Dermoid cyst overview: Difference between revisions
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{{Dermoid cyst}} | {{Dermoid cyst}} | ||
{{CMG}}{{AE}} {{STM}} | {{CMG}}{{AE}} {{STM}} | ||
==Overview== | |||
The term "dermoid cyst" was first coined by Leblanc, in 1831 following the removal of a [[lesion]] that resembled skin at the base of a horse's [[skull]].<ref name="pmid8008317">{{cite journal| author=Comerci JT, Licciardi F, Bergh PA, Gregori C, Breen JL| title=Mature cystic teratoma: a clinicopathologic evaluation of 517 cases and review of the literature. | journal=Obstet Gynecol | year= 1994 | volume= 84 | issue= 1 | pages= 22-8 | pmid=8008317 | doi= | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=8008317 }} </ref> Dermoid cysts were first clearly described in 1885 by Bytlin. In 1891, Chairi was the first to propose that the [[tumor]]s in the floor of the mouth originated from the entrapped epidermoid cells during the [[embryonic]] age.<ref name="pmid21922020">{{cite journal| author=Makos C, Noussios G, Peios M, Gougousis S, Chouridis P| title=Dermoid cysts of the floor of the mouth: two case reports. | journal=Case Rep Med | year= 2011 | volume= 2011 | issue= | pages= 362170 | pmid=21922020 | doi=10.1155/2011/362170 | pmc=PMC3172983 | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=21922020 }} </ref> Dermoid cysts may be classified according to the mode of occurrence into [[congenital]] and aquired types and into several subtypes based on the anatomical location.<ref name=wd>Dermoid cyst. Wikipedia. https://en.wikipedia.org/wiki/Dermoid_cyst Accessed on February 4, 2016.</ref><ref>Spinal dermoid cyst. Radiopedia. http://radiopaedia.org/articles/spinal-dermoid-cyst Accessed on February 10, 2016.</ref><ref name="pmid23056976">{{cite journal| author=Ohta N, Watanabe T, Ito T, Kubota T, Suzuki Y, Ishida A et al.| title=A case of sublingual dermoid cyst: extending the limits of the oral approach. | journal=Case Rep Otolaryngol | year= 2012 | volume= 2012 | issue= | pages= 634949 | pmid=23056976 | doi=10.1155/2012/634949 | pmc=PMC3465894 | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=23056976 }} </ref> Dermoid cyst arises from the entrapped [[embryonal]] [[ectoderm]]al cells during the fetal development and are generally formed of skin, hair follicles, hair follicles, teeth and [[sebaceous gland]]s.<ref name=bm>{{Citation |last=Joseph Schuetz |first=Maurice |last= Elsheikh |first=Tarik |year=2002 |title=Dermoid Cyst (Mature Cystic Teratoma) of the Cecum |publisher=Archives of Pathology & Laboratory Medicine |publication-place= Muncie, IN |page=97-99 |url=http://www.archivesofpathology.org/doi/full/10.1043/0003-9985%282002%29126%3C0097%3ADCMCTO%3E2.0.CO%3B2 |accessdate=February 2, 2016}}</ref> Acquired dermoid cysts may result from [[iatrogenic]] or traumatic implantation of the epithelial cells that subsequently grow.<ref name="pmid21922020">{{cite journal| author=Makos C, Noussios G, Peios M, Gougousis S, Chouridis P| title=Dermoid cysts of the floor of the mouth: two case reports. | journal=Case Rep Med | year= 2011 | volume= 2011 | issue= | pages= 362170 | pmid=21922020 | doi=10.1155/2011/362170 | pmc=PMC3172983 | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=21922020 }} </ref><ref name=bm>Dermoid cyst.Wikipedia. https://en.wikipedia.org/wiki/Dermoid_cyst Accessed on February 22, 2016. </ref> On gross pathology, uniloculated cysts lined by skin, containing sebaceous glands, hair follicles, and teeth are characteristic findings of dermoid cysts.<ref name=bm>{{Citation |first=Maurice |last= Elsheikh |first=Tarik |last=Joseph Schuetz |year=2002 |title=Dermoid Cyst (Mature Cystic Teratoma) of the Cecum |publisher=Archives of Pathology & Laboratory Medicine |publication-place= Muncie, IN |page=97-99 |url=http://www.archivesofpathology.org/doi/full/10.1043/0003-9985%282002%29126%3C0097%3ADCMCTO%3E2.0.CO%3B2 |accessdate=February 2, 2016}}</ref> On microscopic histopathological analysis, fibro collagenous cysts lined by [[stratified squamous epithelium]], with epidermal appendages such as hair follicles, sweat and [[sebaceous gland]]s are characteristic findings of dermoid cysts.<ref>Intracranial dermoid cyst. Radiopedia. http://radiopaedia.org/articles/intracranial-dermoid-cyst-1 Accessed on February 18, 2016.</ref><ref name="pmid23508636">{{cite journal| author=Sharma M, Mally R, Velho V| title=Ruptured conus medullaris dermoid cyst with fat droplets in the central canal [corrected]. | journal=Asian Spine J | year= 2013 | volume= 7 | issue= 1 | pages= 50-4 | pmid=23508636 | doi=10.4184/asj.2013.7.1.50 | pmc=PMC3596585 | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=23508636 }} </ref> Dermoid cyst must be differentiated from [[teratoma]], as well as other common [[benign tumor]]s that develop in the head and neck, [[ovaries]], or spine (such as [[pilar cyst]]s, steatocystoma, pilomatrixoma, [[encephalocele]], [[vascular malformation]]s, lipoleiomyoma, [[pilonidal cyst]], and [[lipoma]]).<ref name="pmid23056976">{{cite journal| author=Ohta N, Watanabe T, Ito T, Kubota T, Suzuki Y, Ishida A et al.| title=A case of sublingual dermoid cyst: extending the limits of the oral approach. | journal=Case Rep Otolaryngol | year= 2012 | volume= 2012 | issue= | pages= 634949 | pmid=23056976 | doi=10.1155/2012/634949 | pmc=PMC3465894 | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=23056976 }} </ref><ref name="wd">Dermoid cyst. Wikipedia. https://en.wikipedia.org/wiki/Dermoid_cyst Accessed on February 4, 2016.</ref><ref name="pmid23508636">{{cite journal| author=Sharma M, Mally R, Velho V| title=Ruptured conus medullaris dermoid cyst with fat droplets in the central canal [corrected]. | journal=Asian Spine J | year= 2013 | volume= 7 | issue= 1 | pages= 50-4 | pmid=23508636 | doi=10.4184/asj.2013.7.1.50 | pmc=PMC3596585 | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=23508636 }} </ref><ref name="pmid23508636">{{cite journal| author=Sharma M, Mally R, Velho V| title=Ruptured conus medullaris dermoid cyst with fat droplets in the central canal [corrected]. | journal=Asian Spine J | year= 2013 | volume= 7 | issue= 1 | pages= 50-4 | pmid=23508636 | doi=10.4184/asj.2013.7.1.50 | pmc=PMC3596585 | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=23508636 }} </ref><ref>Intracranial dermoid cyst. Radiopaedia.org. http://radiopaedia.org/articles/intracranial-dermoid-cyst-1 Accessed on February 5, 2016.</ref> Dermoid cysts are rare [[benign]] [[tumor]]s. Spinal dermoid cysts commonly affect individuals in their second or third decades of life.<ref name="pmid23508636">{{cite journal| author=Sharma M, Mally R, Velho V| title=Ruptured conus medullaris dermoid cyst with fat droplets in the central canal [corrected]. | journal=Asian Spine J | year= 2013 | volume= 7 | issue= 1 | pages= 50-4 | pmid=23508636 | doi=10.4184/asj.2013.7.1.50 | pmc=PMC3596585 | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=23508636 }} </ref> Males are more commonly affected with spinal dermoid cysts than females.<ref name="pmid23508636">{{cite journal| author=Sharma M, Mally R, Velho V| title=Ruptured conus medullaris dermoid cyst with fat droplets in the central canal [corrected]. | journal=Asian Spine J | year= 2013 | volume= 7 | issue= 1 | pages= 50-4 | pmid=23508636 | doi=10.4184/asj.2013.7.1.50 | pmc=PMC3596585 | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=23508636 }} </ref> Dermoid cysts in other locations affect men and women equally. There is no racial predilection to the dermoid cysts. The majority of patients with dermoid cysts are asymptomatic. If left untreated, dermoid cysts gradually increase in size and produce symptoms depending upon their anatomical location. Depending on the anatomical location of the tumor, the prognosis may vary. The majority of patients with ovarian dermoid cysts are asymptomatic. They are discovered incidentally on routine physical exam or imaging for other reasons.<ref name="pmid8008317">{{cite journal| author=Comerci JT, Licciardi F, Bergh PA, Gregori C, Breen JL| title=Mature cystic teratoma: a clinicopathologic evaluation of 517 cases and review of the literature. | journal=Obstet Gynecol | year= 1994 | volume= 84 | issue= 1 | pages= 22-8 | pmid=8008317 | doi= | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=8008317 }} </ref> Physical examination findings in patients with dermoid cyst may include a painless swelling that may be freely mobile or fixed to the skin and deeper structures. [[Congenital]] dermoid cysts localized to the [[scalp]], neck or trunk are usually visible at birth. Xray, CT, MRI, and ultrasound are helpful in the diagnosis of dermoid cysts. Surgery is the mainstay of treatment for dermoid cysts.<ref name=wp>Dermoid cyst. Wikipedia. https://en.wikipedia.org/wiki/Dermoid_cyst Accessed on February 2, 2016</ref> | |||
==Historical Perspective== | ==Historical Perspective== | ||
The term "dermoid cyst" was first coined by Leblanc, in 1831 following the removal of a [[lesion]] that resembled skin at the base of a horse's [[skull]].<ref name="pmid8008317">{{cite journal| author=Comerci JT, Licciardi F, Bergh PA, Gregori C, Breen JL| title=Mature cystic teratoma: a clinicopathologic evaluation of 517 cases and review of the literature. | journal=Obstet Gynecol | year= 1994 | volume= 84 | issue= 1 | pages= 22-8 | pmid=8008317 | doi= | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=8008317 }} </ref> Dermoid cysts were first clearly described in 1885 by Bytlin. In 1891, Chairi was the first to propose that the [[tumor]]s in the floor of the mouth originated from the | The term "dermoid cyst" was first coined by Leblanc, in 1831 following the removal of a [[lesion]] that resembled skin at the base of a horse's [[skull]].<ref name="pmid8008317">{{cite journal| author=Comerci JT, Licciardi F, Bergh PA, Gregori C, Breen JL| title=Mature cystic teratoma: a clinicopathologic evaluation of 517 cases and review of the literature. | journal=Obstet Gynecol | year= 1994 | volume= 84 | issue= 1 | pages= 22-8 | pmid=8008317 | doi= | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=8008317 }} </ref> Dermoid cysts were first clearly described in 1885 by Bytlin. In 1891, Chairi was the first to propose that the [[tumor]]s in the floor of the mouth originated from the entrapped epidermoid cells during the [[embryonic]] age.<ref name="pmid21922020">{{cite journal| author=Makos C, Noussios G, Peios M, Gougousis S, Chouridis P| title=Dermoid cysts of the floor of the mouth: two case reports. | journal=Case Rep Med | year= 2011 | volume= 2011 | issue= | pages= 362170 | pmid=21922020 | doi=10.1155/2011/362170 | pmc=PMC3172983 | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=21922020 }} </ref> | ||
==Classification== | ==Classification== | ||
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==Pathophysiology== | ==Pathophysiology== | ||
Dermoid cyst arises from the | Dermoid cyst arises from the entrapped [[embryonal]] [[ectoderm]]al cells during the fetal development and are generally formed of skin, hair follicles, hair follicles, teeth and [[sebaceous gland]]s.<ref name=bm>{{Citation |last=Joseph Schuetz |first=Maurice |last= Elsheikh |first=Tarik |year=2002 |title=Dermoid Cyst (Mature Cystic Teratoma) of the Cecum |publisher=Archives of Pathology & Laboratory Medicine |publication-place= Muncie, IN |page=97-99 |url=http://www.archivesofpathology.org/doi/full/10.1043/0003-9985%282002%29126%3C0097%3ADCMCTO%3E2.0.CO%3B2 |accessdate=February 2, 2016}}</ref> Acquired dermoid cysts may result from [[iatrogenic]] or traumatic implantation of the epithelial cells that subsequently grow.<ref name="pmid21922020">{{cite journal| author=Makos C, Noussios G, Peios M, Gougousis S, Chouridis P| title=Dermoid cysts of the floor of the mouth: two case reports. | journal=Case Rep Med | year= 2011 | volume= 2011 | issue= | pages= 362170 | pmid=21922020 | doi=10.1155/2011/362170 | pmc=PMC3172983 | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=21922020 }} </ref><ref name=bm>Dermoid cyst.Wikipedia. https://en.wikipedia.org/wiki/Dermoid_cyst Accessed on February 22, 2016. </ref> On gross pathology, uniloculated cysts lined by skin, containing sebaceous glands, hair follicles, and teeth are characteristic findings of dermoid cysts.<ref name=bm>{{Citation |first=Maurice |last= Elsheikh |first=Tarik |last=Joseph Schuetz |year=2002 |title=Dermoid Cyst (Mature Cystic Teratoma) of the Cecum |publisher=Archives of Pathology & Laboratory Medicine |publication-place= Muncie, IN |page=97-99 |url=http://www.archivesofpathology.org/doi/full/10.1043/0003-9985%282002%29126%3C0097%3ADCMCTO%3E2.0.CO%3B2 |accessdate=February 2, 2016}}</ref> On microscopic histopathological analysis, fibro collagenous cysts lined by [[stratified squamous epithelium]], with epidermal appendages such as hair follicles, sweat and [[sebaceous gland]]s are characteristic findings of dermoid cysts.<ref>Intracranial dermoid cyst. Radiopedia. http://radiopaedia.org/articles/intracranial-dermoid-cyst-1 Accessed on February 18, 2016.</ref><ref name="pmid23508636">{{cite journal| author=Sharma M, Mally R, Velho V| title=Ruptured conus medullaris dermoid cyst with fat droplets in the central canal [corrected]. | journal=Asian Spine J | year= 2013 | volume= 7 | issue= 1 | pages= 50-4 | pmid=23508636 | doi=10.4184/asj.2013.7.1.50 | pmc=PMC3596585 | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=23508636 }} </ref> | ||
==Causes== | ==Causes== | ||
Dermoid cysts are caused by the | Dermoid cysts are caused by the entrapped [[embryonic]] [[ectoderm]]al cells in the [[embryonic]] lines of fusion during the [[fetal development]]. Acquired dermoid cysts may be caused by [[iatrogenic]] or traumatic implantation of the [[epithelial cell]]s that subsequently grow.<ref name=bm>Dermoid cyst.Wikipedia. https://en.wikipedia.org/wiki/Dermoid_cyst Accessed on February 22, 2016. </ref> | ||
==Differentiating Dermoid Cyst from other Diseases== | ==Differentiating Dermoid Cyst from other Diseases== | ||
Dermoid cyst must be differentiated from [[teratoma]], as well as other common [[benign tumor]]s that develop in the head and neck, [[ovaries]], or spine (such as [[pilar cyst]]s, steatocystoma, pilomatrixoma, [[encephalocele]], [[vascular malformation]]s, lipoleiomyoma, [[pilonidal cyst]], and [[lipoma]]).<ref name="pmid23056976">{{cite journal| author=Ohta N, Watanabe T, Ito T, Kubota T, Suzuki Y, Ishida A et al.| title=A case of sublingual dermoid cyst: extending the limits of the oral approach. | journal=Case Rep Otolaryngol | year= 2012 | volume= 2012 | issue= | pages= 634949 | pmid=23056976 | doi=10.1155/2012/634949 | pmc=PMC3465894 | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=23056976 }} </ref><ref name="wd">Dermoid cyst. Wikipedia. https://en.wikipedia.org/wiki/Dermoid_cyst Accessed on February 4, 2016. | Dermoid cyst must be differentiated from [[teratoma]], as well as other common [[benign tumor]]s that develop in the head and neck, [[ovaries]], or spine (such as [[pilar cyst]]s, steatocystoma, pilomatrixoma, [[encephalocele]], [[vascular malformation]]s, lipoleiomyoma, [[pilonidal cyst]], and [[lipoma]]).<ref name="pmid23056976">{{cite journal| author=Ohta N, Watanabe T, Ito T, Kubota T, Suzuki Y, Ishida A et al.| title=A case of sublingual dermoid cyst: extending the limits of the oral approach. | journal=Case Rep Otolaryngol | year= 2012 | volume= 2012 | issue= | pages= 634949 | pmid=23056976 | doi=10.1155/2012/634949 | pmc=PMC3465894 | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=23056976 }} </ref><ref name="wd">Dermoid cyst. Wikipedia. https://en.wikipedia.org/wiki/Dermoid_cyst Accessed on February 4, 2016.</ref><ref name="pmid23508636">{{cite journal| author=Sharma M, Mally R, Velho V| title=Ruptured conus medullaris dermoid cyst with fat droplets in the central canal [corrected]. | journal=Asian Spine J | year= 2013 | volume= 7 | issue= 1 | pages= 50-4 | pmid=23508636 | doi=10.4184/asj.2013.7.1.50 | pmc=PMC3596585 | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=23508636 }} </ref><ref>Intracranial dermoid cyst. Radiopaedia.org. http://radiopaedia.org/articles/intracranial-dermoid-cyst-1 Accessed on February 5, 2016.</ref> | ||
==Epidemiology and Demographics== | ==Epidemiology and Demographics== | ||
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There is insufficient evidence to recommend routine screening for dermoid cysts. | There is insufficient evidence to recommend routine screening for dermoid cysts. | ||
==Natural History, | ==Natural History, Complications and Prognosis== | ||
The majority of patients with dermoid cysts are asymptomatic. If left untreated, dermoid cysts gradually increase in size and produce symptoms depending upon their anatomical location. Common complications of ovarian dermoid cysts include [[torsion]], rupture, and infection.<ref name=kl>Dermoid cyst. Wikipedia. https://en.wikipedia.org/wiki/Dermoid_cyst Accessed on February 11, 2016</ref><ref name=rb>Mature (cystic) ovarian teratoma. http://radiopaedia.org/articles/mature-cystic-ovarian-teratoma Radiopedia. Accessed on February 11, 2016</ref> Common complications of periorbital dermoid cysts include [[inflammation]] and recurrence when not completely excised.<ref name=kl>Dermoid cyst. Wikipedia. https://en.wikipedia.org/wiki/Dermoid_cyst Accessed on February 11, 2016</ref> Rupture is the most common complication of spinal dermoid cysts.<ref name=kl> Spinal dermoid cyst. Radiopedia. http://radiopaedia.org/articles/spinal-dermoid-cyst. Accessed on February 11, 2016.</ref> Common complications of intracranial dermoid cysts include compression of adjacent structures from the mass effect and rupture of the cysts.<ref name=wx>Intracranial dermoid cyst. http://radiopaedia.org/articles/intracranial-dermoid-cyst-1. Accessed on February 11, 2016.</ref><ref name="pmid19846186">{{cite journal| author=Jacquin A, Béjot Y, Hervieu M, Biotti D, Caillier M, Ricolfi FC et al.| title=[Rupture of intracranial dermoid cyst with disseminated lipid droplets]. | journal=Rev Neurol (Paris) | year= 2010 | volume= 166 | issue= 4 | pages= 451-7 | pmid=19846186 | doi=10.1016/j.neurol.2009.09.003 | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=19846186 }} </ref> Infection is the most common complication of dermoid cysts of the floor of the mouth.<ref name="pmid21922020">{{cite journal| author=Makos C, Noussios G, Peios M, Gougousis S, Chouridis P| title=Dermoid cysts of the floor of the mouth: two case reports. | journal=Case Rep Med | year= 2011 | volume= 2011 | issue= | pages= 362170 | pmid=21922020 | doi=10.1155/2011/362170 | pmc=PMC3172983 | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=21922020 }} </ref> [[Malignant]] transformation usually into [[squamous cell carcinoma]] is a rare complication of dermoid cysts.<ref name="pmid16714456">{{cite journal| author=Osborn AG, Preece MT| title=Intracranial cysts: radiologic-pathologic correlation and imaging approach. | journal=Radiology | year= 2006 | volume= 239 | issue= 3 | pages= 650-64 | pmid=16714456 | doi=10.1148/radiol.2393050823 | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=16714456 }} </ref><ref name=rb>Mature (cystic) ovarian teratoma. http://radiopaedia.org/articles/mature-cystic-ovarian-teratoma Radiopedia. Accessed on February 11, 2016</ref> Depending on the anatomical location of the tumor, the prognosis may vary. | The majority of patients with dermoid cysts are asymptomatic. If left untreated, dermoid cysts gradually increase in size and produce symptoms depending upon their anatomical location. Common complications of ovarian dermoid cysts include [[torsion]], rupture, and infection.<ref name=kl>Dermoid cyst. Wikipedia. https://en.wikipedia.org/wiki/Dermoid_cyst Accessed on February 11, 2016</ref><ref name=rb>Mature (cystic) ovarian teratoma. http://radiopaedia.org/articles/mature-cystic-ovarian-teratoma Radiopedia. Accessed on February 11, 2016</ref> Common complications of periorbital dermoid cysts include [[inflammation]] and recurrence when not completely excised.<ref name=kl>Dermoid cyst. Wikipedia. https://en.wikipedia.org/wiki/Dermoid_cyst Accessed on February 11, 2016</ref> Rupture is the most common complication of spinal dermoid cysts.<ref name=kl> Spinal dermoid cyst. Radiopedia. http://radiopaedia.org/articles/spinal-dermoid-cyst. Accessed on February 11, 2016.</ref> Common complications of intracranial dermoid cysts include compression of adjacent structures from the mass effect and rupture of the cysts.<ref name=wx>Intracranial dermoid cyst. http://radiopaedia.org/articles/intracranial-dermoid-cyst-1. Accessed on February 11, 2016.</ref><ref name="pmid19846186">{{cite journal| author=Jacquin A, Béjot Y, Hervieu M, Biotti D, Caillier M, Ricolfi FC et al.| title=[Rupture of intracranial dermoid cyst with disseminated lipid droplets]. | journal=Rev Neurol (Paris) | year= 2010 | volume= 166 | issue= 4 | pages= 451-7 | pmid=19846186 | doi=10.1016/j.neurol.2009.09.003 | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=19846186 }} </ref> Infection is the most common complication of dermoid cysts of the floor of the mouth.<ref name="pmid21922020">{{cite journal| author=Makos C, Noussios G, Peios M, Gougousis S, Chouridis P| title=Dermoid cysts of the floor of the mouth: two case reports. | journal=Case Rep Med | year= 2011 | volume= 2011 | issue= | pages= 362170 | pmid=21922020 | doi=10.1155/2011/362170 | pmc=PMC3172983 | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=21922020 }} </ref> [[Malignant]] transformation usually into [[squamous cell carcinoma]] is a rare complication of dermoid cysts.<ref name="pmid16714456">{{cite journal| author=Osborn AG, Preece MT| title=Intracranial cysts: radiologic-pathologic correlation and imaging approach. | journal=Radiology | year= 2006 | volume= 239 | issue= 3 | pages= 650-64 | pmid=16714456 | doi=10.1148/radiol.2393050823 | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=16714456 }} </ref><ref name=rb>Mature (cystic) ovarian teratoma. http://radiopaedia.org/articles/mature-cystic-ovarian-teratoma Radiopedia. Accessed on February 11, 2016</ref> Depending on the anatomical location of the tumor, the prognosis may vary. | ||
==History and Symptoms== | ==Diagnosis== | ||
===History and Symptoms=== | |||
[[Congenital]] dermoid cysts localized to the [[scalp]], neck or trunk are usually visible at birth and gradually grow in size. The majority of patients with ovarian dermoid cysts are asymptomatic. They are discovered incidentally on routine physical exam or imaging for other reasons.<ref name="pmid8008317">{{cite journal| author=Comerci JT, Licciardi F, Bergh PA, Gregori C, Breen JL| title=Mature cystic teratoma: a clinicopathologic evaluation of 517 cases and review of the literature. | journal=Obstet Gynecol | year= 1994 | volume= 84 | issue= 1 | pages= 22-8 | pmid=8008317 | doi= | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=8008317 }} </ref> Large ovarian dermoid cysts may present with abdominal pain or abdominal mass.<ref name=qs> Mature (cystic) ovarian teratoma. Radiopedia. http://radiopaedia.org/articles/mature-cystic-ovarian-teratoma. Accessed on February 11, 2016.</ref> Symptoms of spinal dermoid cyst may include motor disturbances ([[hemiplegia]]), sensory disturbances, [[bowel]] and/or [[bladder]] dysfunction, fecal retention or [[incontinence]], and urinary retention or incontinence. Headache is the most prominent symptom of intracranial dermoid cyst.<ref>Intracranial dermoid cyst. Radiopedia. http://radiopaedia.org/articles/intracranial-dermoid-cyst-1. Accessed on February 11, 2016.</ref> Symptoms of dermoid cysts of the floor of the mouth may include dysphagia, dysarthria, dyspnea (when the lesions are quiet large), and speech delay.<ref name="pmid21922020">{{cite journal| author=Makos C, Noussios G, Peios M, Gougousis S, Chouridis P| title=Dermoid cysts of the floor of the mouth: two case reports. | journal=Case Rep Med | year= 2011 | volume= 2011 | issue= | pages= 362170 | pmid=21922020 | doi=10.1155/2011/362170 | pmc=PMC3172983 | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=21922020 }} </ref> | [[Congenital]] dermoid cysts localized to the [[scalp]], neck or trunk are usually visible at birth and gradually grow in size. The majority of patients with ovarian dermoid cysts are asymptomatic. They are discovered incidentally on routine physical exam or imaging for other reasons.<ref name="pmid8008317">{{cite journal| author=Comerci JT, Licciardi F, Bergh PA, Gregori C, Breen JL| title=Mature cystic teratoma: a clinicopathologic evaluation of 517 cases and review of the literature. | journal=Obstet Gynecol | year= 1994 | volume= 84 | issue= 1 | pages= 22-8 | pmid=8008317 | doi= | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=8008317 }} </ref> Large ovarian dermoid cysts may present with abdominal pain or abdominal mass.<ref name=qs> Mature (cystic) ovarian teratoma. Radiopedia. http://radiopaedia.org/articles/mature-cystic-ovarian-teratoma. Accessed on February 11, 2016.</ref> Symptoms of spinal dermoid cyst may include motor disturbances ([[hemiplegia]]), sensory disturbances, [[bowel]] and/or [[bladder]] dysfunction, fecal retention or [[incontinence]], and urinary retention or incontinence. Headache is the most prominent symptom of intracranial dermoid cyst.<ref>Intracranial dermoid cyst. Radiopedia. http://radiopaedia.org/articles/intracranial-dermoid-cyst-1. Accessed on February 11, 2016.</ref> Symptoms of dermoid cysts of the floor of the mouth may include dysphagia, dysarthria, dyspnea (when the lesions are quiet large), and speech delay.<ref name="pmid21922020">{{cite journal| author=Makos C, Noussios G, Peios M, Gougousis S, Chouridis P| title=Dermoid cysts of the floor of the mouth: two case reports. | journal=Case Rep Med | year= 2011 | volume= 2011 | issue= | pages= 362170 | pmid=21922020 | doi=10.1155/2011/362170 | pmc=PMC3172983 | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=21922020 }} </ref> | ||
==Physical Examination== | ===Physical Examination=== | ||
Physical examination findings in patients with dermoid cyst may include a painless swelling that may be freely mobile or fixed to the skin and deeper structures. [[Congenital]] dermoid cysts localized to the [[scalp]], neck or trunk are usually visible at birth. A tuft of hairs emanating from a midline nasal depression or nodule may represent a nasal dermoid cyst. A [[tarsal]] dermoid cyst may present as a firm, non tender nodule in the eyelid. Periorbital demoid cysts usually appear on the lateral aspect of the eyebrow. Dermoid cysts of the [[scalp]] or [[orbit]] may cause pressure erosion of the underlying bone which appears as a punched out defect in the skull x rays. A double-chin appearance is a common finding if the cyst develops below the [[mylohyoid]] muscle.<ref name="pmid24350035">{{cite journal| author=Madke B, Nayak C, Giri A, Jain M| title=Nasal dermoid sinus cyst in a young female. | journal=Indian Dermatol Online J | year= 2013 | volume= 4 | issue= 4 | pages= 380-1 | pmid=24350035 | doi=10.4103/2229-5178.120669 | pmc=PMC3853920 | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=24350035 | Physical examination findings in patients with dermoid cyst may include a painless swelling that may be freely mobile or fixed to the skin and deeper structures. [[Congenital]] dermoid cysts localized to the [[scalp]], neck or trunk are usually visible at birth. A tuft of hairs emanating from a midline nasal depression or nodule may represent a nasal dermoid cyst. A [[tarsal]] dermoid cyst may present as a firm, non tender nodule in the eyelid. Periorbital demoid cysts usually appear on the lateral aspect of the eyebrow. Dermoid cysts of the [[scalp]] or [[orbit]] may cause pressure erosion of the underlying bone which appears as a punched out defect in the skull x rays. A double-chin appearance is a common finding if the cyst develops below the [[mylohyoid]] muscle.<ref name="pmid24350035">{{cite journal| author=Madke B, Nayak C, Giri A, Jain M| title=Nasal dermoid sinus cyst in a young female. | journal=Indian Dermatol Online J | year= 2013 | volume= 4 | issue= 4 | pages= 380-1 | pmid=24350035 | doi=10.4103/2229-5178.120669 | pmc=PMC3853920 | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=24350035 }} </ref><ref name="pmid19300165">{{cite journal| author=Koreen IV, Kahana A, Gausas RE, Potter HD, Lemke BN, Elner VM| title=Tarsal dermoid cyst: clinical presentation and treatment. | journal=Ophthal Plast Reconstr Surg | year= 2009 | volume= 25 | issue= 2 | pages= 146-7 | pmid=19300165 | doi=10.1097/IOP.0b013e31819aae6e | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=19300165 }} </ref><ref name=oo>Dermoid cyst. Wikipedia.https://en.wikipedia.org/wiki/Dermoid_cyst.Accessed on February 22, 2016</ref><ref name="pmid22337456">{{cite journal| author=Maurice SM, Burstein FD| title=Disappearing dermoid: fact or fiction? | journal=J Craniofac Surg | year= 2012 | volume= 23 | issue= 1 | pages= e31-3 | pmid=22337456 | doi=10.1097/SCS.0b013e3182420981 | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=22337456 }} </ref><ref name="pmid21922020">{{cite journal| author=Makos C, Noussios G, Peios M, Gougousis S, Chouridis P| title=Dermoid cysts of the floor of the mouth: two case reports. | journal=Case Rep Med | year= 2011 | volume= 2011 | issue= | pages= 362170 | pmid=21922020 | doi=10.1155/2011/362170 | pmc=PMC3172983 | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=21922020 }} </ref> | ||
==Laboratory Findings== | ===Laboratory Findings=== | ||
There are no diagnostic laboratory findings associated with dermoid cysts. | There are no diagnostic laboratory findings associated with dermoid cysts. | ||
==X Ray== | ===X Ray=== | ||
X rays may be helpful in the diagnosis of dermoid cysts. Findings on [[pelvic]] x ray suggestive of ovarian demoid cyst may include [[calcification]]s and tooth components.<ref name=wp>Mature (cystic) ovarian teratoma. Radiopedia. http://radiopaedia.org/articles/mature-cystic-ovarian-teratoma Accessed on February 17, 2016.</ref> On x-rays, dermoid cysts are characterized by a focal lucency due to the fatty [[sebum]].<ref>Intracranial dermoid cyst. Radiopedia. http://radiopaedia.org/articles/intracranial-dermoid-cyst-1 Accessed on February 17, 2016.</ref> X rays may appear normal in other dermoid cysts. | X rays may be helpful in the diagnosis of dermoid cysts. Findings on [[pelvic]] x ray suggestive of ovarian demoid cyst may include [[calcification]]s and tooth components.<ref name=wp>Mature (cystic) ovarian teratoma. Radiopedia. http://radiopaedia.org/articles/mature-cystic-ovarian-teratoma Accessed on February 17, 2016.</ref> On x-rays, dermoid cysts are characterized by a focal lucency due to the fatty [[sebum]].<ref>Intracranial dermoid cyst. Radiopedia. http://radiopaedia.org/articles/intracranial-dermoid-cyst-1 Accessed on February 17, 2016.</ref> X rays may appear normal in other dermoid cysts. | ||
==CT== | ===CT=== | ||
CT scan may be helpful in the diagnosis of dermoid cyst. Findings on CT scan suggestive of ovarian dermoid cyst include low attenuating areas of fat and fat-fluid levels, rokitansky protuberance, soft [[tissue]] plugs, and cauliflower appearance with irregular borders.<ref name="pmid3293377">{{cite journal| author=Sheth S, Fishman EK, Buck JL, Hamper UM, Sanders RC| title=The variable sonographic appearances of ovarian teratomas: correlation with CT. | journal=AJR Am J Roentgenol | year= 1988 | volume= 151 | issue= 2 | pages= 331-4 | pmid=3293377 | doi=10.2214/ajr.151.2.331 | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=3293377 }} </ref><ref name="pmid8362057">{{cite journal| author=Occhipinti KA, Frankel SD, Hricak H| title=The ovary. Computed tomography and magnetic resonance imaging. | journal=Radiol Clin North Am | year= 1993 | volume= 31 | issue= 5 | pages= 1115-32 | pmid=8362057 | doi= | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=8362057 }} </ref> Findings on CT scan suggestive of spinal dermoid cysts include well defined mass isodense to [[cerebrospinal fluid]], often with hypodense components (fat) and [[calcification]], widening of the spinal canal, flattening of the [[pedicle]]s and [[laminae]], and osseous erosions.<ref name=wb>Spinal dermoid cyst. http://radiopaedia.org/articles/spinal-dermoid-cyst. Accessed on February 18, 2016.</ref> Findings on CT scan suggestive of intracranial dermoid cyst include well defined low attenuating (fat density) lobulated mass with [[calcification]]s in the wall.<ref name=wx>Intracranial dermoid cyst. http://radiopaedia.org/articles/intracranial-dermoid-cyst-1. Accessed on February 11, 2016.</ref> | CT scan may be helpful in the diagnosis of dermoid cyst. Findings on CT scan suggestive of ovarian dermoid cyst include low attenuating areas of fat and fat-fluid levels, rokitansky protuberance, soft [[tissue]] plugs, and cauliflower appearance with irregular borders.<ref name="pmid3293377">{{cite journal| author=Sheth S, Fishman EK, Buck JL, Hamper UM, Sanders RC| title=The variable sonographic appearances of ovarian teratomas: correlation with CT. | journal=AJR Am J Roentgenol | year= 1988 | volume= 151 | issue= 2 | pages= 331-4 | pmid=3293377 | doi=10.2214/ajr.151.2.331 | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=3293377 }} </ref><ref name="pmid8362057">{{cite journal| author=Occhipinti KA, Frankel SD, Hricak H| title=The ovary. Computed tomography and magnetic resonance imaging. | journal=Radiol Clin North Am | year= 1993 | volume= 31 | issue= 5 | pages= 1115-32 | pmid=8362057 | doi= | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=8362057 }} </ref> Findings on CT scan suggestive of spinal dermoid cysts include well defined mass isodense to [[cerebrospinal fluid]], often with hypodense components (fat) and [[calcification]], widening of the spinal canal, flattening of the [[pedicle]]s and [[laminae]], and osseous erosions.<ref name=wb>Spinal dermoid cyst. http://radiopaedia.org/articles/spinal-dermoid-cyst. Accessed on February 18, 2016.</ref> Findings on CT scan suggestive of intracranial dermoid cyst include well defined low attenuating (fat density) lobulated mass with [[calcification]]s in the wall.<ref name=wx>Intracranial dermoid cyst. http://radiopaedia.org/articles/intracranial-dermoid-cyst-1. Accessed on February 11, 2016.</ref> | ||
==MRI== | ===MRI=== | ||
MRI is helpful in the diagnosis of dermoid cyst. Findings on MRI suggestive of dermoid cyst include hypointense (due to the water content) or hyperintense (due to the presence of fatty secretions of [[sebaceous gland]]s) T1 signal, hyperintense T2 signal, and no enhancement or mild rim enhancement on contrast T1 signal.<ref name="pmid23590721">{{cite journal| author=Sanaullah M, Mumtaz S, Memon AA, Hashim AS, Bashir S| title=Intramedullary dermoid cyst with relatively atypical symptoms: a case report and review of the literature. | journal=J Med Case Rep | year= 2013 | volume= 7 | issue= | pages= 104 | pmid=23590721 | doi=10.1186/1752-1947-7-104 | pmc=PMC3639845 | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=23590721 }} </ref><ref name=jn>Intracranial dermoid cyst.Radiopedia. http://radiopaedia.org/articles/intracranial-dermoid-cyst-1 Accessed on February 19, 2016</ref> | MRI is helpful in the diagnosis of dermoid cyst. Findings on MRI suggestive of dermoid cyst include hypointense (due to the water content) or hyperintense (due to the presence of fatty secretions of [[sebaceous gland]]s) T1 signal, hyperintense T2 signal, and no enhancement or mild rim enhancement on contrast T1 signal.<ref name="pmid23590721">{{cite journal| author=Sanaullah M, Mumtaz S, Memon AA, Hashim AS, Bashir S| title=Intramedullary dermoid cyst with relatively atypical symptoms: a case report and review of the literature. | journal=J Med Case Rep | year= 2013 | volume= 7 | issue= | pages= 104 | pmid=23590721 | doi=10.1186/1752-1947-7-104 | pmc=PMC3639845 | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=23590721 }} </ref><ref name=jn>Intracranial dermoid cyst.Radiopedia. http://radiopaedia.org/articles/intracranial-dermoid-cyst-1 Accessed on February 19, 2016</ref> | ||
==Ultrasound== | ===Ultrasound=== | ||
Ultrasound may be helpful in the diagnosis of ovarian dermoid cyst. Findings on pelvic ultrasound suggestive of ovarian dermoid include unilocular, cystic [[adnexa]]l mass with mural components, diffusely or partially [[echogenic]] mass with posterior sound attenuation (from the [[sebaceous]] material and hair within the cyst cavity), an echogenic interface at the edge of mass that obscures deep structures, mural hyperechoic dermoid plug, presence of fluid-fluid levels, and multiple thin, [[echogenic]] bands caused by hair in the cyst cavity (the dot-dash pattern).<ref name=ok>Mature (cystic) ovarian teratoma. Radiopedia. http://radiopaedia.org/articles/mature-cystic-ovarian-teratoma Accessed on February 19, 2016</ref><ref name="pmid9762997">{{cite journal| author=Patel MD, Feldstein VA, Lipson SD, Chen DC, Filly RA| title=Cystic teratomas of the ovary: diagnostic value of sonography. | journal=AJR Am J Roentgenol | year= 1998 | volume= 171 | issue= 4 | pages= 1061-5 | pmid=9762997 | doi=10.2214/ajr.171.4.9762997 | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=9762997 }} </ref> | Ultrasound may be helpful in the diagnosis of ovarian dermoid cyst. Findings on pelvic ultrasound suggestive of ovarian dermoid include unilocular, cystic [[adnexa]]l mass with mural components, diffusely or partially [[echogenic]] mass with posterior sound attenuation (from the [[sebaceous]] material and hair within the cyst cavity), an echogenic interface at the edge of mass that obscures deep structures, mural hyperechoic dermoid plug, presence of fluid-fluid levels, and multiple thin, [[echogenic]] bands caused by hair in the cyst cavity (the dot-dash pattern).<ref name=ok>Mature (cystic) ovarian teratoma. Radiopedia. http://radiopaedia.org/articles/mature-cystic-ovarian-teratoma Accessed on February 19, 2016</ref><ref name="pmid9762997">{{cite journal| author=Patel MD, Feldstein VA, Lipson SD, Chen DC, Filly RA| title=Cystic teratomas of the ovary: diagnostic value of sonography. | journal=AJR Am J Roentgenol | year= 1998 | volume= 171 | issue= 4 | pages= 1061-5 | pmid=9762997 | doi=10.2214/ajr.171.4.9762997 | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=9762997 }} </ref> | ||
==Other Imaging Findings== | ===Other Imaging Findings=== | ||
[[Scintigraphy]] may be performed to differentiate a [[submental]] dermoid cyst from an [[ectopic]] [[thyroid]] tissue swelling.<ref name="pmid21922020">{{cite journal| author=Makos C, Noussios G, Peios M, Gougousis S, Chouridis P| title=Dermoid cysts of the floor of the mouth: two case reports. | journal=Case Rep Med | year= 2011 | volume= 2011 | issue= | pages= 362170 | pmid=21922020 | doi=10.1155/2011/362170 | pmc=PMC3172983 | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=21922020 }} </ref> | [[Scintigraphy]] may be performed to differentiate a [[submental]] dermoid cyst from an [[ectopic]] [[thyroid]] tissue swelling.<ref name="pmid21922020">{{cite journal| author=Makos C, Noussios G, Peios M, Gougousis S, Chouridis P| title=Dermoid cysts of the floor of the mouth: two case reports. | journal=Case Rep Med | year= 2011 | volume= 2011 | issue= | pages= 362170 | pmid=21922020 | doi=10.1155/2011/362170 | pmc=PMC3172983 | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=21922020 }} </ref> | ||
==Other Diagnostic Studies== | ===Other Diagnostic Studies=== | ||
There are no other diagnostic findings associated with dermoid cysts. | There are no other diagnostic findings associated with dermoid cysts. | ||
==Medical Therapy== | ==Treatment== | ||
===Medical Therapy=== | |||
The mainstay of therapy for dermoid cysts is surgery.<ref name=wp>Dermoid cyst. Wikipedia. https://en.wikipedia.org/wiki/Dermoid_cyst Accessed on February 2, 2016</ref> | The mainstay of therapy for dermoid cysts is surgery.<ref name=wp>Dermoid cyst. Wikipedia. https://en.wikipedia.org/wiki/Dermoid_cyst Accessed on February 2, 2016</ref> | ||
==Surgery== | ===Surgery=== | ||
Surgery is the mainstay of treatment for dermoid cysts.<ref name=wp>Dermoid cyst. Wikipedia. https://en.wikipedia.org/wiki/Dermoid_cyst Accessed on February 2, 2016</ref> | Surgery is the mainstay of treatment for dermoid cysts.<ref name=wp>Dermoid cyst. Wikipedia. https://en.wikipedia.org/wiki/Dermoid_cyst Accessed on February 2, 2016</ref> | ||
==References== | |||
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Latest revision as of 22:09, 26 November 2017
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Dermoid cyst Microchapters |
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Case Studies |
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Dermoid cyst overview On the Web |
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American Roentgen Ray Society Images of Dermoid cyst overview |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Associate Editor(s)-in-Chief: Soujanya Thummathati, MBBS [2]
Overview
The term "dermoid cyst" was first coined by Leblanc, in 1831 following the removal of a lesion that resembled skin at the base of a horse's skull.[1] Dermoid cysts were first clearly described in 1885 by Bytlin. In 1891, Chairi was the first to propose that the tumors in the floor of the mouth originated from the entrapped epidermoid cells during the embryonic age.[2] Dermoid cysts may be classified according to the mode of occurrence into congenital and aquired types and into several subtypes based on the anatomical location.[3][4][5] Dermoid cyst arises from the entrapped embryonal ectodermal cells during the fetal development and are generally formed of skin, hair follicles, hair follicles, teeth and sebaceous glands.[6] Acquired dermoid cysts may result from iatrogenic or traumatic implantation of the epithelial cells that subsequently grow.[2][6] On gross pathology, uniloculated cysts lined by skin, containing sebaceous glands, hair follicles, and teeth are characteristic findings of dermoid cysts.[6] On microscopic histopathological analysis, fibro collagenous cysts lined by stratified squamous epithelium, with epidermal appendages such as hair follicles, sweat and sebaceous glands are characteristic findings of dermoid cysts.[7][8] Dermoid cyst must be differentiated from teratoma, as well as other common benign tumors that develop in the head and neck, ovaries, or spine (such as pilar cysts, steatocystoma, pilomatrixoma, encephalocele, vascular malformations, lipoleiomyoma, pilonidal cyst, and lipoma).[5][3][8][8][9] Dermoid cysts are rare benign tumors. Spinal dermoid cysts commonly affect individuals in their second or third decades of life.[8] Males are more commonly affected with spinal dermoid cysts than females.[8] Dermoid cysts in other locations affect men and women equally. There is no racial predilection to the dermoid cysts. The majority of patients with dermoid cysts are asymptomatic. If left untreated, dermoid cysts gradually increase in size and produce symptoms depending upon their anatomical location. Depending on the anatomical location of the tumor, the prognosis may vary. The majority of patients with ovarian dermoid cysts are asymptomatic. They are discovered incidentally on routine physical exam or imaging for other reasons.[1] Physical examination findings in patients with dermoid cyst may include a painless swelling that may be freely mobile or fixed to the skin and deeper structures. Congenital dermoid cysts localized to the scalp, neck or trunk are usually visible at birth. Xray, CT, MRI, and ultrasound are helpful in the diagnosis of dermoid cysts. Surgery is the mainstay of treatment for dermoid cysts.[10]
Historical Perspective
The term "dermoid cyst" was first coined by Leblanc, in 1831 following the removal of a lesion that resembled skin at the base of a horse's skull.[1] Dermoid cysts were first clearly described in 1885 by Bytlin. In 1891, Chairi was the first to propose that the tumors in the floor of the mouth originated from the entrapped epidermoid cells during the embryonic age.[2]
Classification
Dermoid cysts may be classified according to the mode of occurrence into congenital and aquired types and into several subtypes based on the anatomical location.[3][11][5]
Pathophysiology
Dermoid cyst arises from the entrapped embryonal ectodermal cells during the fetal development and are generally formed of skin, hair follicles, hair follicles, teeth and sebaceous glands.[6] Acquired dermoid cysts may result from iatrogenic or traumatic implantation of the epithelial cells that subsequently grow.[2][6] On gross pathology, uniloculated cysts lined by skin, containing sebaceous glands, hair follicles, and teeth are characteristic findings of dermoid cysts.[6] On microscopic histopathological analysis, fibro collagenous cysts lined by stratified squamous epithelium, with epidermal appendages such as hair follicles, sweat and sebaceous glands are characteristic findings of dermoid cysts.[12][8]
Causes
Dermoid cysts are caused by the entrapped embryonic ectodermal cells in the embryonic lines of fusion during the fetal development. Acquired dermoid cysts may be caused by iatrogenic or traumatic implantation of the epithelial cells that subsequently grow.[6]
Differentiating Dermoid Cyst from other Diseases
Dermoid cyst must be differentiated from teratoma, as well as other common benign tumors that develop in the head and neck, ovaries, or spine (such as pilar cysts, steatocystoma, pilomatrixoma, encephalocele, vascular malformations, lipoleiomyoma, pilonidal cyst, and lipoma).[5][3][8][13]
Epidemiology and Demographics
Dermoid cysts are rare benign tumors. Spinal dermoid cysts commonly affect individuals in their second or third decades of life.[8] Males are more commonly affected with spinal dermoid cysts than females.[8] Dermoid cysts in other locations affect men and women equally. There is no racial predilection to the dermoid cysts.
Risk Factors
There are no established risk factors for dermoid cysts.
Screening
There is insufficient evidence to recommend routine screening for dermoid cysts.
Natural History, Complications and Prognosis
The majority of patients with dermoid cysts are asymptomatic. If left untreated, dermoid cysts gradually increase in size and produce symptoms depending upon their anatomical location. Common complications of ovarian dermoid cysts include torsion, rupture, and infection.[14][15] Common complications of periorbital dermoid cysts include inflammation and recurrence when not completely excised.[14] Rupture is the most common complication of spinal dermoid cysts.[14] Common complications of intracranial dermoid cysts include compression of adjacent structures from the mass effect and rupture of the cysts.[16][17] Infection is the most common complication of dermoid cysts of the floor of the mouth.[2] Malignant transformation usually into squamous cell carcinoma is a rare complication of dermoid cysts.[18][15] Depending on the anatomical location of the tumor, the prognosis may vary.
Diagnosis
History and Symptoms
Congenital dermoid cysts localized to the scalp, neck or trunk are usually visible at birth and gradually grow in size. The majority of patients with ovarian dermoid cysts are asymptomatic. They are discovered incidentally on routine physical exam or imaging for other reasons.[1] Large ovarian dermoid cysts may present with abdominal pain or abdominal mass.[19] Symptoms of spinal dermoid cyst may include motor disturbances (hemiplegia), sensory disturbances, bowel and/or bladder dysfunction, fecal retention or incontinence, and urinary retention or incontinence. Headache is the most prominent symptom of intracranial dermoid cyst.[20] Symptoms of dermoid cysts of the floor of the mouth may include dysphagia, dysarthria, dyspnea (when the lesions are quiet large), and speech delay.[2]
Physical Examination
Physical examination findings in patients with dermoid cyst may include a painless swelling that may be freely mobile or fixed to the skin and deeper structures. Congenital dermoid cysts localized to the scalp, neck or trunk are usually visible at birth. A tuft of hairs emanating from a midline nasal depression or nodule may represent a nasal dermoid cyst. A tarsal dermoid cyst may present as a firm, non tender nodule in the eyelid. Periorbital demoid cysts usually appear on the lateral aspect of the eyebrow. Dermoid cysts of the scalp or orbit may cause pressure erosion of the underlying bone which appears as a punched out defect in the skull x rays. A double-chin appearance is a common finding if the cyst develops below the mylohyoid muscle.[21][22][23][24][2]
Laboratory Findings
There are no diagnostic laboratory findings associated with dermoid cysts.
X Ray
X rays may be helpful in the diagnosis of dermoid cysts. Findings on pelvic x ray suggestive of ovarian demoid cyst may include calcifications and tooth components.[10] On x-rays, dermoid cysts are characterized by a focal lucency due to the fatty sebum.[25] X rays may appear normal in other dermoid cysts.
CT
CT scan may be helpful in the diagnosis of dermoid cyst. Findings on CT scan suggestive of ovarian dermoid cyst include low attenuating areas of fat and fat-fluid levels, rokitansky protuberance, soft tissue plugs, and cauliflower appearance with irregular borders.[26][27] Findings on CT scan suggestive of spinal dermoid cysts include well defined mass isodense to cerebrospinal fluid, often with hypodense components (fat) and calcification, widening of the spinal canal, flattening of the pedicles and laminae, and osseous erosions.[28] Findings on CT scan suggestive of intracranial dermoid cyst include well defined low attenuating (fat density) lobulated mass with calcifications in the wall.[16]
MRI
MRI is helpful in the diagnosis of dermoid cyst. Findings on MRI suggestive of dermoid cyst include hypointense (due to the water content) or hyperintense (due to the presence of fatty secretions of sebaceous glands) T1 signal, hyperintense T2 signal, and no enhancement or mild rim enhancement on contrast T1 signal.[29][30]
Ultrasound
Ultrasound may be helpful in the diagnosis of ovarian dermoid cyst. Findings on pelvic ultrasound suggestive of ovarian dermoid include unilocular, cystic adnexal mass with mural components, diffusely or partially echogenic mass with posterior sound attenuation (from the sebaceous material and hair within the cyst cavity), an echogenic interface at the edge of mass that obscures deep structures, mural hyperechoic dermoid plug, presence of fluid-fluid levels, and multiple thin, echogenic bands caused by hair in the cyst cavity (the dot-dash pattern).[31][32]
Other Imaging Findings
Scintigraphy may be performed to differentiate a submental dermoid cyst from an ectopic thyroid tissue swelling.[2]
Other Diagnostic Studies
There are no other diagnostic findings associated with dermoid cysts.
Treatment
Medical Therapy
The mainstay of therapy for dermoid cysts is surgery.[10]
Surgery
Surgery is the mainstay of treatment for dermoid cysts.[10]
References
- ↑ 1.0 1.1 1.2 1.3 Comerci JT, Licciardi F, Bergh PA, Gregori C, Breen JL (1994). "Mature cystic teratoma: a clinicopathologic evaluation of 517 cases and review of the literature". Obstet Gynecol. 84 (1): 22–8. PMID 8008317.
- ↑ 2.0 2.1 2.2 2.3 2.4 2.5 2.6 2.7 Makos C, Noussios G, Peios M, Gougousis S, Chouridis P (2011). "Dermoid cysts of the floor of the mouth: two case reports". Case Rep Med. 2011: 362170. doi:10.1155/2011/362170. PMC 3172983. PMID 21922020.
- ↑ 3.0 3.1 3.2 3.3 Dermoid cyst. Wikipedia. https://en.wikipedia.org/wiki/Dermoid_cyst Accessed on February 4, 2016.
- ↑ Spinal dermoid cyst. Radiopedia. http://radiopaedia.org/articles/spinal-dermoid-cyst Accessed on February 10, 2016.
- ↑ 5.0 5.1 5.2 5.3 Ohta N, Watanabe T, Ito T, Kubota T, Suzuki Y, Ishida A; et al. (2012). "A case of sublingual dermoid cyst: extending the limits of the oral approach". Case Rep Otolaryngol. 2012: 634949. doi:10.1155/2012/634949. PMC 3465894. PMID 23056976.
- ↑ 6.0 6.1 6.2 6.3 6.4 6.5 6.6 Elsheikh, Tarik (2002), Dermoid Cyst (Mature Cystic Teratoma) of the Cecum, Muncie, IN: Archives of Pathology & Laboratory Medicine, p. 97-99, retrieved February 2, 2016
- ↑ Intracranial dermoid cyst. Radiopedia. http://radiopaedia.org/articles/intracranial-dermoid-cyst-1 Accessed on February 18, 2016.
- ↑ 8.0 8.1 8.2 8.3 8.4 8.5 8.6 8.7 8.8 Sharma M, Mally R, Velho V (2013). "Ruptured conus medullaris dermoid cyst with fat droplets in the central canal [corrected]". Asian Spine J. 7 (1): 50–4. doi:10.4184/asj.2013.7.1.50. PMC 3596585. PMID 23508636.
- ↑ Intracranial dermoid cyst. Radiopaedia.org. http://radiopaedia.org/articles/intracranial-dermoid-cyst-1 Accessed on February 5, 2016.
- ↑ 10.0 10.1 10.2 10.3 Dermoid cyst. Wikipedia. https://en.wikipedia.org/wiki/Dermoid_cyst Accessed on February 2, 2016
- ↑ Spinal dermoid cyst. Radiopedia. http://radiopaedia.org/articles/spinal-dermoid-cyst Accessed on February 10, 2016.
- ↑ Intracranial dermoid cyst. Radiopedia. http://radiopaedia.org/articles/intracranial-dermoid-cyst-1 Accessed on February 18, 2016.
- ↑ Intracranial dermoid cyst. Radiopaedia.org. http://radiopaedia.org/articles/intracranial-dermoid-cyst-1 Accessed on February 5, 2016.
- ↑ 14.0 14.1 14.2 Dermoid cyst. Wikipedia. https://en.wikipedia.org/wiki/Dermoid_cyst Accessed on February 11, 2016
- ↑ 15.0 15.1 Mature (cystic) ovarian teratoma. http://radiopaedia.org/articles/mature-cystic-ovarian-teratoma Radiopedia. Accessed on February 11, 2016
- ↑ 16.0 16.1 Intracranial dermoid cyst. http://radiopaedia.org/articles/intracranial-dermoid-cyst-1. Accessed on February 11, 2016.
- ↑ Jacquin A, Béjot Y, Hervieu M, Biotti D, Caillier M, Ricolfi FC; et al. (2010). "[Rupture of intracranial dermoid cyst with disseminated lipid droplets]". Rev Neurol (Paris). 166 (4): 451–7. doi:10.1016/j.neurol.2009.09.003. PMID 19846186.
- ↑ Osborn AG, Preece MT (2006). "Intracranial cysts: radiologic-pathologic correlation and imaging approach". Radiology. 239 (3): 650–64. doi:10.1148/radiol.2393050823. PMID 16714456.
- ↑ Mature (cystic) ovarian teratoma. Radiopedia. http://radiopaedia.org/articles/mature-cystic-ovarian-teratoma. Accessed on February 11, 2016.
- ↑ Intracranial dermoid cyst. Radiopedia. http://radiopaedia.org/articles/intracranial-dermoid-cyst-1. Accessed on February 11, 2016.
- ↑ Madke B, Nayak C, Giri A, Jain M (2013). "Nasal dermoid sinus cyst in a young female". Indian Dermatol Online J. 4 (4): 380–1. doi:10.4103/2229-5178.120669. PMC 3853920. PMID 24350035.
- ↑ Koreen IV, Kahana A, Gausas RE, Potter HD, Lemke BN, Elner VM (2009). "Tarsal dermoid cyst: clinical presentation and treatment". Ophthal Plast Reconstr Surg. 25 (2): 146–7. doi:10.1097/IOP.0b013e31819aae6e. PMID 19300165.
- ↑ Dermoid cyst. Wikipedia.https://en.wikipedia.org/wiki/Dermoid_cyst.Accessed on February 22, 2016
- ↑ Maurice SM, Burstein FD (2012). "Disappearing dermoid: fact or fiction?". J Craniofac Surg. 23 (1): e31–3. doi:10.1097/SCS.0b013e3182420981. PMID 22337456.
- ↑ Intracranial dermoid cyst. Radiopedia. http://radiopaedia.org/articles/intracranial-dermoid-cyst-1 Accessed on February 17, 2016.
- ↑ Sheth S, Fishman EK, Buck JL, Hamper UM, Sanders RC (1988). "The variable sonographic appearances of ovarian teratomas: correlation with CT". AJR Am J Roentgenol. 151 (2): 331–4. doi:10.2214/ajr.151.2.331. PMID 3293377.
- ↑ Occhipinti KA, Frankel SD, Hricak H (1993). "The ovary. Computed tomography and magnetic resonance imaging". Radiol Clin North Am. 31 (5): 1115–32. PMID 8362057.
- ↑ Spinal dermoid cyst. http://radiopaedia.org/articles/spinal-dermoid-cyst. Accessed on February 18, 2016.
- ↑ Sanaullah M, Mumtaz S, Memon AA, Hashim AS, Bashir S (2013). "Intramedullary dermoid cyst with relatively atypical symptoms: a case report and review of the literature". J Med Case Rep. 7: 104. doi:10.1186/1752-1947-7-104. PMC 3639845. PMID 23590721.
- ↑ Intracranial dermoid cyst.Radiopedia. http://radiopaedia.org/articles/intracranial-dermoid-cyst-1 Accessed on February 19, 2016
- ↑ Mature (cystic) ovarian teratoma. Radiopedia. http://radiopaedia.org/articles/mature-cystic-ovarian-teratoma Accessed on February 19, 2016
- ↑ Patel MD, Feldstein VA, Lipson SD, Chen DC, Filly RA (1998). "Cystic teratomas of the ovary: diagnostic value of sonography". AJR Am J Roentgenol. 171 (4): 1061–5. doi:10.2214/ajr.171.4.9762997. PMID 9762997.