KCNIP2: Difference between revisions

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{{Infobox_gene}}
{{PBB_Controls
'''K<sub>v</sub> channel-interacting protein 2''' also known as '''KChIP2''' is a [[protein]] that in humans is encoded by the ''KCNIP2'' [[gene]].<ref name="pmid10676964">{{cite journal | vauthors = An WF, Bowlby MR, Betty M, Cao J, Ling HP, Mendoza G, Hinson JW, Mattsson KI, Strassle BW, Trimmer JS, Rhodes KJ | title = Modulation of A-type potassium channels by a family of calcium sensors | journal = Nature | volume = 403 | issue = 6769 | pages = 553–6 | date = Feb 2000 | pmid = 10676964 | pmc = | doi = 10.1038/35000592 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: KCNIP2 Kv channel interacting protein 2| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=30819| accessdate = }}</ref>
| update_page = yes
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| update_protein_box = yes
| update_summary = yes
| update_citations = yes
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Function ==
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Kv channel interacting protein 2
| HGNCid = 15522
| Symbol = KCNIP2
| AltSymbols =; DKFZp566L1246; KCHIP2; MGC17241
| OMIM = 604661
| ECnumber = 
| Homologene = 23710
| MGIid = 
| GeneAtlas_image1 = PBB_GE_KCNIP2_221321_s_at_tn.png
| Function = {{GNF_GO|id=GO:0005216 |text = ion channel activity}} {{GNF_GO|id=GO:0005244 |text = voltage-gated ion channel activity}} {{GNF_GO|id=GO:0005250 |text = A-type (transient outward) potassium channel activity}} {{GNF_GO|id=GO:0005267 |text = potassium channel activity}} {{GNF_GO|id=GO:0005509 |text = calcium ion binding}} {{GNF_GO|id=GO:0030955 |text = potassium ion binding}} {{GNF_GO|id=GO:0046923 |text = ER retention sequence binding}} {{GNF_GO|id=GO:0047485 |text = protein N-terminus binding}}
| Component = {{GNF_GO|id=GO:0005737 |text = cytoplasm}} {{GNF_GO|id=GO:0008076 |text = voltage-gated potassium channel complex}} {{GNF_GO|id=GO:0016020 |text = membrane}}
| Process = {{GNF_GO|id=GO:0005513 |text = detection of calcium ion}} {{GNF_GO|id=GO:0006811 |text = ion transport}} {{GNF_GO|id=GO:0006813 |text = potassium ion transport}} {{GNF_GO|id=GO:0006936 |text = muscle contraction}} {{GNF_GO|id=GO:0007165 |text = signal transduction}} {{GNF_GO|id=GO:0007268 |text = synaptic transmission}} {{GNF_GO|id=GO:0008016 |text = regulation of heart contraction}} {{GNF_GO|id=GO:0045163 |text = clustering of voltage-gated potassium channels}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 30819
    | Hs_Ensembl = ENSG00000120049
    | Hs_RefseqProtein = NP_055406
    | Hs_RefseqmRNA = NM_014591
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 10
    | Hs_GenLoc_start = 103575721
    | Hs_GenLoc_end = 103593667
    | Hs_Uniprot = Q9NS61
    | Mm_EntrezGene = 
    | Mm_Ensembl = 
    | Mm_RefseqmRNA = 
    | Mm_RefseqProtein = 
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 
    | Mm_GenLoc_start = 
    | Mm_GenLoc_end = 
    | Mm_Uniprot = 
  }}
}}
'''Kv channel interacting protein 2''', also known as '''KCNIP2''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: KCNIP2 Kv channel interacting protein 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=30819| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
This gene encodes a member of the family of voltage-gated potassium ([[voltage-gated potassium channel|K<sub>v</sub>]]) channel-interacting proteins (KCNIPs, also frequently called "KChIP"), which belong to the [[recoverin]] branch of the [[EF hand|EF-hand]] superfamily.<ref name="pmid17311005">{{cite journal | vauthors = Burgoyne RD | title = Neuronal calcium sensor proteins: generating diversity in neuronal Ca2+ signalling | journal = Nature Reviews. Neuroscience | volume = 8 | issue = 3 | pages = 182–93 | date = Mar 2007 | pmid = 17311005 | pmc = 1887812 | doi = 10.1038/nrn2093 }}</ref> Members of the KCNIP family are small calcium binding proteins. They all have EF-hand-like domains, and differ from each other in the [[N-terminus]]. They are integral subunit components of native K<sub>v</sub>4 channel complexes. They may regulate A-type currents, and hence neuronal excitability, in response to changes in intracellular calcium. Alternative splicing results in multiple transcript variant encoding different isoforms.<ref name="entrez" />
{{PBB_Summary
| section_title =
| summary_text = This gene encodes a member of the family of voltage-gated potassium (Kv) channel-interacting proteins (KCNIPs), which belongs to the recoverin branch of the EF-hand superfamily. Members of the KCNIP family are small calcium binding proteins. They all have EF-hand-like domains, and differ from each other in the N-terminus. They are integral subunit components of native Kv4 channel complexes. They may regulate A-type currents, and hence neuronal excitability, in response to changes in intracellular calcium. Multiple alternatively spliced transcript variants encoding distinct isoforms have been identified from this gene.<ref name="entrez">{{cite web | title = Entrez Gene: KCNIP2 Kv channel interacting protein 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=30819| accessdate = }}</ref>
}}


==See also==
== See also ==
* [[Voltage-gated potassium channel]]
* [[Voltage-gated potassium channel]]


==References==
== References ==
{{reflist|2}}
{{reflist}}


==Further reading==
== Further reading ==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
* {{cite journal | vauthors = Hartley JL, Temple GF, Brasch MA | title = DNA cloning using in vitro site-specific recombination | journal = Genome Research | volume = 10 | issue = 11 | pages = 1788–95 | date = Nov 2000 | pmid = 11076863 | pmc = 310948 | doi = 10.1101/gr.143000 }}
| citations =
* {{cite journal | vauthors = Wiemann S, Weil B, Wellenreuther R, Gassenhuber J, Glassl S, Ansorge W, Böcher M, Blöcker H, Bauersachs S, Blum H, Lauber J, Düsterhöft A, Beyer A, Köhrer K, Strack N, Mewes HW, Ottenwälder B, Obermaier B, Tampe J, Heubner D, Wambutt R, Korn B, Klein M, Poustka A | title = Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs | journal = Genome Research | volume = 11 | issue = 3 | pages = 422–35 | date = Mar 2001 | pmid = 11230166 | pmc = 311072 | doi = 10.1101/gr.GR1547R }}
*{{cite journal  | author=An WF, Bowlby MR, Betty M, ''et al.'' |title=Modulation of A-type potassium channels by a family of calcium sensors. |journal=Nature |volume=403 |issue= 6769 |pages= 553-6 |year= 2000 |pmid= 10676964 |doi= 10.1038/35000592 }}
* {{cite journal | vauthors = Ohya S, Morohashi Y, Muraki K, Tomita T, Watanabe M, Iwatsubo T, Imaizumi Y | title = Molecular cloning and expression of the novel splice variants of K(+) channel-interacting protein 2 | journal = Biochemical and Biophysical Research Communications | volume = 282 | issue = 1 | pages = 96–102 | date = Mar 2001 | pmid = 11263977 | doi = 10.1006/bbrc.2001.4558 }}
*{{cite journal | author=Hartley JL, Temple GF, Brasch MA |title=DNA cloning using in vitro site-specific recombination. |journal=Genome Res. |volume=10 |issue= 11 |pages= 1788-95 |year= 2001 |pmid= 11076863 |doi= }}
* {{cite journal | vauthors = Bähring R, Dannenberg J, Peters HC, Leicher T, Pongs O, Isbrandt D | title = Conserved Kv4 N-terminal domain critical for effects of Kv channel-interacting protein 2.2 on channel expression and gating | journal = The Journal of Biological Chemistry | volume = 276 | issue = 26 | pages = 23888–94 | date = Jun 2001 | pmid = 11287421 | doi = 10.1074/jbc.M101320200 }}
*{{cite journal | author=Wiemann S, Weil B, Wellenreuther R, ''et al.'' |title=Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. |journal=Genome Res. |volume=11 |issue= 3 |pages= 422-35 |year= 2001 |pmid= 11230166 |doi= 10.1101/gr.154701 }}
* {{cite journal | vauthors = Rosati B, Pan Z, Lypen S, Wang HS, Cohen I, Dixon JE, McKinnon D | title = Regulation of KChIP2 potassium channel beta subunit gene expression underlies the gradient of transient outward current in canine and human ventricle | journal = The Journal of Physiology | volume = 533 | issue = Pt 1 | pages = 119–25 | date = May 2001 | pmid = 11351020 | pmc = 2278594 | doi = 10.1111/j.1469-7793.2001.0119b.x }}
*{{cite journal | author=Ohya S, Morohashi Y, Muraki K, ''et al.'' |title=Molecular cloning and expression of the novel splice variants of K(+) channel-interacting protein 2. |journal=Biochem. Biophys. Res. Commun. |volume=282 |issue= 1 |pages= 96-102 |year= 2001 |pmid= 11263977 |doi= 10.1006/bbrc.2001.4558 }}
* {{cite journal | vauthors = Decher N, Uyguner O, Scherer CR, Karaman B, Yüksel-Apak M, Busch AE, Steinmeyer K, Wollnik B | title = hKChIP2 is a functional modifier of hKv4.3 potassium channels: cloning and expression of a short hKChIP2 splice variant | journal = Cardiovascular Research | volume = 52 | issue = 2 | pages = 255–64 | date = Nov 2001 | pmid = 11684073 | doi = 10.1016/S0008-6363(01)00374-1 }}
*{{cite journal | author=Bähring R, Dannenberg J, Peters HC, ''et al.'' |title=Conserved Kv4 N-terminal domain critical for effects of Kv channel-interacting protein 2.2 on channel expression and gating. |journal=J. Biol. Chem. |volume=276 |issue= 26 |pages= 23888-94 |year= 2001 |pmid= 11287421 |doi= 10.1074/jbc.M101320200 }}
* {{cite journal | vauthors = Kuo HC, Cheng CF, Clark RB, Lin JJ, Lin JL, Hoshijima M, Nguyêñ-Trân VT, Gu Y, Ikeda Y, Chu PH, Ross J, Giles WR, Chien KR | title = A defect in the Kv channel-interacting protein 2 (KChIP2) gene leads to a complete loss of I(to) and confers susceptibility to ventricular tachycardia | journal = Cell | volume = 107 | issue = 6 | pages = 801–13 | date = Dec 2001 | pmid = 11747815 | doi = 10.1016/S0092-8674(01)00588-8 }}
*{{cite journal | author=Rosati B, Pan Z, Lypen S, ''et al.'' |title=Regulation of KChIP2 potassium channel beta subunit gene expression underlies the gradient of transient outward current in canine and human ventricle. |journal=J. Physiol. (Lond.) |volume=533 |issue= Pt 1 |pages= 119-25 |year= 2001 |pmid= 11351020 |doi= }}
* {{cite journal | vauthors = Deschênes I, DiSilvestre D, Juang GJ, Wu RC, An WF, Tomaselli GF | title = Regulation of Kv4.3 current by KChIP2 splice variants: a component of native cardiac I(to)? | journal = Circulation | volume = 106 | issue = 4 | pages = 423–9 | date = Jul 2002 | pmid = 12135940 | doi = 10.1161/01.CIR.0000025417.65658.B6 }}
*{{cite journal | author=Decher N, Uyguner O, Scherer CR, ''et al.'' |title=hKChIP2 is a functional modifier of hKv4.3 potassium channels: cloning and expression of a short hKChIP2 splice variant. |journal=Cardiovasc. Res. |volume=52 |issue= 2 |pages= 255-64 |year= 2002 |pmid= 11684073 |doi= }}
* {{cite journal | vauthors = Deschênes I, Tomaselli GF | title = Modulation of Kv4.3 current by accessory subunits | journal = FEBS Letters | volume = 528 | issue = 1-3 | pages = 183–8 | date = Sep 2002 | pmid = 12297301 | doi = 10.1016/S0014-5793(02)03296-9 }}
*{{cite journal | author=Kuo HC, Cheng CF, Clark RB, ''et al.'' |title=A defect in the Kv channel-interacting protein 2 (KChIP2) gene leads to a complete loss of I(to) and confers susceptibility to ventricular tachycardia. |journal=Cell |volume=107 |issue= 6 |pages= 801-13 |year= 2002 |pmid= 11747815 |doi= }}
* {{cite journal | vauthors = Shibata R, Misonou H, Campomanes CR, Anderson AE, Schrader LA, Doliveira LC, Carroll KI, Sweatt JD, Rhodes KJ, Trimmer JS | title = A fundamental role for KChIPs in determining the molecular properties and trafficking of Kv4.2 potassium channels | journal = The Journal of Biological Chemistry | volume = 278 | issue = 38 | pages = 36445–54 | date = Sep 2003 | pmid = 12829703 | doi = 10.1074/jbc.M306142200 }}
*{{cite journal | author=Deschênes I, DiSilvestre D, Juang GJ, ''et al.'' |title=Regulation of Kv4.3 current by KChIP2 splice variants: a component of native cardiac I(to)? |journal=Circulation |volume=106 |issue= 4 |pages= 423-9 |year= 2002 |pmid= 12135940 |doi= }}
* {{cite journal | vauthors = Ren X, Shand SH, Takimoto K | title = Effective association of Kv channel-interacting proteins with Kv4 channel is mediated with their unique core peptide | journal = The Journal of Biological Chemistry | volume = 278 | issue = 44 | pages = 43564–70 | date = Oct 2003 | pmid = 12928444 | doi = 10.1074/jbc.M302337200 }}
*{{cite journal | author=Deschênes I, Tomaselli GF |title=Modulation of Kv4.3 current by accessory subunits. |journal=FEBS Lett. |volume=528 |issue= 1-3 |pages= 183-8 |year= 2002 |pmid= 12297301 |doi= }}
* {{cite journal | vauthors = Kim LA, Furst J, Butler MH, Xu S, Grigorieff N, Goldstein SA | title = Ito channels are octomeric complexes with four subunits of each Kv4.2 and K+ channel-interacting protein 2 | journal = The Journal of Biological Chemistry | volume = 279 | issue = 7 | pages = 5549–54 | date = Feb 2004 | pmid = 14623880 | doi = 10.1074/jbc.M311332200 }}
*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
* {{cite journal | vauthors = Kim LA, Furst J, Gutierrez D, Butler MH, Xu S, Goldstein SA, Grigorieff N | title = Three-dimensional structure of I(to); Kv4.2-KChIP2 ion channels by electron microscopy at 21 Angstrom resolution | journal = Neuron | volume = 41 | issue = 4 | pages = 513–9 | date = Feb 2004 | pmid = 14980201 | doi = 10.1016/S0896-6273(04)00050-9 }}
*{{cite journal | author=Shibata R, Misonou H, Campomanes CR, ''et al.'' |title=A fundamental role for KChIPs in determining the molecular properties and trafficking of Kv4.2 potassium channels. |journal=J. Biol. Chem. |volume=278 |issue= 38 |pages= 36445-54 |year= 2003 |pmid= 12829703 |doi= 10.1074/jbc.M306142200 }}
* {{cite journal | vauthors = Lin YL, Lin SR, Wu TT, Chang LS | title = Evidence showing an intermolecular interaction between KChIP proteins and Taiwan cobra cardiotoxins | journal = Biochemical and Biophysical Research Communications | volume = 319 | issue = 3 | pages = 720–4 | date = Jul 2004 | pmid = 15184042 | doi = 10.1016/j.bbrc.2004.05.064 }}
*{{cite journal | author=Ren X, Shand SH, Takimoto K |title=Effective association of Kv channel-interacting proteins with Kv4 channel is mediated with their unique core peptide. |journal=J. Biol. Chem. |volume=278 |issue= 44 |pages= 43564-70 |year= 2003 |pmid= 12928444 |doi= 10.1074/jbc.M302337200 }}
* {{cite journal | vauthors = Rhodes KJ, Carroll KI, Sung MA, Doliveira LC, Monaghan MM, Burke SL, Strassle BW, Buchwalder L, Menegola M, Cao J, An WF, Trimmer JS | title = KChIPs and Kv4 alpha subunits as integral components of A-type potassium channels in mammalian brain | journal = The Journal of Neuroscience | volume = 24 | issue = 36 | pages = 7903–15 | date = Sep 2004 | pmid = 15356203 | doi = 10.1523/JNEUROSCI.0776-04.2004 }}
*{{cite journal | author=Kim LA, Furst J, Butler MH, ''et al.'' |title=Ito channels are octomeric complexes with four subunits of each Kv4.2 and K+ channel-interacting protein 2. |journal=J. Biol. Chem. |volume=279 |issue= 7 |pages= 5549-54 |year= 2004 |pmid= 14623880 |doi= 10.1074/jbc.M311332200 }}
* {{cite journal | vauthors = Lin YL, Chen CY, Cheng CP, Chang LS | title = Protein-protein interactions of KChIP proteins and Kv4.2 | journal = Biochemical and Biophysical Research Communications | volume = 321 | issue = 3 | pages = 606–10 | date = Aug 2004 | pmid = 15358149 | doi = 10.1016/j.bbrc.2004.07.006 }}
*{{cite journal | author=Ota T, Suzuki Y, Nishikawa T, ''et al.'' |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40-5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
*{{cite journal  | author=Kim LA, Furst J, Gutierrez D, ''et al.'' |title=Three-dimensional structure of I(to); Kv4.2-KChIP2 ion channels by electron microscopy at 21 Angstrom resolution. |journal=Neuron |volume=41 |issue= 4 |pages= 513-9 |year= 2004 |pmid= 14980201 |doi= }}
*{{cite journal | author=Lin YL, Lin SR, Wu TT, Chang LS |title=Evidence showing an intermolecular interaction between KChIP proteins and Taiwan cobra cardiotoxins. |journal=Biochem. Biophys. Res. Commun. |volume=319 |issue= 3 |pages= 720-4 |year= 2004 |pmid= 15184042 |doi= 10.1016/j.bbrc.2004.05.064 }}
*{{cite journal | author=Rhodes KJ, Carroll KI, Sung MA, ''et al.'' |title=KChIPs and Kv4 alpha subunits as integral components of A-type potassium channels in mammalian brain. |journal=J. Neurosci. |volume=24 |issue= 36 |pages= 7903-15 |year= 2005 |pmid= 15356203 |doi= 10.1523/JNEUROSCI.0776-04.2004 }}
*{{cite journal | author=Lin YL, Chen CY, Cheng CP, Chang LS |title=Protein-protein interactions of KChIP proteins and Kv4.2. |journal=Biochem. Biophys. Res. Commun. |volume=321 |issue= 3 |pages= 606-10 |year= 2004 |pmid= 15358149 |doi= 10.1016/j.bbrc.2004.07.006 }}
*{{cite journal  | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
}}
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[[Category:EF-hand-containing proteins]]

Latest revision as of 01:55, 27 October 2017

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External IDsGeneCards: [1]
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SpeciesHumanMouse
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Wikidata
View/Edit Human

Kv channel-interacting protein 2 also known as KChIP2 is a protein that in humans is encoded by the KCNIP2 gene.[1][2]

Function

This gene encodes a member of the family of voltage-gated potassium (Kv) channel-interacting proteins (KCNIPs, also frequently called "KChIP"), which belong to the recoverin branch of the EF-hand superfamily.[3] Members of the KCNIP family are small calcium binding proteins. They all have EF-hand-like domains, and differ from each other in the N-terminus. They are integral subunit components of native Kv4 channel complexes. They may regulate A-type currents, and hence neuronal excitability, in response to changes in intracellular calcium. Alternative splicing results in multiple transcript variant encoding different isoforms.[2]

See also

References

  1. ↑ An WF, Bowlby MR, Betty M, Cao J, Ling HP, Mendoza G, Hinson JW, Mattsson KI, Strassle BW, Trimmer JS, Rhodes KJ (Feb 2000). "Modulation of A-type potassium channels by a family of calcium sensors". Nature. 403 (6769): 553–6. doi:10.1038/35000592. PMID 10676964.
  2. ↑ 2.0 2.1 "Entrez Gene: KCNIP2 Kv channel interacting protein 2".
  3. ↑ Burgoyne RD (Mar 2007). "Neuronal calcium sensor proteins: generating diversity in neuronal Ca2+ signalling". Nature Reviews. Neuroscience. 8 (3): 182–93. doi:10.1038/nrn2093. PMC 1887812. PMID 17311005.

Further reading

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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