Interleukin-10 receptor: Difference between revisions
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{{protein | {{infobox protein | ||
| Name = [[Interleukin 10 receptor, alpha subunit|interleukin 10 receptor, alpha]] | | Name = [[Interleukin 10 receptor, alpha subunit|interleukin 10 receptor, alpha]] | ||
| caption = | | caption = | ||
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| LocusSupplementaryData = | | LocusSupplementaryData = | ||
}} | }} | ||
{{protein | {{infobox protein | ||
| Name = [[Interleukin 10 receptor, beta subunit|interleukin 10 receptor, beta]] | | Name = [[Interleukin 10 receptor, beta subunit|interleukin 10 receptor, beta]] | ||
| caption = | | caption = | ||
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| LocusSupplementaryData = | | LocusSupplementaryData = | ||
}} | }} | ||
'''Interleukin-10 receptor''' is a [[type II cytokine receptor]]. The receptor is tetrameric, composed of 2[[Interleukin 10 receptor, alpha subunit|α]]<ref name="pmid8120391">{{cite journal |vauthors=Liu Y, Wei SH, Ho AS, de Waal Malefyt R, Moore KW | title = Expression cloning and characterization of a human IL-10 receptor | journal = J. Immunol. | volume = 152 | issue = 4 | pages = 1821–9 | year = 1994 | pmid = 8120391 | doi = | url = http://www.jimmunol.org/cgi/content/abstract/152/4/1821 }}</ref> and 2[[Interleukin 10 receptor, beta subunit|β]]<ref name="pmid9312047">{{cite journal |vauthors=Kotenko SV, Krause CD, Izotova LS, Pollack BP, Wu W, Pestka S | title = Identification and functional characterization of a second chain of the interleukin-10 receptor complex | journal = EMBO J. | volume = 16 | issue = 19 | pages = 5894–903 | year = 1997 | pmid = 9312047 | doi = 10.1093/emboj/16.19.5894| pmc = 1170220 }}</ref> subunits. The [[Interleukin 10 receptor, alpha subunit|α]] subunit is expressed on haematopoietic cells (such as T, B, NK, mast, and dendritic cells) whilst the [[Interleukin 10 receptor, beta subunit|β]] subunit is expressed ubiquitously. | |||
'''Interleukin-10 receptor''' is a [[type II cytokine receptor]]. | |||
==References== | ==References== | ||
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* {{MeshName|Receptors,+Interleukin-10}} | * {{MeshName|Receptors,+Interleukin-10}} | ||
{{Cytokine receptors}} | |||
{{Interleukin receptor modulators}} | |||
[[Category:Type II cytokine receptors]] | [[Category:Type II cytokine receptors]] | ||
{{ | {{membrane-protein-stub}} | ||
Latest revision as of 16:22, 4 June 2016
| interleukin 10 receptor, alpha | |
|---|---|
| Identifiers | |
| Symbol | IL10RA |
| Alt. symbols | IL10R |
| Entrez | 3587 |
| HUGO | 5964 |
| OMIM | 146933 |
| RefSeq | NM_001558 |
| UniProt | Q13651 |
| Other data | |
| Locus | Chr. 11 q23 |
| interleukin 10 receptor, beta | |
|---|---|
| Identifiers | |
| Symbol | IL10RB |
| Alt. symbols | CRFB4, D21S58, D21S66 |
| Entrez | 3588 |
| HUGO | 5965 |
| OMIM | 123889 |
| RefSeq | NM_000628 |
| UniProt | Q08334 |
| Other data | |
| Locus | Chr. 21 q22.1-22.2 |
Interleukin-10 receptor is a type II cytokine receptor. The receptor is tetrameric, composed of 2α[1] and 2β[2] subunits. The α subunit is expressed on haematopoietic cells (such as T, B, NK, mast, and dendritic cells) whilst the β subunit is expressed ubiquitously.
References
- ↑ Liu Y, Wei SH, Ho AS, de Waal Malefyt R, Moore KW (1994). "Expression cloning and characterization of a human IL-10 receptor". J. Immunol. 152 (4): 1821–9. PMID 8120391.
- ↑ Kotenko SV, Krause CD, Izotova LS, Pollack BP, Wu W, Pestka S (1997). "Identification and functional characterization of a second chain of the interleukin-10 receptor complex". EMBO J. 16 (19): 5894–903. doi:10.1093/emboj/16.19.5894. PMC 1170220. PMID 9312047.
External links
- Receptors,+Interleukin-10 at the US National Library of Medicine Medical Subject Headings (MeSH)
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