Cyclin E2: Difference between revisions
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'''Cyclin E2''' is a [[protein]] that in humans is encoded by the ''CCNE2'' gene. It is a G1 [[cyclin]] that binds [[Cdk2]] and is inhibited by p27(Kip1) and p21(Cip1).<ref name=pmid9858585>{{ | '''Cyclin E2''' is a [[protein]] that in humans is encoded by the ''CCNE2'' gene. It is a G1 [[cyclin]] that binds [[Cdk2]] and is inhibited by p27(Kip1) and p21(Cip1).<ref name=pmid9858585>{{cite journal | vauthors = Gudas JM, Payton M, Thukral S, Chen E, Bass M, Robinson MO, Coats S | title = Cyclin E2, a novel G1 cyclin that binds Cdk2 and is aberrantly expressed in human cancers | journal = Molecular and Cellular Biology | volume = 19 | issue = 1 | pages = 612–22 | date = January 1999 | pmid = 9858585 | pmc = 83919 | doi = 10.1128/mcb.19.1.612 }}</ref> It plays a role in the G1/S portion of the [[cell cycle]] and also has putative interactions with proteins [[CDKN1A]], [[CDKN1B]], and [[CDK3]]. Aberrant expression can lead to cancer.<ref name=pmid9858585/> | ||
| | |||
| title = Cyclin E2, a novel G1 cyclin that binds Cdk2 and is aberrantly expressed in human cancers | |||
| journal = Molecular and Cellular Biology | |||
| volume = 19 | |||
| issue = 1 | |||
| pages = 612–22 | |||
| pmc = 83919 | doi=10.1128/mcb.19.1.612 | |||
}}</ref> It plays a role in the G1/S portion of the [[cell cycle]] and also has putative interactions with proteins [[CDKN1A]], [[CDKN1B]], and [[CDK3]]. Aberrant expression can lead to cancer.<ref name=pmid9858585/> | |||
==References== | == References == | ||
{{reflist}} | {{reflist}} | ||
{{Cell_cycle_proteins}} | {{Cell_cycle_proteins}} | ||
[[Category:Proteins]] | [[Category:Proteins]] | ||
Latest revision as of 08:34, 10 January 2019
| cyclin E2 | |
|---|---|
| Identifiers | |
| Symbol | CCNE2 |
| Entrez | 9134 |
| HUGO | 1590 |
| OMIM | 603775 |
| RefSeq | NM_057749 |
| UniProt | O96020 |
| Other data | |
| Locus | Chr. 8 q22.1 |
Cyclin E2 is a protein that in humans is encoded by the CCNE2 gene. It is a G1 cyclin that binds Cdk2 and is inhibited by p27(Kip1) and p21(Cip1).[1] It plays a role in the G1/S portion of the cell cycle and also has putative interactions with proteins CDKN1A, CDKN1B, and CDK3. Aberrant expression can lead to cancer.[1]
References
- ↑ 1.0 1.1 Gudas JM, Payton M, Thukral S, Chen E, Bass M, Robinson MO, Coats S (January 1999). "Cyclin E2, a novel G1 cyclin that binds Cdk2 and is aberrantly expressed in human cancers". Molecular and Cellular Biology. 19 (1): 612–22. doi:10.1128/mcb.19.1.612. PMC 83919. PMID 9858585.