DUSP6: Difference between revisions
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'''Dual specificity phosphatase 6''' ('''DUSP6''') is an [[enzyme]] that in humans is encoded by the ''DUSP6'' [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: DUSP6 dual specificity phosphatase 6| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1848| | '''Dual specificity phosphatase 6''' ('''DUSP6''') is an [[enzyme]] that in humans is encoded by the ''DUSP6'' [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: DUSP6 dual specificity phosphatase 6| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1848| access-date = }}</ref><ref name="pmid8626780">{{cite journal | vauthors = Muda M, Boschert U, Dickinson R, Martinou JC, Martinou I, Camps M, Schlegel W, Arkinstall S | title = MKP-3, a novel cytosolic protein-tyrosine phosphatase that exemplifies a new class of mitogen-activated protein kinase phosphatase | journal = The Journal of Biological Chemistry | volume = 271 | issue = 8 | pages = 4319–26 | date = February 1996 | pmid = 8626780 | doi = 10.1074/jbc.271.8.4319 }}</ref><ref name="pmid9205128">{{cite journal | vauthors = Smith A, Price C, Cullen M, Muda M, King A, Ozanne B, Arkinstall S, Ashworth A | title = Chromosomal localization of three human dual specificity phosphatase genes (DUSP4, DUSP6, and DUSP7) | journal = Genomics | volume = 42 | issue = 3 | pages = 524–7 | date = June 1997 | pmid = 9205128 | doi = 10.1006/geno.1997.4756 }}</ref> | ||
== Function == | == Function == | ||
The [[protein]] encoded by this gene is a member of the dual specificity protein [[phosphatase]] subfamily. These phosphatases inactivate their target [[kinase]]s by dephosphorylating both the [[phosphoserine]]/[[threonine]] and [[phosphotyrosine]] residues. They negatively regulate members of the [[mitogen-activated protein kinase|mitogen-activated protein]] (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which are associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene product inactivates [[MAPK1|ERK2]], is expressed in a variety of tissues with the highest levels in heart and pancreas and, unlike most other members of this family, is localized in the cytoplasm. Two transcript variants encoding different isoforms have been found for this gene.<ref name="entrez" /> Upregulation of MKP-3 has been shown to alleviate chronic postoperative pain.<ref>{{cite journal | vauthors = Saha M, Skopelja S, Martinez E, Alvarez DL, Liponis BS, Romero-Sandoval EA | title = Spinal mitogen-activated protein kinase phosphatase-3 (MKP-3) is necessary for the normal resolution of mechanical allodynia in a mouse model of acute postoperative pain | journal = The Journal of Neuroscience | volume = 33 | issue = 43 | pages = 17182–7 | date = | The [[protein]] encoded by this gene is a member of the dual specificity protein [[phosphatase]] subfamily. These phosphatases inactivate their target [[kinase]]s by dephosphorylating both the [[phosphoserine]]/[[threonine]] and [[phosphotyrosine]] residues. They negatively regulate members of the [[mitogen-activated protein kinase|mitogen-activated protein]] (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which are associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene product inactivates [[MAPK1|ERK2]], is expressed in a variety of tissues with the highest levels in heart and pancreas and, unlike most other members of this family, is localized in the cytoplasm. Two transcript variants encoding different isoforms have been found for this gene.<ref name="entrez" /> Upregulation of MKP-3 has been shown to alleviate chronic postoperative pain.<ref>{{cite journal | vauthors = Saha M, Skopelja S, Martinez E, Alvarez DL, Liponis BS, Romero-Sandoval EA | title = Spinal mitogen-activated protein kinase phosphatase-3 (MKP-3) is necessary for the normal resolution of mechanical allodynia in a mouse model of acute postoperative pain | journal = The Journal of Neuroscience | volume = 33 | issue = 43 | pages = 17182–7 | date = October 2013 | pmid = 24155322 | doi = 10.1523/JNEUROSCI.5605-12.2013 }}</ref><ref>{{cite journal | vauthors = Skopelja-Gardner S, Saha M, Alvarado-Vazquez PA, Liponis BS, Martinez E, Romero-Sandoval EA | title = Mitogen-activated protein kinase phosphatase-3 (MKP-3) in the surgical wound is necessary for the resolution of postoperative pain in mice | journal = Journal of Pain Research | volume = 10 | pages = 763–774 | date = 2017-03-28 | pmid = 28405172 | doi = 10.2147/jpr.s129826 }}</ref> | ||
== Interactions == | == Interactions == | ||
DUSP6 has been shown to [[Protein-protein interaction|interact]] with [[MAPK3]].<ref name=pmid9535927>{{cite journal | vauthors = Muda M, Theodosiou A, Gillieron C, Smith A, Chabert C, Camps M, Boschert U, Rodrigues N, Davies K, Ashworth A, Arkinstall S | title = The mitogen-activated protein kinase phosphatase-3 N-terminal noncatalytic region is responsible for tight substrate binding and enzymatic specificity | journal = The Journal of Biological Chemistry | volume = 273 | issue = 15 | pages = 9323–9 | date = | DUSP6 has been shown to [[Protein-protein interaction|interact]] with [[MAPK3]].<ref name=pmid9535927>{{cite journal | vauthors = Muda M, Theodosiou A, Gillieron C, Smith A, Chabert C, Camps M, Boschert U, Rodrigues N, Davies K, Ashworth A, Arkinstall S | title = The mitogen-activated protein kinase phosphatase-3 N-terminal noncatalytic region is responsible for tight substrate binding and enzymatic specificity | journal = The Journal of Biological Chemistry | volume = 273 | issue = 15 | pages = 9323–9 | date = April 1998 | pmid = 9535927 | doi = 10.1074/jbc.273.15.9323 }}</ref> | ||
== References == | == References == | ||
| Line 14: | Line 14: | ||
== Further reading == | == Further reading == | ||
{{refbegin | 2}} | {{refbegin|2}} | ||
* {{cite journal | vauthors = Maruyama K, Sugano S | title = Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides | journal = Gene | volume = 138 | issue = 1-2 | pages = 171–4 | date = | * {{cite journal | vauthors = Maruyama K, Sugano S | title = Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides | journal = Gene | volume = 138 | issue = 1-2 | pages = 171–4 | date = January 1994 | pmid = 8125298 | doi = 10.1016/0378-1119(94)90802-8 }} | ||
* {{cite journal | vauthors = Groom LA, Sneddon AA, Alessi DR, Dowd S, Keyse SM | title = Differential regulation of the MAP, SAP and RK/p38 kinases by Pyst1, a novel cytosolic dual-specificity phosphatase | journal = The EMBO Journal | volume = 15 | issue = 14 | pages = 3621–32 | date = July 1996 | pmid = 8670865 | pmc = 451978 | doi = }} | |||
* {{cite journal | vauthors = Groom LA, Sneddon AA, Alessi DR, Dowd S, Keyse SM | title = Differential regulation of the MAP, SAP and RK/p38 kinases by Pyst1, a novel cytosolic dual-specificity phosphatase | journal = The EMBO Journal | volume = 15 | issue = 14 | pages = 3621–32 | date = | * {{cite journal | vauthors = Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S | title = Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library | journal = Gene | volume = 200 | issue = 1-2 | pages = 149–56 | date = October 1997 | pmid = 9373149 | doi = 10.1016/S0378-1119(97)00411-3 }} | ||
* {{cite journal | vauthors = Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S | title = Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library | journal = Gene | volume = 200 | issue = 1-2 | pages = 149–56 | date = | |||
* {{cite journal | vauthors = Furukawa T, Yatsuoka T, Youssef EM, Abe T, Yokoyama T, Fukushige S, Soeda E, Hoshi M, Hayashi Y, Sunamura M, Kobari M, Horii A | title = Genomic analysis of DUSP6, a dual specificity MAP kinase phosphatase, in pancreatic cancer | journal = Cytogenetics and Cell Genetics | volume = 82 | issue = 3-4 | pages = 156–9 | year = 1999 | pmid = 9858808 | doi = 10.1159/000015091 }} | * {{cite journal | vauthors = Furukawa T, Yatsuoka T, Youssef EM, Abe T, Yokoyama T, Fukushige S, Soeda E, Hoshi M, Hayashi Y, Sunamura M, Kobari M, Horii A | title = Genomic analysis of DUSP6, a dual specificity MAP kinase phosphatase, in pancreatic cancer | journal = Cytogenetics and Cell Genetics | volume = 82 | issue = 3-4 | pages = 156–9 | year = 1999 | pmid = 9858808 | doi = 10.1159/000015091 }} | ||
* {{cite journal | vauthors = Stewart AE, Dowd S, Keyse SM, McDonald NQ | title = Crystal structure of the MAPK phosphatase Pyst1 catalytic domain and implications for regulated activation | journal = Nature Structural Biology | volume = 6 | issue = 2 | pages = 174–81 | date = | * {{cite journal | vauthors = Stewart AE, Dowd S, Keyse SM, McDonald NQ | title = Crystal structure of the MAPK phosphatase Pyst1 catalytic domain and implications for regulated activation | journal = Nature Structural Biology | volume = 6 | issue = 2 | pages = 174–81 | date = February 1999 | pmid = 10048930 | doi = 10.1038/5861 }} | ||
* {{cite journal | vauthors = Rössig L, Hermann C, Haendeler J, Assmus B, Zeiher AM, Dimmeler S | title = Angiotensin II-induced upregulation of MAP kinase phosphatase-3 mRNA levels mediates endothelial cell apoptosis | journal = Basic Research in Cardiology | volume = 97 | issue = 1 | pages = 1–8 | date = | * {{cite journal | vauthors = Rössig L, Hermann C, Haendeler J, Assmus B, Zeiher AM, Dimmeler S | title = Angiotensin II-induced upregulation of MAP kinase phosphatase-3 mRNA levels mediates endothelial cell apoptosis | journal = Basic Research in Cardiology | volume = 97 | issue = 1 | pages = 1–8 | date = January 2002 | pmid = 11998972 | doi = 10.1007/s395-002-8381-2 }} | ||
* {{cite journal | vauthors = Furukawa T, Sunamura M, Motoi F, Matsuno S, Horii A | title = Potential tumor suppressive pathway involving DUSP6/MKP-3 in pancreatic cancer | journal = The American Journal of Pathology | volume = 162 | issue = 6 | pages = 1807–15 | date = | * {{cite journal | vauthors = Furukawa T, Sunamura M, Motoi F, Matsuno S, Horii A | title = Potential tumor suppressive pathway involving DUSP6/MKP-3 in pancreatic cancer | journal = The American Journal of Pathology | volume = 162 | issue = 6 | pages = 1807–15 | date = June 2003 | pmid = 12759238 | pmc = 1868131 | doi = 10.1016/S0002-9440(10)64315-5 }} | ||
* {{cite journal | vauthors = Kim HS, Song MC, Kwak IH, Park TJ, Lim IK | title = Constitutive induction of p-Erk1/2 accompanied by reduced activities of protein phosphatases 1 and 2A and MKP3 due to reactive oxygen species during cellular senescence | journal = The Journal of Biological Chemistry | volume = 278 | issue = 39 | pages = 37497–510 | date = | * {{cite journal | vauthors = Kim HS, Song MC, Kwak IH, Park TJ, Lim IK | title = Constitutive induction of p-Erk1/2 accompanied by reduced activities of protein phosphatases 1 and 2A and MKP3 due to reactive oxygen species during cellular senescence | journal = The Journal of Biological Chemistry | volume = 278 | issue = 39 | pages = 37497–510 | date = September 2003 | pmid = 12840032 | doi = 10.1074/jbc.M211739200 }} | ||
* {{cite journal | vauthors = Kim Y, Rice AE, Denu JM | title = Intramolecular dephosphorylation of ERK by MKP3 | journal = Biochemistry | volume = 42 | issue = 51 | pages = 15197–207 | date = | * {{cite journal | vauthors = Kim Y, Rice AE, Denu JM | title = Intramolecular dephosphorylation of ERK by MKP3 | journal = Biochemistry | volume = 42 | issue = 51 | pages = 15197–207 | date = December 2003 | pmid = 14690430 | doi = 10.1021/bi035346b }} | ||
* {{cite journal | vauthors = Karlsson M, Mathers J, Dickinson RJ, Mandl M, Keyse SM | title = Both nuclear-cytoplasmic shuttling of the dual specificity phosphatase MKP-3 and its ability to anchor MAP kinase in the cytoplasm are mediated by a conserved nuclear export signal | journal = The Journal of Biological Chemistry | volume = 279 | issue = 40 | pages = 41882–91 | date = | * {{cite journal | vauthors = Karlsson M, Mathers J, Dickinson RJ, Mandl M, Keyse SM | title = Both nuclear-cytoplasmic shuttling of the dual specificity phosphatase MKP-3 and its ability to anchor MAP kinase in the cytoplasm are mediated by a conserved nuclear export signal | journal = The Journal of Biological Chemistry | volume = 279 | issue = 40 | pages = 41882–91 | date = October 2004 | pmid = 15269220 | doi = 10.1074/jbc.M406720200 }} | ||
* {{cite journal | vauthors = Marchetti S, Gimond C, Chambard JC, Touboul T, Roux D, Pouysségur J, Pagès G | title = Extracellular signal-regulated kinases phosphorylate mitogen-activated protein kinase phosphatase 3/DUSP6 at serines 159 and 197, two sites critical for its proteasomal degradation | journal = Molecular and Cellular Biology | volume = 25 | issue = 2 | pages = 854–64 | date = | * {{cite journal | vauthors = Marchetti S, Gimond C, Chambard JC, Touboul T, Roux D, Pouysségur J, Pagès G | title = Extracellular signal-regulated kinases phosphorylate mitogen-activated protein kinase phosphatase 3/DUSP6 at serines 159 and 197, two sites critical for its proteasomal degradation | journal = Molecular and Cellular Biology | volume = 25 | issue = 2 | pages = 854–64 | date = January 2005 | pmid = 15632084 | pmc = 543408 | doi = 10.1128/MCB.25.2.854-864.2005 }} | ||
* {{cite journal | vauthors = Kamata H, Honda S, Maeda S, Chang L, Hirata H, Karin M | title = Reactive oxygen species promote TNFalpha-induced death and sustained JNK activation by inhibiting MAP kinase phosphatases | journal = Cell | volume = 120 | issue = 5 | pages = 649–61 | date = | * {{cite journal | vauthors = Kamata H, Honda S, Maeda S, Chang L, Hirata H, Karin M | title = Reactive oxygen species promote TNFalpha-induced death and sustained JNK activation by inhibiting MAP kinase phosphatases | journal = Cell | volume = 120 | issue = 5 | pages = 649–61 | date = March 2005 | pmid = 15766528 | doi = 10.1016/j.cell.2004.12.041 }} | ||
* {{cite journal | vauthors = Xu S, Furukawa T, Kanai N, Sunamura M, Horii A | title = Abrogation of DUSP6 by hypermethylation in human pancreatic cancer | journal = Journal of Human Genetics | volume = 50 | issue = 4 | pages = 159–67 | year = 2005 | pmid = 15824892 | doi = 10.1007/s10038-005-0235-y }} | * {{cite journal | vauthors = Xu S, Furukawa T, Kanai N, Sunamura M, Horii A | title = Abrogation of DUSP6 by hypermethylation in human pancreatic cancer | journal = Journal of Human Genetics | volume = 50 | issue = 4 | pages = 159–67 | year = 2005 | pmid = 15824892 | doi = 10.1007/s10038-005-0235-y }} | ||
* {{cite journal | vauthors = Furukawa T, Fujisaki R, Yoshida Y, Kanai N, Sunamura M, Abe T, Takeda K, Matsuno S, Horii A | title = Distinct progression pathways involving the dysfunction of DUSP6/MKP-3 in pancreatic intraepithelial neoplasia and intraductal papillary-mucinous neoplasms of the pancreas | journal = Modern Pathology | volume = 18 | issue = 8 | pages = 1034–42 | date = | * {{cite journal | vauthors = Furukawa T, Fujisaki R, Yoshida Y, Kanai N, Sunamura M, Abe T, Takeda K, Matsuno S, Horii A | title = Distinct progression pathways involving the dysfunction of DUSP6/MKP-3 in pancreatic intraepithelial neoplasia and intraductal papillary-mucinous neoplasms of the pancreas | journal = Modern Pathology | volume = 18 | issue = 8 | pages = 1034–42 | date = August 2005 | pmid = 15832194 | doi = 10.1038/modpathol.3800383 }} | ||
{{refend}} | {{refend}} | ||
{{PDB Gallery|geneid=1848}} | {{PDB Gallery|geneid=1848}} | ||
{{Protein tyrosine phosphatases}} | {{Protein tyrosine phosphatases}} | ||
{{gene-12-stub}} | {{gene-12-stub}} | ||
Latest revision as of 20:17, 2 June 2018
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| External IDs | GeneCards: [1] | ||||||
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| Location (UCSC) | n/a | n/a | |||||
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Dual specificity phosphatase 6 (DUSP6) is an enzyme that in humans is encoded by the DUSP6 gene.[1][2][3]
Function
The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which are associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene product inactivates ERK2, is expressed in a variety of tissues with the highest levels in heart and pancreas and, unlike most other members of this family, is localized in the cytoplasm. Two transcript variants encoding different isoforms have been found for this gene.[1] Upregulation of MKP-3 has been shown to alleviate chronic postoperative pain.[4][5]
Interactions
DUSP6 has been shown to interact with MAPK3.[6]
References
- ↑ 1.0 1.1 "Entrez Gene: DUSP6 dual specificity phosphatase 6".
- ↑ Muda M, Boschert U, Dickinson R, Martinou JC, Martinou I, Camps M, Schlegel W, Arkinstall S (February 1996). "MKP-3, a novel cytosolic protein-tyrosine phosphatase that exemplifies a new class of mitogen-activated protein kinase phosphatase". The Journal of Biological Chemistry. 271 (8): 4319–26. doi:10.1074/jbc.271.8.4319. PMID 8626780.
- ↑ Smith A, Price C, Cullen M, Muda M, King A, Ozanne B, Arkinstall S, Ashworth A (June 1997). "Chromosomal localization of three human dual specificity phosphatase genes (DUSP4, DUSP6, and DUSP7)". Genomics. 42 (3): 524–7. doi:10.1006/geno.1997.4756. PMID 9205128.
- ↑ Saha M, Skopelja S, Martinez E, Alvarez DL, Liponis BS, Romero-Sandoval EA (October 2013). "Spinal mitogen-activated protein kinase phosphatase-3 (MKP-3) is necessary for the normal resolution of mechanical allodynia in a mouse model of acute postoperative pain". The Journal of Neuroscience. 33 (43): 17182–7. doi:10.1523/JNEUROSCI.5605-12.2013. PMID 24155322.
- ↑ Skopelja-Gardner S, Saha M, Alvarado-Vazquez PA, Liponis BS, Martinez E, Romero-Sandoval EA (2017-03-28). "Mitogen-activated protein kinase phosphatase-3 (MKP-3) in the surgical wound is necessary for the resolution of postoperative pain in mice". Journal of Pain Research. 10: 763–774. doi:10.2147/jpr.s129826. PMID 28405172.
- ↑ Muda M, Theodosiou A, Gillieron C, Smith A, Chabert C, Camps M, Boschert U, Rodrigues N, Davies K, Ashworth A, Arkinstall S (April 1998). "The mitogen-activated protein kinase phosphatase-3 N-terminal noncatalytic region is responsible for tight substrate binding and enzymatic specificity". The Journal of Biological Chemistry. 273 (15): 9323–9. doi:10.1074/jbc.273.15.9323. PMID 9535927.
Further reading
- Maruyama K, Sugano S (January 1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
- Groom LA, Sneddon AA, Alessi DR, Dowd S, Keyse SM (July 1996). "Differential regulation of the MAP, SAP and RK/p38 kinases by Pyst1, a novel cytosolic dual-specificity phosphatase". The EMBO Journal. 15 (14): 3621–32. PMC 451978. PMID 8670865.
- Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (October 1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
- Furukawa T, Yatsuoka T, Youssef EM, Abe T, Yokoyama T, Fukushige S, Soeda E, Hoshi M, Hayashi Y, Sunamura M, Kobari M, Horii A (1999). "Genomic analysis of DUSP6, a dual specificity MAP kinase phosphatase, in pancreatic cancer". Cytogenetics and Cell Genetics. 82 (3–4): 156–9. doi:10.1159/000015091. PMID 9858808.
- Stewart AE, Dowd S, Keyse SM, McDonald NQ (February 1999). "Crystal structure of the MAPK phosphatase Pyst1 catalytic domain and implications for regulated activation". Nature Structural Biology. 6 (2): 174–81. doi:10.1038/5861. PMID 10048930.
- Rössig L, Hermann C, Haendeler J, Assmus B, Zeiher AM, Dimmeler S (January 2002). "Angiotensin II-induced upregulation of MAP kinase phosphatase-3 mRNA levels mediates endothelial cell apoptosis". Basic Research in Cardiology. 97 (1): 1–8. doi:10.1007/s395-002-8381-2. PMID 11998972.
- Furukawa T, Sunamura M, Motoi F, Matsuno S, Horii A (June 2003). "Potential tumor suppressive pathway involving DUSP6/MKP-3 in pancreatic cancer". The American Journal of Pathology. 162 (6): 1807–15. doi:10.1016/S0002-9440(10)64315-5. PMC 1868131. PMID 12759238.
- Kim HS, Song MC, Kwak IH, Park TJ, Lim IK (September 2003). "Constitutive induction of p-Erk1/2 accompanied by reduced activities of protein phosphatases 1 and 2A and MKP3 due to reactive oxygen species during cellular senescence". The Journal of Biological Chemistry. 278 (39): 37497–510. doi:10.1074/jbc.M211739200. PMID 12840032.
- Kim Y, Rice AE, Denu JM (December 2003). "Intramolecular dephosphorylation of ERK by MKP3". Biochemistry. 42 (51): 15197–207. doi:10.1021/bi035346b. PMID 14690430.
- Karlsson M, Mathers J, Dickinson RJ, Mandl M, Keyse SM (October 2004). "Both nuclear-cytoplasmic shuttling of the dual specificity phosphatase MKP-3 and its ability to anchor MAP kinase in the cytoplasm are mediated by a conserved nuclear export signal". The Journal of Biological Chemistry. 279 (40): 41882–91. doi:10.1074/jbc.M406720200. PMID 15269220.
- Marchetti S, Gimond C, Chambard JC, Touboul T, Roux D, Pouysségur J, Pagès G (January 2005). "Extracellular signal-regulated kinases phosphorylate mitogen-activated protein kinase phosphatase 3/DUSP6 at serines 159 and 197, two sites critical for its proteasomal degradation". Molecular and Cellular Biology. 25 (2): 854–64. doi:10.1128/MCB.25.2.854-864.2005. PMC 543408. PMID 15632084.
- Kamata H, Honda S, Maeda S, Chang L, Hirata H, Karin M (March 2005). "Reactive oxygen species promote TNFalpha-induced death and sustained JNK activation by inhibiting MAP kinase phosphatases". Cell. 120 (5): 649–61. doi:10.1016/j.cell.2004.12.041. PMID 15766528.
- Xu S, Furukawa T, Kanai N, Sunamura M, Horii A (2005). "Abrogation of DUSP6 by hypermethylation in human pancreatic cancer". Journal of Human Genetics. 50 (4): 159–67. doi:10.1007/s10038-005-0235-y. PMID 15824892.
- Furukawa T, Fujisaki R, Yoshida Y, Kanai N, Sunamura M, Abe T, Takeda K, Matsuno S, Horii A (August 2005). "Distinct progression pathways involving the dysfunction of DUSP6/MKP-3 in pancreatic intraepithelial neoplasia and intraductal papillary-mucinous neoplasms of the pancreas". Modern Pathology. 18 (8): 1034–42. doi:10.1038/modpathol.3800383. PMID 15832194.
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