Transient receptor potential channel: Difference between revisions
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Latest revision as of 15:36, 6 September 2012
Transient receptor potential or TRP channels are a family of loosely related ion channels that are non-selectively permeable to cations, including calcium and magnesium. TRP channels are so named because they were discovered in mutant Drosophila that, instead of having sustained photoreceptor activity in response to light, had only a transient response to light.[1] Most TRP channels are comprised of 6 membrane-spanning helices with intracellular N- and C-termini. TRP channels are activated and regulated by a wide variety of stimuli and are expressed widely throughout the body.
Genes
They are encoded by at least 33 channel subunit genes divided into seven sub-families:
- TRPC (canonical) - associated with Focal segmental glomerulosclerosis
- TRPV (vanilloid)
- TRPA (ankyrin)
- TRPM (melastatin) -- associated with Hypomagnesemia with secondary hypocalcemia
- TRPP (polycystin) -- associated with Polycystic kidney disease
- TRPML (mucolipin) -- associated with Mucolipidosis type IV
- TRPN (NOMPC) - no mechanoreceptor potential C - not found in mammals
References
- ↑ Minke B, Wu C, Pak WL (1975). "Induction of photoreceptor voltage noise in the dark in Drosophila mutant". Nature. 258 (5530): 84–7. doi:10.1038/258084a0. PMID 810728.
External links
- IUPHAR
- Transient+Receptor+Potential+Channels at the US National Library of Medicine Medical Subject Headings (MeSH)