cite journal | vauthors = Ashford ML, Bond CT, Blair TA, Adelman JP | title = Cloning and functional expression of a rat heart KATP channel | journal = Nature | volume = 378 | issue = 6559 | pages = 792 | year = 1996 | pmid = 8524415 | doi = 10.1038/378792a0 }}
*{{cite journal | author=Kubo Y, Adelman JP, Clapham DE, ''et al.'' |title=International Union of Pharmacology. LIV. Nomenclature and molecular relationships of inwardly rectifying potassium channels. |journal=Pharmacol. Rev. |volume=57 |issue= 4 |pages= 509-26 |year= 2006 |pmid= 16382105 |doi= 10.1124/pr.57.4.11 }}
* {{cite journal | vauthors = Spauschus A, Lentes KU, Wischmeyer E, Dissmann E, Karschin C, Karschin A | title = A G-protein-activated inwardly rectifying K+ channel (GIRK4) from human hippocampus associates with other GIRK channels | journal = The Journal of Neuroscience | volume = 16 | issue = 3 | pages = 930–8 | date = February 1996 | pmid = 8558261 | doi =  }}
*{{cite journal  | author=Tucker SJ, James MR, Adelman JP |title=Assignment of KATP-1, the cardiac ATP-sensitive potassium channel gene (KCNJ5), to human chromosome 11q24. |journal=Genomics |volume=28 |issue= 1 |pages= 127-8 |year= 1995 |pmid= 7590741 |doi= 10.1006/geno.1995.1121 }}
* {{cite journal | vauthors = Iizuka M, Kubo Y, Tsunenari I, Pan CX, Akiba I, Kono T | title = Functional characterization and localization of a cardiac-type inwardly rectifying K+ channel | journal = Receptors & Channels | volume = 3 | issue = 4 | pages = 299–315 | year = 1996 | pmid = 8834003 | doi =  }}
*{{cite journal | author=Ashford ML, Bond CT, Blair TA, Adelman JP |title=Cloning and functional expression of a rat heart KATP channel. |journal=Nature |volume=370 |issue= 6489 |pages= 456-9 |year= 1994 |pmid= 8047164 |doi= 10.1038/370456a0 }}
* {{cite journal | vauthors = Chan KW, Langan MN, Sui JL, Kozak JA, Pabon A, Ladias JA, Logothetis DE | title = A recombinant inwardly rectifying potassium channel coupled to GTP-binding proteins | journal = The Journal of General Physiology | volume = 107 | issue = 3 | pages = 381–97 | date = March 1996 | pmid = 8868049 | pmc = 2216996 | doi = 10.1085/jgp.107.3.381 }}
*{{cite journal  | author=Ashford ML, Bond CT, Blair TA, Adelman JP |title=Cloning and functional expression of a rat heart KATP channel. |journal=Nature |volume=378 |issue= 6559 |pages= 792 |year= 1996 |pmid= 8524415 |doi= 10.1038/378792a0 }}
* {{cite journal | vauthors = Huang CL, Jan YN, Jan LY | title = Binding of the G protein betagamma subunit to multiple regions of G protein-gated inward-rectifying K+ channels | journal = FEBS Letters | volume = 405 | issue = 3 | pages = 291–8 | date = April 1997 | pmid = 9108307 | doi = 10.1016/S0014-5793(97)00197-X }}
*{{cite journal | author=Spauschus A, Lentes KU, Wischmeyer E, ''et al.'' |title=A G-protein-activated inwardly rectifying K+ channel (GIRK4) from human hippocampus associates with other GIRK channels. |journal=J. Neurosci. |volume=16 |issue= 3 |pages= 930-8 |year= 1996 |pmid= 8558261 |doi=  }}
* {{cite journal | vauthors = Kanzaki M, Lindorfer MA, Garrison JC, Kojima I | title = Activation of the calcium-permeable cation channel CD20 by alpha subunits of the Gi protein | journal = The Journal of Biological Chemistry | volume = 272 | issue = 23 | pages = 14733–9 | date = June 1997 | pmid = 9169438 | doi = 10.1074/jbc.272.23.14733 }}
*{{cite journal | author=Iizuka M, Kubo Y, Tsunenari I, ''et al.'' |title=Functional characterization and localization of a cardiac-type inwardly rectifying K+ channel. |journal=Recept. Channels |volume=3 |issue= 4 |pages= 299-315 |year= 1996 |pmid= 8834003 |doi=  }}
* {{cite journal | vauthors = Wischmeyer E, Döring F, Wischmeyer E, Spauschus A, Thomzig A, Veh R, Karschin A | title = Subunit interactions in the assembly of neuronal Kir3.0 inwardly rectifying K+ channels | journal = Molecular and Cellular Neurosciences | volume = 9 | issue = 3 | pages = 194–206 | year = 1997 | pmid = 9245502 | doi = 10.1006/mcne.1997.0614 }}
*{{cite journal | author=Chan KW, Langan MN, Sui JL, ''et al.'' |title=A recombinant inwardly rectifying potassium channel coupled to GTP-binding proteins. |journal=J. Gen. Physiol. |volume=107 |issue= 3 |pages= 381-97 |year= 1996 |pmid= 8868049 |doi= }}
* {{cite journal | vauthors = Krapivinsky G, Kennedy ME, Nemec J, Medina I, Krapivinsky L, Clapham DE | title = Gbeta binding to GIRK4 subunit is critical for G protein-gated K+ channel activation | journal = The Journal of Biological Chemistry | volume = 273 | issue = 27 | pages = 16946–52 | date = July 1998 | pmid = 9642257 | doi = 10.1074/jbc.273.27.16946 }}
*{{cite journal | author=Huang CL, Jan YN, Jan LY |title=Binding of the G protein betagamma subunit to multiple regions of G protein-gated inward-rectifying K+ channels. |journal=FEBS Lett. |volume=405 |issue= 3 |pages= 291-8 |year= 1997 |pmid= 9108307 |doi= }}
* {{cite journal | vauthors = Corey S, Clapham DE | title = Identification of native atrial G-protein-regulated inwardly rectifying K+ (GIRK4) channel homomultimers | journal = The Journal of Biological Chemistry | volume = 273 | issue = 42 | pages = 27499–504 | date = October 1998 | pmid = 9765280 | doi = 10.1074/jbc.273.42.27499 }}
*{{cite journal | author=Kanzaki M, Lindorfer MA, Garrison JC, Kojima I |title=Activation of the calcium-permeable cation channel CD20 by alpha subunits of the Gi protein. |journal=J. Biol. Chem. |volume=272 |issue= 23 |pages= 14733-9 |year= 1997 |pmid= 9169438 |doi= }}
* {{cite journal | vauthors = Kennedy ME, Nemec J, Corey S, Wickman K, Clapham DE | title = GIRK4 confers appropriate processing and cell surface localization to G-protein-gated potassium channels | journal = The Journal of Biological Chemistry | volume = 274 | issue = 4 | pages = 2571–82 | date = January 1999 | pmid = 9891030 | doi = 10.1074/jbc.274.4.2571 }}
*{{cite journal | author=Wischmeyer E, Döring F, Wischmeyer E, ''et al.'' |title=Subunit interactions in the assembly of neuronal Kir3.0 inwardly rectifying K+ channels. |journal=Mol. Cell. Neurosci. |volume=9 |issue= 3 |pages= 194-206 |year= 1997 |pmid= 9245502 |doi= 10.1006/mcne.1997.0614 }}
* {{cite journal | vauthors = Schoots O, Wilson JM, Ethier N, Bigras E, Hebert TE, Van Tol HH | title = Co-expression of human Kir3 subunits can yield channels with different functional properties | journal = Cellular Signalling | volume = 11 | issue = 12 | pages = 871–83 | date = December 1999 | pmid = 10659995 | doi = 10.1016/S0898-6568(99)00059-5 }}
*{{cite journal | author=Krapivinsky G, Kennedy ME, Nemec J, ''et al.'' |title=Gbeta binding to GIRK4 subunit is critical for G protein-gated K+ channel activation. |journal=J. Biol. Chem. |volume=273 |issue= 27 |pages= 16946-52 |year= 1998 |pmid= 9642257 |doi= }}
* {{cite journal | vauthors = He C, Yan X, Zhang H, Mirshahi T, Jin T, Huang A, Logothetis DE | title = Identification of critical residues controlling G protein-gated inwardly rectifying K(+) channel activity through interactions with the beta gamma subunits of G proteins | journal = The Journal of Biological Chemistry | volume = 277 | issue = 8 | pages = 6088–96 | date = February 2002 | pmid = 11741896 | doi = 10.1074/jbc.M104851200 }}
*{{cite journal | author=Corey S, Clapham DE |title=Identification of native atrial G-protein-regulated inwardly rectifying K+ (GIRK4) channel homomultimers. |journal=J. Biol. Chem. |volume=273 |issue= 42 |pages= 27499-504 |year= 1998 |pmid= 9765280 |doi= }}
* {{cite journal | vauthors = Ma D, Zerangue N, Raab-Graham K, Fried SR, Jan YN, Jan LY | title = Diverse trafficking patterns due to multiple traffic motifs in G protein-activated inwardly rectifying potassium channels from brain and heart | journal = Neuron | volume = 33 | issue = 5 | pages = 715–29 | date = February 2002 | pmid = 11879649 | doi = 10.1016/S0896-6273(02)00614-1 }}
*{{cite journal | author=Kennedy ME, Nemec J, Corey S, ''et al.'' |title=GIRK4 confers appropriate processing and cell surface localization to G-protein-gated potassium channels. |journal=J. Biol. Chem. |volume=274 |issue= 4 |pages= 2571-82 |year= 1999 |pmid= 9891030 |doi= }}
* {{cite journal | vauthors = Lavine N, Ethier N, Oak JN, Pei L, Liu F, Trieu P, Rebois RV, Bouvier M, Hebert TE, Van Tol HH | title = G protein-coupled receptors form stable complexes with inwardly rectifying potassium channels and adenylyl cyclase | journal = The Journal of Biological Chemistry | volume = 277 | issue = 48 | pages = 46010–9 | date = November 2002 | pmid = 12297500 | doi = 10.1074/jbc.M205035200 }}
*{{cite journal | author=Schoots O, Wilson JM, Ethier N, ''et al.'' |title=Co-expression of human Kir3 subunits can yield channels with different functional properties. |journal=Cell. Signal. |volume=11 |issue= 12 |pages= 871-83 |year= 2000 |pmid= 10659995 |doi= }}
* {{cite journal | vauthors = Shankar H, Murugappan S, Kim S, Jin J, Ding Z, Wickman K, Kunapuli SP | title = Role of G protein-gated inwardly rectifying potassium channels in P2Y12 receptor-mediated platelet functional responses | journal = Blood | volume = 104 | issue = 5 | pages = 1335–43 | date = September 2004 | pmid = 15142872 | doi = 10.1182/blood-2004-01-0069 }}
*{{cite journal | author=He C, Yan X, Zhang H, ''et al.'' |title=Identification of critical residues controlling G protein-gated inwardly rectifying K(+) channel activity through interactions with the beta gamma subunits of G proteins. |journal=J. Biol. Chem. |volume=277 |issue= 8 |pages= 6088-96 |year= 2002 |pmid= 11741896 |doi= 10.1074/jbc.M104851200 }}
*{{cite journal | author=Ma D, Zerangue N, Raab-Graham K, ''et al.'' |title=Diverse trafficking patterns due to multiple traffic motifs in G protein-activated inwardly rectifying potassium channels from brain and heart. |journal=Neuron |volume=33 |issue= 5 |pages= 715-29 |year= 2002 |pmid= 11879649 |doi= }}
*{{cite journal | author=Lavine N, Ethier N, Oak JN, ''et al.'' |title=G protein-coupled receptors form stable complexes with inwardly rectifying potassium channels and adenylyl cyclase. |journal=J. Biol. Chem. |volume=277 |issue= 48 |pages= 46010-9 |year= 2003 |pmid= 12297500 |doi= 10.1074/jbc.M205035200 }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal  | author=Shankar H, Murugappan S, Kim S, ''et al.'' |title=Role of G protein-gated inwardly rectifying potassium channels in P2Y12 receptor-mediated platelet functional responses. |journal=Blood |volume=104 |issue= 5 |pages= 1335-43 |year= 2004 |pmid= 15142872 |doi= 10.1182/blood-2004-01-0069 }}
}}
{{refend}}
{{refend}}


== External links ==
== External links ==
* {{MeshName|KCNJ5+protein,+human}}
* {{MeshName|KCNJ5+protein,+human}}
*[https://gtexportal.org/home/gene/KCNJ5 GTEX portal: KCNJ5 expression in human tissue]


{{membrane-protein-stub}}
{{NLM content}}
{{NLM content}}
{{Ion channels}}
{{Ion channels|g3}}
 
 
[[Category:Ion channels]]
[[Category:Ion channels]]
{{WikiDoc Sources}}

Latest revision as of 20:11, 18 October 2018

VALUE_ERROR (nil)
Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

n/a

n/a

Ensembl

n/a

n/a

UniProt

n/a

n/a

RefSeq (mRNA)

n/a

n/a

RefSeq (protein)

n/a

n/a

Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

G protein-activated inward rectifier potassium channel 4 is a protein that in humans is encoded by the KCNJ5 gene and is a type of G protein-gated ion channel.[1][2]

Function

Potassium channels are present in most mammalian cells, where they participate in a wide range of physiologic responses. The protein encoded by this gene is an integral membrane protein and inward-rectifier type potassium channel. The encoded protein, which has a greater tendency to allow potassium to flow into a cell rather than out of a cell, is controlled by G-proteins. It may associate with other G-protein-activated potassium channel subunits to form a heterotetrameric pore-forming complex.[2]

In humans KCNJ5 is mainly expressed in adrenal gland and pituitary, although it is also detected at low levels in pancreas, spleen, lung, heart and brain [3]. Consistent with this expression pattern, mutations in KCNJ5/Kir3.4 can cause familial hyperaldosteronism type III and a type of long QT syndrome.[4]

Interactions

KCNJ5 has been shown to interact with KCNJ3.[5][6]

See also

References

  1. ↑ Kubo Y, Adelman JP, Clapham DE, Jan LY, Karschin A, Kurachi Y, Lazdunski M, Nichols CG, Seino S, Vandenberg CA (December 2005). "International Union of Pharmacology. LIV. Nomenclature and molecular relationships of inwardly rectifying potassium channels". Pharmacological Reviews. 57 (4): 509–26. doi:10.1124/pr.57.4.11. PMID 16382105.
  2. ↑ 2.0 2.1 "Entrez Gene: KCNJ5 potassium inwardly-rectifying channel, subfamily J, member 5".
  3. ↑ "Gtexportal". GETEX portal.
  4. ↑ Online Mendelian Inheritance in Man (OMIM) potassium channel, inwardly rectifying, subfamily j, member 5; KCNJ5 -600734
  5. ↑ Huang CL, Jan YN, Jan LY (April 1997). "Binding of the G protein betagamma subunit to multiple regions of G protein-gated inward-rectifying K+ channels". FEBS Letters. 405 (3): 291–8. doi:10.1016/S0014-5793(97)00197-X. PMID 9108307.
  6. ↑ He C, Yan X, Zhang H, Mirshahi T, Jin T, Huang A, Logothetis DE (February 2002). "Identification of critical residues controlling G protein-gated inwardly rectifying K(+) channel activity through interactions with the beta gamma subunits of G proteins". The Journal of Biological Chemistry. 277 (8): 6088–96. doi:10.1074/jbc.M104851200. PMID 11741896.

Further reading

  • Zhuo ML, Huang Y, Liu DP, Liang CC (April 2005). "KATP channel: relation with cell metabolism and role in the cardiovascular system". The International Journal of Biochemistry & Cell Biology. 37 (4): 751–64. doi:10.1016/j.biocel.2004.10.008. PMID 15694835.
  • Tucker SJ, James MR, Adelman JP (July 1995). "Assignment of KATP-1, the cardiac ATP-sensitive potassium channel gene (KCNJ5), to human chromosome 11q24". Genomics. 28 (1): 127–8. doi:10.1006/geno.1995.1121. PMID 7590741.
  • Ashford ML, Bond CT, Blair TA, Adelman JP (1996). "Cloning and functional expression of a rat heart KATP channel". Nature. 378 (6559): 792. doi:10.1038/378792a0. PMID 8524415.
  • Spauschus A, Lentes KU, Wischmeyer E, Dissmann E, Karschin C, Karschin A (February 1996). "A G-protein-activated inwardly rectifying K+ channel (GIRK4) from human hippocampus associates with other GIRK channels". The Journal of Neuroscience. 16 (3): 930–8. PMID 8558261.
  • Iizuka M, Kubo Y, Tsunenari I, Pan CX, Akiba I, Kono T (1996). "Functional characterization and localization of a cardiac-type inwardly rectifying K+ channel". Receptors & Channels. 3 (4): 299–315. PMID 8834003.
  • Chan KW, Langan MN, Sui JL, Kozak JA, Pabon A, Ladias JA, Logothetis DE (March 1996). "A recombinant inwardly rectifying potassium channel coupled to GTP-binding proteins". The Journal of General Physiology. 107 (3): 381–97. doi:10.1085/jgp.107.3.381. PMC 2216996. PMID 8868049.
  • Huang CL, Jan YN, Jan LY (April 1997). "Binding of the G protein betagamma subunit to multiple regions of G protein-gated inward-rectifying K+ channels". FEBS Letters. 405 (3): 291–8. doi:10.1016/S0014-5793(97)00197-X. PMID 9108307.
  • Kanzaki M, Lindorfer MA, Garrison JC, Kojima I (June 1997). "Activation of the calcium-permeable cation channel CD20 by alpha subunits of the Gi protein". The Journal of Biological Chemistry. 272 (23): 14733–9. doi:10.1074/jbc.272.23.14733. PMID 9169438.
  • Wischmeyer E, Döring F, Wischmeyer E, Spauschus A, Thomzig A, Veh R, Karschin A (1997). "Subunit interactions in the assembly of neuronal Kir3.0 inwardly rectifying K+ channels". Molecular and Cellular Neurosciences. 9 (3): 194–206. doi:10.1006/mcne.1997.0614. PMID 9245502.
  • Krapivinsky G, Kennedy ME, Nemec J, Medina I, Krapivinsky L, Clapham DE (July 1998). "Gbeta binding to GIRK4 subunit is critical for G protein-gated K+ channel activation". The Journal of Biological Chemistry. 273 (27): 16946–52. doi:10.1074/jbc.273.27.16946. PMID 9642257.
  • Corey S, Clapham DE (October 1998). "Identification of native atrial G-protein-regulated inwardly rectifying K+ (GIRK4) channel homomultimers". The Journal of Biological Chemistry. 273 (42): 27499–504. doi:10.1074/jbc.273.42.27499. PMID 9765280.
  • Kennedy ME, Nemec J, Corey S, Wickman K, Clapham DE (January 1999). "GIRK4 confers appropriate processing and cell surface localization to G-protein-gated potassium channels". The Journal of Biological Chemistry. 274 (4): 2571–82. doi:10.1074/jbc.274.4.2571. PMID 9891030.
  • Schoots O, Wilson JM, Ethier N, Bigras E, Hebert TE, Van Tol HH (December 1999). "Co-expression of human Kir3 subunits can yield channels with different functional properties". Cellular Signalling. 11 (12): 871–83. doi:10.1016/S0898-6568(99)00059-5. PMID 10659995.
  • He C, Yan X, Zhang H, Mirshahi T, Jin T, Huang A, Logothetis DE (February 2002). "Identification of critical residues controlling G protein-gated inwardly rectifying K(+) channel activity through interactions with the beta gamma subunits of G proteins". The Journal of Biological Chemistry. 277 (8): 6088–96. doi:10.1074/jbc.M104851200. PMID 11741896.
  • Ma D, Zerangue N, Raab-Graham K, Fried SR, Jan YN, Jan LY (February 2002). "Diverse trafficking patterns due to multiple traffic motifs in G protein-activated inwardly rectifying potassium channels from brain and heart". Neuron. 33 (5): 715–29. doi:10.1016/S0896-6273(02)00614-1. PMID 11879649.
  • Lavine N, Ethier N, Oak JN, Pei L, Liu F, Trieu P, Rebois RV, Bouvier M, Hebert TE, Van Tol HH (November 2002). "G protein-coupled receptors form stable complexes with inwardly rectifying potassium channels and adenylyl cyclase". The Journal of Biological Chemistry. 277 (48): 46010–9. doi:10.1074/jbc.M205035200. PMID 12297500.
  • Shankar H, Murugappan S, Kim S, Jin J, Ding Z, Wickman K, Kunapuli SP (September 2004). "Role of G protein-gated inwardly rectifying potassium channels in P2Y12 receptor-mediated platelet functional responses". Blood. 104 (5): 1335–43. doi:10.1182/blood-2004-01-0069. PMID 15142872.

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

Retrieved from "https://www.wikidoc.org/index.php?title=KCNJ5&oldid=1527756"