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<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{Infobox_gene}}
{{PBB_Controls
'''Protein kinase C iota type''' is an [[enzyme]] that in humans is encoded by the ''PRKCI'' [[gene]].<ref name="pmid7607695">{{cite journal | vauthors = Mazzarella R, Ciccodicola A, Esposito T, Arcucci A, Migliaccio C, Jones C, Schlessinger D, D'Urso M, D'Esposito M | title = Human protein kinase C Iota gene (PRKCI) is closely linked to the BTK gene in Xq21.3 | journal = Genomics | volume = 26 | issue = 3 | pages = 629–31 | date = Apr 1995 | pmid = 7607695 | pmc =  | doi = 10.1016/0888-7543(95)80190-W }}</ref><ref name="pmid11978974">{{cite journal | vauthors = De Donato M, Gallagher DS, Davis SK, Stelly DM, Taylor JF | title = The assignment of PRKCI to bovine chromosome 1q34-->q36 by FISH suggests a new assignment to human chromosome 3 | journal = Cytogenetics and Cell Genetics | volume = 95 | issue = 1–2 | pages = 79–81 | date = April 2002 | pmid = 11978974 | pmc = | doi = 10.1159/000057021 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: PRKCI protein kinase C, iota| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5584| accessdate = }}</ref>
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}


<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Function ==
{{GNF_Protein_box
| image = PBB_Protein_PRKCI_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1vd2.
| PDB = {{PDB2|1vd2}}, {{PDB2|1wmh}}, {{PDB2|1zrz}}
| Name = Protein kinase C, iota
| HGNCid = 9404
| Symbol = PRKCI
| AltSymbols =; DXS1179E; MGC26534; PKCI; nPKC-iota
| OMIM = 600539
| ECnumber = 
| Homologene = 37667
| MGIid = 99260
| GeneAtlas_image1 = PBB_GE_PRKCI_209678_s_at_tn.png
| GeneAtlas_image2 = PBB_GE_PRKCI_209677_at_tn.png
| GeneAtlas_image3 = PBB_GE_PRKCI_213518_at_tn.png
| Function = {{GNF_GO|id=GO:0000166 |text = nucleotide binding}} {{GNF_GO|id=GO:0004674 |text = protein serine/threonine kinase activity}} {{GNF_GO|id=GO:0004700 |text = atypical protein kinase C activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0005524 |text = ATP binding}} {{GNF_GO|id=GO:0005543 |text = phospholipid binding}} {{GNF_GO|id=GO:0008270 |text = zinc ion binding}} {{GNF_GO|id=GO:0016740 |text = transferase activity}} {{GNF_GO|id=GO:0019992 |text = diacylglycerol binding}} {{GNF_GO|id=GO:0046872 |text = metal ion binding}}
| Component = {{GNF_GO|id=GO:0000133 |text = polarisome}} {{GNF_GO|id=GO:0005634 |text = nucleus}} {{GNF_GO|id=GO:0005737 |text = cytoplasm}} {{GNF_GO|id=GO:0005829 |text = cytosol}} {{GNF_GO|id=GO:0045177 |text = apical part of cell}}
| Process = {{GNF_GO|id=GO:0006468 |text = protein amino acid phosphorylation}} {{GNF_GO|id=GO:0006612 |text = protein targeting to membrane}} {{GNF_GO|id=GO:0007010 |text = cytoskeleton organization and biogenesis}} {{GNF_GO|id=GO:0007015 |text = actin filament organization}} {{GNF_GO|id=GO:0007242 |text = intracellular signaling cascade}} {{GNF_GO|id=GO:0016044 |text = membrane organization and biogenesis}} {{GNF_GO|id=GO:0016192 |text = vesicle-mediated transport}} {{GNF_GO|id=GO:0035089 |text = establishment of apical/basal cell polarity}} {{GNF_GO|id=GO:0042462 |text = eye photoreceptor cell development}} {{GNF_GO|id=GO:0045197 |text = establishment and/or maintenance of epithelial cell polarity}} {{GNF_GO|id=GO:0045216 |text = intercellular junction assembly and maintenance}} {{GNF_GO|id=GO:0046903 |text = secretion}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 5584
    | Hs_Ensembl = ENSG00000163558
    | Hs_RefseqProtein = NP_002731
    | Hs_RefseqmRNA = NM_002740
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 3
    | Hs_GenLoc_start = 171422919
    | Hs_GenLoc_end = 171506458
    | Hs_Uniprot = P41743
    | Mm_EntrezGene = 18759
    | Mm_Ensembl = ENSMUSG00000037643
    | Mm_RefseqmRNA = NM_008857
    | Mm_RefseqProtein = NP_032883
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 3
    | Mm_GenLoc_start = 31186625
    | Mm_GenLoc_end = 31243615
    | Mm_Uniprot = Q3TJJ5
  }}
}}
'''Protein kinase C, iota''', also known as '''PRKCI''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: PRKCI protein kinase C, iota| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5584| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
This gene encodes a member of the protein kinase C (PKC) family of serine/threonine protein kinases. The PKC family comprises at least eight members, which are differentially expressed and are involved in a wide variety of cellular processes. This protein kinase is calcium-independent and phospholipid-dependent. It is not activated by phorbolesters or diacylglycerol. This kinase can be recruited to vesicle tubular clusters (VTCs) by direct interaction with the small GTPase RAB2, where this kinase phosphorylates glyceraldehyde-3-phosphate dehydrogenase (GAPD/GAPDH) and plays a role in microtubule dynamics in the early secretory pathway. This kinase is found to be necessary for BCL-ABL-mediated resistance to drug-induced apoptosis and therefore protects leukemia cells against drug-induced apoptosis. There is a single exon pseudogene mapped on chromosome X.<ref name="entrez"/>
{{PBB_Summary
| section_title =
| summary_text = This gene encodes a member of the protein kinase C (PKC) family of serine/threonine protein kinases. The PKC family comprises at least eight members, which are differentially expressed and are involved in a wide variety of cellular processes. This protein kinase is calcium-independent and phospholipid-dependent. It is not activated by phorbolesters or diacylglycerol. This kinase can be recruited to vesicle tubular clusters (VTCs) by direct interaction with the small GTPase RAB2, where this kinase phosphorylates glyceraldehyde-3-phosphate dehydrogenase (GAPD/GAPDH) and plays a role in microtubule dynamics in the early secretory pathway. This kinase is found to be necessary for BCL-ABL-mediated resistance to drug-induced apoptosis and therefore protects leukemia cells against drug-induced apoptosis. There is a single exon pseudogene mapped on chromosome X.<ref name="entrez">{{cite web | title = Entrez Gene: PRKCI protein kinase C, iota| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5584| accessdate = }}</ref>
}}


==References==
== Interactions ==
{{reflist|2}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal  | author=Suzuki A, Akimoto K, Ohno S |title=Protein kinase C lambda/iota (PKClambda/iota): a PKC isotype essential for the development of multicellular organisms. |journal=J. Biochem. |volume=133 |issue= 1 |pages= 9-16 |year= 2003 |pmid= 12761193 |doi=  }}
*{{cite journal  | author=Fields AP, Regala RP |title=Protein kinase C iota: human oncogene, prognostic marker and therapeutic target. |journal=Pharmacol. Res. |volume=55 |issue= 6 |pages= 487-97 |year= 2007 |pmid= 17570678 |doi= 10.1016/j.phrs.2007.04.015 }}
*{{cite journal  | author=Ruegg CL, Strand M |title=A synthetic peptide with sequence identity to the transmembrane protein GP41 of HIV-1 inhibits distinct lymphocyte activation pathways dependent on protein kinase C and intracellular calcium influx. |journal=Cell. Immunol. |volume=137 |issue= 1 |pages= 1-13 |year= 1991 |pmid= 1832084 |doi=  }}
*{{cite journal  | author=Chowdhury IH, Koyanagi Y, Kobayashi S, ''et al.'' |title=The phorbol ester TPA strongly inhibits HIV-1-induced syncytia formation but enhances virus production: possible involvement of protein kinase C pathway. |journal=Virology |volume=176 |issue= 1 |pages= 126-32 |year= 1990 |pmid= 1970444 |doi=  }}
*{{cite journal  | author=Ruegg CL, Strand M |title=Inhibition of protein kinase C and anti-CD3-induced Ca2+ influx in Jurkat T cells by a synthetic peptide with sequence identity to HIV-1 gp41. |journal=J. Immunol. |volume=144 |issue= 10 |pages= 3928-35 |year= 1990 |pmid= 2139676 |doi=  }}
*{{cite journal  | author=Jakobovits A, Rosenthal A, Capon DJ |title=Trans-activation of HIV-1 LTR-directed gene expression by tat requires protein kinase C. |journal=EMBO J. |volume=9 |issue= 4 |pages= 1165-70 |year= 1990 |pmid= 2182321 |doi=  }}
*{{cite journal  | author=Fields AP, Bednarik DP, Hess A, May WS |title=Human immunodeficiency virus induces phosphorylation of its cell surface receptor. |journal=Nature |volume=333 |issue= 6170 |pages= 278-80 |year= 1988 |pmid= 3259291 |doi= 10.1038/333278a0 }}
*{{cite journal  | author=Mazzarella R, Ciccodicola A, Esposito T, ''et al.'' |title=Human protein kinase C Iota gene (PRKCI) is closely linked to the BTK gene in Xq21.3. |journal=Genomics |volume=26 |issue= 3 |pages= 629-31 |year= 1995 |pmid= 7607695 |doi=  }}
*{{cite journal  | author=Chirmule N, Goonewardena H, Pahwa S, ''et al.'' |title=HIV-1 envelope glycoproteins induce activation of activated protein-1 in CD4+ T cells. |journal=J. Biol. Chem. |volume=270 |issue= 33 |pages= 19364-9 |year= 1995 |pmid= 7642615 |doi=  }}
*{{cite journal  | author=Ward NE, Gravitt KR, O'Brian CA |title=Inhibition of protein kinase C by a synthetic peptide corresponding to cytoplasmic domain residues 828-848 of the human immunodeficiency virus type 1 envelope glycoprotein. |journal=Cancer Lett. |volume=88 |issue= 1 |pages= 37-40 |year= 1995 |pmid= 7850771 |doi=  }}
*{{cite journal  | author=Gupta S, Aggarwal S, Kim C, Gollapudi S |title=Human immunodeficiency virus-1 recombinant gp120 induces changes in protein kinase C isozymes--a preliminary report. |journal=Int. J. Immunopharmacol. |volume=16 |issue= 3 |pages= 197-204 |year= 1994 |pmid= 8206685 |doi=  }}
*{{cite journal  | author=Selbie LA, Schmitz-Peiffer C, Sheng Y, Biden TJ |title=Molecular cloning and characterization of PKC iota, an atypical isoform of protein kinase C derived from insulin-secreting cells. |journal=J. Biol. Chem. |volume=268 |issue= 32 |pages= 24296-302 |year= 1993 |pmid= 8226978 |doi=  }}
*{{cite journal  | author=Diaz-Meco MT, Municio MM, Sanchez P, ''et al.'' |title=Lambda-interacting protein, a novel protein that specifically interacts with the zinc finger domain of the atypical protein kinase C isotype lambda/iota and stimulates its kinase activity in vitro and in vivo. |journal=Mol. Cell. Biol. |volume=16 |issue= 1 |pages= 105-14 |year= 1996 |pmid= 8524286 |doi=  }}
*{{cite journal  | author=Parada NA, Cruikshank WW, Danis HL, ''et al.'' |title=IL-16- and other CD4 ligand-induced migration is dependent upon protein kinase C. |journal=Cell. Immunol. |volume=168 |issue= 1 |pages= 100-6 |year= 1996 |pmid= 8599832 |doi= 10.1006/cimm.1996.0054 }}
*{{cite journal  | author=Conant K, Ma M, Nath A, Major EO |title=Extracellular human immunodeficiency virus type 1 Tat protein is associated with an increase in both NF-kappa B binding and protein kinase C activity in primary human astrocytes. |journal=J. Virol. |volume=70 |issue= 3 |pages= 1384-9 |year= 1996 |pmid= 8627654 |doi=  }}
*{{cite journal  | author=Díaz-Meco MT, Municio MM, Frutos S, ''et al.'' |title=The product of par-4, a gene induced during apoptosis, interacts selectively with the atypical isoforms of protein kinase C. |journal=Cell |volume=86 |issue= 5 |pages= 777-86 |year= 1996 |pmid= 8797824 |doi=  }}
*{{cite journal  | author=Holmes AM |title=In vitro phosphorylation of human immunodeficiency virus type 1 Tat protein by protein kinase C: evidence for the phosphorylation of amino acid residue serine-46. |journal=Arch. Biochem. Biophys. |volume=335 |issue= 1 |pages= 8-12 |year= 1996 |pmid= 8914829 |doi= 10.1006/abbi.1996.0476 }}
*{{cite journal  | author=Murray NR, Fields AP |title=Atypical protein kinase C iota protects human leukemia cells against drug-induced apoptosis. |journal=J. Biol. Chem. |volume=272 |issue= 44 |pages= 27521-4 |year= 1997 |pmid= 9346882 |doi=  }}
*{{cite journal  | author=Borgatti P, Zauli G, Cantley LC, Capitani S |title=Extracellular HIV-1 Tat protein induces a rapid and selective activation of protein kinase C (PKC)-alpha, and -epsilon and -zeta isoforms in PC12 cells. |journal=Biochem. Biophys. Res. Commun. |volume=242 |issue= 2 |pages= 332-7 |year= 1998 |pmid= 9446795 |doi=  }}
*{{cite journal  | author=Sanchez P, De Carcer G, Sandoval IV, ''et al.'' |title=Localization of atypical protein kinase C isoforms into lysosome-targeted endosomes through interaction with p62. |journal=Mol. Cell. Biol. |volume=18 |issue= 5 |pages= 3069-80 |year= 1998 |pmid= 9566925 |doi=  }}
}}
{{refend}}


{{protein-stub}}
PRKCI has been shown to [[Protein-protein interaction|interact]] with:
{{WikiDoc Sources}}
{{div col|colwidth=20em}}
* [[Centaurin, alpha 1]],<ref name = pmid12893243>{{cite journal | vauthors = Zemlickova E, Dubois T, Kerai P, Clokie S, Cronshaw AD, Wakefield RI, Johannes FJ, Aitken A | title = Centaurin-alpha(1) associates with and is phosphorylated by isoforms of protein kinase C | journal = Biochemical and Biophysical Research Communications | volume = 307 | issue = 3 | pages = 459–65 | date = Aug 2003 | pmid = 12893243 | doi =  10.1016/s0006-291x(03)01187-2}}</ref>
* [[FRS2]],<ref name = pmid10383403>{{cite journal | vauthors = Lim YP, Low BC, Lim J, Wong ES, Guy GR | title = Association of atypical protein kinase C isotypes with the docker protein FRS2 in fibroblast growth factor signaling | journal = The Journal of Biological Chemistry | volume = 274 | issue = 27 | pages = 19025–34 | date = Jul 1999 | pmid = 10383403 | doi =  10.1074/jbc.274.27.19025}}</ref>
* [[Glyceraldehyde 3-phosphate dehydrogenase]],<ref name = pmid11724794>{{cite journal | vauthors = Tisdale EJ | title = Glyceraldehyde-3-phosphate dehydrogenase is phosphorylated by protein kinase Ciota /lambda and plays a role in microtubule dynamics in the early secretory pathway | journal = The Journal of Biological Chemistry | volume = 277 | issue = 5 | pages = 3334–41 | date = Feb 2002 | pmid = 11724794 | doi = 10.1074/jbc.M109744200 }}</ref>
* [[PARD3]],<ref name = pmid9566925>{{cite journal | vauthors = Sanchez P, De Carcer G, Sandoval IV, Moscat J, Diaz-Meco MT | title = Localization of atypical protein kinase C isoforms into lysosome-targeted endosomes through interaction with p62 | journal = Molecular and Cellular Biology | volume = 18 | issue = 5 | pages = 3069–80 | date = May 1998 | pmid = 9566925 | pmc = 110686 | doi =  10.1128/mcb.18.5.3069}}</ref><ref name = pmid12459187>{{cite journal | vauthors = Kohjima M, Noda Y, Takeya R, Saito N, Takeuchi K, Sumimoto H | title = PAR3beta, a novel homologue of the cell polarity protein PAR3, localizes to tight junctions | journal = Biochemical and Biophysical Research Communications | volume = 299 | issue = 4 | pages = 641–6 | date = Dec 2002 | pmid = 12459187 | doi =  10.1016/s0006-291x(02)02698-0}}</ref>
* [[Phosphoinositide-dependent kinase-1]],<ref name = pmid10764742>{{cite journal | vauthors = Balendran A, Biondi RM, Cheung PC, Casamayor A, Deak M, Alessi DR | title = A 3-phosphoinositide-dependent protein kinase-1 (PDK1) docking site is required for the phosphorylation of protein kinase Czeta (PKCzeta ) and PKC-related kinase 2 by PDK1 | journal = The Journal of Biological Chemistry | volume = 275 | issue = 27 | pages = 20806–13 | date = Jul 2000 | pmid = 10764742 | doi = 10.1074/jbc.M000421200 }}</ref>
* [[SMG1 (gene)]],<ref name = pmid8524286>{{cite journal | vauthors = Diaz-Meco MT, Municio MM, Sanchez P, Lozano J, Moscat J | title = Lambda-interacting protein, a novel protein that specifically interacts with the zinc finger domain of the atypical protein kinase C isotype lambda/iota and stimulates its kinase activity in vitro and in vivo | journal = Molecular and Cellular Biology | volume = 16 | issue = 1 | pages = 105–14 | date = Jan 1996 | pmid = 8524286 | pmc = 230983 | doi =  }}</ref>
* [[Sequestosome 1]],
* [[KRAS]].<ref name = pmid18794128>{{cite journal | vauthors = Guo W, Wu S, Liu J, Fang B | title = Identification of a small molecule with synthetic lethality for K-ras and protein kinase C iota. | journal = Cancer Research | volume = 68 | issue = 18 | pages = 7403–8 | date = Sep 2008 | pmid = 18794128 | doi = 10.1158/0008-5472.CAN-08-1449 | pmc=2678915}}</ref>
{{Div col end}}
* [[Vimentin]] <ref name = pmid29048609>{{cite journal |vauthors=Ratnayake WS, Apostolatos AH, Ostrov DA, Acevedo-Duncan M | title = Two novel atypical PKC inhibitors; ACPD and DNDA effectively mitigate cell proliferation and epithelial to mesenchymal transition of metastatic melanoma while inducing apoptosis | journal = Int. J. Oncol. | volume = 51 | issue = 5 | pages = 1370-1382 | year = 2017 | pmid = 29048609 | doi = 10.3892/ijo.2017.4131 | pmc=5642393}}</ref>
{{Div col end}} <ref name = pmid29781749>{{cite journal |vauthors=Ratnayake WS, Apostolatos CA, Apostolatos AH, Schutte RJ, Huynh MA, Ostrov DA, Acevedo-Duncan M | title = Oncogenic PKC-ι activates Vimentin during epithelial-mesenchymal transition in melanoma; a study based on PKC-ι and PKC-ζ specific inhibitors | journal = Cell Adhes. Migr.| volume = 0 | issue = 0 | pages = 1-17 | year = 2018 | pmid = 29781749 | doi = 10.1080/19336918.2018.1471323}}</ref>
{{Div col end}}
 
== References ==
{{Reflist}}
== Further reading ==
{{Refbegin | 2}}
* {{cite journal | vauthors = Suzuki A, Akimoto K, Ohno S | title = Protein kinase C lambda/iota (PKClambda/iota): a PKC isotype essential for the development of multicellular organisms | journal = Journal of Biochemistry | volume = 133 | issue = 1 | pages = 9–16 | date = Jan 2003 | pmid = 12761193 | doi = 10.1093/jb/mvg018 }}
* {{cite journal | vauthors = Fields AP, Regala RP | title = Protein kinase C iota: human oncogene, prognostic marker and therapeutic target | journal = Pharmacological Research | volume = 55 | issue = 6 | pages = 487–97 | date = Jun 2007 | pmid = 17570678 | pmc = 2705893 | doi = 10.1016/j.phrs.2007.04.015 }}
* {{cite journal | vauthors = Ruegg CL, Strand M | title = A synthetic peptide with sequence identity to the transmembrane protein GP41 of HIV-1 inhibits distinct lymphocyte activation pathways dependent on protein kinase C and intracellular calcium influx | journal = Cellular Immunology | volume = 137 | issue = 1 | pages = 1–13 | date = Oct 1991 | pmid = 1832084 | doi = 10.1016/0008-8749(91)90051-C }}
* {{cite journal | vauthors = Chowdhury IH, Koyanagi Y, Kobayashi S, Hamamoto Y, Yoshiyama H, Yoshida T, Yamamoto N | title = The phorbol ester TPA strongly inhibits HIV-1-induced syncytia formation but enhances virus production: possible involvement of protein kinase C pathway | journal = Virology | volume = 176 | issue = 1 | pages = 126–32 | date = May 1990 | pmid = 1970444 | doi = 10.1016/0042-6822(90)90237-L }}
* {{cite journal | vauthors = Ruegg CL, Strand M | title = Inhibition of protein kinase C and anti-CD3-induced Ca2+ influx in Jurkat T cells by a synthetic peptide with sequence identity to HIV-1 gp41 | journal = Journal of Immunology | volume = 144 | issue = 10 | pages = 3928–35 | date = May 1990 | pmid = 2139676 | url = http://www.jimmunol.org/cgi/pmidlookup?view=long&pmid=2139676 }}
* {{cite journal | vauthors = Jakobovits A, Rosenthal A, Capon DJ | title = Trans-activation of HIV-1 LTR-directed gene expression by tat requires protein kinase C | journal = The EMBO Journal | volume = 9 | issue = 4 | pages = 1165–70 | date = Apr 1990 | pmid = 2182321 | pmc = 551792 }}
* {{cite journal | vauthors = Fields AP, Bednarik DP, Hess A, May WS | title = Human immunodeficiency virus induces phosphorylation of its cell surface receptor | journal = Nature | volume = 333 | issue = 6170 | pages = 278–80 | date = May 1988 | pmid = 3259291 | doi = 10.1038/333278a0 }}
* {{cite journal | vauthors = Chirmule N, Goonewardena H, Pahwa S, Pasieka R, Kalyanaraman VS, Pahwa S | title = HIV-1 envelope glycoproteins induce activation of activated protein-1 in CD4+ T cells | journal = The Journal of Biological Chemistry | volume = 270 | issue = 33 | pages = 19364–9 | date = Aug 1995 | pmid = 7642615 | doi = 10.1074/jbc.270.33.19364 }}
* {{cite journal | vauthors = Ward NE, Gravitt KR, O'Brian CA | title = Inhibition of protein kinase C by a synthetic peptide corresponding to cytoplasmic domain residues 828-848 of the human immunodeficiency virus type 1 envelope glycoprotein | journal = Cancer Letters | volume = 88 | issue = 1 | pages = 37–40 | date = Jan 1995 | pmid = 7850771 | doi = 10.1016/0304-3835(94)03610-U }}
* {{cite journal | vauthors = Gupta S, Aggarwal S, Kim C, Gollapudi S | title = Human immunodeficiency virus-1 recombinant gp120 induces changes in protein kinase C isozymes--a preliminary report | journal = International Journal of Immunopharmacology | volume = 16 | issue = 3 | pages = 197–204 | date = Mar 1994 | pmid = 8206685 | doi = 10.1016/0192-0561(94)90013-2 }}
* {{cite journal | vauthors = Selbie LA, Schmitz-Peiffer C, Sheng Y, Biden TJ | title = Molecular cloning and characterization of PKC iota, an atypical isoform of protein kinase C derived from insulin-secreting cells | journal = The Journal of Biological Chemistry | volume = 268 | issue = 32 | pages = 24296–302 | date = Nov 1993 | pmid = 8226978 }}
* {{cite journal | vauthors = Diaz-Meco MT, Municio MM, Sanchez P, Lozano J, Moscat J | title = Lambda-interacting protein, a novel protein that specifically interacts with the zinc finger domain of the atypical protein kinase C isotype lambda/iota and stimulates its kinase activity in vitro and in vivo | journal = Molecular and Cellular Biology | volume = 16 | issue = 1 | pages = 105–14 | date = Jan 1996 | pmid = 8524286 | pmc = 230983 | url = http://mcb.asm.org/cgi/pmidlookup?view=long&pmid=8524286 }}
* {{cite journal | vauthors = Parada NA, Cruikshank WW, Danis HL, Ryan TC, Center DM | title = IL-16- and other CD4 ligand-induced migration is dependent upon protein kinase C | journal = Cellular Immunology | volume = 168 | issue = 1 | pages = 100–6 | date = Feb 1996 | pmid = 8599832 | doi = 10.1006/cimm.1996.0054 }}
* {{cite journal | vauthors = Conant K, Ma M, Nath A, Major EO | title = Extracellular human immunodeficiency virus type 1 Tat protein is associated with an increase in both NF-kappa B binding and protein kinase C activity in primary human astrocytes | journal = Journal of Virology | volume = 70 | issue = 3 | pages = 1384–9 | date = Mar 1996 | pmid = 8627654 | pmc = 189957 | url = http://jvi.asm.org/cgi/pmidlookup?view=long&pmid=8627654 }}
* {{cite journal | vauthors = Díaz-Meco MT, Municio MM, Frutos S, Sanchez P, Lozano J, Sanz L, Moscat J | title = The product of par-4, a gene induced during apoptosis, interacts selectively with the atypical isoforms of protein kinase C | journal = Cell | volume = 86 | issue = 5 | pages = 777–86 | date = Sep 1996 | pmid = 8797824 | doi = 10.1016/S0092-8674(00)80152-X }}
* {{cite journal | vauthors = Holmes AM | title = In vitro phosphorylation of human immunodeficiency virus type 1 Tat protein by protein kinase C: evidence for the phosphorylation of amino acid residue serine-46 | journal = Archives of Biochemistry and Biophysics | volume = 335 | issue = 1 | pages = 8–12 | date = Nov 1996 | pmid = 8914829 | doi = 10.1006/abbi.1996.0476 }}
* {{cite journal | vauthors = Murray NR, Fields AP | title = Atypical protein kinase C iota protects human leukemia cells against drug-induced apoptosis | journal = The Journal of Biological Chemistry | volume = 272 | issue = 44 | pages = 27521–4 | date = Oct 1997 | pmid = 9346882 | doi = 10.1074/jbc.272.44.27521 }}
* {{cite journal | vauthors = Borgatti P, Zauli G, Cantley LC, Capitani S | title = Extracellular HIV-1 Tat protein induces a rapid and selective activation of protein kinase C (PKC)-alpha, and -epsilon and -zeta isoforms in PC12 cells | journal = Biochemical and Biophysical Research Communications | volume = 242 | issue = 2 | pages = 332–7 | date = Jan 1998 | pmid = 9446795 | doi = 10.1006/bbrc.1997.7877 }}
* {{cite journal | vauthors = Sanchez P, De Carcer G, Sandoval IV, Moscat J, Diaz-Meco MT | title = Localization of atypical protein kinase C isoforms into lysosome-targeted endosomes through interaction with p62 | journal = Molecular and Cellular Biology | volume = 18 | issue = 5 | pages = 3069–80 | date = May 1998 | pmid = 9566925 | pmc = 110686 | url = http://mcb.asm.org/cgi/pmidlookup?view=long&pmid=9566925 | doi=10.1128/mcb.18.5.3069}}
{{Refend}}
{{PDB Gallery|geneid=5584}}
 
{{Serine/threonine-specific protein kinases}}
{{Enzymes}}
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[[Category:EC 2.7.11]]

Latest revision as of 19:17, 10 June 2018

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Protein kinase C iota type is an enzyme that in humans is encoded by the PRKCI gene.[1][2][3]

Function

This gene encodes a member of the protein kinase C (PKC) family of serine/threonine protein kinases. The PKC family comprises at least eight members, which are differentially expressed and are involved in a wide variety of cellular processes. This protein kinase is calcium-independent and phospholipid-dependent. It is not activated by phorbolesters or diacylglycerol. This kinase can be recruited to vesicle tubular clusters (VTCs) by direct interaction with the small GTPase RAB2, where this kinase phosphorylates glyceraldehyde-3-phosphate dehydrogenase (GAPD/GAPDH) and plays a role in microtubule dynamics in the early secretory pathway. This kinase is found to be necessary for BCL-ABL-mediated resistance to drug-induced apoptosis and therefore protects leukemia cells against drug-induced apoptosis. There is a single exon pseudogene mapped on chromosome X.[3]

Interactions

PRKCI has been shown to interact with:

[13]

References

  1. ↑ Mazzarella R, Ciccodicola A, Esposito T, Arcucci A, Migliaccio C, Jones C, Schlessinger D, D'Urso M, D'Esposito M (Apr 1995). "Human protein kinase C Iota gene (PRKCI) is closely linked to the BTK gene in Xq21.3". Genomics. 26 (3): 629–31. doi:10.1016/0888-7543(95)80190-W. PMID 7607695.
  2. ↑ De Donato M, Gallagher DS, Davis SK, Stelly DM, Taylor JF (April 2002). "The assignment of PRKCI to bovine chromosome 1q34-->q36 by FISH suggests a new assignment to human chromosome 3". Cytogenetics and Cell Genetics. 95 (1–2): 79–81. doi:10.1159/000057021. PMID 11978974.
  3. ↑ 3.0 3.1 "Entrez Gene: PRKCI protein kinase C, iota".
  4. ↑ Zemlickova E, Dubois T, Kerai P, Clokie S, Cronshaw AD, Wakefield RI, Johannes FJ, Aitken A (Aug 2003). "Centaurin-alpha(1) associates with and is phosphorylated by isoforms of protein kinase C". Biochemical and Biophysical Research Communications. 307 (3): 459–65. doi:10.1016/s0006-291x(03)01187-2. PMID 12893243.
  5. ↑ Lim YP, Low BC, Lim J, Wong ES, Guy GR (Jul 1999). "Association of atypical protein kinase C isotypes with the docker protein FRS2 in fibroblast growth factor signaling". The Journal of Biological Chemistry. 274 (27): 19025–34. doi:10.1074/jbc.274.27.19025. PMID 10383403.
  6. ↑ Tisdale EJ (Feb 2002). "Glyceraldehyde-3-phosphate dehydrogenase is phosphorylated by protein kinase Ciota /lambda and plays a role in microtubule dynamics in the early secretory pathway". The Journal of Biological Chemistry. 277 (5): 3334–41. doi:10.1074/jbc.M109744200. PMID 11724794.
  7. ↑ Sanchez P, De Carcer G, Sandoval IV, Moscat J, Diaz-Meco MT (May 1998). "Localization of atypical protein kinase C isoforms into lysosome-targeted endosomes through interaction with p62". Molecular and Cellular Biology. 18 (5): 3069–80. doi:10.1128/mcb.18.5.3069. PMC 110686. PMID 9566925.
  8. ↑ Kohjima M, Noda Y, Takeya R, Saito N, Takeuchi K, Sumimoto H (Dec 2002). "PAR3beta, a novel homologue of the cell polarity protein PAR3, localizes to tight junctions". Biochemical and Biophysical Research Communications. 299 (4): 641–6. doi:10.1016/s0006-291x(02)02698-0. PMID 12459187.
  9. ↑ Balendran A, Biondi RM, Cheung PC, Casamayor A, Deak M, Alessi DR (Jul 2000). "A 3-phosphoinositide-dependent protein kinase-1 (PDK1) docking site is required for the phosphorylation of protein kinase Czeta (PKCzeta ) and PKC-related kinase 2 by PDK1". The Journal of Biological Chemistry. 275 (27): 20806–13. doi:10.1074/jbc.M000421200. PMID 10764742.
  10. ↑ Diaz-Meco MT, Municio MM, Sanchez P, Lozano J, Moscat J (Jan 1996). "Lambda-interacting protein, a novel protein that specifically interacts with the zinc finger domain of the atypical protein kinase C isotype lambda/iota and stimulates its kinase activity in vitro and in vivo". Molecular and Cellular Biology. 16 (1): 105–14. PMC 230983. PMID 8524286.
  11. ↑ Guo W, Wu S, Liu J, Fang B (Sep 2008). "Identification of a small molecule with synthetic lethality for K-ras and protein kinase C iota". Cancer Research. 68 (18): 7403–8. doi:10.1158/0008-5472.CAN-08-1449. PMC 2678915. PMID 18794128.
  12. ↑ Ratnayake WS, Apostolatos AH, Ostrov DA, Acevedo-Duncan M (2017). "Two novel atypical PKC inhibitors; ACPD and DNDA effectively mitigate cell proliferation and epithelial to mesenchymal transition of metastatic melanoma while inducing apoptosis". Int. J. Oncol. 51 (5): 1370–1382. doi:10.3892/ijo.2017.4131. PMC 5642393. PMID 29048609.
  13. ↑ Ratnayake WS, Apostolatos CA, Apostolatos AH, Schutte RJ, Huynh MA, Ostrov DA, Acevedo-Duncan M (2018). "Oncogenic PKC-ι activates Vimentin during epithelial-mesenchymal transition in melanoma; a study based on PKC-ι and PKC-ζ specific inhibitors". Cell Adhes. Migr. 0 (0): 1–17. doi:10.1080/19336918.2018.1471323. PMID 29781749.

Further reading

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