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<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{Infobox_gene}}
{{PBB_Controls
'''Interferon-alpha/beta receptor alpha chain''' is a [[protein]] that in humans is encoded by the ''IFNAR1'' [[gene]].<ref name="pmid8181059">{{cite journal | vauthors = Novick D, Cohen B, Rubinstein M | title = The human interferon alpha/beta receptor: characterization and molecular cloning | journal = Cell | volume = 77 | issue = 3 | pages = 391–400  | date = Jun 1994 | pmid = 8181059 | pmc =  | doi = 10.1016/0092-8674(94)90154-6 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: IFNAR1 interferon (alpha, beta and omega) receptor 1| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3454| accessdate = }}</ref>
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}


<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Function ==
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Interferon (alpha, beta and omega) receptor 1
| HGNCid = 5432
| Symbol = IFNAR1
| AltSymbols =; AVP; IFN-alpha-REC; IFNAR; IFNBR; IFRC
| OMIM = 107450
| ECnumber = 
| Homologene = 524
| MGIid = 107658
| GeneAtlas_image1 = PBB_GE_IFNAR1_204191_at_tn.png
| Function = {{GNF_GO|id=GO:0004872 |text = receptor activity}} {{GNF_GO|id=GO:0004905 |text = interferon-alpha/beta receptor activity}}
| Component = {{GNF_GO|id=GO:0005887 |text = integral to plasma membrane}} {{GNF_GO|id=GO:0016020 |text = membrane}}
| Process = {{GNF_GO|id=GO:0007166 |text = cell surface receptor linked signal transduction}} {{GNF_GO|id=GO:0007259 |text = JAK-STAT cascade}} {{GNF_GO|id=GO:0009615 |text = response to virus}} {{GNF_GO|id=GO:0045351 |text = interferon type I biosynthetic process}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 3454
    | Hs_Ensembl = ENSG00000142166
    | Hs_RefseqProtein = NP_000620
    | Hs_RefseqmRNA = NM_000629
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 21
    | Hs_GenLoc_start = 33619079
    | Hs_GenLoc_end = 33654038
    | Hs_Uniprot = P17181
    | Mm_EntrezGene = 15975
    | Mm_Ensembl = ENSMUSG00000022967
    | Mm_RefseqmRNA = NM_010508
    | Mm_RefseqProtein = NP_034638
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 16
    | Mm_GenLoc_start = 91374108
    | Mm_GenLoc_end = 91396296
    | Mm_Uniprot = Q3U5G8
  }}
}}
{{CMG}}
__NOTOC__


The protein encoded by this gene is a type I membrane protein that forms one of the two chains of a receptor for interferons alpha and beta. Binding and activation of the receptor stimulates Janus protein kinases, which in turn phosphorylate several proteins, including STAT1 and STAT2. The encoded protein also functions as an antiviral factor.<ref name="entrez"/>


==Overview==
== Interactions ==


'''Interferon (alpha, beta and omega) receptor 1''', also known as '''IFNAR1''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: IFNAR1 interferon (alpha, beta and omega) receptor 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3454| accessdate = }}</ref>
IFNAR1 has been shown to [[Protein-protein interaction|interact]] with:
* [[PRMT1]],<ref name = pmid9029147>{{cite journal | vauthors = Abramovich C, Yakobson B, Chebath J, Revel M | title = A protein-arginine methyltransferase binds to the intracytoplasmic domain of the IFNAR1 chain in the type I interferon receptor | journal = EMBO J. | volume = 16 | issue = 2 | pages = 260–6  | date = Jan 1997 | pmid = 9029147 | pmc = 1169633 | doi = 10.1093/emboj/16.2.260 }}</ref>
* [[STAT2]],<ref name = pmid9121453>{{cite journal | vauthors = Li X, Leung S, Kerr IM, Stark GR | title = Functional subdomains of STAT2 required for preassociation with the alpha interferon receptor and for signaling | journal = Mol. Cell. Biol. | volume = 17 | issue = 4 | pages = 2048–56  | date = Apr 1997 | pmid = 9121453 | pmc = 232052 | doi =  10.1128/mcb.17.4.2048}}</ref><ref name = pmid7559568>{{cite journal | vauthors = Uddin S, Chamdin A, Platanias LC | title = Interaction of the transcriptional activator Stat-2 with the type I interferon receptor | journal = J. Biol. Chem. | volume = 270 | issue = 42 | pages = 24627–30  | date = Oct 1995 | pmid = 7559568 | doi =  10.1074/jbc.270.42.24627}}</ref><ref name = pmid8605876>{{cite journal | vauthors = Yan H, Krishnan K, Greenlund AC, Gupta S, Lim JT, Schreiber RD, Schindler CW, Krolewski JJ | title = Phosphorylated interferon-alpha receptor 1 subunit (IFNaR1) acts as a docking site for the latent form of the 113 kDa STAT2 protein | journal = EMBO J. | volume = 15 | issue = 5 | pages = 1064–74  | date = Mar 1996 | pmid = 8605876 | pmc = 450004 | doi =  }}</ref>  and
* [[Tyrosine kinase 2]].<ref name = pmid9733772>{{cite journal | vauthors = Richter MF, Duménil G, Uzé G, Fellous M, Pellegrini S | title = Specific contribution of Tyk2 JH regions to the binding and the expression of the interferon alpha/beta receptor component IFNAR1 | journal = J. Biol. Chem. | volume = 273 | issue = 38 | pages = 24723–9  | date = Sep 1998 | pmid = 9733772 | doi =  10.1074/jbc.273.38.24723}}</ref><ref name = pmid18474601>{{cite journal | vauthors = Kumar KG, Varghese B, Banerjee A, Baker DP, Constantinescu SN, Pellegrini S, Fuchs SY | title = Basal ubiquitin-independent internalization of interferon alpha receptor is prevented by Tyk2-mediated masking of a linear endocytic motif | journal = J. Biol. Chem. | volume = 283 | issue = 27 | pages = 18566–72  | date = Jul 2008 | pmid = 18474601 | pmc = 2441555 | doi = 10.1074/jbc.M800991200 }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== References ==
{{PBB_Summary
{{reflist}}
| section_title =  
| summary_text = The protein encoded by this gene is a type I membrane protein that forms one of the two chains of a receptor for interferons alpha and beta. Binding and activation of the receptor stimulates Janus protein kinases, which in turn phosphorylate several proteins, including STAT1 and STAT2. The encoded protein also functions as an antiviral factor.<ref name="entrez">{{cite web | title = Entrez Gene: IFNAR1 interferon (alpha, beta and omega) receptor 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3454| accessdate = }}</ref>
}}


==References==
== Further reading ==
{{reflist}}
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
* {{cite journal | vauthors = Bürglin TR, Barnes TM | title = Introns in sequence tags | journal = Nature | volume = 357 | issue = 6377 | pages = 367–8 | year = 1992 | pmid = 1350660 | doi = 10.1038/357367a0 }}
| citations =
* {{cite journal | authors = Qiujing Yu, Yuliya V Katlinskaya| title = DNA-Damage-Induced Type I Interferon Promotes Senescence and Inhibits Stem Cell Function | journal = Cell Reports | year = 2015 | doi = 10.1016/j.celrep.2015.03.069 |display-authors=etal | volume=11 | pages=785–797 | pmid=25921537 | pmc=4426031}}
*{{cite journal | author=Bürglin TR, Barnes TM |title=Introns in sequence tags. |journal=Nature |volume=357 |issue= 6377 |pages= 367-8 |year= 1992 |pmid= 1350660 |doi= 10.1038/357367a0 }}
* {{cite journal | vauthors = Lutfalla G, Gardiner K, Proudhon D, Vielh E, Uzé G | title = The structure of the human interferon alpha/beta receptor gene | journal = J. Biol. Chem. | volume = 267 | issue = 4 | pages = 2802–9 | year = 1992 | pmid = 1370833 | doi =  }}
*{{cite journal | author=Lutfalla G, Gardiner K, Proudhon D, ''et al.'' |title=The structure of the human interferon alpha/beta receptor gene. |journal=J. Biol. Chem. |volume=267 |issue= 4 |pages= 2802-9 |year= 1992 |pmid= 1370833 |doi= }}
* {{cite journal | vauthors = Flores I, Mariano TM, Pestka S | title = Human interferon omega (omega) binds to the alpha/beta receptor | journal = J. Biol. Chem. | volume = 266 | issue = 30 | pages = 19875–7 | year = 1991 | pmid = 1834641 | doi =  }}
*{{cite journal | author=Flores I, Mariano TM, Pestka S |title=Human interferon omega (omega) binds to the alpha/beta receptor. |journal=J. Biol. Chem. |volume=266 |issue= 30 |pages= 19875-7 |year= 1991 |pmid= 1834641 |doi=  }}
* {{cite journal | vauthors = Lutfalla G, Roeckel N, Mogensen KE, Mattei MG, Uzé G | title = Assignment of the human interferon-alpha receptor gene to chromosome 21q22.1 by in situ hybridization | journal = J. Interferon Res. | volume = 10 | issue = 5 | pages = 515–7 | year = 1990 | pmid = 2148760 | doi = 10.1089/jir.1990.10.515 }}
*{{cite journal | author=Lutfalla G, Roeckel N, Mogensen KE, ''et al.'' |title=Assignment of the human interferon-alpha receptor gene to chromosome 21q22.1 by in situ hybridization. |journal=J. Interferon Res. |volume=10 |issue= 5 |pages= 515-7 |year= 1991 |pmid= 2148760 |doi=  }}
* {{cite journal | vauthors = Uzé G, Lutfalla G, Gresser I | title = Genetic transfer of a functional human interferon alpha receptor into mouse cells: cloning and expression of its cDNA | journal = Cell | volume = 60 | issue = 2 | pages = 225–34 | year = 1990 | pmid = 2153461 | doi = 10.1016/0092-8674(90)90738-Z }}
*{{cite journal | author=Uzé G, Lutfalla G, Gresser I |title=Genetic transfer of a functional human interferon alpha receptor into mouse cells: cloning and expression of its cDNA. |journal=Cell |volume=60 |issue= 2 |pages= 225-34 |year= 1990 |pmid= 2153461 |doi= }}
* {{cite journal | vauthors = Colamonici O, Yan H, Domanski P, Handa R, Smalley D, Mullersman J, Witte M, Krishnan K, Krolewski J | title = Direct binding to and tyrosine phosphorylation of the alpha subunit of the type I interferon receptor by p135tyk2 tyrosine kinase | journal = Mol. Cell. Biol. | volume = 14 | issue = 12 | pages = 8133–42 | year = 1994 | pmid = 7526154 | pmc = 359352 | doi =  10.1128/mcb.14.12.8133}}
*{{cite journal | author=Colamonici O, Yan H, Domanski P, ''et al.'' |title=Direct binding to and tyrosine phosphorylation of the alpha subunit of the type I interferon receptor by p135tyk2 tyrosine kinase. |journal=Mol. Cell. Biol. |volume=14 |issue= 12 |pages= 8133-42 |year= 1994 |pmid= 7526154 |doi= }}
* {{cite journal | vauthors = Uddin S, Chamdin A, Platanias LC | title = Interaction of the transcriptional activator Stat-2 with the type I interferon receptor | journal = J. Biol. Chem. | volume = 270 | issue = 42 | pages = 24627–30 | year = 1995 | pmid = 7559568 | doi = 10.1074/jbc.270.42.24627 }}
*{{cite journal | author=Uddin S, Chamdin A, Platanias LC |title=Interaction of the transcriptional activator Stat-2 with the type I interferon receptor. |journal=J. Biol. Chem. |volume=270 |issue= 42 |pages= 24627-30 |year= 1995 |pmid= 7559568 |doi=  }}
* {{cite journal | vauthors = Domanski P, Witte M, Kellum M, Rubinstein M, Hackett R, Pitha P, Colamonici OR | title = Cloning and expression of a long form of the beta subunit of the interferon alpha beta receptor that is required for signaling | journal = J. Biol. Chem. | volume = 270 | issue = 37 | pages = 21606–11 | year = 1995 | pmid = 7665574 | doi = 10.1074/jbc.270.37.21606 }}
*{{cite journal | author=Domanski P, Witte M, Kellum M, ''et al.'' |title=Cloning and expression of a long form of the beta subunit of the interferon alpha beta receptor that is required for signaling. |journal=J. Biol. Chem. |volume=270 |issue= 37 |pages= 21606-11 |year= 1995 |pmid= 7665574 |doi= }}
* {{cite journal | vauthors = Maruyama K, Sugano S | title = Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides | journal = Gene | volume = 138 | issue = 1–2 | pages = 171–4 | year = 1994 | pmid = 8125298 | doi = 10.1016/0378-1119(94)90802-8 }}
*{{cite journal | author=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. |journal=Gene |volume=138 |issue= 1-2 |pages= 171-4 |year= 1994 |pmid= 8125298 |doi= }}
* {{cite journal | vauthors = Yan H, Krishnan K, Greenlund AC, Gupta S, Lim JT, Schreiber RD, Schindler CW, Krolewski JJ | title = Phosphorylated interferon-alpha receptor 1 subunit (IFNaR1) acts as a docking site for the latent form of the 113 kDa STAT2 protein | journal = EMBO J. | volume = 15 | issue = 5 | pages = 1064–74 | year = 1996 | pmid = 8605876 | pmc = 450004 | doi =  }}
*{{cite journal | author=Novick D, Cohen B, Rubinstein M |title=The human interferon alpha/beta receptor: characterization and molecular cloning. |journal=Cell |volume=77 |issue= 3 |pages= 391-400 |year= 1994 |pmid= 8181059 |doi= }}
* {{cite journal | vauthors = Yang CH, Shi W, Basu L, Murti A, Constantinescu SN, Blatt L, Croze E, Mullersman JE, Pfeffer LM | title = Direct association of STAT3 with the IFNAR-1 chain of the human type I interferon receptor | journal = J. Biol. Chem. | volume = 271 | issue = 14 | pages = 8057–61 | year = 1996 | pmid = 8626489 | doi = 10.1074/jbc.271.14.8057 }}
*{{cite journal | author=Yan H, Krishnan K, Greenlund AC, ''et al.'' |title=Phosphorylated interferon-alpha receptor 1 subunit (IFNaR1) acts as a docking site for the latent form of the 113 kDa STAT2 protein. |journal=EMBO J. |volume=15 |issue= 5 |pages= 1064-74 |year= 1996 |pmid= 8605876 |doi=  }}
* {{cite journal | vauthors = Abramovich C, Yakobson B, Chebath J, Revel M | title = A protein-arginine methyltransferase binds to the intracytoplasmic domain of the IFNAR1 chain in the type I interferon receptor | journal = EMBO J. | volume = 16 | issue = 2 | pages = 260–6 | year = 1997 | pmid = 9029147 | pmc = 1169633 | doi = 10.1093/emboj/16.2.260 }}
*{{cite journal | author=Yang CH, Shi W, Basu L, ''et al.'' |title=Direct association of STAT3 with the IFNAR-1 chain of the human type I interferon receptor. |journal=J. Biol. Chem. |volume=271 |issue= 14 |pages= 8057-61 |year= 1996 |pmid= 8626489 |doi= }}
* {{cite journal | vauthors = Eantuzzi L, Eid P, Malorni W, Rainaldi G, Gauzzi MC, Pellegrini S, Belardelli F, Gessani S | title = Post-translational up-regulation of the cell surface-associated alpha component of the human type I interferon receptor during differentiation of peripheral blood monocytes: role in the biological response to type I interferon | journal = Eur. J. Immunol. | volume = 27 | issue = 5 | pages = 1075–81 | year = 1997 | pmid = 9174595 | doi = 10.1002/eji.1830270506 }}
*{{cite journal | author=Abramovich C, Yakobson B, Chebath J, Revel M |title=A protein-arginine methyltransferase binds to the intracytoplasmic domain of the IFNAR1 chain in the type I interferon receptor. |journal=EMBO J. |volume=16 |issue= 2 |pages= 260-6 |year= 1997 |pmid= 9029147 |doi= 10.1093/emboj/16.2.260 }}
* {{cite journal | vauthors = Gessani S, Borghi P, Fantuzzi L, Varano B, Conti L, Puddu P, Belardelli F | title = Induction of cytokines by HIV-1 and its gp120 protein in human peripheral blood monocyte/macrophages and modulation of cytokine response during differentiation | journal = J. Leukoc. Biol. | volume = 62 | issue = 1 | pages = 49–53 | year = 1997 | pmid = 9225992 | doi =  }}
*{{cite journal | author=Eantuzzi L, Eid P, Malorni W, ''et al.'' |title=Post-translational up-regulation of the cell surface-associated alpha component of the human type I interferon receptor during differentiation of peripheral blood monocytes: role in the biological response to type I interferon. |journal=Eur. J. Immunol. |volume=27 |issue= 5 |pages= 1075-81 |year= 1997 |pmid= 9174595 |doi= }}
* {{cite journal | vauthors = Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S | title = Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library | journal = Gene | volume = 200 | issue = 1–2 | pages = 149–56 | year = 1997 | pmid = 9373149 | doi = 10.1016/S0378-1119(97)00411-3 }}
*{{cite journal | author=Gessani S, Borghi P, Fantuzzi L, ''et al.'' |title=Induction of cytokines by HIV-1 and its gp120 protein in human peripheral blood monocyte/macrophages and modulation of cytokine response during differentiation. |journal=J. Leukoc. Biol. |volume=62 |issue= 1 |pages= 49-53 |year= 1997 |pmid= 9225992 |doi=  }}
* {{cite journal | vauthors = Krishnan K, Singh B, Krolewski JJ | title = Identification of amino acid residues critical for the Src-homology 2 domain-dependent docking of Stat2 to the interferon alpha receptor | journal = J. Biol. Chem. | volume = 273 | issue = 31 | pages = 19495–501 | year = 1998 | pmid = 9677371 | doi = 10.1074/jbc.273.31.19495 }}
*{{cite journal | author=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, ''et al.'' |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. |journal=Gene |volume=200 |issue= 1-2 |pages= 149-56 |year= 1997 |pmid= 9373149 |doi= }}
* {{cite journal | vauthors = Richter MF, Duménil G, Uzé G, Fellous M, Pellegrini S | title = Specific contribution of Tyk2 JH regions to the binding and the expression of the interferon alpha/beta receptor component IFNAR1 | journal = J. Biol. Chem. | volume = 273 | issue = 38 | pages = 24723–9 | year = 1998 | pmid = 9733772 | doi = 10.1074/jbc.273.38.24723 }}
*{{cite journal | author=Krishnan K, Singh B, Krolewski JJ |title=Identification of amino acid residues critical for the Src-homology 2 domain-dependent docking of Stat2 to the interferon alpha receptor. |journal=J. Biol. Chem. |volume=273 |issue= 31 |pages= 19495-501 |year= 1998 |pmid= 9677371 |doi= }}
* {{cite journal | vauthors = Rani MR, Leaman DW, Han Y, Leung S, Croze E, Fish EN, Wolfman A, Ransohoff RM | title = Catalytically active TYK2 is essential for interferon-beta-mediated phosphorylation of STAT3 and interferon-alpha receptor-1 (IFNAR-1) but not for activation of phosphoinositol 3-kinase | journal = J. Biol. Chem. | volume = 274 | issue = 45 | pages = 32507–11 | year = 1999 | pmid = 10542297 | doi = 10.1074/jbc.274.45.32507 }}
*{{cite journal | author=Richter MF, Duménil G, Uzé G, ''et al.'' |title=Specific contribution of Tyk2 JH regions to the binding and the expression of the interferon alpha/beta receptor component IFNAR1. |journal=J. Biol. Chem. |volume=273 |issue= 38 |pages= 24723-9 |year= 1998 |pmid= 9733772 |doi= }}
*{{cite journal | author=Rani MR, Leaman DW, Han Y, ''et al.'' |title=Catalytically active TYK2 is essential for interferon-beta-mediated phosphorylation of STAT3 and interferon-alpha receptor-1 (IFNAR-1) but not for activation of phosphoinositol 3-kinase. |journal=J. Biol. Chem. |volume=274 |issue= 45 |pages= 32507-11 |year= 1999 |pmid= 10542297 |doi= }}
*{{cite journal  | author=Hattori M, Fujiyama A, Taylor TD, ''et al.'' |title=The DNA sequence of human chromosome 21. |journal=Nature |volume=405 |issue= 6784 |pages= 311-9 |year= 2000 |pmid= 10830953 |doi= 10.1038/35012518 }}
}}
{{refend}}
{{refend}}


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Latest revision as of 13:18, 6 November 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Interferon-alpha/beta receptor alpha chain is a protein that in humans is encoded by the IFNAR1 gene.[1][2]

Function

The protein encoded by this gene is a type I membrane protein that forms one of the two chains of a receptor for interferons alpha and beta. Binding and activation of the receptor stimulates Janus protein kinases, which in turn phosphorylate several proteins, including STAT1 and STAT2. The encoded protein also functions as an antiviral factor.[2]

Interactions

IFNAR1 has been shown to interact with:

References

  1. ↑ Novick D, Cohen B, Rubinstein M (Jun 1994). "The human interferon alpha/beta receptor: characterization and molecular cloning". Cell. 77 (3): 391–400. doi:10.1016/0092-8674(94)90154-6. PMID 8181059.
  2. ↑ 2.0 2.1 "Entrez Gene: IFNAR1 interferon (alpha, beta and omega) receptor 1".
  3. ↑ Abramovich C, Yakobson B, Chebath J, Revel M (Jan 1997). "A protein-arginine methyltransferase binds to the intracytoplasmic domain of the IFNAR1 chain in the type I interferon receptor". EMBO J. 16 (2): 260–6. doi:10.1093/emboj/16.2.260. PMC 1169633. PMID 9029147.
  4. ↑ Li X, Leung S, Kerr IM, Stark GR (Apr 1997). "Functional subdomains of STAT2 required for preassociation with the alpha interferon receptor and for signaling". Mol. Cell. Biol. 17 (4): 2048–56. doi:10.1128/mcb.17.4.2048. PMC 232052. PMID 9121453.
  5. ↑ Uddin S, Chamdin A, Platanias LC (Oct 1995). "Interaction of the transcriptional activator Stat-2 with the type I interferon receptor". J. Biol. Chem. 270 (42): 24627–30. doi:10.1074/jbc.270.42.24627. PMID 7559568.
  6. ↑ Yan H, Krishnan K, Greenlund AC, Gupta S, Lim JT, Schreiber RD, Schindler CW, Krolewski JJ (Mar 1996). "Phosphorylated interferon-alpha receptor 1 subunit (IFNaR1) acts as a docking site for the latent form of the 113 kDa STAT2 protein". EMBO J. 15 (5): 1064–74. PMC 450004. PMID 8605876.
  7. ↑ Richter MF, Duménil G, Uzé G, Fellous M, Pellegrini S (Sep 1998). "Specific contribution of Tyk2 JH regions to the binding and the expression of the interferon alpha/beta receptor component IFNAR1". J. Biol. Chem. 273 (38): 24723–9. doi:10.1074/jbc.273.38.24723. PMID 9733772.
  8. ↑ Kumar KG, Varghese B, Banerjee A, Baker DP, Constantinescu SN, Pellegrini S, Fuchs SY (Jul 2008). "Basal ubiquitin-independent internalization of interferon alpha receptor is prevented by Tyk2-mediated masking of a linear endocytic motif". J. Biol. Chem. 283 (27): 18566–72. doi:10.1074/jbc.M800991200. PMC 2441555. PMID 18474601.

Further reading

Retrieved from "https://www.wikidoc.org/index.php?title=IFNAR1&oldid=1419875"