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{{ | '''Protein tyrosine phosphatase type IVA 1''' is an [[enzyme]] that in humans is encoded by the ''PTP4A1'' [[gene]].<ref name="pmid9642300">{{cite journal |vauthors=Peng Y, Genin A, Spinner NB, Diamond RH, Taub R | title = The gene encoding human nuclear protein tyrosine phosphatase, PRL-1. Cloning, chromosomal localization, and identification of an intron enhancer | journal = J Biol Chem | volume = 273 | issue = 27 | pages = 17286–95 |date=Aug 1998 | pmid = 9642300 | pmc = | doi =10.1074/jbc.273.27.17286 }}</ref><ref name="entrez"/> | ||
}} | |||
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| summary_text = The protein encoded by this gene belongs to a small class of prenylated protein tyrosine phosphatases (PTPs), which contains a PTP domain and a characteristic C-terminal prenylation motif. PTPs are cell signaling molecules that play regulatory roles in a variety of cellular processes. This tyrosine phosphatase is a nuclear protein, but may primarily associate with plasma membrane. The surface membrane association of this protein depends on its C-terminal prenylation. Overexpression of this gene in mammalian cells conferred a transformed phenotype, which implicated its role in the tumorigenesis. Studies in rat suggested that this gene may be an immediate-early gene in mitogen-stimulated cells.<ref name="entrez">{{cite web | title = Entrez Gene: PTP4A1 protein tyrosine phosphatase type IVA, member 1| url = | | summary_text = The protein encoded by this gene belongs to a small class of prenylated protein tyrosine phosphatases (PTPs), which contains a PTP domain and a characteristic C-terminal prenylation motif. PTPs are cell signaling molecules that play regulatory roles in a variety of cellular processes. This tyrosine phosphatase is a nuclear protein, but may primarily associate with plasma membrane. The surface membrane association of this protein depends on its C-terminal prenylation. Overexpression of this gene in mammalian cells conferred a transformed phenotype, which implicated its role in the tumorigenesis. Studies in rat suggested that this gene may be an immediate-early gene in mitogen-stimulated cells.<ref name="entrez">{{cite web | title = Entrez Gene: PTP4A1 protein tyrosine phosphatase type IVA, member 1| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7803| accessdate = }}</ref> | ||
}} | }} | ||
==Interactions== | |||
PTP4A1 has been shown to [[Protein-protein interaction|interact]] with [[ATF7]].<ref name=pmid11278933>{{cite journal |last=Peters |first=C S |authorlink= |author2=Liang X |author3=Li S |author4=Kannan S |author5=Peng Y |author6=Taub R |author7=Diamond R H |date=Apr 2001 |title=ATF-7, a novel bZIP protein, interacts with the PRL-1 protein-tyrosine phosphatase |journal=J. Biol. Chem. |volume=276 |issue=17 |pages=13718–26 |publisher= |location = United States| issn = 0021-9258| pmid = 11278933 |doi = 10.1074/jbc.M011562200 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = }}</ref> | |||
==References== | ==References== | ||
{{reflist | {{reflist}} | ||
==Further reading== | ==Further reading== | ||
{{refbegin | 2}} | {{refbegin | 2}} | ||
{{PBB_Further_reading | {{PBB_Further_reading | ||
| citations = | | citations = | ||
*{{cite journal | *{{cite journal |vauthors=Cates CA, Michael RL, Stayrook KR, etal |title=Prenylation of oncogenic human PTP(CAAX) protein tyrosine phosphatases |journal=Cancer Lett. |volume=110 |issue= 1–2 |pages= 49–55 |year= 1997 |pmid= 9018080 |doi=10.1016/S0304-3835(96)04459-X }} | ||
*{{cite journal | | *{{cite journal |vauthors=Dayton MA, Knobloch TJ |title=Multiple phosphotyrosine phosphatase mRNAs are expressed in the human lung fibroblast cell line WI-38 |journal=Receptors & signal transduction |volume=7 |issue= 4 |pages= 241–56 |year= 1998 |pmid= 9633825 |doi= }} | ||
*{{cite journal | | *{{cite journal |vauthors=Tsujimoto H, Nishizuka S, Redpath JL, Stanbridge EJ |title=Differential gene expression in tumorigenic and nontumorigenic HeLa x normal human fibroblast hybrid cells |journal=Mol. Carcinog. |volume=26 |issue= 4 |pages= 298–304 |year= 1999 |pmid= 10569806 |doi=10.1002/(SICI)1098-2744(199912)26:4<298::AID-MC8>3.0.CO;2-M }} | ||
*{{cite journal | *{{cite journal |vauthors=Zeng Q, Si X, Horstmann H, etal |title=Prenylation-dependent association of protein-tyrosine phosphatases PRL-1, -2, and -3 with the plasma membrane and the early endosome |journal=J. Biol. Chem. |volume=275 |issue= 28 |pages= 21444–52 |year= 2000 |pmid= 10747914 |doi= 10.1074/jbc.M000453200 }} | ||
*{{cite journal | *{{cite journal |vauthors=Gjörloff-Wingren A, Saxena M, Han S, etal |title=Subcellular localization of intracellular protein tyrosine phosphatases in T cells |journal=Eur. J. Immunol. |volume=30 |issue= 8 |pages= 2412–21 |year= 2000 |pmid= 10940933 |doi=10.1002/1521-4141(2000)30:8<2412::AID-IMMU2412>3.0.CO;2-J }} | ||
*{{cite journal | *{{cite journal |vauthors=Peters CS, Liang X, Li S, etal |title=ATF-7, a novel bZIP protein, interacts with the PRL-1 protein-tyrosine phosphatase |journal=J. Biol. Chem. |volume=276 |issue= 17 |pages= 13718–26 |year= 2001 |pmid= 11278933 |doi= 10.1074/jbc.M011562200 }} | ||
*{{cite journal | *{{cite journal |vauthors=Si X, Zeng Q, Ng CH, etal |title=Interaction of farnesylated PRL-2, a protein-tyrosine phosphatase, with the beta-subunit of geranylgeranyltransferase II |journal=J. Biol. Chem. |volume=276 |issue= 35 |pages= 32875–82 |year= 2001 |pmid= 11447212 |doi= 10.1074/jbc.M010400200 }} | ||
*{{cite journal | *{{cite journal |vauthors=Nicolas G, Fournier CM, Galand C, etal |title=Tyrosine Phosphorylation Regulates Alpha II Spectrin Cleavage by Calpain |journal=Mol. Cell. Biol. |volume=22 |issue= 10 |pages= 3527–36 |year= 2002 |pmid= 11971983 |doi=10.1128/MCB.22.10.3527-3536.2002 | pmc=133798 }} | ||
*{{cite journal | | *{{cite journal |vauthors=Wang J, Kirby CE, Herbst R |title=The tyrosine phosphatase PRL-1 localizes to the endoplasmic reticulum and the mitotic spindle and is required for normal mitosis |journal=J. Biol. Chem. |volume=277 |issue= 48 |pages= 46659–68 |year= 2003 |pmid= 12235145 |doi= 10.1074/jbc.M206407200 }} | ||
*{{cite journal | *{{cite journal |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |bibcode=2002PNAS...9916899M }} | ||
*{{cite journal | *{{cite journal |vauthors=Pathak MK, Dhawan D, Lindner DJ, etal |title=Pentamidine is an inhibitor of PRL phosphatases with anticancer activity |journal=Mol. Cancer Ther. |volume=1 |issue= 14 |pages= 1255–64 |year= 2003 |pmid= 12516958 |doi= }} | ||
*{{cite journal | *{{cite journal |vauthors=Zeng Q, Dong JM, Guo K, etal |title=PRL-3 and PRL-1 promote cell migration, invasion, and metastasis |journal=Cancer Res. |volume=63 |issue= 11 |pages= 2716–22 |year= 2003 |pmid= 12782572 |doi= }} | ||
*{{cite journal | *{{cite journal |vauthors=Mungall AJ, Palmer SA, Sims SK, etal |title=The DNA sequence and analysis of human chromosome 6 |journal=Nature |volume=425 |issue= 6960 |pages= 805–11 |year= 2003 |pmid= 14574404 |doi= 10.1038/nature02055 }} | ||
*{{cite journal | *{{cite journal |vauthors=Werner SR, Lee PA, DeCamp MW, etal |title=Enhanced cell cycle progression and down regulation of p21(Cip1/Waf1) by PRL tyrosine phosphatases |journal=Cancer Lett. |volume=202 |issue= 2 |pages= 201–11 |year= 2004 |pmid= 14643450 |doi=10.1016/S0304-3835(03)00517-2 }} | ||
*{{cite journal | *{{cite journal |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 }} | ||
*{{cite journal | | *{{cite journal |vauthors=Raghavendra Prasad HS, Qi Z, Srinivasan KN, Gopalakrishnakone P |title=Potential effects of tetrodotoxin exposure to human glial cells postulated using microarray approach |journal=Toxicon |volume=44 |issue= 6 |pages= 597–608 |year= 2005 |pmid= 15501285 |doi= 10.1016/j.toxicon.2004.07.018 }} | ||
*{{cite journal | *{{cite journal |vauthors=Jeong DG, Kim SJ, Kim JH, etal |title=Trimeric structure of PRL-1 phosphatase reveals an active enzyme conformation and regulation mechanisms |journal=J. Mol. Biol. |volume=345 |issue= 2 |pages= 401–13 |year= 2005 |pmid= 15571731 |doi= 10.1016/j.jmb.2004.10.061 }} | ||
*{{cite journal | *{{cite journal |vauthors=Sun JP, Wang WQ, Yang H, etal |title=Structure and biochemical properties of PRL-1, a phosphatase implicated in cell growth, differentiation, and tumor invasion |journal=Biochemistry |volume=44 |issue= 36 |pages= 12009–21 |year= 2005 |pmid= 16142898 |doi= 10.1021/bi0509191 }} | ||
*{{cite journal | *{{cite journal |vauthors=Radke I, Götte M, Kersting C, etal |title=Expression and prognostic impact of the protein tyrosine phosphatases PRL-1, PRL-2, and PRL-3 in breast cancer |journal=Br. J. Cancer |volume=95 |issue= 3 |pages= 347–54 |year= 2006 |pmid= 16832410 |doi= 10.1038/sj.bjc.6603261 | pmc=2360632 }} | ||
}} | }} | ||
{{refend}} | {{refend}} | ||
{{PDB Gallery|geneid=7803}} | |||
{{Protein tyrosine phosphatases}} | |||
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{{ | {{gene-6-stub}} | ||
Latest revision as of 20:06, 25 June 2018
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Protein tyrosine phosphatase type IVA 1 is an enzyme that in humans is encoded by the PTP4A1 gene.[1][2]
The protein encoded by this gene belongs to a small class of prenylated protein tyrosine phosphatases (PTPs), which contains a PTP domain and a characteristic C-terminal prenylation motif. PTPs are cell signaling molecules that play regulatory roles in a variety of cellular processes. This tyrosine phosphatase is a nuclear protein, but may primarily associate with plasma membrane. The surface membrane association of this protein depends on its C-terminal prenylation. Overexpression of this gene in mammalian cells conferred a transformed phenotype, which implicated its role in the tumorigenesis. Studies in rat suggested that this gene may be an immediate-early gene in mitogen-stimulated cells.[2]
Interactions
PTP4A1 has been shown to interact with ATF7.[3]
References
- ↑ Peng Y, Genin A, Spinner NB, Diamond RH, Taub R (Aug 1998). "The gene encoding human nuclear protein tyrosine phosphatase, PRL-1. Cloning, chromosomal localization, and identification of an intron enhancer". J Biol Chem. 273 (27): 17286–95. doi:10.1074/jbc.273.27.17286. PMID 9642300.
- ↑ 2.0 2.1 "Entrez Gene: PTP4A1 protein tyrosine phosphatase type IVA, member 1".
- ↑ Peters, C S; Liang X; Li S; Kannan S; Peng Y; Taub R; Diamond R H (Apr 2001). "ATF-7, a novel bZIP protein, interacts with the PRL-1 protein-tyrosine phosphatase". J. Biol. Chem. United States. 276 (17): 13718–26. doi:10.1074/jbc.M011562200. ISSN 0021-9258. PMID 11278933.
Further reading
- Cates CA, Michael RL, Stayrook KR, et al. (1997). "Prenylation of oncogenic human PTP(CAAX) protein tyrosine phosphatases". Cancer Lett. 110 (1–2): 49–55. doi:10.1016/S0304-3835(96)04459-X. PMID 9018080.
- Dayton MA, Knobloch TJ (1998). "Multiple phosphotyrosine phosphatase mRNAs are expressed in the human lung fibroblast cell line WI-38". Receptors & signal transduction. 7 (4): 241–56. PMID 9633825.
- Tsujimoto H, Nishizuka S, Redpath JL, Stanbridge EJ (1999). "Differential gene expression in tumorigenic and nontumorigenic HeLa x normal human fibroblast hybrid cells". Mol. Carcinog. 26 (4): 298–304. doi:10.1002/(SICI)1098-2744(199912)26:4<298::AID-MC8>3.0.CO;2-M. PMID 10569806.
- Zeng Q, Si X, Horstmann H, et al. (2000). "Prenylation-dependent association of protein-tyrosine phosphatases PRL-1, -2, and -3 with the plasma membrane and the early endosome". J. Biol. Chem. 275 (28): 21444–52. doi:10.1074/jbc.M000453200. PMID 10747914.
- Gjörloff-Wingren A, Saxena M, Han S, et al. (2000). "Subcellular localization of intracellular protein tyrosine phosphatases in T cells". Eur. J. Immunol. 30 (8): 2412–21. doi:10.1002/1521-4141(2000)30:8<2412::AID-IMMU2412>3.0.CO;2-J. PMID 10940933.
- Peters CS, Liang X, Li S, et al. (2001). "ATF-7, a novel bZIP protein, interacts with the PRL-1 protein-tyrosine phosphatase". J. Biol. Chem. 276 (17): 13718–26. doi:10.1074/jbc.M011562200. PMID 11278933.
- Si X, Zeng Q, Ng CH, et al. (2001). "Interaction of farnesylated PRL-2, a protein-tyrosine phosphatase, with the beta-subunit of geranylgeranyltransferase II". J. Biol. Chem. 276 (35): 32875–82. doi:10.1074/jbc.M010400200. PMID 11447212.
- Nicolas G, Fournier CM, Galand C, et al. (2002). "Tyrosine Phosphorylation Regulates Alpha II Spectrin Cleavage by Calpain". Mol. Cell. Biol. 22 (10): 3527–36. doi:10.1128/MCB.22.10.3527-3536.2002. PMC 133798. PMID 11971983.
- Wang J, Kirby CE, Herbst R (2003). "The tyrosine phosphatase PRL-1 localizes to the endoplasmic reticulum and the mitotic spindle and is required for normal mitosis". J. Biol. Chem. 277 (48): 46659–68. doi:10.1074/jbc.M206407200. PMID 12235145.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Pathak MK, Dhawan D, Lindner DJ, et al. (2003). "Pentamidine is an inhibitor of PRL phosphatases with anticancer activity". Mol. Cancer Ther. 1 (14): 1255–64. PMID 12516958.
- Zeng Q, Dong JM, Guo K, et al. (2003). "PRL-3 and PRL-1 promote cell migration, invasion, and metastasis". Cancer Res. 63 (11): 2716–22. PMID 12782572.
- Mungall AJ, Palmer SA, Sims SK, et al. (2003). "The DNA sequence and analysis of human chromosome 6". Nature. 425 (6960): 805–11. doi:10.1038/nature02055. PMID 14574404.
- Werner SR, Lee PA, DeCamp MW, et al. (2004). "Enhanced cell cycle progression and down regulation of p21(Cip1/Waf1) by PRL tyrosine phosphatases". Cancer Lett. 202 (2): 201–11. doi:10.1016/S0304-3835(03)00517-2. PMID 14643450.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
- Raghavendra Prasad HS, Qi Z, Srinivasan KN, Gopalakrishnakone P (2005). "Potential effects of tetrodotoxin exposure to human glial cells postulated using microarray approach". Toxicon. 44 (6): 597–608. doi:10.1016/j.toxicon.2004.07.018. PMID 15501285.
- Jeong DG, Kim SJ, Kim JH, et al. (2005). "Trimeric structure of PRL-1 phosphatase reveals an active enzyme conformation and regulation mechanisms". J. Mol. Biol. 345 (2): 401–13. doi:10.1016/j.jmb.2004.10.061. PMID 15571731.
- Sun JP, Wang WQ, Yang H, et al. (2005). "Structure and biochemical properties of PRL-1, a phosphatase implicated in cell growth, differentiation, and tumor invasion". Biochemistry. 44 (36): 12009–21. doi:10.1021/bi0509191. PMID 16142898.
- Radke I, Götte M, Kersting C, et al. (2006). "Expression and prognostic impact of the protein tyrosine phosphatases PRL-1, PRL-2, and PRL-3 in breast cancer". Br. J. Cancer. 95 (3): 347–54. doi:10.1038/sj.bjc.6603261. PMC 2360632. PMID 16832410.
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