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<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{Infobox_gene}}
{{PBB_Controls
'''Potassium voltage-gated channel subfamily KQT member 5''' is a [[protein]] that in humans is encoded by the ''KCNQ5'' [[gene]].<ref name="pmid10787416">{{cite journal |vauthors=Lerche C, Scherer CR, Seebohm G, Derst C, Wei AD, Busch AE, Steinmeyer K | title = Molecular cloning and functional expression of KCNQ5, a potassium channel subunit that may contribute to neuronal M-current diversity | journal = J Biol Chem | volume = 275 | issue = 29 | pages = 22395–400 |date=Aug 2000 | pmid = 10787416 | pmc =  | doi = 10.1074/jbc.M002378200 }}</ref><ref name="pmid10816588">{{cite journal |vauthors=Schroeder BC, Hechenberger M, Weinreich F, Kubisch C, Jentsch TJ | title = KCNQ5, a novel potassium channel broadly expressed in brain, mediates M-type currents | journal = J Biol Chem | volume = 275 | issue = 31 | pages = 24089–95 |date=Sep 2000 | pmid = 10816588 | pmc =  | doi = 10.1074/jbc.M003245200 }}</ref><ref name="pmid16382104">{{cite journal |vauthors=Gutman GA, Chandy KG, Grissmer S, Lazdunski M, McKinnon D, Pardo LA, Robertson GA, Rudy B, Sanguinetti MC, Stuhmer W, Wang X | title = International Union of Pharmacology. LIII. Nomenclature and molecular relationships of voltage-gated potassium channels | journal = Pharmacol Rev | volume = 57 | issue = 4 | pages = 473–508 |date=Dec 2005 | pmid = 16382104 | pmc = | doi = 10.1124/pr.57.4.10 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: KCNQ5 potassium voltage-gated channel, KQT-like subfamily, member 5| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=56479| accessdate = }}</ref>
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{{GNF_Protein_box
| image = 
| image_source = 
| PDB =
| Name = Potassium voltage-gated channel, KQT-like subfamily, member 5
| HGNCid = 6299
| Symbol = KCNQ5
| AltSymbols =; Kv7.5
| OMIM = 607357
| ECnumber = 
| Homologene = 28270
| MGIid = 1924937
| Function = {{GNF_GO|id=GO:0005242 |text = inward rectifier potassium channel activity}} {{GNF_GO|id=GO:0030955 |text = potassium ion binding}}
| Component = {{GNF_GO|id=GO:0008076 |text = voltage-gated potassium channel complex}} {{GNF_GO|id=GO:0016020 |text = membrane}} {{GNF_GO|id=GO:0016021 |text = integral to membrane}}
  | Process = {{GNF_GO|id=GO:0006461 |text = protein complex assembly}} {{GNF_GO|id=GO:0006811 |text = ion transport}} {{GNF_GO|id=GO:0006813 |text = potassium ion transport}} {{GNF_GO|id=GO:0007268 |text = synaptic transmission}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 56479
    | Hs_Ensembl = ENSG00000185760
    | Hs_RefseqProtein = NP_062816
    | Hs_RefseqmRNA = NM_019842
    | Hs_GenLoc_db =   
    | Hs_GenLoc_chr = 6
    | Hs_GenLoc_start = 73388530
    | Hs_GenLoc_end = 73965295
    | Hs_Uniprot = Q9NR82
    | Mm_EntrezGene = 226922
    | Mm_Ensembl = ENSMUSG00000028033
    | Mm_RefseqmRNA = NM_023872
    | Mm_RefseqProtein = NP_076361
    | Mm_GenLoc_db =
    | Mm_GenLoc_chr = 1
    | Mm_GenLoc_start = 21387314
    | Mm_GenLoc_end = 21946732
    | Mm_Uniprot = Q9CTU2
  }}
}}
'''Potassium voltage-gated channel, KQT-like subfamily, member 5''', also known as '''KCNQ5''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: KCNQ5 potassium voltage-gated channel, KQT-like subfamily, member 5| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=56479| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
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{{PBB_Summary
{{PBB_Summary
| section_title =  
| section_title =  
| summary_text = This gene is a member of the KCNQ potassium channel gene family that is differentially expressed in subregions of the brain and in skeletal muscle. The protein encoded by this gene yields currents that activate slowly with depolarization and can form heteromeric channels with the protein encoded by the KCNQ3 gene. Currents expressed from this protein have voltage dependences and inhibitor sensitivities in common with M-currents. They are also inhibited by M1 muscarinic receptor activation. Three alternatively spliced transcript variants encoding distinct isoforms have been found for this gene, but the full-length nature of only one has been determined.<ref name="entrez">{{cite web | title = Entrez Gene: KCNQ5 potassium voltage-gated channel, KQT-like subfamily, member 5| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=56479| accessdate = }}</ref>
| summary_text = This gene is a member of the KCNQ potassium channel gene family that is differentially expressed in subregions of the brain and in skeletal muscle. The protein encoded by this gene yields currents that activate slowly with depolarization and can form heteromeric channels with the protein encoded by the KCNQ3 gene. Currents expressed from this protein have voltage dependences and inhibitor sensitivities in common with M-currents. They are also inhibited by M1 muscarinic receptor activation. Three alternatively spliced transcript variants encoding distinct isoforms have been found for this gene, but the full-length nature of only one has been determined.<ref name="entrez">{{cite web | title = Entrez Gene: KCNQ5 potassium voltage-gated channel, KQT-like subfamily, member 5| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=56479| accessdate = }}</ref>
}}
}}
==Interactions==
KCNQ5 has been shown to [[Protein-protein interaction|interact]] with [[KvLQT3]].<ref name=pmid12890507>{{cite journal |doi=10.1016/S0306-4522(03)00321-X |last=Yus-Nájera |first=E |authorlink= |author2=Muñoz A |author3=Salvador N |author4=Jensen B S |author5=Rasmussen H B |author6=Defelipe J |author7=Villarroel A  |year=2003|title=Localization of KCNQ5 in the normal and epileptic human temporal neocortex and hippocampal formation |journal=Neuroscience |volume=120 |issue=2 |pages=353–64 |publisher= |location = United States| issn = 0306-4522| pmid = 12890507 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = }}</ref>


==See also==
==See also==
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==References==
==References==
{{reflist|2}}
{{reflist}}


==Further reading==
==Further reading==
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{{PBB_Further_reading  
{{PBB_Further_reading  
| citations =  
| citations =  
*{{cite journal  | author=Gutman GA, Chandy KG, Grissmer S, ''et al.'' |title=International Union of Pharmacology. LIII. Nomenclature and molecular relationships of voltage-gated potassium channels. |journal=Pharmacol. Rev. |volume=57 |issue= 4 |pages= 473-508 |year= 2006 |pmid= 16382104 |doi= 10.1124/pr.57.4.10 }}
*{{cite journal  |vauthors=Wickenden AD, Zou A, Wagoner PK, Jegla T |title=Characterization of KCNQ5/Q3 potassium channels expressed in mammalian cells. |journal=Br. J. Pharmacol. |volume=132 |issue= 2 |pages= 381–4 |year= 2001 |pmid= 11159685 |doi= 10.1038/sj.bjp.0703861 | pmc=1572592 }}
*{{cite journal  | author=Lerche C, Scherer CR, Seebohm G, ''et al.'' |title=Molecular cloning and functional expression of KCNQ5, a potassium channel subunit that may contribute to neuronal M-current diversity. |journal=J. Biol. Chem. |volume=275 |issue= 29 |pages= 22395-400 |year= 2000 |pmid= 10787416 |doi= 10.1074/jbc.M002378200 }}
*{{cite journal  |vauthors=Yus-Najera E, Santana-Castro I, Villarroel A |title=The identification and characterization of a noncontinuous calmodulin-binding site in noninactivating voltage-dependent KCNQ potassium channels. |journal=J. Biol. Chem. |volume=277 |issue= 32 |pages= 28545–53 |year= 2002 |pmid= 12032157 |doi= 10.1074/jbc.M204130200 }}
*{{cite journal  | author=Schroeder BC, Hechenberger M, Weinreich F, ''et al.'' |title=KCNQ5, a novel potassium channel broadly expressed in brain, mediates M-type currents. |journal=J. Biol. Chem. |volume=275 |issue= 31 |pages= 24089-95 |year= 2000 |pmid= 10816588 |doi= 10.1074/jbc.M003245200 }}
*{{cite journal   |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |bibcode=2002PNAS...9916899M }}
*{{cite journal  | author=Wickenden AD, Zou A, Wagoner PK, Jegla T |title=Characterization of KCNQ5/Q3 potassium channels expressed in mammalian cells. |journal=Br. J. Pharmacol. |volume=132 |issue= 2 |pages= 381-4 |year= 2001 |pmid= 11159685 |doi= 10.1038/sj.bjp.0703861 }}
*{{cite journal   |vauthors=Ozeki Y, Tomoda T, Kleiderlein J, etal |title=Disrupted-in-Schizophrenia-1 (DISC-1): mutant truncation prevents binding to NudE-like (NUDEL) and inhibits neurite outgrowth. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=100 |issue= 1 |pages= 289–94 |year= 2003 |pmid= 12506198 |doi= 10.1073/pnas.0136913100 | pmc=140954 |bibcode=2003PNAS..100..289O }}
*{{cite journal  | author=Yus-Najera E, Santana-Castro I, Villarroel A |title=The identification and characterization of a noncontinuous calmodulin-binding site in noninactivating voltage-dependent KCNQ potassium channels. |journal=J. Biol. Chem. |volume=277 |issue= 32 |pages= 28545-53 |year= 2002 |pmid= 12032157 |doi= 10.1074/jbc.M204130200 }}
*{{cite journal   |vauthors=Yus-Nájera E, Muñoz A, Salvador N, etal |title=Localization of KCNQ5 in the normal and epileptic human temporal neocortex and hippocampal formation. |journal=Neuroscience |volume=120 |issue= 2 |pages= 353–64 |year= 2003 |pmid= 12890507 |doi=10.1016/S0306-4522(03)00321-X }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal   |vauthors=Mungall AJ, Palmer SA, Sims SK, etal |title=The DNA sequence and analysis of human chromosome 6. |journal=Nature |volume=425 |issue= 6960 |pages= 805–11 |year= 2003 |pmid= 14574404 |doi= 10.1038/nature02055 }}
*{{cite journal | author=Ozeki Y, Tomoda T, Kleiderlein J, ''et al.'' |title=Disrupted-in-Schizophrenia-1 (DISC-1): mutant truncation prevents binding to NudE-like (NUDEL) and inhibits neurite outgrowth. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=100 |issue= 1 |pages= 289-94 |year= 2003 |pmid= 12506198 |doi= 10.1073/pnas.0136913100 }}
*{{cite journal   |vauthors=Li Y, Langlais P, Gamper N, etal |title=Dual phosphorylations underlie modulation of unitary KCNQ K(+) channels by Src tyrosine kinase. |journal=J. Biol. Chem. |volume=279 |issue= 44 |pages= 45399–407 |year= 2004 |pmid= 15304482 |doi= 10.1074/jbc.M408410200 }}
*{{cite journal | author=Yus-Nájera E, Muñoz A, Salvador N, ''et al.'' |title=Localization of KCNQ5 in the normal and epileptic human temporal neocortex and hippocampal formation. |journal=Neuroscience |volume=120 |issue= 2 |pages= 353-64 |year= 2003 |pmid= 12890507 |doi=  }}
*{{cite journal   |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 }}
*{{cite journal | author=Mungall AJ, Palmer SA, Sims SK, ''et al.'' |title=The DNA sequence and analysis of human chromosome 6. |journal=Nature |volume=425 |issue= 6960 |pages= 805-11 |year= 2003 |pmid= 14574404 |doi= 10.1038/nature02055 }}
*{{cite journal  |vauthors=Jensen HS, Grunnet M, Olesen SP |title=Inactivation as a new regulatory mechanism for neuronal Kv7 channels. |journal=Biophys. J. |volume=92 |issue= 8 |pages= 2747–56 |year= 2007 |pmid= 17237198 |doi= 10.1529/biophysj.106.101287 | pmc=1831682 |bibcode=2007BpJ....92.2747J }}
*{{cite journal | author=Li Y, Langlais P, Gamper N, ''et al.'' |title=Dual phosphorylations underlie modulation of unitary KCNQ K(+) channels by Src tyrosine kinase. |journal=J. Biol. Chem. |volume=279 |issue= 44 |pages= 45399-407 |year= 2004 |pmid= 15304482 |doi= 10.1074/jbc.M408410200 }}
*{{cite journal | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal  | author=Jensen HS, Grunnet M, Olesen SP |title=Inactivation as a new regulatory mechanism for neuronal Kv7 channels. |journal=Biophys. J. |volume=92 |issue= 8 |pages= 2747-56 |year= 2007 |pmid= 17237198 |doi= 10.1529/biophysj.106.101287 }}
}}
}}
{{refend}}
{{refend}}


{{membrane-protein-stub}}
{{NLM content}}
{{NLM content}}
{{Ion channels}}
{{Ion channels|g3}}
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[[Category:Ion channels]]
[[Category:Ion channels]]
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{{membrane-protein-stub}}

Latest revision as of 17:36, 24 June 2018

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
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Wikidata
View/Edit Human

Potassium voltage-gated channel subfamily KQT member 5 is a protein that in humans is encoded by the KCNQ5 gene.[1][2][3][4]

This gene is a member of the KCNQ potassium channel gene family that is differentially expressed in subregions of the brain and in skeletal muscle. The protein encoded by this gene yields currents that activate slowly with depolarization and can form heteromeric channels with the protein encoded by the KCNQ3 gene. Currents expressed from this protein have voltage dependences and inhibitor sensitivities in common with M-currents. They are also inhibited by M1 muscarinic receptor activation. Three alternatively spliced transcript variants encoding distinct isoforms have been found for this gene, but the full-length nature of only one has been determined.[4]

Interactions

KCNQ5 has been shown to interact with KvLQT3.[5]

See also

References

  1. ↑ Lerche C, Scherer CR, Seebohm G, Derst C, Wei AD, Busch AE, Steinmeyer K (Aug 2000). "Molecular cloning and functional expression of KCNQ5, a potassium channel subunit that may contribute to neuronal M-current diversity". J Biol Chem. 275 (29): 22395–400. doi:10.1074/jbc.M002378200. PMID 10787416.
  2. ↑ Schroeder BC, Hechenberger M, Weinreich F, Kubisch C, Jentsch TJ (Sep 2000). "KCNQ5, a novel potassium channel broadly expressed in brain, mediates M-type currents". J Biol Chem. 275 (31): 24089–95. doi:10.1074/jbc.M003245200. PMID 10816588.
  3. ↑ Gutman GA, Chandy KG, Grissmer S, Lazdunski M, McKinnon D, Pardo LA, Robertson GA, Rudy B, Sanguinetti MC, Stuhmer W, Wang X (Dec 2005). "International Union of Pharmacology. LIII. Nomenclature and molecular relationships of voltage-gated potassium channels". Pharmacol Rev. 57 (4): 473–508. doi:10.1124/pr.57.4.10. PMID 16382104.
  4. ↑ 4.0 4.1 "Entrez Gene: KCNQ5 potassium voltage-gated channel, KQT-like subfamily, member 5".
  5. ↑ Yus-Nájera, E; Muñoz A; Salvador N; Jensen B S; Rasmussen H B; Defelipe J; Villarroel A (2003). "Localization of KCNQ5 in the normal and epileptic human temporal neocortex and hippocampal formation". Neuroscience. United States. 120 (2): 353–64. doi:10.1016/S0306-4522(03)00321-X. ISSN 0306-4522. PMID 12890507.

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


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