CDKN2C: Difference between revisions

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<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{Infobox_gene}}
{{PBB_Controls
'''Cyclin-dependent kinase 4 inhibitor C''' is an [[enzyme]] that in humans is encoded by the ''CDKN2C'' [[gene]].<ref name="pmid8001816">{{cite journal | vauthors = Guan KL, Jenkins CW, Li Y, Nichols MA, Wu X, O'Keefe CL, Matera AG, Xiong Y | title = Growth suppression by p18, a p16INK4/MTS1- and p14INK4B/MTS2-related CDK6 inhibitor, correlates with wild-type pRb function | journal = Genes Dev. | volume = 8 | issue = 24 | pages = 2939–52 | date = January 1995 | pmid = 8001816 | pmc =  | doi = 10.1101/gad.8.24.2939 }}</ref><ref name="pmid9636670">{{cite journal | vauthors = Blais A, Labrie Y, Pouliot F, Lachance Y, Labrie C | title = Structure of the gene encoding the human cyclin-dependent kinase inhibitor p18 and mutational analysis in breast cancer | journal = Biochem. Biophys. Res. Commun. | volume = 247 | issue = 1 | pages = 146–53  | date = July 1998 | pmid = 9636670 | pmc = | doi = 10.1006/bbrc.1998.8497 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: CDKN2C cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1031| accessdate = }}</ref>
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}


<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Function ==
{{GNF_Protein_box
| image = PBB_Protein_CDKN2C_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1bu9.
| PDB = {{PDB2|1bu9}}, {{PDB2|1g3n}}, {{PDB2|1ihb}}, {{PDB2|1mx2}}, {{PDB2|1mx4}}, {{PDB2|1mx6}}
| Name = Cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4)
| HGNCid = 1789
| Symbol = CDKN2C
| AltSymbols =; INK4C; p18; p18-INK4C
| OMIM = 603369
| ECnumber = 
| Homologene = 966
| MGIid = 105388
| GeneAtlas_image1 = PBB_GE_CDKN2C_204159_at_tn.png
| GeneAtlas_image2 = PBB_GE_CDKN2C_211792_s_at_tn.png
| Function = {{GNF_GO|id=GO:0004861 |text = cyclin-dependent protein kinase inhibitor activity}}
| Component = {{GNF_GO|id=GO:0005634 |text = nucleus}} {{GNF_GO|id=GO:0005737 |text = cytoplasm}}
| Process = {{GNF_GO|id=GO:0007049 |text = cell cycle}} {{GNF_GO|id=GO:0007050 |text = cell cycle arrest}} {{GNF_GO|id=GO:0008285 |text = negative regulation of cell proliferation}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 1031
    | Hs_Ensembl = ENSG00000123080
    | Hs_RefseqProtein = NP_001253
    | Hs_RefseqmRNA = NM_001262
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 1
    | Hs_GenLoc_start = 51199005
    | Hs_GenLoc_end = 51212893
    | Hs_Uniprot = P42773
    | Mm_EntrezGene = 12580
    | Mm_Ensembl = ENSMUSG00000028551
    | Mm_RefseqmRNA = NM_007671
    | Mm_RefseqProtein = NP_031697
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 4
    | Mm_GenLoc_start = 109158808
    | Mm_GenLoc_end = 109163607
    | Mm_Uniprot = Q3U054
  }}
}}
'''Cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4)''', also known as '''CDKN2C''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: CDKN2C cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1031| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
The protein encoded by this gene is a member of the INK4 family of cyclin-dependent kinase inhibitors. This protein has been shown to interact with CDK4 or CDK6, and prevent the activation of the CDK kinases, thus function as a cell growth regulator that controls cell cycle G1 progression. [[Ectopic expression]] of this gene was shown to suppress the growth of human cells in a manner that appears to correlate with the presence of a wild-type RB1 function. Studies in the knockout mice suggested the roles of this gene in regulating spermatogenesis, as well as in suppressing tumorigenesis. Two alternatively spliced transcript variants of this gene, which encode an identical protein, have been reported.<ref name="entrez" />
{{PBB_Summary
| section_title =
| summary_text = The protein encoded by this gene is a member of the INK4 family of cyclin-dependent kinase inhibitors. This protein has been shown to interact with CDK4 or CDK6, and prevent the activation of the CDK kinases, thus function as a cell growth regulator that controls cell cycle G1 progression. Ectopic expression of this gene was shown to suppress the growth of human cells in a manner that appears to correlate with the presence of a wild-type RB1 function. Studies in the knockout mice suggested the roles of this gene in regulating spermatogenesis, as well as in suppressing tumorigenesis. Two alternatively spliced transcript variants of this gene, which encode an identical protein, have been reported.<ref name="entrez">{{cite web | title = Entrez Gene: CDKN2C cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1031| accessdate = }}</ref>
}}


==References==
== Interactions ==
{{reflist|2}}
 
==Further reading==
CDKN2C has been shown to [[Protein-protein interaction|interact]] with [[Cyclin-dependent kinase 4]]<ref name=pmid8001816 /><ref name=pmid17353931>{{cite journal | vauthors = Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D | title = Large-scale mapping of human protein-protein interactions by mass spectrometry | journal = Mol. Syst. Biol. | volume = 3 | issue = 1 | pages = 89 | year = 2007 | pmid = 17353931 | pmc = 1847948 | doi = 10.1038/msb4100134 }}</ref> and [[Cyclin-dependent kinase 6]].<ref name=pmid8001816/><ref name=pmid17353931/><ref name=pmid11124804>{{cite journal | vauthors = Jeffrey PD, Tong L, Pavletich NP | title = Structural basis of inhibition of CDK-cyclin complexes by INK4 inhibitors | journal = Genes Dev. | volume = 14 | issue = 24 | pages = 3115–25  | date = December 2000 | pmid = 11124804 | pmc = 317144 | doi = 10.1101/gad.851100 }}</ref>
 
== References ==
{{reflist}}
 
== Further reading ==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
* {{cite journal | vauthors = Serrano M, Hannon GJ, Beach D | title = A new regulatory motif in cell-cycle control causing specific inhibition of cyclin D/CDK4 | journal = Nature | volume = 366 | issue = 6456 | pages = 704–7 | year = 1993 | pmid = 8259215 | doi = 10.1038/366704a0 }}
| citations =
* {{cite journal | vauthors = Ghosh PK, Anderson J, Cohen N, Takeshita K, Atweh GF, Lebowitz P | title = Expression of the leukemia-associated gene, p18, in normal and malignant tissues; inactivation of expression in a patient with cleaved B cell lymphoma/leukemia | journal = Oncogene | volume = 8 | issue = 10 | pages = 2869–72 | year = 1993 | pmid = 8397372 | doi = }}
*{{cite journal | author=Guan KL, Jenkins CW, Li Y, ''et al.'' |title=Growth suppression by p18, a p16INK4/MTS1- and p14INK4B/MTS2-related CDK6 inhibitor, correlates with wild-type pRb function. |journal=Genes Dev. |volume=8 |issue= 24 |pages= 2939-52 |year= 1995 |pmid= 8001816 |doi= }}
* {{cite journal | vauthors = Simos G, Maison C, Georgatos SD | title = Characterization of p18, a component of the lamin B receptor complex and a new integral membrane protein of the avian erythrocyte nuclear envelope | journal = J. Biol. Chem. | volume = 271 | issue = 21 | pages = 12617–25 | year = 1996 | pmid = 8647873 | doi = 10.1074/jbc.271.21.12617 }}
*{{cite journal | author=Serrano M, Hannon GJ, Beach D |title=A new regulatory motif in cell-cycle control causing specific inhibition of cyclin D/CDK4. |journal=Nature |volume=366 |issue= 6456 |pages= 704-7 |year= 1994 |pmid= 8259215 |doi= 10.1038/366704a0 }}
* {{cite journal | vauthors = Ragione FD, Russo GL, Oliva A, Mercurio C, Mastropietro S, Pietra VD, Zappia V | title = Biochemical characterization of p16INK4- and p18-containing complexes in human cell lines | journal = J. Biol. Chem. | volume = 271 | issue = 27 | pages = 15942–9 | year = 1996 | pmid = 8663131 | doi = 10.1074/jbc.271.27.15942 }}
*{{cite journal | author=Ghosh PK, Anderson J, Cohen N, ''et al.'' |title=Expression of the leukemia-associated gene, p18, in normal and malignant tissues; inactivation of expression in a patient with cleaved B cell lymphoma/leukemia. |journal=Oncogene |volume=8 |issue= 10 |pages= 2869-72 |year= 1993 |pmid= 8397372 |doi= }}
* {{cite journal | vauthors = Lapointe J, Lachance Y, Labrie Y, Labrie C | title = A p18 mutant defective in CDK6 binding in human breast cancer cells | journal = Cancer Res. | volume = 56 | issue = 20 | pages = 4586–9 | year = 1996 | pmid = 8840966 | doi =  }}
*{{cite journal | author=Simos G, Maison C, Georgatos SD |title=Characterization of p18, a component of the lamin B receptor complex and a new integral membrane protein of the avian erythrocyte nuclear envelope. |journal=J. Biol. Chem. |volume=271 |issue= 21 |pages= 12617-25 |year= 1996 |pmid= 8647873 |doi= }}
* {{cite journal | vauthors = Venkataramani R, Swaminathan K, Marmorstein R | title = Crystal structure of the CDK4/6 inhibitory protein p18INK4c provides insights into ankyrin-like repeat structure/function and tumor-derived p16INK4 mutations | journal = Nat. Struct. Biol. | volume = 5 | issue = 1 | pages = 74–81 | year = 1998 | pmid = 9437433 | doi = 10.1038/nsb0198-74 }}
*{{cite journal | author=Ragione FD, Russo GL, Oliva A, ''et al.'' |title=Biochemical characterization of p16INK4- and p18-containing complexes in human cell lines. |journal=J. Biol. Chem. |volume=271 |issue= 27 |pages= 15942-9 |year= 1996 |pmid= 8663131 |doi=  }}
* {{cite journal | vauthors = Fåhraeus R, Laín S, Ball KL, Lane DP | title = Characterization of the cyclin-dependent kinase inhibitory domain of the INK4 family as a model for a synthetic tumour suppressor molecule | journal = Oncogene | volume = 16 | issue = 5 | pages = 587–96 | year = 1998 | pmid = 9482104 | doi = 10.1038/sj.onc.1201580 }}
*{{cite journal | author=Lapointe J, Lachance Y, Labrie Y, Labrie C |title=A p18 mutant defective in CDK6 binding in human breast cancer cells. |journal=Cancer Res. |volume=56 |issue= 20 |pages= 4586-9 |year= 1996 |pmid= 8840966 |doi= }}
* {{cite journal | vauthors = Iolascon A, Giordani L, Moretti A, Basso G, Borriello A, Della Ragione F | title = Analysis of CDKN2A, CDKN2B, CDKN2C, and cyclin Ds gene status in hepatoblastoma | journal = Hepatology | volume = 27 | issue = 4 | pages = 989–95 | year = 1998 | pmid = 9537438 | doi = 10.1002/hep.510270414 }}
*{{cite journal | author=Venkataramani R, Swaminathan K, Marmorstein R |title=Crystal structure of the CDK4/6 inhibitory protein p18INK4c provides insights into ankyrin-like repeat structure/function and tumor-derived p16INK4 mutations. |journal=Nat. Struct. Biol. |volume=5 |issue= 1 |pages= 74-81 |year= 1998 |pmid= 9437433 |doi= }}
* {{cite journal | vauthors = Noh SJ, Li Y, Xiong Y, Guan KL | title = Identification of functional elements of p18INK4C essential for binding and inhibition of cyclin-dependent kinase (CDK) 4 and CDK6 | journal = Cancer Res. | volume = 59 | issue = 3 | pages = 558–64 | year = 1999 | pmid = 9973200 | doi = }}
*{{cite journal | author=Fåhraeus R, Laín S, Ball KL, Lane DP |title=Characterization of the cyclin-dependent kinase inhibitory domain of the INK4 family as a model for a synthetic tumour suppressor molecule. |journal=Oncogene |volume=16 |issue= 5 |pages= 587-96 |year= 1998 |pmid= 9482104 |doi= 10.1038/sj.onc.1201580 }}
* {{cite journal | vauthors = Li J, Byeon IJ, Ericson K, Poi MJ, O'Maille P, Selby T, Tsai MD | title = Tumor suppressor INK4: determination of the solution structure of p18INK4C and demonstration of the functional significance of loops in p18INK4C and p16INK4A | journal = Biochemistry | volume = 38 | issue = 10 | pages = 2930–40 | year = 1999 | pmid = 10074345 | doi = 10.1021/bi982286e }}
*{{cite journal | author=Iolascon A, Giordani L, Moretti A, ''et al.'' |title=Analysis of CDKN2A, CDKN2B, CDKN2C, and cyclin Ds gene status in hepatoblastoma. |journal=Hepatology |volume=27 |issue= 4 |pages= 989-95 |year= 1998 |pmid= 9537438 |doi= 10.1002/hep.510270414 }}
* {{cite journal | vauthors = Schreiber M, Muller WJ, Singh G, Graham FL | title = Comparison of the effectiveness of adenovirus vectors expressing cyclin kinase inhibitors p16INK4A, p18INK4C, p19INK4D, p21(WAF1/CIP1) and p27KIP1 in inducing cell cycle arrest, apoptosis and inhibition of tumorigenicity | journal = Oncogene | volume = 18 | issue = 9 | pages = 1663–76 | year = 1999 | pmid = 10208428 | doi = 10.1038/sj.onc.1202466 }}
*{{cite journal | author=Blais A, Labrie Y, Pouliot F, ''et al.'' |title=Structure of the gene encoding the human cyclin-dependent kinase inhibitor p18 and mutational analysis in breast cancer. |journal=Biochem. Biophys. Res. Commun. |volume=247 |issue= 1 |pages= 146-53 |year= 1998 |pmid= 9636670 |doi= 10.1006/bbrc.1998.8497 }}
* {{cite journal | vauthors = Dias Neto E, Correa RG, Verjovski-Almeida S, Briones MR, Nagai MA, da Silva W, Zago MA, Bordin S, Costa FF, Goldman GH, Carvalho AF, Matsukuma A, Baia GS, Simpson DH, Brunstein A, de Oliveira PS, Bucher P, Jongeneel CV, O'Hare MJ, Soares F, Brentani RR, Reis LF, de Souza SJ, Simpson AJ | title = Shotgun sequencing of the human transcriptome with ORF expressed sequence tags | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 97 | issue = 7 | pages = 3491–6 | year = 2000 | pmid = 10737800 | pmc = 16267 | doi = 10.1073/pnas.97.7.3491 }}
*{{cite journal | author=Noh SJ, Li Y, Xiong Y, Guan KL |title=Identification of functional elements of p18INK4C essential for binding and inhibition of cyclin-dependent kinase (CDK) 4 and CDK6. |journal=Cancer Res. |volume=59 |issue= 3 |pages= 558-64 |year= 1999 |pmid= 9973200 |doi= }}
* {{cite journal | vauthors = Korshunov A, Golanov A | title = Immunohistochemical analysis of p18INK4C and p14ARF protein expression in 117 oligodendrogliomas: correlation with tumor grade and clinical outcome | journal = Arch. Pathol. Lab. Med. | volume = 126 | issue = 1 | pages = 42–8 | year = 2002 | pmid = 11800646 | doi = 10.1043/0003-9985(2002)126<0042:IAOPAP>2.0.CO;2 }}
*{{cite journal | author=Li J, Byeon IJ, Ericson K, ''et al.'' |title=Tumor suppressor INK4: determination of the solution structure of p18INK4C and demonstration of the functional significance of loops in p18INK4C and p16INK4A. |journal=Biochemistry |volume=38 |issue= 10 |pages= 2930-40 |year= 1999 |pmid= 10074345 |doi= 10.1021/bi982286e }}
* {{cite journal | vauthors = Blais A, Monté D, Pouliot F, Labrie C | title = Regulation of the human cyclin-dependent kinase inhibitor p18INK4c by the transcription factors E2F1 and Sp1 | journal = J. Biol. Chem. | volume = 277 | issue = 35 | pages = 31679–93 | year = 2002 | pmid = 12077144 | doi = 10.1074/jbc.M204554200 }}
*{{cite journal | author=Schreiber M, Muller WJ, Singh G, Graham FL |title=Comparison of the effectiveness of adenovirus vectors expressing cyclin kinase inhibitors p16INK4A, p18INK4C, p19INK4D, p21(WAF1/CIP1) and p27KIP1 in inducing cell cycle arrest, apoptosis and inhibition of tumorigenicity. |journal=Oncogene |volume=18 |issue= 9 |pages= 1663-76 |year= 1999 |pmid= 10208428 |doi= 10.1038/sj.onc.1202466 }}
* {{cite journal | vauthors = Arcellana-Panlilio MY, Egeler RM, Ujack E, Magliocco A, Stuart GC, Robbins SM, Coppes MJ | title = Evidence of a role for the INK4 family of cyclin-dependent kinase inhibitors in ovarian granulosa cell tumors | journal = Genes Chromosomes Cancer | volume = 35 | issue = 2 | pages = 176–81 | year = 2002 | pmid = 12203782 | doi = 10.1002/gcc.10108 }}
*{{cite journal | author=Dias Neto E, Correa RG, Verjovski-Almeida S, ''et al.'' |title=Shotgun sequencing of the human transcriptome with ORF expressed sequence tags. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=97 |issue= 7 |pages= 3491-6 |year= 2000 |pmid= 10737800 |doi= }}
* {{cite journal | vauthors = Komata T, Kanzawa T, Takeuchi H, Germano IM, Schreiber M, Kondo Y, Kondo S | title = Antitumour effect of cyclin-dependent kinase inhibitors (p16(INK4A), p18(INK4C), p19(INK4D), p21(WAF1/CIP1) and p27(KIP1)) on malignant glioma cells | journal = Br. J. Cancer | volume = 88 | issue = 8 | pages = 1277–80 | year = 2003 | pmid = 12698196 | pmc = 2747579 | doi = 10.1038/sj.bjc.6600862 }}
*{{cite journal | author=Korshunov A, Golanov A |title=Immunohistochemical analysis of p18INK4C and p14ARF protein expression in 117 oligodendrogliomas: correlation with tumor grade and clinical outcome. |journal=Arch. Pathol. Lab. Med. |volume=126 |issue= 1 |pages= 42-8 |year= 2002 |pmid= 11800646 |doi= }}
* {{cite journal | vauthors = Sánchez-Aguilera A, Delgado J, Camacho FI, Sánchez-Beato M, Sánchez L, Montalbán C, Fresno MF, Martín C, Piris MA, García JF | title = Silencing of the p18INK4c gene by promoter hypermethylation in Reed-Sternberg cells in Hodgkin lymphomas | journal = Blood | volume = 103 | issue = 6 | pages = 2351–7 | year = 2004 | pmid = 14645011 | doi = 10.1182/blood-2003-07-2356 }}
*{{cite journal | author=Blais A, Monté D, Pouliot F, Labrie C |title=Regulation of the human cyclin-dependent kinase inhibitor p18INK4c by the transcription factors E2F1 and Sp1. |journal=J. Biol. Chem. |volume=277 |issue= 35 |pages= 31679-93 |year= 2002 |pmid= 12077144 |doi= 10.1074/jbc.M204554200 }}
*{{cite journal | author=Arcellana-Panlilio MY, Egeler RM, Ujack E, ''et al.'' |title=Evidence of a role for the INK4 family of cyclin-dependent kinase inhibitors in ovarian granulosa cell tumors. |journal=Genes Chromosomes Cancer |volume=35 |issue= 2 |pages= 176-81 |year= 2002 |pmid= 12203782 |doi= 10.1002/gcc.10108 }}
*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal  | author=Komata T, Kanzawa T, Takeuchi H, ''et al.'' |title=Antitumour effect of cyclin-dependent kinase inhibitors (p16(INK4A), p18(INK4C), p19(INK4D), p21(WAF1/CIP1) and p27(KIP1)) on malignant glioma cells. |journal=Br. J. Cancer |volume=88 |issue= 8 |pages= 1277-80 |year= 2004 |pmid= 12698196 |doi= 10.1038/sj.bjc.6600862 }}
*{{cite journal  | author=Sánchez-Aguilera A, Delgado J, Camacho FI, ''et al.'' |title=Silencing of the p18INK4c gene by promoter hypermethylation in Reed-Sternberg cells in Hodgkin lymphomas. |journal=Blood |volume=103 |issue= 6 |pages= 2351-7 |year= 2004 |pmid= 14645011 |doi= 10.1182/blood-2003-07-2356 }}
}}
{{refend}}
{{refend}}


{{protein-stub}}
== External links ==
{{WikiDoc Sources}}
* {{UCSC genome browser|CDKN2C}}
* {{UCSC gene details|CDKN2C}}
 
{{PDB Gallery|geneid=1031}}
 
{{Cell cycle proteins}}
 
 
{{gene-1-stub}}

Latest revision as of 01:59, 27 October 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

n/a

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Cyclin-dependent kinase 4 inhibitor C is an enzyme that in humans is encoded by the CDKN2C gene.[1][2][3]

Function

The protein encoded by this gene is a member of the INK4 family of cyclin-dependent kinase inhibitors. This protein has been shown to interact with CDK4 or CDK6, and prevent the activation of the CDK kinases, thus function as a cell growth regulator that controls cell cycle G1 progression. Ectopic expression of this gene was shown to suppress the growth of human cells in a manner that appears to correlate with the presence of a wild-type RB1 function. Studies in the knockout mice suggested the roles of this gene in regulating spermatogenesis, as well as in suppressing tumorigenesis. Two alternatively spliced transcript variants of this gene, which encode an identical protein, have been reported.[3]

Interactions

CDKN2C has been shown to interact with Cyclin-dependent kinase 4[1][4] and Cyclin-dependent kinase 6.[1][4][5]

References

  1. ↑ 1.0 1.1 1.2 Guan KL, Jenkins CW, Li Y, Nichols MA, Wu X, O'Keefe CL, Matera AG, Xiong Y (January 1995). "Growth suppression by p18, a p16INK4/MTS1- and p14INK4B/MTS2-related CDK6 inhibitor, correlates with wild-type pRb function". Genes Dev. 8 (24): 2939–52. doi:10.1101/gad.8.24.2939. PMID 8001816.
  2. ↑ Blais A, Labrie Y, Pouliot F, Lachance Y, Labrie C (July 1998). "Structure of the gene encoding the human cyclin-dependent kinase inhibitor p18 and mutational analysis in breast cancer". Biochem. Biophys. Res. Commun. 247 (1): 146–53. doi:10.1006/bbrc.1998.8497. PMID 9636670.
  3. ↑ 3.0 3.1 "Entrez Gene: CDKN2C cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4)".
  4. ↑ 4.0 4.1 Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.
  5. ↑ Jeffrey PD, Tong L, Pavletich NP (December 2000). "Structural basis of inhibition of CDK-cyclin complexes by INK4 inhibitors". Genes Dev. 14 (24): 3115–25. doi:10.1101/gad.851100. PMC 317144. PMID 11124804.

Further reading

  • Serrano M, Hannon GJ, Beach D (1993). "A new regulatory motif in cell-cycle control causing specific inhibition of cyclin D/CDK4". Nature. 366 (6456): 704–7. doi:10.1038/366704a0. PMID 8259215.
  • Ghosh PK, Anderson J, Cohen N, Takeshita K, Atweh GF, Lebowitz P (1993). "Expression of the leukemia-associated gene, p18, in normal and malignant tissues; inactivation of expression in a patient with cleaved B cell lymphoma/leukemia". Oncogene. 8 (10): 2869–72. PMID 8397372.
  • Simos G, Maison C, Georgatos SD (1996). "Characterization of p18, a component of the lamin B receptor complex and a new integral membrane protein of the avian erythrocyte nuclear envelope". J. Biol. Chem. 271 (21): 12617–25. doi:10.1074/jbc.271.21.12617. PMID 8647873.
  • Ragione FD, Russo GL, Oliva A, Mercurio C, Mastropietro S, Pietra VD, Zappia V (1996). "Biochemical characterization of p16INK4- and p18-containing complexes in human cell lines". J. Biol. Chem. 271 (27): 15942–9. doi:10.1074/jbc.271.27.15942. PMID 8663131.
  • Lapointe J, Lachance Y, Labrie Y, Labrie C (1996). "A p18 mutant defective in CDK6 binding in human breast cancer cells". Cancer Res. 56 (20): 4586–9. PMID 8840966.
  • Venkataramani R, Swaminathan K, Marmorstein R (1998). "Crystal structure of the CDK4/6 inhibitory protein p18INK4c provides insights into ankyrin-like repeat structure/function and tumor-derived p16INK4 mutations". Nat. Struct. Biol. 5 (1): 74–81. doi:10.1038/nsb0198-74. PMID 9437433.
  • Fåhraeus R, Laín S, Ball KL, Lane DP (1998). "Characterization of the cyclin-dependent kinase inhibitory domain of the INK4 family as a model for a synthetic tumour suppressor molecule". Oncogene. 16 (5): 587–96. doi:10.1038/sj.onc.1201580. PMID 9482104.
  • Iolascon A, Giordani L, Moretti A, Basso G, Borriello A, Della Ragione F (1998). "Analysis of CDKN2A, CDKN2B, CDKN2C, and cyclin Ds gene status in hepatoblastoma". Hepatology. 27 (4): 989–95. doi:10.1002/hep.510270414. PMID 9537438.
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