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{{Infobox_gene}}
{{PBB_Controls
'''Synaptotagmin-9''' is a [[protein]] that in humans is encoded by the ''SYT9'' [[gene]].<ref name="pmid11543631">{{cite journal | vauthors = Craxton M | title = Genomic analysis of synaptotagmin genes | journal = Genomics | volume = 77 | issue = 1-2 | pages = 43–9 | date = Sep 2001 | pmid = 11543631 | pmc = | doi = 10.1006/geno.2001.6619 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: SYT9 synaptotagmin IX| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=143425| accessdate = }}</ref>
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Interactions ==
{{GNF_Protein_box
| image =
| image_source =
| PDB =  
| Name = Synaptotagmin IX
| HGNCid = 19265
| Symbol = SYT9
| AltSymbols =; FLJ45896
| OMIM = 
| ECnumber = 
| Homologene = 11062
| MGIid = 1926373
| GeneAtlas_image1 = PBB_GE_SYT9_gnf1h06444_at_tn.png
| Function = {{GNF_GO|id=GO:0005215 |text = transporter activity}} {{GNF_GO|id=GO:0005509 |text = calcium ion binding}} {{GNF_GO|id=GO:0005515 |text = protein binding}}
| Component = {{GNF_GO|id=GO:0008021 |text = synaptic vesicle}} {{GNF_GO|id=GO:0016020 |text = membrane}} {{GNF_GO|id=GO:0016021 |text = integral to membrane}} {{GNF_GO|id=GO:0045202 |text = synapse}}
| Process = {{GNF_GO|id=GO:0006810 |text = transport}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 143425
    | Hs_Ensembl = ENSG00000170743
    | Hs_RefseqProtein = NP_783860
    | Hs_RefseqmRNA = NM_175733
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 11
    | Hs_GenLoc_start = 7229757
    | Hs_GenLoc_end = 7446844
    | Hs_Uniprot = Q86SS6
    | Mm_EntrezGene = 60510
    | Mm_Ensembl = ENSMUSG00000062542
    | Mm_RefseqmRNA = NM_021889
    | Mm_RefseqProtein = NP_068689
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 7
    | Mm_GenLoc_start = 107162168
    | Mm_GenLoc_end = 107297801
    | Mm_Uniprot = Q3U0R7
  }}
}}
'''Synaptotagmin IX''', also known as '''SYT9''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: SYT9 synaptotagmin IX| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=143425| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
SYT9 has been shown to [[Protein-protein interaction|interact]] with [[SYNCRIP]],<ref name=pmid10734137>{{cite journal | vauthors = Mizutani A, Fukuda M, Ibata K, Shiraishi Y, Mikoshiba K | title = SYNCRIP, a cytoplasmic counterpart of heterogeneous nuclear ribonucleoprotein R, interacts with ubiquitous synaptotagmin isoforms | journal = The Journal of Biological Chemistry | volume = 275 | issue = 13 | pages = 9823–31 | date = Mar 2000 | pmid = 10734137 | doi = 10.1074/jbc.275.13.9823 }}</ref> [[TUBB]]<ref name=pmid12966166>{{cite journal | vauthors = Haberman Y, Grimberg E, Fukuda M, Sagi-Eisenberg R | title = Synaptotagmin IX, a possible linker between the perinuclear endocytic recycling compartment and the microtubules | journal = Journal of Cell Science | volume = 116 | issue = Pt 21 | pages = 4307–18 | date = Nov 2003 | pmid = 12966166 | doi = 10.1242/jcs.00719 }}</ref> and [[TRPV1]].<ref name=pmid15066994>{{cite journal | vauthors = Morenilla-Palao C, Planells-Cases R, García-Sanz N, Ferrer-Montiel A | title = Regulated exocytosis contributes to protein kinase C potentiation of vanilloid receptor activity | journal = The Journal of Biological Chemistry | volume = 279 | issue = 24 | pages = 25665–72 | date = Jun 2004 | pmid = 15066994 | doi = 10.1074/jbc.M311515200 }}</ref>
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| summary_text =  
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==References==
== References ==
{{reflist|2}}
{{reflist}}
==Further reading==
 
== Further reading ==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
* {{cite journal|authorlink30=Huda Zoghbi | vauthors = Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M | title = Towards a proteome-scale map of the human protein-protein interaction network | journal = Nature | volume = 437 | issue = 7062 | pages = 1173–8 | date = Oct 2005 | pmid = 16189514 | doi = 10.1038/nature04209 }}
| citations =
* {{cite journal | vauthors = Morenilla-Palao C, Planells-Cases R, García-Sanz N, Ferrer-Montiel A | title = Regulated exocytosis contributes to protein kinase C potentiation of vanilloid receptor activity | journal = The Journal of Biological Chemistry | volume = 279 | issue = 24 | pages = 25665–72 | date = Jun 2004 | pmid = 15066994 | doi = 10.1074/jbc.M311515200 }}
*{{cite journal | author=Rual JF, Venkatesan K, Hao T, ''et al.'' |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173-8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 }}
* {{cite journal | vauthors = Haberman Y, Grimberg E, Fukuda M, Sagi-Eisenberg R | title = Synaptotagmin IX, a possible linker between the perinuclear endocytic recycling compartment and the microtubules | journal = Journal of Cell Science | volume = 116 | issue = Pt 21 | pages = 4307–18 | date = Nov 2003 | pmid = 12966166 | doi = 10.1242/jcs.00719 }}
*{{cite journal | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
\* {{cite journal | vauthors = Dubois T, Howell S, Zemlickova E, Aitken A | title = Identification of casein kinase Ialpha interacting protein partners | journal = FEBS Letters | volume = 517 | issue = 1-3 | pages = 167–71 | date = Apr 2002 | pmid = 12062430 | doi = 10.1016/S0014-5793(02)02614-5 }}
*{{cite journal  | author=Morenilla-Palao C, Planells-Cases R, García-Sanz N, Ferrer-Montiel A |title=Regulated exocytosis contributes to protein kinase C potentiation of vanilloid receptor activity. |journal=J. Biol. Chem. |volume=279 |issue= 24 |pages= 25665-72 |year= 2004 |pmid= 15066994 |doi= 10.1074/jbc.M311515200 }}
* {{cite journal | vauthors = Zhang X, Kim-Miller MJ, Fukuda M, Kowalchyk JA, Martin TF | title = Ca2+-dependent synaptotagmin binding to SNAP-25 is essential for Ca2+-triggered exocytosis | journal = Neuron | volume = 34 | issue = 4 | pages = 599–611 | date = May 2002 | pmid = 12062043 | doi = 10.1016/S0896-6273(02)00671-2 }}
*{{cite journal | author=Ota T, Suzuki Y, Nishikawa T, ''et al.'' |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40-5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
* {{cite journal | vauthors = Fukuda M, Kowalchyk JA, Zhang X, Martin TF, Mikoshiba K | title = Synaptotagmin IX regulates Ca2+-dependent secretion in PC12 cells | journal = The Journal of Biological Chemistry | volume = 277 | issue = 7 | pages = 4601–4 | date = Feb 2002 | pmid = 11751925 | doi = 10.1074/jbc.C100588200 }}
*{{cite journal  | author=Haberman Y, Grimberg E, Fukuda M, Sagi-Eisenberg R |title=Synaptotagmin IX, a possible linker between the perinuclear endocytic recycling compartment and the microtubules. |journal=J. Cell. Sci. |volume=116 |issue= Pt 21 |pages= 4307-18 |year= 2004 |pmid= 12966166 |doi= 10.1242/jcs.00719 }}
* {{cite journal | vauthors = Mizutani A, Fukuda M, Ibata K, Shiraishi Y, Mikoshiba K | title = SYNCRIP, a cytoplasmic counterpart of heterogeneous nuclear ribonucleoprotein R, interacts with ubiquitous synaptotagmin isoforms | journal = The Journal of Biological Chemistry | volume = 275 | issue = 13 | pages = 9823–31 | date = Mar 2000 | pmid = 10734137 | doi = 10.1074/jbc.275.13.9823 }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
* {{cite journal | vauthors = Perin MS | title = Mirror image motifs mediate the interaction of the COOH terminus of multiple synaptotagmins with the neurexins and calmodulin | journal = Biochemistry | volume = 35 | issue = 43 | pages = 13808–16 | date = Oct 1996 | pmid = 8901523 | doi = 10.1021/bi960853x }}
*{{cite journal  | author=Dubois T, Howell S, Zemlickova E, Aitken A |title=Identification of casein kinase Ialpha interacting protein partners. |journal=FEBS Lett. |volume=517 |issue= 1-3 |pages= 167-71 |year= 2002 |pmid= 12062430 |doi= }}
*{{cite journal | author=Zhang X, Kim-Miller MJ, Fukuda M, ''et al.'' |title=Ca2+-dependent synaptotagmin binding to SNAP-25 is essential for Ca2+-triggered exocytosis. |journal=Neuron |volume=34 |issue= 4 |pages= 599-611 |year= 2002 |pmid= 12062043 |doi= }}
*{{cite journal | author=Fukuda M, Kowalchyk JA, Zhang X, ''et al.'' |title=Synaptotagmin IX regulates Ca2+-dependent secretion in PC12 cells. |journal=J. Biol. Chem. |volume=277 |issue= 7 |pages= 4601-4 |year= 2002 |pmid= 11751925 |doi= 10.1074/jbc.C100588200 }}
*{{cite journal | author=Craxton M |title=Genomic analysis of synaptotagmin genes. |journal=Genomics |volume=77 |issue= 1-2 |pages= 43-9 |year= 2001 |pmid= 11543631 |doi= 10.1006/geno.2001.6619 }}
*{{cite journal  | author=Mizutani A, Fukuda M, Ibata K, ''et al.'' |title=SYNCRIP, a cytoplasmic counterpart of heterogeneous nuclear ribonucleoprotein R, interacts with ubiquitous synaptotagmin isoforms. |journal=J. Biol. Chem. |volume=275 |issue= 13 |pages= 9823-31 |year= 2000 |pmid= 10734137 |doi= }}
*{{cite journal | author=Perin MS |title=Mirror image motifs mediate the interaction of the COOH terminus of multiple synaptotagmins with the neurexins and calmodulin. |journal=Biochemistry |volume=35 |issue= 43 |pages= 13808-16 |year= 1996 |pmid= 8901523 |doi= 10.1021/bi960853x }}
}}
{{refend}}
{{refend}}


{{protein-stub}}
{{Vesicular transport proteins}}
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{{gene-11-stub}}

Latest revision as of 03:11, 27 October 2017

VALUE_ERROR (nil)
Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

n/a

n/a

Ensembl

n/a

n/a

UniProt

n/a

n/a

RefSeq (mRNA)

n/a

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RefSeq (protein)

n/a

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Synaptotagmin-9 is a protein that in humans is encoded by the SYT9 gene.[1][2]

Interactions

SYT9 has been shown to interact with SYNCRIP,[3] TUBB[4] and TRPV1.[5]

References

  1. ↑ Craxton M (Sep 2001). "Genomic analysis of synaptotagmin genes". Genomics. 77 (1–2): 43–9. doi:10.1006/geno.2001.6619. PMID 11543631.
  2. ↑ "Entrez Gene: SYT9 synaptotagmin IX".
  3. ↑ Mizutani A, Fukuda M, Ibata K, Shiraishi Y, Mikoshiba K (Mar 2000). "SYNCRIP, a cytoplasmic counterpart of heterogeneous nuclear ribonucleoprotein R, interacts with ubiquitous synaptotagmin isoforms". The Journal of Biological Chemistry. 275 (13): 9823–31. doi:10.1074/jbc.275.13.9823. PMID 10734137.
  4. ↑ Haberman Y, Grimberg E, Fukuda M, Sagi-Eisenberg R (Nov 2003). "Synaptotagmin IX, a possible linker between the perinuclear endocytic recycling compartment and the microtubules". Journal of Cell Science. 116 (Pt 21): 4307–18. doi:10.1242/jcs.00719. PMID 12966166.
  5. ↑ Morenilla-Palao C, Planells-Cases R, García-Sanz N, Ferrer-Montiel A (Jun 2004). "Regulated exocytosis contributes to protein kinase C potentiation of vanilloid receptor activity". The Journal of Biological Chemistry. 279 (24): 25665–72. doi:10.1074/jbc.M311515200. PMID 15066994.

Further reading

  • Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (Oct 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
  • Morenilla-Palao C, Planells-Cases R, García-Sanz N, Ferrer-Montiel A (Jun 2004). "Regulated exocytosis contributes to protein kinase C potentiation of vanilloid receptor activity". The Journal of Biological Chemistry. 279 (24): 25665–72. doi:10.1074/jbc.M311515200. PMID 15066994.
  • Haberman Y, Grimberg E, Fukuda M, Sagi-Eisenberg R (Nov 2003). "Synaptotagmin IX, a possible linker between the perinuclear endocytic recycling compartment and the microtubules". Journal of Cell Science. 116 (Pt 21): 4307–18. doi:10.1242/jcs.00719. PMID 12966166.

\* Dubois T, Howell S, Zemlickova E, Aitken A (Apr 2002). "Identification of casein kinase Ialpha interacting protein partners". FEBS Letters. 517 (1–3): 167–71. doi:10.1016/S0014-5793(02)02614-5. PMID 12062430.

  • Zhang X, Kim-Miller MJ, Fukuda M, Kowalchyk JA, Martin TF (May 2002). "Ca2+-dependent synaptotagmin binding to SNAP-25 is essential for Ca2+-triggered exocytosis". Neuron. 34 (4): 599–611. doi:10.1016/S0896-6273(02)00671-2. PMID 12062043.
  • Fukuda M, Kowalchyk JA, Zhang X, Martin TF, Mikoshiba K (Feb 2002). "Synaptotagmin IX regulates Ca2+-dependent secretion in PC12 cells". The Journal of Biological Chemistry. 277 (7): 4601–4. doi:10.1074/jbc.C100588200. PMID 11751925.
  • Mizutani A, Fukuda M, Ibata K, Shiraishi Y, Mikoshiba K (Mar 2000). "SYNCRIP, a cytoplasmic counterpart of heterogeneous nuclear ribonucleoprotein R, interacts with ubiquitous synaptotagmin isoforms". The Journal of Biological Chemistry. 275 (13): 9823–31. doi:10.1074/jbc.275.13.9823. PMID 10734137.
  • Perin MS (Oct 1996). "Mirror image motifs mediate the interaction of the COOH terminus of multiple synaptotagmins with the neurexins and calmodulin". Biochemistry. 35 (43): 13808–16. doi:10.1021/bi960853x. PMID 8901523.


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