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<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{DISPLAYTITLE:''MIP'' (gene)}}
{{PBB_Controls
{{Infobox_gene}}
| update_page = yes
'''Lens fiber major intrinsic protein''' is a [[protein]] that in humans is encoded by the ''MIP'' [[gene]].<ref name="pmid1840563">{{cite journal |vauthors=Pisano MM, Chepelinsky AB | title = Genomic cloning, complete nucleotide sequence, and structure of the human gene encoding the major intrinsic protein (MIP) of the lens | journal = Genomics | volume = 11 | issue = 4 | pages = 981–90 |date=Mar 1992 | pmid = 1840563 | pmc =  | doi =10.1016/0888-7543(91)90023-8  }}</ref><ref name="pmid7536742">{{cite journal |vauthors=Mulders SM, Preston GM, Deen PM, Guggino WB, van Os CH, Agre P | title = Water channel properties of major intrinsic protein of lens | journal = J Biol Chem | volume = 270 | issue = 15 | pages = 9010–16 |date=May 1995 | pmid = 7536742 | pmc = | doi =10.1074/jbc.270.15.9010  }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: MIP major intrinsic protein of lens fiber| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4284| accessdate = }}</ref>
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}


<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Function ==
{{GNF_Protein_box
| image = PBB_Protein_MIP_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1sor.
| PDB = {{PDB2|1sor}}, {{PDB2|1ymg}}, {{PDB2|2b6o}}, {{PDB2|2b6p}}, {{PDB2|2c32}}
| Name = Major intrinsic protein of lens fiber
| HGNCid = 7103
| Symbol = MIP
| AltSymbols =; LIM1; AQP0; MIP26; MP26
| OMIM = 154050
| ECnumber = 
| Homologene = 40627
| MGIid = 96990
| GeneAtlas_image1 = PBB_GE_MIP_220863_at_tn.png
| Function = {{GNF_GO|id=GO:0005212 |text = structural constituent of eye lens}} {{GNF_GO|id=GO:0005215 |text = transporter activity}} {{GNF_GO|id=GO:0015250 |text = water channel activity}}
| Component = {{GNF_GO|id=GO:0005624 |text = membrane fraction}} {{GNF_GO|id=GO:0005887 |text = integral to plasma membrane}} {{GNF_GO|id=GO:0005921 |text = gap junction}} {{GNF_GO|id=GO:0016020 |text = membrane}}
| Process = {{GNF_GO|id=GO:0006810 |text = transport}} {{GNF_GO|id=GO:0006833 |text = water transport}} {{GNF_GO|id=GO:0007267 |text = cell-cell signaling}} {{GNF_GO|id=GO:0007601 |text = visual perception}} {{GNF_GO|id=GO:0050896 |text = response to stimulus}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 4284
    | Hs_Ensembl = ENSG00000135517
    | Hs_RefseqProtein = NP_036196
    | Hs_RefseqmRNA = NM_012064
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 12
    | Hs_GenLoc_start = 55130151
    | Hs_GenLoc_end = 55134696
    | Hs_Uniprot = P30301
    | Mm_EntrezGene = 17339
    | Mm_Ensembl = ENSMUSG00000025389
    | Mm_RefseqmRNA = NM_008600
    | Mm_RefseqProtein = NP_032626
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 10
    | Mm_GenLoc_start = 127628787
    | Mm_GenLoc_end = 127634760
    | Mm_Uniprot = Q640N8
  }}
}}
'''Major intrinsic protein of lens fiber''', also known as '''MIP''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: MIP major intrinsic protein of lens fiber| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4284| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
Major intrinsic protein is a member of the water-transporting [[aquaporin]]s as well as the original member of the MIP family of channel proteins. The function of the fiber cell membrane protein encoded by this gene is undetermined, yet this protein is speculated to play a role in intracellular communication. The MIP protein is expressed in the ocular lens and is required for correct lens function. This gene has been mapped among aquaporins [[AQP2]], [[AQP5]], and [[AQP6]], in a potential gene cluster at 12q13.<ref name="entrez"/>
{{PBB_Summary
| section_title =
| summary_text = Major intrinsic protein is a member of the water-transporting aquaporins as well as the original member of the MIP family of channel proteins. The function of the fiber cell membrane protein encoded by this gene is undetermined, yet this protein is speculated to play a role in intracellular communication. The MIP protein is expressed in the ocular lens and is required for correct lens function. This gene has been mapped among aquaporins AQP2, AQP5, and AQP6, in a potential gene cluster at 12q13.<ref name="entrez">{{cite web | title = Entrez Gene: MIP major intrinsic protein of lens fiber| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4284| accessdate = }}</ref>
}}


==References==
==References==
{{reflist|2}}
{{reflist}}
 
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
*{{cite journal   |vauthors=Chepelinsky AB, Piatigorsky J, Pisano MM, etal |title=Lens protein gene expression: alpha-crystallins and MIP. |journal=Lens and eye toxicity research |volume=8 |issue= 2–3 |pages= 319–44 |year= 1991 |pmid= 1911643 |doi=  }}
| citations =
*{{cite journal  |vauthors=Griffin CS, Shiels A |title=In situ hybridisation localises the gene for the major intrinsic protein of eye lens fibre cell membranes to human chromosome 12q14 |journal=Cytogenet. Cell Genet. |volume=61 |issue= 1 |pages= 8–9 |year= 1992 |pmid= 1505237 |doi=10.1159/000133360 }}
*{{cite journal | author=Chepelinsky AB, Piatigorsky J, Pisano MM, ''et al.'' |title=Lens protein gene expression: alpha-crystallins and MIP. |journal=Lens and eye toxicity research |volume=8 |issue= 2-3 |pages= 319-44 |year= 1991 |pmid= 1911643 |doi=  }}
*{{cite journal  |vauthors=Girsch SJ, Peracchia C |title=Calmodulin interacts with a C-terminus peptide from the lens membrane protein MIP26 |journal=Curr. Eye Res. |volume=10 |issue= 9 |pages= 839–49 |year= 1992 |pmid= 1790714 |doi=10.3109/02713689109013880 }}
*{{cite journal  | author=Griffin CS, Shiels A |title=In situ hybridisation localises the gene for the major intrinsic protein of eye lens fibre cell membranes to human chromosome 12q14. |journal=Cytogenet. Cell Genet. |volume=61 |issue= 1 |pages= 8-9 |year= 1992 |pmid= 1505237 |doi=  }}
*{{cite journal  |vauthors=Lampe PD, Johnson RG |title=Amino acid sequence of in vivo phosphorylation sites in the main intrinsic protein (MIP) of lens membranes |journal=Eur. J. Biochem. |volume=194 |issue= 2 |pages= 541–7 |year= 1991 |pmid= 2176601 |doi=10.1111/j.1432-1033.1990.tb15650.x }}
*{{cite journal  | author=Girsch SJ, Peracchia C |title=Calmodulin interacts with a C-terminus peptide from the lens membrane protein MIP26. |journal=Curr. Eye Res. |volume=10 |issue= 9 |pages= 839-49 |year= 1992 |pmid= 1790714 |doi= }}
*{{cite journal  |vauthors=Manenti S, Dunia I, Benedetti EL |title=Fatty acid acylation of lens fiber plasma membrane proteins. MP26 and alpha-crystallin are palmitoylated |journal=FEBS Lett. |volume=262 |issue= 2 |pages= 356–8 |year= 1990 |pmid= 2335219 |doi=10.1016/0014-5793(90)80228-B }}
*{{cite journal  | author=Pisano MM, Chepelinsky AB |title=Genomic cloning, complete nucleotide sequence, and structure of the human gene encoding the major intrinsic protein (MIP) of the lens. |journal=Genomics |volume=11 |issue= 4 |pages= 981-90 |year= 1992 |pmid= 1840563 |doi= }}
*{{cite journal  |vauthors=Peracchia C, Girsch SJ |title=Calmodulin site at the C-terminus of the putative lens gap junction protein MIP26 |journal=Lens and eye toxicity research |volume=6 |issue= 4 |pages= 613–21 |year= 1991 |pmid= 2487274 |doi=  }}
*{{cite journal  | author=Lampe PD, Johnson RG |title=Amino acid sequence of in vivo phosphorylation sites in the main intrinsic protein (MIP) of lens membranes. |journal=Eur. J. Biochem. |volume=194 |issue= 2 |pages= 541-7 |year= 1991 |pmid= 2176601 |doi=  }}
*{{cite journal   |vauthors=Saito F, Sasaki S, Chepelinsky AB, etal |title=Human AQP2 and MIP genes, two members of the MIP family, map within chromosome band 12q13 on the basis of two-color FISH |journal=Cytogenet. Cell Genet. |volume=68 |issue= 1–2 |pages= 45–8 |year= 1994 |pmid= 7525161 |doi=10.1159/000133885 }}
*{{cite journal  | author=Manenti S, Dunia I, Benedetti EL |title=Fatty acid acylation of lens fiber plasma membrane proteins. MP26 and alpha-crystallin are palmitoylated. |journal=FEBS Lett. |volume=262 |issue= 2 |pages= 356-8 |year= 1990 |pmid= 2335219 |doi=  }}
*{{cite journal  |vauthors=Jarvis LJ, Louis CF |title=Purification and oligomeric state of the major lens fiber cell membrane proteins |journal=Curr. Eye Res. |volume=14 |issue= 9 |pages= 799–808 |year= 1996 |pmid= 8529419 |doi=10.3109/02713689508995802 }}
*{{cite journal  | author=Peracchia C, Girsch SJ |title=Calmodulin site at the C-terminus of the putative lens gap junction protein MIP26. |journal=Lens and eye toxicity research |volume=6 |issue= 4 |pages= 613-21 |year= 1991 |pmid= 2487274 |doi=  }}
*{{cite journal   |vauthors=Wang XY, Ohtaka-Maruyama C, Pisano MM, etal |title=Isolation and characterization of the 5'-flanking sequence of the human ocular lens MIP gene |journal=Gene |volume=167 |issue= 1–2 |pages= 321–5 |year= 1996 |pmid= 8566800 |doi=10.1016/0378-1119(95)00637-0 }}
*{{cite journal | author=Saito F, Sasaki S, Chepelinsky AB, ''et al.'' |title=Human AQP2 and MIP genes, two members of the MIP family, map within chromosome band 12q13 on the basis of two-color FISH. |journal=Cytogenet. Cell Genet. |volume=68 |issue= 1-2 |pages= 45-8 |year= 1994 |pmid= 7525161 |doi= }}
*{{cite journal  |vauthors=Bonaldo MF, Lennon G, Soares MB |title=Normalization and subtraction: two approaches to facilitate gene discovery |journal=Genome Res. |volume=6 |issue= 9 |pages= 791–806 |year= 1997 |pmid= 8889548 |doi=10.1101/gr.6.9.791 }}
*{{cite journal  | author=Mulders SM, Preston GM, Deen PM, ''et al.'' |title=Water channel properties of major intrinsic protein of lens. |journal=J. Biol. Chem. |volume=270 |issue= 15 |pages= 9010-16 |year= 1995 |pmid= 7536742 |doi= }}
*{{cite journal  |vauthors=Prabhakaram M, Katz ML, Ortwerth BJ |title=Glycation mediated crosslinking between alpha-crystallin and MP26 in intact lens membranes |journal=Mech. Ageing Dev. |volume=91 |issue= 1 |pages= 65–78 |year= 1997 |pmid= 8910261 |doi=10.1016/0047-6374(96)01781-2 }}
*{{cite journal  | author=Jarvis LJ, Louis CF |title=Purification and oligomeric state of the major lens fiber cell membrane proteins. |journal=Curr. Eye Res. |volume=14 |issue= 9 |pages= 799-808 |year= 1996 |pmid= 8529419 |doi=  }}
*{{cite journal  |vauthors=Ma T, Yang B, Umenishi F, Verkman AS |title=Closely spaced tandem arrangement of AQP2, AQP5, and AQP6 genes in a 27-kilobase segment at chromosome locus 12q13 |journal=Genomics |volume=43 |issue= 3 |pages= 387–9 |year= 1997 |pmid= 9268644 |doi= 10.1006/geno.1997.4836 }}
*{{cite journal | author=Wang XY, Ohtaka-Maruyama C, Pisano MM, ''et al.'' |title=Isolation and characterization of the 5'-flanking sequence of the human ocular lens MIP gene. |journal=Gene |volume=167 |issue= 1-2 |pages= 321-5 |year= 1996 |pmid= 8566800 |doi=  }}
*{{cite journal  |vauthors=Ohtaka-Maruyama C, Wang X, Ge H, Chepelinsky AB |title=Overlapping Sp1 and AP2 binding sites in a promoter element of the lens-specific MIP gene |journal=Nucleic Acids Res. |volume=26 |issue= 2 |pages= 407–14 |year= 1998 |pmid= 9421492 |doi=10.1093/nar/26.2.407  | pmc=147274 }}
*{{cite journal  | author=Bonaldo MF, Lennon G, Soares MB |title=Normalization and subtraction: two approaches to facilitate gene discovery. |journal=Genome Res. |volume=6 |issue= 9 |pages= 791-806 |year= 1997 |pmid= 8889548 |doi=  }}
*{{cite journal   |vauthors=Dunia I, Recouvreur M, Nicolas P, etal |title=Assembly of connexins and MP26 in lens fiber plasma membranes studied by SDS-fracture immunolabeling |journal=J. Cell Sci. |volume=111 |issue=  15|pages= 2109–20 |year= 1998 |pmid= 9664032 |doi=  }}
*{{cite journal  | author=Prabhakaram M, Katz ML, Ortwerth BJ |title=Glycation mediated crosslinking between alpha-crystallin and MP26 in intact lens membranes. |journal=Mech. Ageing Dev. |volume=91 |issue= 1 |pages= 65-78 |year= 1997 |pmid= 8910261 |doi=  }}
*{{cite journal  |vauthors=Schey KL, Fowler JG, Shearer TR, David L |title=Modifications to rat lens major intrinsic protein in selenite-induced cataract |journal=Invest. Ophthalmol. Vis. Sci. |volume=40 |issue= 3 |pages= 657–67 |year= 1999 |pmid= 10067969 |doi=  }}
*{{cite journal  | author=Ma T, Yang B, Umenishi F, Verkman AS |title=Closely spaced tandem arrangement of AQP2, AQP5, and AQP6 genes in a 27-kilobase segment at chromosome locus 12q13. |journal=Genomics |volume=43 |issue= 3 |pages= 387-9 |year= 1997 |pmid= 9268644 |doi= 10.1006/geno.1997.4836 }}
*{{cite journal  |vauthors=Schey KL, Little M, Fowler JG, Crouch RK |title=Characterization of human lens major intrinsic protein structure |journal=Invest. Ophthalmol. Vis. Sci. |volume=41 |issue= 1 |pages= 175–82 |year= 2000 |pmid= 10634618 |doi=  }}
*{{cite journal  | author=Ohtaka-Maruyama C, Wang X, Ge H, Chepelinsky AB |title=Overlapping Sp1 and AP2 binding sites in a promoter element of the lens-specific MIP gene. |journal=Nucleic Acids Res. |volume=26 |issue= 2 |pages= 407-14 |year= 1998 |pmid= 9421492 |doi=  }}
*{{cite journal   |vauthors=Berry V, Francis P, Kaushal S, etal |title=Missense mutations in MIP underlie autosomal dominant 'polymorphic' and lamellar cataracts linked to 12q |journal=Nat. Genet. |volume=25 |issue= 1 |pages= 15–7 |year= 2000 |pmid= 10802646 |doi= 10.1038/75538 }}
*{{cite journal | author=Dunia I, Recouvreur M, Nicolas P, ''et al.'' |title=Assembly of connexins and MP26 in lens fiber plasma membranes studied by SDS-fracture immunolabeling. |journal=J. Cell. Sci. |volume=111 ( Pt 15) |issue=  |pages= 2109-20 |year= 1998 |pmid= 9664032 |doi=  }}
*{{cite journal  | author=Schey KL, Fowler JG, Shearer TR, David L |title=Modifications to rat lens major intrinsic protein in selenite-induced cataract. |journal=Invest. Ophthalmol. Vis. Sci. |volume=40 |issue= 3 |pages= 657-67 |year= 1999 |pmid= 10067969 |doi=  }}
*{{cite journal  | author=Schey KL, Little M, Fowler JG, Crouch RK |title=Characterization of human lens major intrinsic protein structure. |journal=Invest. Ophthalmol. Vis. Sci. |volume=41 |issue= 1 |pages= 175-82 |year= 2000 |pmid= 10634618 |doi=  }}
*{{cite journal | author=Berry V, Francis P, Kaushal S, ''et al.'' |title=Missense mutations in MIP underlie autosomal dominant 'polymorphic' and lamellar cataracts linked to 12q. |journal=Nat. Genet. |volume=25 |issue= 1 |pages= 15-7 |year= 2000 |pmid= 10802646 |doi= 10.1038/75538 }}
}}
{{refend}}
{{refend}}


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Latest revision as of 20:19, 8 November 2017

VALUE_ERROR (nil)
Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

n/a

n/a

Ensembl

n/a

n/a

UniProt

n/a

n/a

RefSeq (mRNA)

n/a

n/a

RefSeq (protein)

n/a

n/a

Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Lens fiber major intrinsic protein is a protein that in humans is encoded by the MIP gene.[1][2][3]

Function

Major intrinsic protein is a member of the water-transporting aquaporins as well as the original member of the MIP family of channel proteins. The function of the fiber cell membrane protein encoded by this gene is undetermined, yet this protein is speculated to play a role in intracellular communication. The MIP protein is expressed in the ocular lens and is required for correct lens function. This gene has been mapped among aquaporins AQP2, AQP5, and AQP6, in a potential gene cluster at 12q13.[3]

References

  1. ↑ Pisano MM, Chepelinsky AB (Mar 1992). "Genomic cloning, complete nucleotide sequence, and structure of the human gene encoding the major intrinsic protein (MIP) of the lens". Genomics. 11 (4): 981–90. doi:10.1016/0888-7543(91)90023-8. PMID 1840563.
  2. ↑ Mulders SM, Preston GM, Deen PM, Guggino WB, van Os CH, Agre P (May 1995). "Water channel properties of major intrinsic protein of lens". J Biol Chem. 270 (15): 9010–16. doi:10.1074/jbc.270.15.9010. PMID 7536742.
  3. ↑ 3.0 3.1 "Entrez Gene: MIP major intrinsic protein of lens fiber".

Further reading

  • Chepelinsky AB, Piatigorsky J, Pisano MM, et al. (1991). "Lens protein gene expression: alpha-crystallins and MIP". Lens and eye toxicity research. 8 (2–3): 319–44. PMID 1911643.
  • Griffin CS, Shiels A (1992). "In situ hybridisation localises the gene for the major intrinsic protein of eye lens fibre cell membranes to human chromosome 12q14". Cytogenet. Cell Genet. 61 (1): 8–9. doi:10.1159/000133360. PMID 1505237.
  • Girsch SJ, Peracchia C (1992). "Calmodulin interacts with a C-terminus peptide from the lens membrane protein MIP26". Curr. Eye Res. 10 (9): 839–49. doi:10.3109/02713689109013880. PMID 1790714.
  • Lampe PD, Johnson RG (1991). "Amino acid sequence of in vivo phosphorylation sites in the main intrinsic protein (MIP) of lens membranes". Eur. J. Biochem. 194 (2): 541–7. doi:10.1111/j.1432-1033.1990.tb15650.x. PMID 2176601.
  • Manenti S, Dunia I, Benedetti EL (1990). "Fatty acid acylation of lens fiber plasma membrane proteins. MP26 and alpha-crystallin are palmitoylated". FEBS Lett. 262 (2): 356–8. doi:10.1016/0014-5793(90)80228-B. PMID 2335219.
  • Peracchia C, Girsch SJ (1991). "Calmodulin site at the C-terminus of the putative lens gap junction protein MIP26". Lens and eye toxicity research. 6 (4): 613–21. PMID 2487274.
  • Saito F, Sasaki S, Chepelinsky AB, et al. (1994). "Human AQP2 and MIP genes, two members of the MIP family, map within chromosome band 12q13 on the basis of two-color FISH". Cytogenet. Cell Genet. 68 (1–2): 45–8. doi:10.1159/000133885. PMID 7525161.
  • Jarvis LJ, Louis CF (1996). "Purification and oligomeric state of the major lens fiber cell membrane proteins". Curr. Eye Res. 14 (9): 799–808. doi:10.3109/02713689508995802. PMID 8529419.
  • Wang XY, Ohtaka-Maruyama C, Pisano MM, et al. (1996). "Isolation and characterization of the 5'-flanking sequence of the human ocular lens MIP gene". Gene. 167 (1–2): 321–5. doi:10.1016/0378-1119(95)00637-0. PMID 8566800.
  • Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
  • Prabhakaram M, Katz ML, Ortwerth BJ (1997). "Glycation mediated crosslinking between alpha-crystallin and MP26 in intact lens membranes". Mech. Ageing Dev. 91 (1): 65–78. doi:10.1016/0047-6374(96)01781-2. PMID 8910261.
  • Ma T, Yang B, Umenishi F, Verkman AS (1997). "Closely spaced tandem arrangement of AQP2, AQP5, and AQP6 genes in a 27-kilobase segment at chromosome locus 12q13". Genomics. 43 (3): 387–9. doi:10.1006/geno.1997.4836. PMID 9268644.
  • Ohtaka-Maruyama C, Wang X, Ge H, Chepelinsky AB (1998). "Overlapping Sp1 and AP2 binding sites in a promoter element of the lens-specific MIP gene". Nucleic Acids Res. 26 (2): 407–14. doi:10.1093/nar/26.2.407. PMC 147274. PMID 9421492.
  • Dunia I, Recouvreur M, Nicolas P, et al. (1998). "Assembly of connexins and MP26 in lens fiber plasma membranes studied by SDS-fracture immunolabeling". J. Cell Sci. 111 (15): 2109–20. PMID 9664032.
  • Schey KL, Fowler JG, Shearer TR, David L (1999). "Modifications to rat lens major intrinsic protein in selenite-induced cataract". Invest. Ophthalmol. Vis. Sci. 40 (3): 657–67. PMID 10067969.
  • Schey KL, Little M, Fowler JG, Crouch RK (2000). "Characterization of human lens major intrinsic protein structure". Invest. Ophthalmol. Vis. Sci. 41 (1): 175–82. PMID 10634618.
  • Berry V, Francis P, Kaushal S, et al. (2000). "Missense mutations in MIP underlie autosomal dominant 'polymorphic' and lamellar cataracts linked to 12q". Nat. Genet. 25 (1): 15–7. doi:10.1038/75538. PMID 10802646.


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