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{{Infobox_gene}}
{{PBB_Controls
The '''nuclear receptor coactivator 2''' also known as '''NCoA-2''' is a [[protein]] that in humans is encoded by the NCOA2 [[gene]]. NCoA-2 is also frequently called glucocorticoid receptor-interacting protein 1 ('''GRIP1'''), steroid receptor coactivator-2 ('''SRC-2'''), or transcriptional mediators/intermediary factor 2 ('''TIF2''').
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Function ==
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Nuclear receptor coactivator 2
| HGNCid = 7669
| Symbol = NCOA2
| AltSymbols =; GRIP1; MGC138808; NCoA-2; TIF2
| OMIM = 601993
| ECnumber = 
| Homologene = 4768
| MGIid = 1276533
| GeneAtlas_image1 = PBB_GE_NCOA2_gnf1h04995_s_at_tn.png
| Function = {{GNF_GO|id=GO:0004871 |text = signal transducer activity}} {{GNF_GO|id=GO:0005102 |text = receptor binding}} {{GNF_GO|id=GO:0016564 |text = transcription repressor activity}} {{GNF_GO|id=GO:0030375 |text = thyroid hormone receptor coactivator activity}}
| Component = {{GNF_GO|id=GO:0005634 |text = nucleus}} {{GNF_GO|id=GO:0005737 |text = cytoplasm}}
| Process = {{GNF_GO|id=GO:0000122 |text = negative regulation of transcription from RNA polymerase II promoter}} {{GNF_GO|id=GO:0006355 |text = regulation of transcription, DNA-dependent}} {{GNF_GO|id=GO:0007165 |text = signal transduction}} {{GNF_GO|id=GO:0045944 |text = positive regulation of transcription from RNA polymerase II promoter}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 10499
    | Hs_Ensembl = ENSG00000140396
    | Hs_RefseqProtein = NP_006531
    | Hs_RefseqmRNA = NM_006540
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 8
    | Hs_GenLoc_start = 71196006
    | Hs_GenLoc_end = 71478574
    | Hs_Uniprot = Q15596
    | Mm_EntrezGene = 17978
    | Mm_Ensembl = ENSMUSG00000005886
    | Mm_RefseqmRNA = NM_001077695
    | Mm_RefseqProtein = NP_001071163
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 1
    | Mm_GenLoc_start = 13127689
    | Mm_GenLoc_end = 13359278
    | Mm_Uniprot = Q61026
  }}
}}


The '''nuclear receptor coactivator 2''' ({{gene|NCOA2}}) is a [[transcription coregulator|transcriptional coregulatory]] protein which contains several [[nuclear receptor]] interacting domains and an intrinsic [[histone acetyltransferase]] activity.  NCOA2 is recruited to DNA promotion sites by ligand activated nuclear receptors.  NCOA2 in turn acylates histones which makes downsteam DNA more accessible to transcription.  Hence NCOA2 assists nuclear receptors in the upregulation of DNA expression.<ref name="Voegel_1996">{{cite journal |author=Voegel JJ, Heine MJ, Zechel C, Chambon P, Gronemeyer H|title=TIF2, a 160 kDa transcriptional mediator for the ligand-dependent activation function AF-2 of nuclear receptors|journal= EMBO J |volume= 15 |issue= 14 |pages= 3667-75 |year= 1996| doi =  |pmid= 8670870}}</ref><ref name="Hong_1997">{{cite journal |author=Hong H, Kohli K, Garabedian MJ, Stallcup MR|title=GRIP1, a transcriptional coactivator for the AF-2 transactivation domain of steroid, thyroid, retinoid, and vitamin D receptors|journal=Mol Cell Biol |volume= 17 |issue= 5 |pages= 2735-44 |year= 1997| doi = |pmid= 9111344}}</ref>
NCoA-2 is a [[transcription coregulator|transcriptional coregulatory]] protein that contains several [[nuclear receptor]] interacting domains and an intrinsic [[histone acetyltransferase]] activity.  NCOA2 is recruited to DNA promotion sites by ligand-activated nuclear receptors.  NCOA2 in turn acetylates histones, which makes downstream DNA more accessible to transcription.  Hence, NCOA2 assists nuclear receptors in the upregulation of DNA expression.<ref name="Voegel_1996">{{cite journal | vauthors = Voegel JJ, Heine MJ, Zechel C, Chambon P, Gronemeyer H | title = TIF2, a 160 kDa transcriptional mediator for the ligand-dependent activation function AF-2 of nuclear receptors | journal = EMBO J | volume = 15 | issue = 14 | pages = 3667–75 | year = 1996 | pmid = 8670870 | pmc = 452006 | doi =  }}</ref><ref name="Hong_1997">{{cite journal | vauthors = Hong H, Kohli K, Garabedian MJ, Stallcup MR | title = GRIP1, a transcriptional coactivator for the AF-2 transactivation domain of steroid, thyroid, retinoid, and vitamin D receptors | journal = Mol Cell Biol | volume = 17 | issue = 5 | pages = 2735–44 | year = 1997 | pmid = 9111344 | pmc = 232124 | doi = }}</ref>


NCOA2 is also frequently called glucocorticoid receptor interacting protein 1 ('''GRIP1'''), steroid receptor coactivator-2 ('''SRC-2'''), or transcriptional mediators/intermediary factor 2 ('''TIF2''').
GRIP1 is a transcriptional [[co-activator]] of the [[glucocorticoid receptor]] and interferon regulatory factor 1 ([[IRF1]]).<ref name="pmid19805480">{{cite journal | vauthors = Bhandare R, Damera G, Banerjee A, Flammer JR, Keslacy S, Rogatsky I, Panettieri RA, Amrani Y, Tliba O | title = Glucocorticoid receptor interacting protein-1 restores glucocorticoid responsiveness in steroid-resistant airway structural cells | journal = Am. J. Respir. Cell Mol. Biol. | volume = 42 | issue = 1 | pages = 9–15 | date = January 2010 | pmid = 19805480 | pmc = 2809222 | doi = 10.1165/rcmb.2009-0239RC }}</ref>


==References==
== Interactions ==
<div class="references-small">{{reflist|2}}</div>


==Further reading==
Nuclear receptor coactivator 2 has been shown to [[Protein-protein interaction|interact]] with:
{{refbegin | 2}}
{{div col|colwidth=20em}}
{{PBB_Further_reading
* [[Androgen receptor|AR]],<ref name = pmid14593076>{{cite journal | vauthors = Song LN, Coghlan M, Gelmann EP | title = Antiandrogen effects of mifepristone on coactivator and corepressor interactions with the androgen receptor | journal = Mol. Endocrinol. | volume = 18 | issue = 1 | pages = 70–85 | year = 2004 | pmid = 14593076 | doi = 10.1210/me.2003-0189 }}</ref><ref name = pmid12810069>{{cite journal | vauthors = Ishitani K, Yoshida T, Kitagawa H, Ohta H, Nozawa S, Kato S | title = p54nrb acts as a transcriptional coactivator for activation function 1 of the human androgen receptor | journal = Biochem. Biophys. Res. Commun. | volume = 306 | issue = 3 | pages = 660–5 | year = 2003 | pmid = 12810069 | doi = 10.1016/S0006-291X(03)01021-0 }}</ref><ref name = pmid14966121>{{cite journal | vauthors = Wang Q, Udayakumar TS, Vasaitis TS, Brodie AM, Fondell JD | title = Mechanistic relationship between androgen receptor polyglutamine tract truncation and androgen-dependent transcriptional hyperactivity in prostate cancer cells | journal = J. Biol. Chem. | volume = 279 | issue = 17 | pages = 17319–28 | year = 2004 | pmid = 14966121 | doi = 10.1074/jbc.M400970200 }}</ref><ref name = pmid12612084>{{cite journal | vauthors = He B, Wilson EM | title = Electrostatic modulation in steroid receptor recruitment of LXXLL and FXXLF motifs | journal = Mol. Cell. Biol. | volume = 23 | issue = 6 | pages = 2135–50 | year = 2003 | pmid = 12612084 | pmc = 149467 | doi = 10.1128/MCB.23.6.2135-2150.2003 }}</ref><ref name = pmid15684378>{{cite journal | vauthors = Bai S, He B, Wilson EM | title = Melanoma antigen gene protein MAGE-11 regulates androgen receptor function by modulating the interdomain interaction | journal = Mol. Cell. Biol. | volume = 25 | issue = 4 | pages = 1238–57 | year = 2005 | pmid = 15684378 | pmc = 548016 | doi = 10.1128/MCB.25.4.1238-1257.2005 }}</ref>
| citations =  
* [[Aryl hydrocarbon receptor nuclear translocator|ARNT]],<ref name = pmid12024042>{{cite journal | vauthors = Beischlag TV, Wang S, Rose DW, Torchia J, Reisz-Porszasz S, Muhammad K, Nelson WE, Probst MR, Rosenfeld MG, Hankinson O | title = Recruitment of the NCoA/SRC-1/p160 family of transcriptional coactivators by the aryl hydrocarbon receptor/aryl hydrocarbon receptor nuclear translocator complex | journal = Mol. Cell. Biol. | volume = 22 | issue = 12 | pages = 4319–33 | year = 2002 | pmid = 12024042 | pmc = 133867 | doi = 10.1128/MCB.22.12.4319-4333.2002 }}</ref>
*{{cite journal | author=Voegel JJ, Heine MJ, Zechel C, ''et al.'' |title=TIF2, a 160 kDa transcriptional mediator for the ligand-dependent activation function AF-2 of nuclear receptors. |journal=EMBO J. |volume=15 |issue= 14 |pages= 3667-75 |year= 1996 |pmid= 8670870 |doi= }}
* [[BRCA1]],<ref name = pmid14578343>{{cite journal | vauthors = Rodriguez M, Yu X, Chen J, Songyang Z | title = Phosphopeptide binding specificities of BRCA1 COOH-terminal (BRCT) domains | journal = J. Biol. Chem. | volume = 278 | issue = 52 | pages = 52914–8 | year = 2003 | pmid = 14578343 | doi = 10.1074/jbc.C300407200 }}</ref><ref name = pmid11085509>{{cite journal | vauthors = Park JJ, Irvine RA, Buchanan G, Koh SS, Park JM, Tilley WD, Stallcup MR, Press MF, Coetzee GA | title = Breast cancer susceptibility gene 1 (BRCAI) is a coactivator of the androgen receptor | journal = Cancer Res. | volume = 60 | issue = 21 | pages = 5946–9 | year = 2000 | pmid = 11085509 | doi =  }}</ref>
*{{cite journal | author=Hong H, Kohli K, Garabedian MJ, Stallcup MR |title=GRIP1, a transcriptional coactivator for the AF-2 transactivation domain of steroid, thyroid, retinoid, and vitamin D receptors. |journal=Mol. Cell. Biol. |volume=17 |issue= 5 |pages= 2735-44 |year= 1997 |pmid= 9111344 |doi= }}
* [[DDX17]],<ref name = pmid11250900>{{cite journal | vauthors = Watanabe M, Yanagisawa J, Kitagawa H, Takeyama K, Ogawa S, Arao Y, Suzawa M, Kobayashi Y, Yano T, Yoshikawa H, Masuhiro Y, Kato S | title = A subfamily of RNA-binding DEAD-box proteins acts as an estrogen receptor alpha coactivator through the N-terminal activation domain (AF-1) with an RNA coactivator, SRA | journal = EMBO J. | volume = 20 | issue = 6 | pages = 1341–52 | year = 2001 | pmid = 11250900 | pmc = 145523 | doi = 10.1093/emboj/20.6.1341 }}</ref>
*{{cite journal | author=Voegel JJ, Heine MJ, Tini M, ''et al.'' |title=The coactivator TIF2 contains three nuclear receptor-binding motifs and mediates transactivation through CBP binding-dependent and -independent pathways. |journal=EMBO J. |volume=17 |issue= 2 |pages= 507-19 |year= 1998 |pmid= 9430642 |doi= 10.1093/emboj/17.2.507 }}
* [[DDX5]],<ref name = pmid11250900/>
*{{cite journal | author=Carapeti M, Aguiar RC, Goldman JM, Cross NC |title=A novel fusion between MOZ and the nuclear receptor coactivator TIF2 in acute myeloid leukemia. |journal=Blood |volume=91 |issue= 9 |pages= 3127-33 |year= 1998 |pmid= 9558366 |doi= }}
* [[Estrogen receptor alpha|ESR1]],<ref name = pmid12612084/><ref name = pmid11250900/><ref name = pmid12837248>{{cite journal | vauthors = Kitagawa H, Fujiki R, Yoshimura K, Mezaki Y, Uematsu Y, Matsui D, Ogawa S, Unno K, Okubo M, Tokita A, Nakagawa T, Ito T, Ishimi Y, Nagasawa H, Matsumoto T, Yanagisawa J, Kato S | title = The chromatin-remodeling complex WINAC targets a nuclear receptor to promoters and is impaired in Williams syndrome | journal = Cell | volume = 113 | issue = 7 | pages = 905–17 | year = 2003 | pmid = 12837248 | doi = 10.1016/S0092-8674(03)00436-7 }}</ref><ref name = pmid11937504>{{cite journal | vauthors = Wärnmark A, Treuter E, Gustafsson JA, Hubbard RE, Brzozowski AM, Pike AC | title = Interaction of transcriptional intermediary factor 2 nuclear receptor box peptides with the coactivator binding site of estrogen receptor alpha | journal = J. Biol. Chem. | volume = 277 | issue = 24 | pages = 21862–8 | year = 2002 | pmid = 11937504 | doi = 10.1074/jbc.M200764200 }}</ref><ref name = pmid18499756>{{cite journal | vauthors = Fenne IS, Hoang T, Hauglid M, Sagen JV, Lien EA, Mellgren G | title = Recruitment of coactivator glucocorticoid receptor interacting protein 1 to an estrogen receptor transcription complex is regulated by the 3',5'-cyclic adenosine 5'-monophosphate-dependent protein kinase | journal = Endocrinology | volume = 149 | issue = 9 | pages = 4336–45 | year = 2008 | pmid = 18499756 | doi = 10.1210/en.2008-0037 }}</ref>
*{{cite journal | author=Fryer CJ, Archer TK |title=Chromatin remodelling by the glucocorticoid receptor requires the BRG1 complex. |journal=Nature |volume=393 |issue= 6680 |pages= 88-91 |year= 1998 |pmid= 9590696 |doi= 10.1038/30032 }}
* [[Glucocorticoid receptor|NR3C1]],<ref name = pmid11266503>{{cite journal | vauthors = Zilliacus J, Holter E, Wakui H, Tazawa H, Treuter E, Gustafsson JA | title = Regulation of glucocorticoid receptor activity by 14--3-3-dependent intracellular relocalization of the corepressor RIP140 | journal = Mol. Endocrinol. | volume = 15 | issue = 4 | pages = 501–11 | year = 2001 | pmid = 11266503 | doi = 10.1210/mend.15.4.0624 }}</ref><ref name = pmid12151000>{{cite journal | vauthors = Bledsoe RK, Montana VG, Stanley TB, Delves CJ, Apolito CJ, McKee DD, Consler TG, Parks DJ, Stewart EL, Willson TM, Lambert MH, Moore JT, Pearce KH, Xu HE | title = Crystal structure of the glucocorticoid receptor ligand binding domain reveals a novel mode of receptor dimerization and coactivator recognition | journal = Cell | volume = 110 | issue = 1 | pages = 93–105 | year = 2002 | pmid = 12151000 | doi = 10.1016/S0092-8674(02)00817-6 }}</ref>
*{{cite journal | author=Berrevoets CA, Doesburg P, Steketee K, ''et al.'' |title=Functional interactions of the AF-2 activation domain core region of the human androgen receptor with the amino-terminal domain and with the transcriptional coactivator TIF2 (transcriptional intermediary factor2). |journal=Mol. Endocrinol. |volume=12 |issue= 8 |pages= 1172-83 |year= 1998 |pmid= 9717843 |doi= }}
* [[PPFIA4]],<ref name = pmid11931740>{{cite journal | vauthors = Wyszynski M, Kim E, Dunah AW, Passafaro M, Valtschanoff JG, Serra-Pagès C, Streuli M, Weinberg RJ, Sheng M | title = Interaction between GRIP and liprin-alpha/SYD2 is required for AMPA receptor targeting | journal = Neuron | volume = 34 | issue = 1 | pages = 39–52 | year = 2002 | pmid = 11931740 | doi = 10.1016/S0896-6273(02)00640-2 }}</ref>
*{{cite journal | author=Wang JC, Stafford JM, Granner DK |title=SRC-1 and GRIP1 coactivate transcription with hepatocyte nuclear factor 4. |journal=J. Biol. Chem. |volume=273 |issue= 47 |pages= 30847-50 |year= 1998 |pmid= 9812974 |doi= }}
* [[Peroxisome proliferator-activated receptor gamma|PPARG]],<ref name = pmid10944516>{{cite journal | vauthors = Kodera Y, Takeyama K, Murayama A, Suzawa M, Masuhiro Y, Kato S | title = Ligand type-specific interactions of peroxisome proliferator-activated receptor gamma with transcriptional coactivators | journal = J. Biol. Chem. | volume = 275 | issue = 43 | pages = 33201–4 | year = 2000 | pmid = 10944516 | doi = 10.1074/jbc.C000517200 | pmc = 3798517 }}</ref>
*{{cite journal | author=Hong H, Darimont BD, Ma H, ''et al.'' |title=An additional region of coactivator GRIP1 required for interaction with the hormone-binding domains of a subset of nuclear receptors. |journal=J. Biol. Chem. |volume=274 |issue= 6 |pages= 3496-502 |year= 1999 |pmid= 9920895 |doi=  }}
* [[Retinoid X receptor alpha|RXRA]],<ref name = pmid11514567/><ref name = pmid11851396>{{cite journal | vauthors = Lee WY, Noy N | title = Interactions of RXR with coactivators are differentially mediated by helix 11 of the receptor's ligand binding domain | journal = Biochemistry | volume = 41 | issue = 8 | pages = 2500–8 | year = 2002 | pmid = 11851396 | doi = 10.1021/bi011764 }}</ref>
*{{cite journal | author=Chen D, Ma H, Hong H, ''et al.'' |title=Regulation of transcription by a protein methyltransferase. |journal=Science |volume=284 |issue= 5423 |pages= 2174-7 |year= 1999 |pmid= 10381882 |doi= }}
* [[SRA1]],<ref name = pmid11250900/> and
*{{cite journal | author=Ma H, Hong H, Huang SM, ''et al.'' |title=Multiple signal input and output domains of the 160-kilodalton nuclear receptor coactivator proteins. |journal=Mol. Cell. Biol. |volume=19 |issue= 9 |pages= 6164-73 |year= 1999 |pmid= 10454563 |doi= }}
* [[Calcitriol receptor|VDR]].<ref name = pmid12612084/><ref name = pmid12837248/><ref name = pmid11514567>{{cite journal | vauthors = Zhang C, Baudino TA, Dowd DR, Tokumaru H, Wang W, MacDonald PN | title = Ternary complexes and cooperative interplay between NCoA-62/Ski-interacting protein and steroid receptor coactivators in vitamin D receptor-mediated transcription | journal = J. Biol. Chem. | volume = 276 | issue = 44 | pages = 40614–20 | year = 2001 | pmid = 11514567 | doi = 10.1074/jbc.M106263200 }}</ref><ref name = pmid10748178>{{cite journal | vauthors = Herdick M, Steinmeyer A, Carlberg C | title = Antagonistic action of a 25-carboxylic ester analogue of 1alpha, 25-dihydroxyvitamin D3 is mediated by a lack of ligand-induced vitamin D receptor interaction with coactivators | journal = J. Biol. Chem. | volume = 275 | issue = 22 | pages = 16506–12 | year = 2000 | pmid = 10748178 | doi = 10.1074/jbc.M910000199 }}</ref>
*{{cite journal | author=Atkins GB, Hu X, Guenther MG, ''et al.'' |title=Coactivators for the orphan nuclear receptor RORalpha. |journal=Mol. Endocrinol. |volume=13 |issue= 9 |pages= 1550-7 |year= 1999 |pmid= 10478845 |doi= }}
{{Div col end}}
*{{cite journal | author=Carrero P, Okamoto K, Coumailleau P, ''et al.'' |title=Redox-regulated recruitment of the transcriptional coactivators CREB-binding protein and SRC-1 to hypoxia-inducible factor 1alpha. |journal=Mol. Cell. Biol. |volume=20 |issue= 1 |pages= 402-15 |year= 2000 |pmid= 10594042 |doi= }}
 
*{{cite journal | author=Xie W, Hong H, Yang NN, ''et al.'' |title=Constitutive activation of transcription and binding of coactivator by estrogen-related receptors 1 and 2. |journal=Mol. Endocrinol. |volume=13 |issue= 12 |pages= 2151-62 |year= 2000 |pmid= 10598588 |doi= }}
== References ==
*{{cite journal | author=Naltner A, Ghaffari M, Whitsett JA, Yan C |title=Retinoic acid stimulation of the human surfactant protein B promoter is thyroid transcription factor 1 site-dependent. |journal=J. Biol. Chem. |volume=275 |issue= 1 |pages= 56-62 |year= 2000 |pmid= 10617585 |doi= }}
{{Reflist|33em}}
*{{cite journal | author=Jimenez-Lara AM, Heine MJ, Gronemeyer H |title=Cloning of a mouse glucocorticoid modulatory element binding protein, a new member of the KDWK family. |journal=FEBS Lett. |volume=468 |issue= 2-3 |pages= 203-10 |year= 2000 |pmid= 10692587 |doi= }}
 
*{{cite journal | author=Poelzl G, Kasai Y, Mochizuki N, ''et al.'' |title=Specific association of estrogen receptor beta with the cell cycle spindle assembly checkpoint protein, MAD2. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=97 |issue= 6 |pages= 2836-9 |year= 2000 |pmid= 10706629 |doi= 10.1073/pnas.050580997 }}
== Further reading ==
*{{cite journal | author=Herdick M, Steinmeyer A, Carlberg C |title=Antagonistic action of a 25-carboxylic ester analogue of 1alpha, 25-dihydroxyvitamin D3 is mediated by a lack of ligand-induced vitamin D receptor interaction with coactivators. |journal=J. Biol. Chem. |volume=275 |issue= 22 |pages= 16506-12 |year= 2000 |pmid= 10748178 |doi= 10.1074/jbc.M910000199 }}
{{refbegin |33em}}
*{{cite journal | author=Kodera Y, Takeyama K, Murayama A, ''et al.'' |title=Ligand type-specific interactions of peroxisome proliferator-activated receptor gamma with transcriptional coactivators. |journal=J. Biol. Chem. |volume=275 |issue= 43 |pages= 33201-4 |year= 2000 |pmid= 10944516 |doi= 10.1074/jbc.C000517200 }}
* {{cite journal | vauthors = Voegel JJ, Heine MJ, Zechel C, Chambon P, Gronemeyer H | title = TIF2, a 160 kDa transcriptional mediator for the ligand-dependent activation function AF-2 of nuclear receptors. | journal = EMBO J. | volume = 15 | issue = 14 | pages = 3667–75 | year = 1996 | pmid = 8670870 | pmc = 452006 | doi =  }}
*{{cite journal | author=Koh SS, Chen D, Lee YH, Stallcup MR |title=Synergistic enhancement of nuclear receptor function by p160 coactivators and two coactivators with protein methyltransferase activities. |journal=J. Biol. Chem. |volume=276 |issue= 2 |pages= 1089-98 |year= 2001 |pmid= 11050077 |doi= 10.1074/jbc.M004228200 }}
* {{cite journal | vauthors = Hong H, Kohli K, Garabedian MJ, Stallcup MR | title = GRIP1, a transcriptional coactivator for the AF-2 transactivation domain of steroid, thyroid, retinoid, and vitamin D receptors. | journal = Mol. Cell. Biol. | volume = 17 | issue = 5 | pages = 2735–44 | year = 1997 | pmid = 9111344 | pmc = 232124 | doi =  }}
*{{cite journal  | author=Park JJ, Irvine RA, Buchanan G, ''et al.'' |title=Breast cancer susceptibility gene 1 (BRCAI) is a coactivator of the androgen receptor. |journal=Cancer Res. |volume=60 |issue= 21 |pages= 5946-9 |year= 2000 |pmid= 11085509 |doi=  }}
* {{cite journal | vauthors = Voegel JJ, Heine MJ, Tini M, Vivat V, Chambon P, Gronemeyer H | title = The coactivator TIF2 contains three nuclear receptor-binding motifs and mediates transactivation through CBP binding-dependent and -independent pathways. | journal = EMBO J. | volume = 17 | issue = 2 | pages = 507–19 | year = 1998 | pmid = 9430642 | pmc = 1170401 | doi = 10.1093/emboj/17.2.507 }}
}}
* {{cite journal | vauthors = Carapeti M, Aguiar RC, Goldman JM, Cross NC | title = A novel fusion between MOZ and the nuclear receptor coactivator TIF2 in acute myeloid leukemia. | journal = Blood | volume = 91 | issue = 9 | pages = 3127–33 | year = 1998 | pmid = 9558366 | doi =  }}
* {{cite journal | vauthors = Fryer CJ, Archer TK | title = Chromatin remodelling by the glucocorticoid receptor requires the BRG1 complex. | journal = Nature | volume = 393 | issue = 6680 | pages = 88–91 | year = 1998 | pmid = 9590696 | doi = 10.1038/30032 }}
* {{cite journal | vauthors = Berrevoets CA, Doesburg P, Steketee K, Trapman J, Brinkmann AO | title = Functional interactions of the AF-2 activation domain core region of the human androgen receptor with the amino-terminal domain and with the transcriptional coactivator TIF2 (transcriptional intermediary factor2). | journal = Mol. Endocrinol. | volume = 12 | issue = 8 | pages = 1172–83 | year = 1998 | pmid = 9717843 | doi = 10.1210/me.12.8.1172 }}
* {{cite journal | vauthors = Wang JC, Stafford JM, Granner DK | title = SRC-1 and GRIP1 coactivate transcription with hepatocyte nuclear factor 4. | journal = J. Biol. Chem. | volume = 273 | issue = 47 | pages = 30847–50 | year = 1998 | pmid = 9812974 | doi = 10.1074/jbc.273.47.30847 | pmc = 3968904 }}
* {{cite journal | vauthors = Hong H, Darimont BD, Ma H, Yang L, Yamamoto KR, Stallcup MR | title = An additional region of coactivator GRIP1 required for interaction with the hormone-binding domains of a subset of nuclear receptors. | journal = J. Biol. Chem. | volume = 274 | issue = 6 | pages = 3496–502 | year = 1999 | pmid = 9920895 | doi = 10.1074/jbc.274.6.3496 }}
* {{cite journal | vauthors = Chen D, Ma H, Hong H, Koh SS, Huang SM, Schurter BT, Aswad DW, Stallcup MR | title = Regulation of transcription by a protein methyltransferase. | journal = Science | volume = 284 | issue = 5423 | pages = 2174–7 | year = 1999 | pmid = 10381882 | doi = 10.1126/science.284.5423.2174 }}
* {{cite journal | vauthors = Ma H, Hong H, Huang SM, Irvine RA, Webb P, Kushner PJ, Coetzee GA, Stallcup MR | title = Multiple signal input and output domains of the 160-kilodalton nuclear receptor coactivator proteins. | journal = Mol. Cell. Biol. | volume = 19 | issue = 9 | pages = 6164–73 | year = 1999 | pmid = 10454563 | pmc = 84548 | doi =  }}
* {{cite journal | vauthors = Atkins GB, Hu X, Guenther MG, Rachez C, Freedman LP, Lazar MA | title = Coactivators for the orphan nuclear receptor RORalpha. | journal = Mol. Endocrinol. | volume = 13 | issue = 9 | pages = 1550–7 | year = 1999 | pmid = 10478845 | doi = 10.1210/me.13.9.1550 }}
* {{cite journal | vauthors = Carrero P, Okamoto K, Coumailleau P, O'Brien S, Tanaka H, Poellinger L | title = Redox-regulated recruitment of the transcriptional coactivators CREB-binding protein and SRC-1 to hypoxia-inducible factor 1alpha. | journal = Mol. Cell. Biol. | volume = 20 | issue = 1 | pages = 402–15 | year = 2000 | pmid = 10594042 | pmc = 85095 | doi = 10.1128/MCB.20.1.402-415.2000 }}
* {{cite journal | vauthors = Xie W, Hong H, Yang NN, Lin RJ, Simon CM, Stallcup MR, Evans RM | title = Constitutive activation of transcription and binding of coactivator by estrogen-related receptors 1 and 2. | journal = Mol. Endocrinol. | volume = 13 | issue = 12 | pages = 2151–62 | year = 2000 | pmid = 10598588 | doi = 10.1210/me.13.12.2151 }}
* {{cite journal | vauthors = Naltner A, Ghaffari M, Whitsett JA, Yan C | title = Retinoic acid stimulation of the human surfactant protein B promoter is thyroid transcription factor 1 site-dependent. | journal = J. Biol. Chem. | volume = 275 | issue = 1 | pages = 56–62 | year = 2000 | pmid = 10617585 | doi = 10.1074/jbc.275.1.56 }}
* {{cite journal | vauthors = Jimenez-Lara AM, Heine MJ, Gronemeyer H | title = Cloning of a mouse glucocorticoid modulatory element binding protein, a new member of the KDWK family. | journal = FEBS Lett. | volume = 468 | issue = 2-3 | pages = 203–10 | year = 2000 | pmid = 10692587 | doi = 10.1016/S0014-5793(00)01209-6 }}
* {{cite journal | vauthors = Poelzl G, Kasai Y, Mochizuki N, Shaul PW, Brown M, Mendelsohn ME | title = Specific association of estrogen receptor beta with the cell cycle spindle assembly checkpoint protein, MAD2. | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 97 | issue = 6 | pages = 2836–9 | year = 2000 | pmid = 10706629 | pmc = 16016 | doi = 10.1073/pnas.050580997 }}
* {{cite journal | vauthors = Herdick M, Steinmeyer A, Carlberg C | title = Antagonistic action of a 25-carboxylic ester analogue of 1alpha, 25-dihydroxyvitamin D3 is mediated by a lack of ligand-induced vitamin D receptor interaction with coactivators. | journal = J. Biol. Chem. | volume = 275 | issue = 22 | pages = 16506–12 | year = 2000 | pmid = 10748178 | doi = 10.1074/jbc.M910000199 }}
* {{cite journal | vauthors = Kodera Y, Takeyama K, Murayama A, Suzawa M, Masuhiro Y, Kato S | title = Ligand type-specific interactions of peroxisome proliferator-activated receptor gamma with transcriptional coactivators. | journal = J. Biol. Chem. | volume = 275 | issue = 43 | pages = 33201–4 | year = 2000 | pmid = 10944516 | doi = 10.1074/jbc.C000517200 | pmc = 3798517 }}
* {{cite journal | vauthors = Koh SS, Chen D, Lee YH, Stallcup MR | title = Synergistic enhancement of nuclear receptor function by p160 coactivators and two coactivators with protein methyltransferase activities. | journal = J. Biol. Chem. | volume = 276 | issue = 2 | pages = 1089–98 | year = 2001 | pmid = 11050077 | doi = 10.1074/jbc.M004228200 }}
* {{cite journal | vauthors = Park JJ, Irvine RA, Buchanan G, Koh SS, Park JM, Tilley WD, Stallcup MR, Press MF, Coetzee GA | title = Breast cancer susceptibility gene 1 (BRCAI) is a coactivator of the androgen receptor. | journal = Cancer Res. | volume = 60 | issue = 21 | pages = 5946–9 | year = 2000 | pmid = 11085509 | doi =  }}
{{refend}}
{{refend}}


==External links==
== External links ==
* {{MeshName|nuclear+receptor+coactivator+2}}
* {{MeshName|nuclear+receptor+coactivator+2|3=nuclear receptor coactivator 2}}
* {{NURSA|C90}}


{{Transcription coregulators}}


{{biochem-stub}}
{{Transcription coregulators}}
[[Category:Transcription coregulators]]
[[Category:Transcription coregulators]]
[[Category:PAS-domain-containing proteins]]

Latest revision as of 08:38, 10 January 2019

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Identifiers
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Orthologs
SpeciesHumanMouse
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The nuclear receptor coactivator 2 also known as NCoA-2 is a protein that in humans is encoded by the NCOA2 gene. NCoA-2 is also frequently called glucocorticoid receptor-interacting protein 1 (GRIP1), steroid receptor coactivator-2 (SRC-2), or transcriptional mediators/intermediary factor 2 (TIF2).

Function

NCoA-2 is a transcriptional coregulatory protein that contains several nuclear receptor interacting domains and an intrinsic histone acetyltransferase activity. NCOA2 is recruited to DNA promotion sites by ligand-activated nuclear receptors. NCOA2 in turn acetylates histones, which makes downstream DNA more accessible to transcription. Hence, NCOA2 assists nuclear receptors in the upregulation of DNA expression.[1][2]

GRIP1 is a transcriptional co-activator of the glucocorticoid receptor and interferon regulatory factor 1 (IRF1).[3]

Interactions

Nuclear receptor coactivator 2 has been shown to interact with:

References

  1. ↑ Voegel JJ, Heine MJ, Zechel C, Chambon P, Gronemeyer H (1996). "TIF2, a 160 kDa transcriptional mediator for the ligand-dependent activation function AF-2 of nuclear receptors". EMBO J. 15 (14): 3667–75. PMC 452006. PMID 8670870.
  2. ↑ Hong H, Kohli K, Garabedian MJ, Stallcup MR (1997). "GRIP1, a transcriptional coactivator for the AF-2 transactivation domain of steroid, thyroid, retinoid, and vitamin D receptors". Mol Cell Biol. 17 (5): 2735–44. PMC 232124. PMID 9111344.
  3. ↑ Bhandare R, Damera G, Banerjee A, Flammer JR, Keslacy S, Rogatsky I, Panettieri RA, Amrani Y, Tliba O (January 2010). "Glucocorticoid receptor interacting protein-1 restores glucocorticoid responsiveness in steroid-resistant airway structural cells". Am. J. Respir. Cell Mol. Biol. 42 (1): 9–15. doi:10.1165/rcmb.2009-0239RC. PMC 2809222. PMID 19805480.
  4. ↑ Song LN, Coghlan M, Gelmann EP (2004). "Antiandrogen effects of mifepristone on coactivator and corepressor interactions with the androgen receptor". Mol. Endocrinol. 18 (1): 70–85. doi:10.1210/me.2003-0189. PMID 14593076.
  5. ↑ Ishitani K, Yoshida T, Kitagawa H, Ohta H, Nozawa S, Kato S (2003). "p54nrb acts as a transcriptional coactivator for activation function 1 of the human androgen receptor". Biochem. Biophys. Res. Commun. 306 (3): 660–5. doi:10.1016/S0006-291X(03)01021-0. PMID 12810069.
  6. ↑ Wang Q, Udayakumar TS, Vasaitis TS, Brodie AM, Fondell JD (2004). "Mechanistic relationship between androgen receptor polyglutamine tract truncation and androgen-dependent transcriptional hyperactivity in prostate cancer cells". J. Biol. Chem. 279 (17): 17319–28. doi:10.1074/jbc.M400970200. PMID 14966121.
  7. ↑ 7.0 7.1 7.2 He B, Wilson EM (2003). "Electrostatic modulation in steroid receptor recruitment of LXXLL and FXXLF motifs". Mol. Cell. Biol. 23 (6): 2135–50. doi:10.1128/MCB.23.6.2135-2150.2003. PMC 149467. PMID 12612084.
  8. ↑ Bai S, He B, Wilson EM (2005). "Melanoma antigen gene protein MAGE-11 regulates androgen receptor function by modulating the interdomain interaction". Mol. Cell. Biol. 25 (4): 1238–57. doi:10.1128/MCB.25.4.1238-1257.2005. PMC 548016. PMID 15684378.
  9. ↑ Beischlag TV, Wang S, Rose DW, Torchia J, Reisz-Porszasz S, Muhammad K, Nelson WE, Probst MR, Rosenfeld MG, Hankinson O (2002). "Recruitment of the NCoA/SRC-1/p160 family of transcriptional coactivators by the aryl hydrocarbon receptor/aryl hydrocarbon receptor nuclear translocator complex". Mol. Cell. Biol. 22 (12): 4319–33. doi:10.1128/MCB.22.12.4319-4333.2002. PMC 133867. PMID 12024042.
  10. ↑ Rodriguez M, Yu X, Chen J, Songyang Z (2003). "Phosphopeptide binding specificities of BRCA1 COOH-terminal (BRCT) domains". J. Biol. Chem. 278 (52): 52914–8. doi:10.1074/jbc.C300407200. PMID 14578343.
  11. ↑ Park JJ, Irvine RA, Buchanan G, Koh SS, Park JM, Tilley WD, Stallcup MR, Press MF, Coetzee GA (2000). "Breast cancer susceptibility gene 1 (BRCAI) is a coactivator of the androgen receptor". Cancer Res. 60 (21): 5946–9. PMID 11085509.
  12. ↑ 12.0 12.1 12.2 12.3 Watanabe M, Yanagisawa J, Kitagawa H, Takeyama K, Ogawa S, Arao Y, Suzawa M, Kobayashi Y, Yano T, Yoshikawa H, Masuhiro Y, Kato S (2001). "A subfamily of RNA-binding DEAD-box proteins acts as an estrogen receptor alpha coactivator through the N-terminal activation domain (AF-1) with an RNA coactivator, SRA". EMBO J. 20 (6): 1341–52. doi:10.1093/emboj/20.6.1341. PMC 145523. PMID 11250900.
  13. ↑ 13.0 13.1 Kitagawa H, Fujiki R, Yoshimura K, Mezaki Y, Uematsu Y, Matsui D, Ogawa S, Unno K, Okubo M, Tokita A, Nakagawa T, Ito T, Ishimi Y, Nagasawa H, Matsumoto T, Yanagisawa J, Kato S (2003). "The chromatin-remodeling complex WINAC targets a nuclear receptor to promoters and is impaired in Williams syndrome". Cell. 113 (7): 905–17. doi:10.1016/S0092-8674(03)00436-7. PMID 12837248.
  14. ↑ Wärnmark A, Treuter E, Gustafsson JA, Hubbard RE, Brzozowski AM, Pike AC (2002). "Interaction of transcriptional intermediary factor 2 nuclear receptor box peptides with the coactivator binding site of estrogen receptor alpha". J. Biol. Chem. 277 (24): 21862–8. doi:10.1074/jbc.M200764200. PMID 11937504.
  15. ↑ Fenne IS, Hoang T, Hauglid M, Sagen JV, Lien EA, Mellgren G (2008). "Recruitment of coactivator glucocorticoid receptor interacting protein 1 to an estrogen receptor transcription complex is regulated by the 3',5'-cyclic adenosine 5'-monophosphate-dependent protein kinase". Endocrinology. 149 (9): 4336–45. doi:10.1210/en.2008-0037. PMID 18499756.
  16. ↑ Zilliacus J, Holter E, Wakui H, Tazawa H, Treuter E, Gustafsson JA (2001). "Regulation of glucocorticoid receptor activity by 14--3-3-dependent intracellular relocalization of the corepressor RIP140". Mol. Endocrinol. 15 (4): 501–11. doi:10.1210/mend.15.4.0624. PMID 11266503.
  17. ↑ Bledsoe RK, Montana VG, Stanley TB, Delves CJ, Apolito CJ, McKee DD, Consler TG, Parks DJ, Stewart EL, Willson TM, Lambert MH, Moore JT, Pearce KH, Xu HE (2002). "Crystal structure of the glucocorticoid receptor ligand binding domain reveals a novel mode of receptor dimerization and coactivator recognition". Cell. 110 (1): 93–105. doi:10.1016/S0092-8674(02)00817-6. PMID 12151000.
  18. ↑ Wyszynski M, Kim E, Dunah AW, Passafaro M, Valtschanoff JG, Serra-Pagès C, Streuli M, Weinberg RJ, Sheng M (2002). "Interaction between GRIP and liprin-alpha/SYD2 is required for AMPA receptor targeting". Neuron. 34 (1): 39–52. doi:10.1016/S0896-6273(02)00640-2. PMID 11931740.
  19. ↑ Kodera Y, Takeyama K, Murayama A, Suzawa M, Masuhiro Y, Kato S (2000). "Ligand type-specific interactions of peroxisome proliferator-activated receptor gamma with transcriptional coactivators". J. Biol. Chem. 275 (43): 33201–4. doi:10.1074/jbc.C000517200. PMC 3798517. PMID 10944516.
  20. ↑ 20.0 20.1 Zhang C, Baudino TA, Dowd DR, Tokumaru H, Wang W, MacDonald PN (2001). "Ternary complexes and cooperative interplay between NCoA-62/Ski-interacting protein and steroid receptor coactivators in vitamin D receptor-mediated transcription". J. Biol. Chem. 276 (44): 40614–20. doi:10.1074/jbc.M106263200. PMID 11514567.
  21. ↑ Lee WY, Noy N (2002). "Interactions of RXR with coactivators are differentially mediated by helix 11 of the receptor's ligand binding domain". Biochemistry. 41 (8): 2500–8. doi:10.1021/bi011764. PMID 11851396.
  22. ↑ Herdick M, Steinmeyer A, Carlberg C (2000). "Antagonistic action of a 25-carboxylic ester analogue of 1alpha, 25-dihydroxyvitamin D3 is mediated by a lack of ligand-induced vitamin D receptor interaction with coactivators". J. Biol. Chem. 275 (22): 16506–12. doi:10.1074/jbc.M910000199. PMID 10748178.

Further reading

External links

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