Romifidine: Difference between revisions

Jump to navigation Jump to search
VisualWikitext
m (Robot: Automated text replacement (-{{SIB}} +, -{{EH}} +, -{{EJ}} +, -{{Editor Help}} +, -{{Editor Join}} +))
No edit summary
Line 1: Line 1:
{{drugbox |
<div style="float: right;">
| IUPAC_name        = N-(2-bromo-6-fluorophenyl)-4,5-dihydro-1H-imidazol-2-amine
[[File:Romifidine.png|thumb|none|400px|This image is provided by the National Library of Medicine.]]</div>
| image            = Romifidine.png
 
| CAS_number        = 65896-16-4
__NOTOC__
| ATC_prefix        =
| ATC_suffix        =
| PubChem          = 71969
| DrugBank          =
| C=9 | H=9 | Br=1 | F=1 | N=3
| molecular_weight  = 258.09
| smiles            = C1CN=C(N1)NC2=C(C=CC=C2Br)F
| bioavailability  =
| protein_bound    =
| metabolism        =
| elimination_half-life =
| excretion        =
| pregnancy_AU      =  <!-- A / B1 / B2 / B3 / C / D / X -->
| pregnancy_US      =  <!-- A / B            / C / D / X -->
| pregnancy_category= 
| legal_AU          =  <!-- Unscheduled / S2 / S3 / S4 / S5 / S6 / S7 / S8 / S9 -->
| legal_CA          =  <!--            / Schedule I, II, III, IV, V, VI, VII, VIII -->
| legal_UK          =  <!-- GSL        / P      / POM / CD / Class A, B, C -->
| legal_US          =  <!-- OTC                  / Rx-only  / Schedule I, II, III, IV, V -->
| legal_status      = Veterinary Use
| routes_of_administration = IV
}}
{{CMG}}


{{SI}}


{{CMG}}
==Overview==
'''Romifidine''' is a [[medication|drug]] that is used in [[veterinary medicine]] as a sedative mainly in large animals such as horses,<ref>Spadavecchia C, Arendt-Nielsen L, Andersen OK, Spadavecchia L, Schatzmann U. Effect of romifidine on the nociceptive withdrawal reflex and temporal summation in conscious horses. ''American Journal of Veterinary Research''. 2005 Nov;66(11):1992-8. PMID 16334961</ref> although it may be used in a wide variety of species.<ref>De Lucas JJ, Rodríguez C, Marín M, González F, Ballesteros C, San Andrés MI. Pharmacokinetics of intramuscular ketamine in young ostriches premedicated with romifidine. ''Journal of Veterinary Medicine A. Physiology, Pathology, Clinical Medicine''. 2007 Feb;54(1):48-50. PMID 17359455</ref><ref>Belda E, Laredo FG, Escobar M, Soler M, Lucas X, Agut A. Sedative and cardiorespiratory effects of three doses of romifidine in comparison with medetomidine in five cats. ''Veterinary Record''. 2008 Jan 19;162(3):82-7. PMID 18204032</ref> It is not used in humans, but is closely related in structure to the commonly used drug [[clonidine]].


'''Romifidine''' is a [[medication|drug]] that is used in [[veterinary medicine]] as a [[sedative]], [[anesthetic]] and [[analgesic]], mainly in large animals such as horses,<ref>Spadavecchia C, Arendt-Nielsen L, Andersen OK, Spadavecchia L, Schatzmann U. Effect of romifidine on the nociceptive withdrawal reflex and temporal summation in conscious horses. ''American Journal of Veterinary Research''. 2005 Nov;66(11):1992-8. PMID 16334961</ref> although it may be used in a wide variety of species.<ref>De Lucas JJ, Rodríguez C, Marín M, González F, Ballesteros C, San Andrés MI. Pharmacokinetics of intramuscular ketamine in young ostriches premedicated with romifidine. ''Journal of Veterinary Medicine A. Physiology, Pathology, Clinical Medicine''. 2007 Feb;54(1):48-50. PMID 17359455</ref><ref>Belda E, Laredo FG, Escobar M, Soler M, Lucas X, Agut A. Sedative and cardiorespiratory effects of three doses of romifidine in comparison with medetomidine in five cats. ''Veterinary Record''. 2008 Jan 19;162(3):82-7. PMID 18204032</ref> It is not used in humans, but is closely related in structure to the commonly used drug [[clonidine]].


Romifidine acts as an [[agonist]] at the α<sub>2</sub> [[adrenergic receptor]] subtype. Side effects can include [[bradycardia]] and [[respiratory depression]]. It is often used alongside other sedative or analgesic drugs such as [[ketamine]] or [[butorphanol]].<ref>Corletto F, Raisis AA, Brearley JC. Comparison of morphine and butorphanol as pre-anaesthetic agents in combination with romifidine for field castration in ponies. ''Veterinary Anaesthesia and Analgesia''. 2005 Jan;32(1):16-22. PMID 15663735</ref><ref>Kerr CL, McDonell WN, Young SS. Cardiopulmonary effects of romifidine/ketamine or xylazine/ketamine when used for short duration anesthesia in the horse. ''Canadian Journal of Veterinary Research''. 2004 Oct;68(4):274-82. PMID 15581222</ref> [[Yohimbine]] can be used as an [[antidote]] to rapidly reverse the effects.
Romifidine acts as an [[agonist]] at the α<sub>2</sub> [[adrenergic receptor]] subtype. Side effects can include [[bradycardia]] and [[respiratory depression]]. It is often used alongside other sedative or analgesic drugs such as [[ketamine]] or [[butorphanol]].<ref>Corletto F, Raisis AA, Brearley JC. Comparison of morphine and butorphanol as pre-anaesthetic agents in combination with romifidine for field castration in ponies. ''Veterinary Anaesthesia and Analgesia''. 2005 Jan;32(1):16-22. PMID 15663735</ref><ref>Kerr CL, McDonell WN, Young SS. Cardiopulmonary effects of romifidine/ketamine or xylazine/ketamine when used for short duration anesthesia in the horse. ''Canadian Journal of Veterinary Research''. 2004 Oct;68(4):274-82. PMID 15581222</ref> [[Yohimbine]] can be used as an [[antidote]] to rapidly reverse the effects.
Line 36: Line 16:
{{reflist|2}}
{{reflist|2}}


 
{{Hypnotics and sedatives}}
{{Adrenergic agonists}}
{{Adrenergic agonists}}
{{Hypnotics and sedatives}}


[[Category:Analgesics]]
[[Category:Analgesics]]
[[Category:Anesthetics]]
[[Category:Alpha-adrenergic agonists]]
[[Category:Alpha-2 agonists]]
[[Category:Organobromides]]
<nowiki>Insert non-formatted text here</nowiki>
[[Category:Organofluorides]]
 
[[Category:Anilines]]
 
[[Category:Sedatives]]
{{WH}}
[[Category:Drug]]
{{WS}}

Revision as of 14:40, 8 April 2015

This image is provided by the National Library of Medicine.


WikiDoc Resources for Romifidine

Articles

Most recent articles on Romifidine

Most cited articles on Romifidine

Review articles on Romifidine

Articles on Romifidine in N Eng J Med, Lancet, BMJ

Media

Powerpoint slides on Romifidine

Images of Romifidine

Photos of Romifidine

Podcasts & MP3s on Romifidine

Videos on Romifidine

Evidence Based Medicine

Cochrane Collaboration on Romifidine

Bandolier on Romifidine

TRIP on Romifidine

Clinical Trials

Ongoing Trials on Romifidine at Clinical Trials.gov

Trial results on Romifidine

Clinical Trials on Romifidine at Google

Guidelines / Policies / Govt

US National Guidelines Clearinghouse on Romifidine

NICE Guidance on Romifidine

NHS PRODIGY Guidance

FDA on Romifidine

CDC on Romifidine

Books

Books on Romifidine

News

Romifidine in the news

Be alerted to news on Romifidine

News trends on Romifidine

Commentary

Blogs on Romifidine

Definitions

Definitions of Romifidine

Patient Resources / Community

Patient resources on Romifidine

Discussion groups on Romifidine

Patient Handouts on Romifidine

Directions to Hospitals Treating Romifidine

Risk calculators and risk factors for Romifidine

Healthcare Provider Resources

Symptoms of Romifidine

Causes & Risk Factors for Romifidine

Diagnostic studies for Romifidine

Treatment of Romifidine

Continuing Medical Education (CME)

CME Programs on Romifidine

International

Romifidine en Espanol

Romifidine en Francais

Business

Romifidine in the Marketplace

Patents on Romifidine

Experimental / Informatics

List of terms related to Romifidine

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Overview

Romifidine is a drug that is used in veterinary medicine as a sedative mainly in large animals such as horses,[1] although it may be used in a wide variety of species.[2][3] It is not used in humans, but is closely related in structure to the commonly used drug clonidine.


Romifidine acts as an agonist at the α2 adrenergic receptor subtype. Side effects can include bradycardia and respiratory depression. It is often used alongside other sedative or analgesic drugs such as ketamine or butorphanol.[4][5] Yohimbine can be used as an antidote to rapidly reverse the effects.

References

  1. ↑ Spadavecchia C, Arendt-Nielsen L, Andersen OK, Spadavecchia L, Schatzmann U. Effect of romifidine on the nociceptive withdrawal reflex and temporal summation in conscious horses. American Journal of Veterinary Research. 2005 Nov;66(11):1992-8. PMID 16334961
  2. ↑ De Lucas JJ, Rodríguez C, Marín M, González F, Ballesteros C, San Andrés MI. Pharmacokinetics of intramuscular ketamine in young ostriches premedicated with romifidine. Journal of Veterinary Medicine A. Physiology, Pathology, Clinical Medicine. 2007 Feb;54(1):48-50. PMID 17359455
  3. ↑ Belda E, Laredo FG, Escobar M, Soler M, Lucas X, Agut A. Sedative and cardiorespiratory effects of three doses of romifidine in comparison with medetomidine in five cats. Veterinary Record. 2008 Jan 19;162(3):82-7. PMID 18204032
  4. ↑ Corletto F, Raisis AA, Brearley JC. Comparison of morphine and butorphanol as pre-anaesthetic agents in combination with romifidine for field castration in ponies. Veterinary Anaesthesia and Analgesia. 2005 Jan;32(1):16-22. PMID 15663735
  5. ↑ Kerr CL, McDonell WN, Young SS. Cardiopulmonary effects of romifidine/ketamine or xylazine/ketamine when used for short duration anesthesia in the horse. Canadian Journal of Veterinary Research. 2004 Oct;68(4):274-82. PMID 15581222
Retrieved from "https://www.wikidoc.org/index.php?title=Romifidine&oldid=1084615"