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<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{Infobox_gene}}
{{PBB_Controls
'''Tyrosine-protein phosphatase non-receptor type 14''' is an [[enzyme]] that in humans is encoded by the ''PTPN14'' [[gene]].<ref name="pmid7733990">{{cite journal | vauthors = Smith AL, Mitchell PJ, Shipley J, Gusterson BA, Rogers MV, Crompton MR | title = Pez: a novel human cDNA encoding protein tyrosine phosphatase- and ezrin-like domains | journal = Biochemical and Biophysical Research Communications | volume = 209 | issue = 3 | pages = 959–65 | date = Apr 1995 | pmid = 7733990 | pmc =  | doi = 10.1006/bbrc.1995.1591 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: PTPN14 protein tyrosine phosphatase, non-receptor type 14| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5784| accessdate = }}</ref>
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}


<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Function ==
{{GNF_Protein_box
| image = PBB_Protein_PTPN14_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 2bzl.
| PDB = {{PDB2|2bzl}}
| Name = Protein tyrosine phosphatase, non-receptor type 14
| HGNCid = 9647
| Symbol = PTPN14
| AltSymbols =; MGC126803; PEZ; PTP36
| OMIM = 603155
| ECnumber = 
| Homologene = 3941
| MGIid = 102467
| GeneAtlas_image1 = PBB_GE_PTPN14_205503_at_tn.png
| Function = {{GNF_GO|id=GO:0004725 |text = protein tyrosine phosphatase activity}} {{GNF_GO|id=GO:0005198 |text = structural molecule activity}} {{GNF_GO|id=GO:0005488 |text = binding}} {{GNF_GO|id=GO:0016787 |text = hydrolase activity}}
| Component = {{GNF_GO|id=GO:0005856 |text = cytoskeleton}}
| Process = {{GNF_GO|id=GO:0006470 |text = protein amino acid dephosphorylation}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 5784
    | Hs_Ensembl = ENSG00000152104
    | Hs_RefseqProtein = NP_005392
    | Hs_RefseqmRNA = NM_005401
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 1
    | Hs_GenLoc_start = 212597474
    | Hs_GenLoc_end = 212791189
    | Hs_Uniprot = Q15678
    | Mm_EntrezGene = 19250
    | Mm_Ensembl = ENSMUSG00000026604
    | Mm_RefseqmRNA = NM_001033287
    | Mm_RefseqProtein = NP_001028459
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 1
    | Mm_GenLoc_start = 191429056
    | Mm_GenLoc_end = 191571095
    | Mm_Uniprot = Q8C3A0
  }}
}}
'''Protein tyrosine phosphatase, non-receptor type 14''', also known as '''PTPN14''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: PTPN14 protein tyrosine phosphatase, non-receptor type 14| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5784| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
The protein encoded by this gene is a member of the [[protein tyrosine phosphatase|PTP]] family and [http://phosphatome.net/wiki/index.php/Phosphatase_Subfamily_PTPN14 PTPN14] subfamily of tyrosine protein phosphatases. PTPs are known to be signalling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains an [[N-terminal]] noncatalytic domain similar to that of band 4.1 superfamily [[cytoskeleton]]-associated proteins, which suggested the membrane or cytoskeleton localization of this protein. The specific function of this PTP has not yet been determined.<ref name="entrez" />
{{PBB_Summary
| section_title =
| summary_text = The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains an N-terminal noncatalytic domain similar to that of band 4.1 superfamily cytoskeleton-associated proteins, which suggested the membrane or cytoskeleton localization of this protein. The specific function of this PTP has not yet been determined.<ref name="entrez">{{cite web | title = Entrez Gene: PTPN14 protein tyrosine phosphatase, non-receptor type 14| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5784| accessdate = }}</ref>
}}


==References==
== Interactions ==
{{reflist|2}}
 
==Further reading==
PTPN14 has been shown to [[Protein-protein interaction|interact]] with [[Beta-catenin]].<ref name=pmid12808048>{{cite journal | vauthors = Wadham C, Gamble JR, Vadas MA, Khew-Goodall Y | title = The protein tyrosine phosphatase Pez is a major phosphatase of adherens junctions and dephosphorylates beta-catenin | journal = Molecular Biology of the Cell | volume = 14 | issue = 6 | pages = 2520–9 | date = Jun 2003 | pmid = 12808048 | pmc = 194899 | doi = 10.1091/mbc.E02-09-0577 }}</ref>
 
== References ==
{{reflist}}
 
== Further reading ==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
* {{cite journal | vauthors = Gyapay G, Morissette J, Vignal A, Dib C, Fizames C, Millasseau P, Marc S, Bernardi G, Lathrop M, Weissenbach J | title = The 1993-94 Généthon human genetic linkage map | journal = Nature Genetics | volume = 7 | issue = 2 Spec No | pages = 246–339 | date = Jun 1994 | pmid = 7545953 | doi = 10.1038/ng0694supp-246 }}
| citations =
* {{cite journal | vauthors = Ogata M, Takada T, Mori Y, Oh-hora M, Uchida Y, Kosugi A, Miyake K, Hamaoka T | title = Effects of overexpression of PTP36, a putative protein tyrosine phosphatase, on cell adhesion, cell growth, and cytoskeletons in HeLa cells | journal = The Journal of Biological Chemistry | volume = 274 | issue = 18 | pages = 12905–9 | date = Apr 1999 | pmid = 10212280 | doi = 10.1074/jbc.274.18.12905 }}
*{{cite journal | author=Gyapay G, Morissette J, Vignal A, ''et al.'' |title=The 1993-94 Généthon human genetic linkage map. |journal=Nat. Genet. |volume=7 |issue= 2 Spec No |pages= 246-339 |year= 1994 |pmid= 7545953 |doi= 10.1038/ng0694supp-246 }}
* {{cite journal | vauthors = Ogata M, Takada T, Mori Y, Uchida Y, Miki T, Okuyama A, Kosugi A, Sawada M, Oh-hora M, Hamaoka T | title = Regulation of phosphorylation level and distribution of PTP36, a putative protein tyrosine phosphatase, by cell-substrate adhesion | journal = The Journal of Biological Chemistry | volume = 274 | issue = 29 | pages = 20717–24 | date = Jul 1999 | pmid = 10400706 | doi = 10.1074/jbc.274.29.20717 }}
*{{cite journal | author=Smith AL, Mitchell PJ, Shipley J, ''et al.'' |title=Pez: a novel human cDNA encoding protein tyrosine phosphatase- and ezrin-like domains. |journal=Biochem. Biophys. Res. Commun. |volume=209 |issue= 3 |pages= 959-65 |year= 1995 |pmid= 7733990 |doi= 10.1006/bbrc.1995.1591 }}
* {{cite journal | vauthors = Aoyama K, Matsuda T, Aoki N | title = Characterization of newly identified four isoforms for a putative cytosolic protein tyrosine phosphatase PTP36 | journal = Biochemical and Biophysical Research Communications | volume = 266 | issue = 2 | pages = 523–31 | date = Dec 1999 | pmid = 10600535 | doi = 10.1006/bbrc.1999.1845 }}
*{{cite journal  | author=Ogata M, Takada T, Mori Y, ''et al.'' |title=Effects of overexpression of PTP36, a putative protein tyrosine phosphatase, on cell adhesion, cell growth, and cytoskeletons in HeLa cells. |journal=J. Biol. Chem. |volume=274 |issue= 18 |pages= 12905-9 |year= 1999 |pmid= 10212280 |doi= }}
* {{cite journal | vauthors = Wadham C, Gamble JR, Vadas MA, Khew-Goodall Y | title = Translocation of protein tyrosine phosphatase Pez/PTPD2/PTP36 to the nucleus is associated with induction of cell proliferation | journal = Journal of Cell Science | volume = 113 ( Pt 17) | issue = 17 | pages = 3117–23 | date = Sep 2000 | pmid = 10934049 | doi =  }}
*{{cite journal | author=Ogata M, Takada T, Mori Y, ''et al.'' |title=Regulation of phosphorylation level and distribution of PTP36, a putative protein tyrosine phosphatase, by cell-substrate adhesion. |journal=J. Biol. Chem. |volume=274 |issue= 29 |pages= 20717-24 |year= 1999 |pmid= 10400706 |doi= }}
* {{cite journal | vauthors = Wadham C, Gamble JR, Vadas MA, Khew-Goodall Y | title = The protein tyrosine phosphatase Pez is a major phosphatase of adherens junctions and dephosphorylates beta-catenin | journal = Molecular Biology of the Cell | volume = 14 | issue = 6 | pages = 2520–9 | date = Jun 2003 | pmid = 12808048 | pmc = 194899 | doi = 10.1091/mbc.E02-09-0577 }}
*{{cite journal | author=Aoyama K, Matsuda T, Aoki N |title=Characterization of newly identified four isoforms for a putative cytosolic protein tyrosine phosphatase PTP36. |journal=Biochem. Biophys. Res. Commun. |volume=266 |issue= 2 |pages= 523-31 |year= 2000 |pmid= 10600535 |doi= 10.1006/bbrc.1999.1845 }}
* {{cite journal | vauthors = Jin J, Smith FD, Stark C, Wells CD, Fawcett JP, Kulkarni S, Metalnikov P, O'Donnell P, Taylor P, Taylor L, Zougman A, Woodgett JR, Langeberg LK, Scott JD, Pawson T | title = Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization | journal = Current Biology | volume = 14 | issue = 16 | pages = 1436–50 | date = Aug 2004 | pmid = 15324660 | doi = 10.1016/j.cub.2004.07.051 }}
*{{cite journal | author=Wadham C, Gamble JR, Vadas MA, Khew-Goodall Y |title=Translocation of protein tyrosine phosphatase Pez/PTPD2/PTP36 to the nucleus is associated with induction of cell proliferation. |journal=J. Cell. Sci. |volume=113 ( Pt 17) |issue= |pages= 3117-23 |year= 2000 |pmid= 10934049 |doi=  }}
* {{cite journal | vauthors = Barr AJ, Debreczeni JE, Eswaran J, Knapp S | title = Crystal structure of human protein tyrosine phosphatase 14 (PTPN14) at 1.65-A resolution | journal = Proteins | volume = 63 | issue = 4 | pages = 1132–6 | date = Jun 2006 | pmid = 16534812 | doi = 10.1002/prot.20958 }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
* {{cite journal | vauthors = Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M | title = Global, in vivo, and site-specific phosphorylation dynamics in signaling networks | journal = Cell | volume = 127 | issue = 3 | pages = 635–48 | date = Nov 2006 | pmid = 17081983 | doi = 10.1016/j.cell.2006.09.026 }}
*{{cite journal  | author=Wadham C, Gamble JR, Vadas MA, Khew-Goodall Y |title=The protein tyrosine phosphatase Pez is a major phosphatase of adherens junctions and dephosphorylates beta-catenin. |journal=Mol. Biol. Cell |volume=14 |issue= 6 |pages= 2520-9 |year= 2004 |pmid= 12808048 |doi= 10.1091/mbc.E02-09-0577 }}
*{{cite journal | author=Ota T, Suzuki Y, Nishikawa T, ''et al.'' |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40-5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
*{{cite journal  | author=Jin J, Smith FD, Stark C, ''et al.'' |title=Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization. |journal=Curr. Biol. |volume=14 |issue= 16 |pages= 1436-50 |year= 2004 |pmid= 15324660 |doi= 10.1016/j.cub.2004.07.051 }}
*{{cite journal | author=Barr AJ, Debreczeni JE, Eswaran J, Knapp S |title=Crystal structure of human protein tyrosine phosphatase 14 (PTPN14) at 1.65-A resolution. |journal=Proteins |volume=63 |issue= 4 |pages= 1132-6 |year= 2006 |pmid= 16534812 |doi= 10.1002/prot.20958 }}
*{{cite journal | author=Olsen JV, Blagoev B, Gnad F, ''et al.'' |title=Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. |journal=Cell |volume=127 |issue= 3 |pages= 635-48 |year= 2006 |pmid= 17081983 |doi= 10.1016/j.cell.2006.09.026 }}
}}
{{refend}}
{{refend}}


{{protein-stub}}
{{PDB Gallery|geneid=5784}}
{{WikiDoc Sources}}
 
{{Protein tyrosine phosphatases}}
 
{{gene-1-stub}}

Latest revision as of 10:33, 5 November 2018

VALUE_ERROR (nil)
Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

n/a

n/a

Ensembl

n/a

n/a

UniProt

n/a

n/a

RefSeq (mRNA)

n/a

n/a

RefSeq (protein)

n/a

n/a

Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Tyrosine-protein phosphatase non-receptor type 14 is an enzyme that in humans is encoded by the PTPN14 gene.[1][2]

Function

The protein encoded by this gene is a member of the PTP family and PTPN14 subfamily of tyrosine protein phosphatases. PTPs are known to be signalling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains an N-terminal noncatalytic domain similar to that of band 4.1 superfamily cytoskeleton-associated proteins, which suggested the membrane or cytoskeleton localization of this protein. The specific function of this PTP has not yet been determined.[2]

Interactions

PTPN14 has been shown to interact with Beta-catenin.[3]

References

  1. ↑ Smith AL, Mitchell PJ, Shipley J, Gusterson BA, Rogers MV, Crompton MR (Apr 1995). "Pez: a novel human cDNA encoding protein tyrosine phosphatase- and ezrin-like domains". Biochemical and Biophysical Research Communications. 209 (3): 959–65. doi:10.1006/bbrc.1995.1591. PMID 7733990.
  2. ↑ 2.0 2.1 "Entrez Gene: PTPN14 protein tyrosine phosphatase, non-receptor type 14".
  3. ↑ Wadham C, Gamble JR, Vadas MA, Khew-Goodall Y (Jun 2003). "The protein tyrosine phosphatase Pez is a major phosphatase of adherens junctions and dephosphorylates beta-catenin". Molecular Biology of the Cell. 14 (6): 2520–9. doi:10.1091/mbc.E02-09-0577. PMC 194899. PMID 12808048.

Further reading

  • Gyapay G, Morissette J, Vignal A, Dib C, Fizames C, Millasseau P, Marc S, Bernardi G, Lathrop M, Weissenbach J (Jun 1994). "The 1993-94 Généthon human genetic linkage map". Nature Genetics. 7 (2 Spec No): 246–339. doi:10.1038/ng0694supp-246. PMID 7545953.
  • Ogata M, Takada T, Mori Y, Oh-hora M, Uchida Y, Kosugi A, Miyake K, Hamaoka T (Apr 1999). "Effects of overexpression of PTP36, a putative protein tyrosine phosphatase, on cell adhesion, cell growth, and cytoskeletons in HeLa cells". The Journal of Biological Chemistry. 274 (18): 12905–9. doi:10.1074/jbc.274.18.12905. PMID 10212280.
  • Ogata M, Takada T, Mori Y, Uchida Y, Miki T, Okuyama A, Kosugi A, Sawada M, Oh-hora M, Hamaoka T (Jul 1999). "Regulation of phosphorylation level and distribution of PTP36, a putative protein tyrosine phosphatase, by cell-substrate adhesion". The Journal of Biological Chemistry. 274 (29): 20717–24. doi:10.1074/jbc.274.29.20717. PMID 10400706.
  • Aoyama K, Matsuda T, Aoki N (Dec 1999). "Characterization of newly identified four isoforms for a putative cytosolic protein tyrosine phosphatase PTP36". Biochemical and Biophysical Research Communications. 266 (2): 523–31. doi:10.1006/bbrc.1999.1845. PMID 10600535.
  • Wadham C, Gamble JR, Vadas MA, Khew-Goodall Y (Sep 2000). "Translocation of protein tyrosine phosphatase Pez/PTPD2/PTP36 to the nucleus is associated with induction of cell proliferation". Journal of Cell Science. 113 ( Pt 17) (17): 3117–23. PMID 10934049.
  • Wadham C, Gamble JR, Vadas MA, Khew-Goodall Y (Jun 2003). "The protein tyrosine phosphatase Pez is a major phosphatase of adherens junctions and dephosphorylates beta-catenin". Molecular Biology of the Cell. 14 (6): 2520–9. doi:10.1091/mbc.E02-09-0577. PMC 194899. PMID 12808048.
  • Jin J, Smith FD, Stark C, Wells CD, Fawcett JP, Kulkarni S, Metalnikov P, O'Donnell P, Taylor P, Taylor L, Zougman A, Woodgett JR, Langeberg LK, Scott JD, Pawson T (Aug 2004). "Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization". Current Biology. 14 (16): 1436–50. doi:10.1016/j.cub.2004.07.051. PMID 15324660.
  • Barr AJ, Debreczeni JE, Eswaran J, Knapp S (Jun 2006). "Crystal structure of human protein tyrosine phosphatase 14 (PTPN14) at 1.65-A resolution". Proteins. 63 (4): 1132–6. doi:10.1002/prot.20958. PMID 16534812.
  • Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M (Nov 2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.
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