KCNAB1: Difference between revisions

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{{Infobox_gene}}
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'''Voltage-gated potassium channel subunit beta-1''' is a [[protein]] that in humans is encoded by the ''KCNAB1'' [[gene]].<ref name="pmid8838324">{{cite journal |vauthors=Schultz D, Litt M, Smith L, Thayer M, McCormack K | title = Localization of two potassium channel beta subunit genes, KCNA1B and KCNA2B | journal = Genomics | volume = 31 | issue = 3 | pages = 389–91 |date=Mar 1997 | pmid = 8838324 | pmc =  | doi = 10.1006/geno.1996.0065 }}</ref><ref name="pmid7499366">{{cite journal |vauthors=England SK, Uebele VN, Kodali J, Bennett PB, Tamkun MM | title = A novel K+ channel beta-subunit (hKv beta 1.3) is produced via alternative mRNA splicing | journal = J Biol Chem | volume = 270 | issue = 48 | pages = 28531–4 |date=Jan 1996 | pmid = 7499366 | pmc =  | doi =10.1074/jbc.270.48.28531 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: KCNAB1 potassium voltage-gated channel, shaker-related subfamily, beta member 1| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7881| accessdate = }}</ref>
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{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Potassium voltage-gated channel, shaker-related subfamily, beta member 1
| HGNCid = 6228
| Symbol = KCNAB1
| AltSymbols =; AKR6A3; KCNA1B; KV-BETA-1; Kvb1.3; hKvBeta3; hKvb3
| OMIM = 601141
| ECnumber =
| Homologene = 56491
| MGIid = 109155
  | GeneAtlas_image1 = PBB_GE_KCNAB1_210078_s_at_tn.png
| GeneAtlas_image2 = PBB_GE_KCNAB1_208213_s_at_tn.png
| GeneAtlas_image3 = PBB_GE_KCNAB1_210079_x_at_tn.png
| Function = {{GNF_GO|id=GO:0005249 |text = voltage-gated potassium channel activity}} {{GNF_GO|id=GO:0015459 |text = potassium channel regulator activity}} {{GNF_GO|id=GO:0016491 |text = oxidoreductase activity}} {{GNF_GO|id=GO:0030955 |text = potassium ion binding}}
| Component = {{GNF_GO|id=GO:0005737 |text = cytoplasm}} {{GNF_GO|id=GO:0016021 |text = integral to membrane}}
  | Process = {{GNF_GO|id=GO:0006811 |text = ion transport}} {{GNF_GO|id=GO:0006813 |text = potassium ion transport}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 7881
    | Hs_Ensembl = ENSG00000169282
    | Hs_RefseqProtein = NP_003462
    | Hs_RefseqmRNA = NM_003471
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 3
    | Hs_GenLoc_start = 157321095
    | Hs_GenLoc_end = 157739237
    | Hs_Uniprot = Q14722
    | Mm_EntrezGene = 16497
    | Mm_Ensembl = ENSMUSG00000027827
    | Mm_RefseqmRNA = NM_010597
    | Mm_RefseqProtein = NP_034727
    | Mm_GenLoc_db =   
    | Mm_GenLoc_chr = 3
    | Mm_GenLoc_start = 65197313
    | Mm_GenLoc_end = 65466155
    | Mm_Uniprot = Q3U6C5
  }}
}}
'''Potassium voltage-gated channel, shaker-related subfamily, beta member 1''', also known as '''KCNAB1''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: KCNAB1 potassium voltage-gated channel, shaker-related subfamily, beta member 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7881| accessdate = }}</ref>


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{{PBB_Summary
{{PBB_Summary
| section_title =  
| section_title =  
| summary_text = Potassium channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. Four sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in Drosophila, and each has been shown to have human homolog(s). This gene encodes a member of the potassium channel, voltage-gated, shaker-related subfamily. This member includes three distinct isoforms which are encoded by three alternatively spliced transcript variants of this gene. These three isoforms are beta subunits, which form heteromultimeric complex with alpha subunits and modulate the activity of the pore-forming alpha subunits.<ref name="entrez">{{cite web | title = Entrez Gene: KCNAB1 potassium voltage-gated channel, shaker-related subfamily, beta member 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7881| accessdate = }}</ref>
| summary_text = Potassium channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. Four sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in Drosophila, and each has been shown to have human homolog(s). This gene encodes a member of the potassium channel, voltage-gated, shaker-related subfamily. This member includes three distinct isoforms that are encoded by three alternatively spliced transcript variants of this gene. These three isoforms are beta subunits, which form heteromultimeric complex with alpha subunits and modulate the activity of the pore-forming alpha subunits.<ref name="entrez" />
}}
}}


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==References==
==References==
{{reflist|2}}
{{reflist}}


==Further reading==
==Further reading==
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{{PBB_Further_reading  
{{PBB_Further_reading  
| citations =  
| citations =  
*{{cite journal | author=England SK, Uebele VN, Kodali J, ''et al.'' |title=A novel K+ channel beta-subunit (hKv beta 1.3) is produced via alternative mRNA splicing. |journal=J. Biol. Chem. |volume=270 |issue= 48 |pages= 28531-4 |year= 1996 |pmid= 7499366 |doi=  }}
*{{cite journal   |vauthors=England SK, Uebele VN, Shear H, etal |title=Characterization of a voltage-gated K+ channel beta subunit expressed in human heart |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=92 |issue= 14 |pages= 6309–13 |year= 1995 |pmid= 7603988 |doi=10.1073/pnas.92.14.6309  | pmc=41507 }}
*{{cite journal  | author=England SK, Uebele VN, Shear H, ''et al.'' |title=Characterization of a voltage-gated K+ channel beta subunit expressed in human heart. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=92 |issue= 14 |pages= 6309-13 |year= 1995 |pmid= 7603988 |doi=  }}
*{{cite journal   |vauthors=McCormack K, McCormack T, Tanouye M, etal |title=Alternative splicing of the human Shaker K+ channel beta 1 gene and functional expression of the beta 2 gene product |journal=FEBS Lett. |volume=370 |issue= 1–2 |pages= 32–6 |year= 1995 |pmid= 7649300 |doi=10.1016/0014-5793(95)00785-8 }}
*{{cite journal | author=McCormack K, McCormack T, Tanouye M, ''et al.'' |title=Alternative splicing of the human Shaker K+ channel beta 1 gene and functional expression of the beta 2 gene product. |journal=FEBS Lett. |volume=370 |issue= 1-2 |pages= 32-6 |year= 1995 |pmid= 7649300 |doi=  }}
*{{cite journal  |vauthors=Majumder K, De Biasi M, Wang Z, Wible BA |title=Molecular cloning and functional expression of a novel potassium channel beta-subunit from human atrium |journal=FEBS Lett. |volume=361 |issue= 1 |pages= 13–6 |year= 1995 |pmid= 7890032 |doi=10.1016/0014-5793(95)00120-X }}
*{{cite journal  | author=Majumder K, De Biasi M, Wang Z, Wible BA |title=Molecular cloning and functional expression of a novel potassium channel beta-subunit from human atrium. |journal=FEBS Lett. |volume=361 |issue= 1 |pages= 13-6 |year= 1995 |pmid= 7890032 |doi=  }}
*{{cite journal   |vauthors=Morales MJ, Castellino RC, Crews AL, etal |title=A novel beta subunit increases rate of inactivation of specific voltage-gated potassium channel alpha subunits |journal=J. Biol. Chem. |volume=270 |issue= 11 |pages= 6272–7 |year= 1995 |pmid= 7890764 |doi=10.1074/jbc.270.11.6272 }}
*{{cite journal | author=Morales MJ, Castellino RC, Crews AL, ''et al.'' |title=A novel beta subunit increases rate of inactivation of specific voltage-gated potassium channel alpha subunits. |journal=J. Biol. Chem. |volume=270 |issue= 11 |pages= 6272-7 |year= 1995 |pmid= 7890764 |doi=  }}
*{{cite journal  |vauthors=McCormack T, McCormack K |title=Shaker K+ channel beta subunits belong to an NAD(P)H-dependent oxidoreductase superfamily |journal=Cell |volume=79 |issue= 7 |pages= 1133–5 |year= 1995 |pmid= 8001150 |doi=10.1016/0092-8674(94)90004-3 }}
*{{cite journal  | author=McCormack T, McCormack K |title=Shaker K+ channel beta subunits belong to an NAD(P)H-dependent oxidoreductase superfamily. |journal=Cell |volume=79 |issue= 7 |pages= 1133-5 |year= 1995 |pmid= 8001150 |doi=  }}
*{{cite journal  |vauthors=Nakahira K, Shi G, Rhodes KJ, Trimmer JS |title=Selective interaction of voltage-gated K+ channel beta-subunits with alpha-subunits |journal=J. Biol. Chem. |volume=271 |issue= 12 |pages= 7084–9 |year= 1996 |pmid= 8636142 |doi=10.1074/jbc.271.12.7084  }}
*{{cite journal  | author=Nakahira K, Shi G, Rhodes KJ, Trimmer JS |title=Selective interaction of voltage-gated K+ channel beta-subunits with alpha-subunits. |journal=J. Biol. Chem. |volume=271 |issue= 12 |pages= 7084-9 |year= 1996 |pmid= 8636142 |doi=  }}
*{{cite journal   |vauthors=Leicher T, Roeper J, Weber K, etal |title=Structural and functional characterization of human potassium channel subunit beta 1 (KCNA1B) |journal=Neuropharmacology |volume=35 |issue= 7 |pages= 787–95 |year= 1997 |pmid= 8938711 |doi=10.1016/0028-3908(96)00133-5 }}
*{{cite journal  | author=Schultz D, Litt M, Smith L, ''et al.'' |title=Localization of two potassium channel beta subunit genes, KCNA1B and KCNA2B. |journal=Genomics |volume=31 |issue= 3 |pages= 389-91 |year= 1997 |pmid= 8838324 |doi= 10.1006/geno.1996.0065 }}
*{{cite journal   |vauthors=Hanada T, Lin L, Chandy KG, etal |title=Human homologue of the Drosophila discs large tumor suppressor binds to p56lck tyrosine kinase and Shaker type Kv1.3 potassium channel in T lymphocytes |journal=J. Biol. Chem. |volume=272 |issue= 43 |pages= 26899–904 |year= 1997 |pmid= 9341123 |doi=10.1074/jbc.272.43.26899 }}
*{{cite journal | author=Leicher T, Roeper J, Weber K, ''et al.'' |title=Structural and functional characterization of human potassium channel subunit beta 1 (KCNA1B). |journal=Neuropharmacology |volume=35 |issue= 7 |pages= 787-95 |year= 1997 |pmid= 8938711 |doi=  }}
*{{cite journal  |vauthors=Leicher T, Bähring R, Isbrandt D, Pongs O |title=Coexpression of the KCNA3B gene product with Kv1.5 leads to a novel A-type potassium channel |journal=J. Biol. Chem. |volume=273 |issue= 52 |pages= 35095–101 |year= 1999 |pmid= 9857044 |doi=10.1074/jbc.273.52.35095 }}
*{{cite journal | author=Hanada T, Lin L, Chandy KG, ''et al.'' |title=Human homologue of the Drosophila discs large tumor suppressor binds to p56lck tyrosine kinase and Shaker type Kv1.3 potassium channel in T lymphocytes. |journal=J. Biol. Chem. |volume=272 |issue= 43 |pages= 26899-904 |year= 1997 |pmid= 9341123 |doi=  }}
*{{cite journal   |vauthors=Suzuki Y, Ishihara D, Sasaki M, etal |title=Statistical analysis of the 5' untranslated region of human mRNA using "Oligo-Capped" cDNA libraries |journal=Genomics |volume=64 |issue= 3 |pages= 286–97 |year= 2000 |pmid= 10756096 |doi= 10.1006/geno.2000.6076 }}
*{{cite journal  | author=Leicher T, Bähring R, Isbrandt D, Pongs O |title=Coexpression of the KCNA3B gene product with Kv1.5 leads to a novel A-type potassium channel. |journal=J. Biol. Chem. |volume=273 |issue= 52 |pages= 35095-101 |year= 1999 |pmid= 9857044 |doi=  }}
*{{cite journal   |vauthors=Kuryshev YA, Wible BA, Gudz TI, etal |title=KChAP/Kvbeta1.2 interactions and their effects on cardiac Kv channel expression |journal=Am. J. Physiol., Cell Physiol. |volume=281 |issue= 1 |pages= C290–9 |year= 2001 |pmid= 11401852 |doi=  10.1152/ajpcell.2001.281.1.c290}}
*{{cite journal | author=Suzuki Y, Ishihara D, Sasaki M, ''et al.'' |title=Statistical analysis of the 5' untranslated region of human mRNA using "Oligo-Capped" cDNA libraries. |journal=Genomics |volume=64 |issue= 3 |pages= 286-97 |year= 2000 |pmid= 10756096 |doi= 10.1006/geno.2000.6076 }}
*{{cite journal   |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 }}
*{{cite journal | author=Kuryshev YA, Wible BA, Gudz TI, ''et al.'' |title=KChAP/Kvbeta1.2 interactions and their effects on cardiac Kv channel expression. |journal=Am. J. Physiol., Cell Physiol. |volume=281 |issue= 1 |pages= C290-9 |year= 2001 |pmid= 11401852 |doi=  }}
*{{cite journal   |vauthors=Nie DY, Zhou ZH, Ang BT, etal |title=Nogo-A at CNS paranodes is a ligand of Caspr: possible regulation of K+ channel localization |journal=EMBO J. |volume=22 |issue= 21 |pages= 5666–78 |year= 2003 |pmid= 14592966 |doi= 10.1093/emboj/cdg570 | pmc=275427 }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal   |vauthors=Ota T, Suzuki Y, Nishikawa T, etal |title=Complete sequencing and characterization of 21,243 full-length human cDNAs |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
*{{cite journal | author=Nie DY, Zhou ZH, Ang BT, ''et al.'' |title=Nogo-A at CNS paranodes is a ligand of Caspr: possible regulation of K(+) channel localization. |journal=EMBO J. |volume=22 |issue= 21 |pages= 5666-78 |year= 2003 |pmid= 14592966 |doi= 10.1093/emboj/cdg570 }}
*{{cite journal   |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 }}
*{{cite journal | author=Ota T, Suzuki Y, Nishikawa T, ''et al.'' |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40-5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
*{{cite journal   |vauthors=Kimura K, Wakamatsu A, Suzuki Y, etal |title=Diversification of transcriptional modulation: Large-scale identification and characterization of putative alternative promoters of human genes |journal=Genome Res. |volume=16 |issue= 1 |pages= 55–65 |year= 2006 |pmid= 16344560 |doi= 10.1101/gr.4039406 | pmc=1356129 }}
*{{cite journal | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal | author=Kimura K, Wakamatsu A, Suzuki Y, ''et al.'' |title=Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. |journal=Genome Res. |volume=16 |issue= 1 |pages= 55-65 |year= 2006 |pmid= 16344560 |doi= 10.1101/gr.4039406 }}
}}
}}
{{refend}}
{{refend}}
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* {{MeshName|KCNAB1+protein,+human}}
* {{MeshName|KCNAB1+protein,+human}}


{{membrane-protein-stub}}
{{NLM content}}
{{NLM content}}
{{Ion channels}}
{{Ion channels|g3}}
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[[Category:Ion channels]]
[[Category:Ion channels]]
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{{membrane-protein-stub}}

Latest revision as of 10:06, 2 March 2018

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Voltage-gated potassium channel subunit beta-1 is a protein that in humans is encoded by the KCNAB1 gene.[1][2][3]

Potassium channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. Four sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in Drosophila, and each has been shown to have human homolog(s). This gene encodes a member of the potassium channel, voltage-gated, shaker-related subfamily. This member includes three distinct isoforms that are encoded by three alternatively spliced transcript variants of this gene. These three isoforms are beta subunits, which form heteromultimeric complex with alpha subunits and modulate the activity of the pore-forming alpha subunits.[3]

See also

References

  1. ↑ Schultz D, Litt M, Smith L, Thayer M, McCormack K (Mar 1997). "Localization of two potassium channel beta subunit genes, KCNA1B and KCNA2B". Genomics. 31 (3): 389–91. doi:10.1006/geno.1996.0065. PMID 8838324.
  2. ↑ England SK, Uebele VN, Kodali J, Bennett PB, Tamkun MM (Jan 1996). "A novel K+ channel beta-subunit (hKv beta 1.3) is produced via alternative mRNA splicing". J Biol Chem. 270 (48): 28531–4. doi:10.1074/jbc.270.48.28531. PMID 7499366.
  3. ↑ 3.0 3.1 "Entrez Gene: KCNAB1 potassium voltage-gated channel, shaker-related subfamily, beta member 1".

Further reading

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


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