CACNB4: Difference between revisions

Jump to navigation Jump to search
VisualWikitext
m (Robot: Automated text replacement (-{{WikiDoc Cardiology Network Infobox}} +, -<references /> +{{reflist|2}}, -{{reflist}} +{{reflist|2}}))
 
imported>Bibcode Bot
m (Adding 0 arxiv eprint(s), 3 bibcode(s) and 0 doi(s). Did it miss something? Report bugs, errors, and suggestions at User talk:Bibcode Bot)
 
(One intermediate revision by one other user not shown)
Line 1: Line 1:
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{Technical|section=|date=November 2009}}
{{PBB_Controls
 
| update_page = yes
{{Infobox_gene}}
| require_manual_inspection = no
'''Voltage-dependent L-type calcium channel subunit beta-4''' is a [[protein]] that in humans is encoded by the ''CACNB4'' [[gene]].<ref name="pmid9628818">{{Cite journal| vauthors = Escayg A, Jones JM, Kearney JA, Hitchcock PF, Meisler MH | title = Calcium channel beta 4 (CACNB4): human ortholog of the mouse epilepsy gene lethargic | journal = Genomics | volume = 50 | issue = 1 | pages = 14–22 |date=Apr 1999 | pmid = 9628818 | pmc = | doi = 10.1006/geno.1998.5311 }}</ref><ref name="entrez">{{Cite web| title = Entrez Gene: CACNB4 calcium channel, voltage-dependent, beta 4 subunit| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=785| accessdate = }}</ref>
| update_protein_box = yes
 
| update_summary = yes
== Function ==
| update_citations = yes
 
}}
This gene encodes a member of the beta subunit family, a protein in the voltage-dependent [[calcium channel]] complex. Calcium channels mediate the influx of calcium ions into the cell upon membrane polarization and consist of a complex of alpha-1, alpha-2/delta, beta, and gamma subunits in a 1:1:1:1 ratio. Various versions of each of these subunits exist, either expressed from similar genes or the result of [[alternative splicing]]. The protein described in this record plays an important role in calcium channel function by modulating [[G protein]] inhibition, increasing peak calcium current, controlling the alpha-1 subunit membrane targeting and shifting the voltage dependence of activation and inactivation. Alternate transcriptional splice variants of this gene, encoding different isoforms, have been characterized.<ref name="entrez"/>
 
== Clinical significance ==
 
Certain mutations in this gene have been associated with [[idiopathic generalized epilepsy]] (IGE) and [[juvenile myoclonic epilepsy]] (JME).<ref name="entrez"/>


<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Interactions ==
{{GNF_Protein_box
| image = PBB_Protein_CACNB4_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1vyv.
| PDB = {{PDB2|1vyv}}, {{PDB2|2d46}}
| Name = Calcium channel, voltage-dependent, beta 4 subunit
| HGNCid = 1404
| Symbol = CACNB4
| AltSymbols =; CAB4; CACNLB4; EA5; EJM
| OMIM = 601949
| ECnumber = 
| Homologene = 20188
| MGIid = 103301
| GeneAtlas_image1 = PBB_GE_CACNB4_207693_at_tn.png
| Function = {{GNF_GO|id=GO:0005245 |text = voltage-gated calcium channel activity}} {{GNF_GO|id=GO:0005509 |text = calcium ion binding}}
| Component = {{GNF_GO|id=GO:0005891 |text = voltage-gated calcium channel complex}} {{GNF_GO|id=GO:0009898 |text = internal side of plasma membrane}}
| Process = {{GNF_GO|id=GO:0006811 |text = ion transport}} {{GNF_GO|id=GO:0006816 |text = calcium ion transport}} {{GNF_GO|id=GO:0051925 |text = regulation of calcium ion transport via voltage-gated calcium channel}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 785
    | Hs_Ensembl = ENSG00000182389
    | Hs_RefseqProtein = NP_000717
    | Hs_RefseqmRNA = NM_000726
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 2
    | Hs_GenLoc_start = 152403879
    | Hs_GenLoc_end = 152663771
    | Hs_Uniprot = O00305
    | Mm_EntrezGene = 12298
    | Mm_Ensembl = ENSMUSG00000017412
    | Mm_RefseqmRNA = NM_001037099
    | Mm_RefseqProtein = NP_001032176
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 2
    | Mm_GenLoc_start = 52250329
    | Mm_GenLoc_end = 52498840
    | Mm_Uniprot = O54985
  }}
}}
'''Calcium channel, voltage-dependent, beta 4 subunit''', also known as '''CACNB4''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: CACNB4 calcium channel, voltage-dependent, beta 4 subunit| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=785| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
CACNB4 has been shown to [[Protein-protein interaction|interact]] with [[Cav2.1]].<ref name=pmid9442082>{{Cite journal|doi=10.1074/jbc.273.4.2361 |last=Walker |first=D |author2=Bichet D |author3=Campbell K P |author4=De Waard M  |date=Jan 1998 |title=A beta 4 isoform-specific interaction site in the carboxyl-terminal region of the voltage-dependent Ca<sup>2+</sup> channel alpha 1A subunit |journal=J. Biol. Chem. |volume=273 |issue=4 |pages=2361–7 |publisher= |location = United States| issn = 0021-9258| pmid = 9442082 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = }}</ref><ref name=pmid10212211>{{Cite journal|doi=10.1074/jbc.274.18.12383 |last=Walker |first=D |author2=Bichet D |author3=Geib S |author4=Mori E |author5=Cornet V |author6=Snutch T P |author7=Mori Y |author8=De Waard M  |date=Apr 1999 |title=A new beta subtype-specific interaction in alpha1A subunit controls P/Q-type Ca<sup>2+</sup> channel activation |journal=J. Biol. Chem. |volume=274 |issue=18 |pages=12383–90 |publisher= |location = United States| issn = 0021-9258| pmid = 10212211 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = }}</ref>
{{PBB_Summary
| section_title =  
| summary_text = This gene encodes a member of the beta subunit family, a protein in the voltage-dependent calcium channel complex. Calcium channels mediate the influx of calcium ions into the cell upon membrane polarization and consist of a complex of alpha-1, alpha-2/delta, beta, and gamma subunits in a 1:1:1:1 ratio. Various versions of each of these subunits exist, either expressed from similar genes or the result of alternative splicing. The protein described in this record plays an important role in calcium channel function by modulating G protein inhibition, increasing peak calcium current, controlling the alpha-1 subunit membrane targeting and shifting the voltage dependence of activation and inactivation. Certain mutations in this gene have been associated with idiopathic generalized epilepsy (IGE) and juvenile myoclonic epilepsy (JME). Alternate transcriptional splice variants of this gene, encoding different isoforms, have been characterized.<ref name="entrez">{{cite web | title = Entrez Gene: CACNB4 calcium channel, voltage-dependent, beta 4 subunit| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=785| accessdate = }}</ref>
}}


==See also==
==See also==
Line 58: Line 20:


==References==
==References==
{{reflist|2}}
{{Reflist}}


==Further reading==
==Further reading==
{{refbegin | 2}}
{{Refbegin| 2}}
{{PBB_Further_reading  
{{PBB_Further_reading
| citations =  
| citations =
*{{cite journal | author=Volsen SG, Day NC, McCormack AL, ''et al.'' |title=The expression of voltage-dependent calcium channel beta subunits in human cerebellum. |journal=Neuroscience |volume=80 |issue= 1 |pages= 161-74 |year= 1997 |pmid= 9252229 |doi= }}
*{{Cite journal| vauthors=Volsen SG, Day NC, McCormack AL |title=The expression of voltage-dependent calcium channel beta subunits in human cerebellum. |journal=Neuroscience |volume=80 |issue= 1 |pages= 161–74 |year= 1997 |pmid= 9252229 |doi=10.1016/S0306-4522(97)00115-2 |display-authors=etal}}
*{{cite journal | author=Lory P, Ophoff RA, Nahmias J |title=Towards a unified nomenclature describing voltage-gated calcium channel genes. |journal=Hum. Genet. |volume=100 |issue= 2 |pages= 149-50 |year= 1997 |pmid= 9254840 |doi= }}
*{{Cite journal| vauthors=Lory P, Ophoff RA, Nahmias J |title=Towards a unified nomenclature describing voltage-gated calcium channel genes. |journal=Hum. Genet. |volume=100 |issue= 2 |pages= 149–50 |year= 1997 |pmid= 9254840 |doi=10.1007/s004390050481 }}
*{{cite journal | author=Taviaux S, Williams ME, Harpold MM, ''et al.'' |title=Assignment of human genes for beta 2 and beta 4 subunits of voltage-dependent Ca2+ channels to chromosomes 10p12 and 2q22-q23. |journal=Hum. Genet. |volume=100 |issue= 2 |pages= 151-4 |year= 1997 |pmid= 9254841 |doi= }}
*{{Cite journal| vauthors=Taviaux S, Williams ME, Harpold MM |title=Assignment of human genes for beta 2 and beta 4 subunits of voltage-dependent Ca<sup>2+</sup> channels to chromosomes 10p12 and 2q22-q23. |journal=Hum. Genet. |volume=100 |issue= 2 |pages= 151–4 |year= 1997 |pmid= 9254841 |doi=10.1007/PL00008704 |display-authors=etal}}
*{{cite journal | author=Walker D, Bichet D, Campbell KP, De Waard M |title=A beta 4 isoform-specific interaction site in the carboxyl-terminal region of the voltage-dependent Ca2+ channel alpha 1A subunit. |journal=J. Biol. Chem. |volume=273 |issue= 4 |pages= 2361-7 |year= 1998 |pmid= 9442082 |doi= }}
*{{Cite journal| vauthors=Walker D, Bichet D, Campbell KP, De Waard M |title=A beta 4 isoform-specific interaction site in the carboxyl-terminal region of the voltage-dependent Ca<sup>2+</sup> channel alpha 1A subunit. |journal=J. Biol. Chem. |volume=273 |issue= 4 |pages= 2361–7 |year= 1998 |pmid= 9442082 |doi=10.1074/jbc.273.4.2361 }}
*{{cite journal | author=Betz R, Leibiger B, Farnebo F, ''et al.'' |title=Mapping of the human Ca2+ channel beta 4 subunit to 2q22-23 and its expression in developing mouse. |journal=Mamm. Genome |volume=9 |issue= 4 |pages= 310-1 |year= 1998 |pmid= 9530629 |doi= }}
*{{Cite journal| vauthors=Betz R, Leibiger B, Farnebo F |title=Mapping of the human Ca<sup>2+</sup> channel beta 4 subunit to 2q22-23 and its expression in developing mouse. |journal=Mamm. Genome |volume=9 |issue= 4 |pages= 310–1 |year= 1998 |pmid= 9530629 |doi=10.1007/s003359900755 |display-authors=etal}}
*{{cite journal | author=Escayg A, Jones JM, Kearney JA, ''et al.'' |title=Calcium channel beta 4 (CACNB4): human ortholog of the mouse epilepsy gene lethargic. |journal=Genomics |volume=50 |issue= 1 |pages= 14-22 |year= 1999 |pmid= 9628818 |doi= 10.1006/geno.1998.5311 }}
*{{Cite journal| vauthors=Day NC, Volsen SG, McCormack AL |title=The expression of voltage-dependent calcium channel beta subunits in human hippocampus. |journal=Brain Res. Mol. Brain Res. |volume=60 |issue= 2 |pages= 259–69 |year= 1998 |pmid= 9757060 |doi=10.1016/S0169-328X(98)00186-7 |display-authors=etal}}
*{{cite journal | author=Day NC, Volsen SG, McCormack AL, ''et al.'' |title=The expression of voltage-dependent calcium channel beta subunits in human hippocampus. |journal=Brain Res. Mol. Brain Res. |volume=60 |issue= 2 |pages= 259-69 |year= 1998 |pmid= 9757060 |doi= }}
*{{Cite journal| vauthors=Walker D, Bichet D, Geib S |title=A new beta subtype-specific interaction in alpha1A subunit controls P/Q-type Ca<sup>2+</sup> channel activation. |journal=J. Biol. Chem. |volume=274 |issue= 18 |pages= 12383–90 |year= 1999 |pmid= 10212211 |doi=10.1074/jbc.274.18.12383 |display-authors=etal}}
*{{cite journal | author=Walker D, Bichet D, Geib S, ''et al.'' |title=A new beta subtype-specific interaction in alpha1A subunit controls P/Q-type Ca2+ channel activation. |journal=J. Biol. Chem. |volume=274 |issue= 18 |pages= 12383-90 |year= 1999 |pmid= 10212211 |doi= }}
*{{Cite journal| vauthors=Escayg A, De Waard M, Lee DD |title=Coding and noncoding variation of the human calcium-channel beta4-subunit gene CACNB4 in patients with idiopathic generalized epilepsy and episodic ataxia. |journal=Am. J. Hum. Genet. |volume=66 |issue= 5 |pages= 1531–9 |year= 2000 |pmid= 10762541 |doi=10.1086/302909 | pmc=1378014 |display-authors=etal}}
*{{cite journal | author=Escayg A, De Waard M, Lee DD, ''et al.'' |title=Coding and noncoding variation of the human calcium-channel beta4-subunit gene CACNB4 in patients with idiopathic generalized epilepsy and episodic ataxia. |journal=Am. J. Hum. Genet. |volume=66 |issue= 5 |pages= 1531-9 |year= 2000 |pmid= 10762541 |doi= }}
*{{Cite journal| vauthors=Helton TD, Horne WA |title=Alternative splicing of the beta 4 subunit has alpha1 subunit subtype-specific effects on Ca<sup>2+</sup> channel gating. |journal=J. Neurosci. |volume=22 |issue= 5 |pages= 1573–82 |year= 2002 |pmid= 11880487 |doi= }}
*{{cite journal | author=Helton TD, Horne WA |title=Alternative splicing of the beta 4 subunit has alpha1 subunit subtype-specific effects on Ca2+ channel gating. |journal=J. Neurosci. |volume=22 |issue= 5 |pages= 1573-82 |year= 2002 |pmid= 11880487 |doi= }}
*{{Cite journal| vauthors=Strausberg RL, Feingold EA, Grouse LH |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |display-authors=etal|bibcode=2002PNAS...9916899M }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{Cite journal| vauthors=Finlin BS, Crump SM, Satin J, Andres DA |title=Regulation of voltage-gated calcium channel activity by the Rem and Rad GTPases. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=100 |issue= 24 |pages= 14469–74 |year= 2004 |pmid= 14623965 |doi= 10.1073/pnas.2437756100 | pmc=283615 |bibcode=2003PNAS..10014469F }}
*{{cite journal | author=Finlin BS, Crump SM, Satin J, Andres DA |title=Regulation of voltage-gated calcium channel activity by the Rem and Rad GTPases. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=100 |issue= 24 |pages= 14469-74 |year= 2004 |pmid= 14623965 |doi= 10.1073/pnas.2437756100 }}
*{{Cite journal| vauthors=Chen YH, Li MH, Zhang Y |title=Structural basis of the alpha1-beta subunit interaction of voltage-gated Ca<sup>2+</sup> channels. |journal=Nature |volume=429 |issue= 6992 |pages= 675–80 |year= 2004 |pmid= 15170217 |doi= 10.1038/nature02641 |display-authors=etal|bibcode=2004Natur.429..675C }}
*{{cite journal | author=Chen YH, Li MH, Zhang Y, ''et al.'' |title=Structural basis of the alpha1-beta subunit interaction of voltage-gated Ca2+ channels. |journal=Nature |volume=429 |issue= 6992 |pages= 675-80 |year= 2004 |pmid= 15170217 |doi= 10.1038/nature02641 }}
*{{Cite journal| vauthors=Suzuki Y, Yamashita R, Shirota M |title=Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions. |journal=Genome Res. |volume=14 |issue= 9 |pages= 1711–8 |year= 2004 |pmid= 15342556 |doi= 10.1101/gr.2435604 | pmc=515316 |display-authors=etal}}
*{{cite journal | author=Suzuki Y, Yamashita R, Shirota M, ''et al.'' |title=Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions. |journal=Genome Res. |volume=14 |issue= 9 |pages= 1711-8 |year= 2004 |pmid= 15342556 |doi= 10.1101/gr.2435604 }}
*{{Cite journal| vauthors=Gerhard DS, Wagner L, Feingold EA |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 |display-authors=etal}}
*{{cite journal | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{Cite journal| vauthors=Vendel AC, Rithner CD, Lyons BA, Horne WA |title=Solution structure of the N-terminal A domain of the human voltage-gated Ca<sup>2+</sup>channel beta4a subunit. |journal=Protein Sci. |volume=15 |issue= 2 |pages= 378–83 |year= 2006 |pmid= 16385006 |doi= 10.1110/ps.051894506 | pmc=2242464 }}
*{{cite journal | author=Vendel AC, Rithner CD, Lyons BA, Horne WA |title=Solution structure of the N-terminal A domain of the human voltage-gated Ca2+channel beta4a subunit. |journal=Protein Sci. |volume=15 |issue= 2 |pages= 378-83 |year= 2006 |pmid= 16385006 |doi= 10.1110/ps.051894506 }}
*{{Cite journal| vauthors=Vendel AC, Terry MD, Striegel AR |title=Alternative splicing of the voltage-gated Ca<sup>2+</sup> channel beta4 subunit creates a uniquely folded N-terminal protein binding domain with cell-specific expression in the cerebellar cortex. |journal=J. Neurosci. |volume=26 |issue= 10 |pages= 2635–44 |year= 2006 |pmid= 16525042 |doi= 10.1523/JNEUROSCI.0067-06.2006 |display-authors=etal}}
*{{cite journal | author=Vendel AC, Terry MD, Striegel AR, ''et al.'' |title=Alternative splicing of the voltage-gated Ca2+ channel beta4 subunit creates a uniquely folded N-terminal protein binding domain with cell-specific expression in the cerebellar cortex. |journal=J. Neurosci. |volume=26 |issue= 10 |pages= 2635-44 |year= 2006 |pmid= 16525042 |doi= 10.1523/JNEUROSCI.0067-06.2006 }}
*{{Cite journal| vauthors=von Brevern M, Ta N, Shankar A |title=Migrainous vertigo: mutation analysis of the candidate genes CACNA1A, ATP1A2, SCN1A, and CACNB4. |journal=Headache |volume=46 |issue= 7 |pages= 1136–41 |year= 2006 |pmid= 16866717 |doi= 10.1111/j.1526-4610.2006.00504.x |display-authors=etal}}
*{{cite journal | author=von Brevern M, Ta N, Shankar A, ''et al.'' |title=Migrainous vertigo: mutation analysis of the candidate genes CACNA1A, ATP1A2, SCN1A, and CACNB4. |journal=Headache |volume=46 |issue= 7 |pages= 1136-41 |year= 2006 |pmid= 16866717 |doi= 10.1111/j.1526-4610.2006.00504.x }}
*{{Cite journal| vauthors=Kobayashi T, Yamada Y, Fukao M |title=The GK domain of the voltage-dependent calcium channel beta subunit is essential for binding to the alpha subunit. |journal=Biochem. Biophys. Res. Commun. |volume=360 |issue= 3 |pages= 679–83 |year= 2007 |pmid= 17618603 |doi= 10.1016/j.bbrc.2007.06.112 |display-authors=etal}}
*{{cite journal  | author=Kobayashi T, Yamada Y, Fukao M, ''et al.'' |title=The GK domain of the voltage-dependent calcium channel beta subunit is essential for binding to the alpha subunit. |journal=Biochem. Biophys. Res. Commun. |volume=360 |issue= 3 |pages= 679-83 |year= 2007 |pmid= 17618603 |doi= 10.1016/j.bbrc.2007.06.112 }}
}}
}}
{{refend}}
{{Refend}}


== External links ==
==External links==
* {{MeshName|CACNB4+protein,+human}}
* {{MeshName|CACNB4+protein,+human}}
* {{UCSC gene info|CACNB4}}
{{PDB Gallery|geneid=785}}
{{Ion channels|g1}}


{{membrane-protein-stub}}
{{NLM content}}
{{NLM content}}
{{Ion channels}}
 
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = no
| update_citations = yes
}}
 
{{DEFAULTSORT:Cacnb4}}
[[Category:Ion channels]]
[[Category:Ion channels]]
{{WikiDoc Sources}}
 
 
{{Membrane-protein-stub}}

Latest revision as of 01:04, 23 June 2018

VALUE_ERROR (nil)
Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

n/a

n/a

Ensembl

n/a

n/a

UniProt

n/a

n/a

RefSeq (mRNA)

n/a

n/a

RefSeq (protein)

n/a

n/a

Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Voltage-dependent L-type calcium channel subunit beta-4 is a protein that in humans is encoded by the CACNB4 gene.[1][2]

Function

This gene encodes a member of the beta subunit family, a protein in the voltage-dependent calcium channel complex. Calcium channels mediate the influx of calcium ions into the cell upon membrane polarization and consist of a complex of alpha-1, alpha-2/delta, beta, and gamma subunits in a 1:1:1:1 ratio. Various versions of each of these subunits exist, either expressed from similar genes or the result of alternative splicing. The protein described in this record plays an important role in calcium channel function by modulating G protein inhibition, increasing peak calcium current, controlling the alpha-1 subunit membrane targeting and shifting the voltage dependence of activation and inactivation. Alternate transcriptional splice variants of this gene, encoding different isoforms, have been characterized.[2]

Clinical significance

Certain mutations in this gene have been associated with idiopathic generalized epilepsy (IGE) and juvenile myoclonic epilepsy (JME).[2]

Interactions

CACNB4 has been shown to interact with Cav2.1.[3][4]

See also

References

  1. ↑ Escayg A, Jones JM, Kearney JA, Hitchcock PF, Meisler MH (Apr 1999). "Calcium channel beta 4 (CACNB4): human ortholog of the mouse epilepsy gene lethargic". Genomics. 50 (1): 14–22. doi:10.1006/geno.1998.5311. PMID 9628818.
  2. ↑ 2.0 2.1 2.2 "Entrez Gene: CACNB4 calcium channel, voltage-dependent, beta 4 subunit".
  3. ↑ Walker, D; Bichet D; Campbell K P; De Waard M (Jan 1998). "A beta 4 isoform-specific interaction site in the carboxyl-terminal region of the voltage-dependent Ca2+ channel alpha 1A subunit". J. Biol. Chem. United States. 273 (4): 2361–7. doi:10.1074/jbc.273.4.2361. ISSN 0021-9258. PMID 9442082.
  4. ↑ Walker, D; Bichet D; Geib S; Mori E; Cornet V; Snutch T P; Mori Y; De Waard M (Apr 1999). "A new beta subtype-specific interaction in alpha1A subunit controls P/Q-type Ca2+ channel activation". J. Biol. Chem. United States. 274 (18): 12383–90. doi:10.1074/jbc.274.18.12383. ISSN 0021-9258. PMID 10212211.

Further reading

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


Retrieved from "https://www.wikidoc.org/index.php?title=CACNB4&oldid=1531830"