AQP9: Difference between revisions

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Latest revision as of 18:10, 29 August 2017

Aquaporin-9 is a protein that in humans is encoded by the AQP9 gene.^[1]

The aquaporins/major intrinsic protein are a family of water-selective membrane channels. Aquaporin 9 has greater sequence similarity with AQP3 and AQP7 and they may be a subfamily. Aquaporin 9 allows passage of a wide variety of noncharged solutes. AQP9 stimulates urea transport and osmotic water permeability; there are contradicting reports about its role in providing glycerol permeability. Aquaporin 9 may also have some role in specialized leukocyte functions such as immunological response and bactericidal activity.^[1]

References

↑ ^1.0 ^1.1 "Entrez Gene: AQP9 aquaporin 9".

Ishibashi K, Kuwahara M, Gu Y, et al. (1998). "Cloning and functional expression of a new aquaporin (AQP9) abundantly expressed in the peripheral leukocytes permeable to water and urea, but not to glycerol". Biochem. Biophys. Res. Commun. 244 (1): 268–74. doi:10.1006/bbrc.1998.8252. PMID 9514918.
Tsukaguchi H, Shayakul C, Berger UV, et al. (1998). "Molecular characterization of a broad selectivity neutral solute channel". J. Biol. Chem. 273 (38): 24737–43. doi:10.1074/jbc.273.38.24737. PMID 9733774.
Tsukaguchi H, Weremowicz S, Morton CC, Hediger MA (1999). "Functional and molecular characterization of the human neutral solute channel aquaporin-9". Am. J. Physiol. 277 (5 Pt 2): F685–96. PMID 10564231.
Pastor-Soler N, Bagnis C, Sabolic I, et al. (2001). "Aquaporin 9 expression along the male reproductive tract". Biol. Reprod. 65 (2): 384–93. doi:10.1095/biolreprod65.2.384. PMID 11466204.
Damiano A, Zotta E, Goldstein J, et al. (2001). "Water channel proteins AQP3 and AQP9 are present in syncytiotrophoblast of human term placenta". Placenta. 22 (8–9): 776–81. doi:10.1053/plac.2001.0717. PMID 11597198.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Okada S, Misaka T, Matsumoto I, et al. (2003). "Aquaporin-9 is expressed in a mucus-secreting goblet cell subset in the small intestine". FEBS Lett. 540 (1–3): 157–62. doi:10.1016/S0014-5793(03)00256-4. PMID 12681500.
Bhattacharjee H, Carbrey J, Rosen BP, Mukhopadhyay R (2004). "Drug uptake and pharmacological modulation of drug sensitivity in leukemia by AQP9". Biochem. Biophys. Res. Commun. 322 (3): 836–41. doi:10.1016/j.bbrc.2004.08.002. PMID 15336539.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Wang S, Chen J, Beall M, et al. (2005). "Expression of aquaporin 9 in human chorioamniotic membranes and placenta". Am. J. Obstet. Gynecol. 191 (6): 2160–7. doi:10.1016/j.ajog.2004.05.089. PMID 15592307.
Damiano AE, Zotta E, Ibarra C (2006). "Functional and molecular expression of AQP9 channel and UT-A transporter in normal and preeclamptic human placentas". Placenta. 27 (11–12): 1073–81. doi:10.1016/j.placenta.2005.11.014. PMID 16480766.
Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.
Loitto VM, Huang C, Sigal YJ, Jacobson K (2007). "Filopodia are induced by aquaporin-9 expression". Exp. Cell Res. 313 (7): 1295–306. doi:10.1016/j.yexcr.2007.01.023. PMID 17346701.
Warth A, Mittelbronn M, Hülper P, et al. (2007). "Expression of the water channel protein aquaporin-9 in malignant brain tumors". Appl. Immunohistochem. Mol. Morphol. 15 (2): 193–8. doi:10.1097/01.pai.0000213110.05108.e9. PMID 17525633.

External links

AQP9+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)
Human AQP9 genome location and AQP9 gene details page in the UCSC Genome Browser.

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This membrane protein–related article is a stub. You can help Wikipedia by expanding it.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

[entrez-1] 1.0 ^1.1 "Entrez Gene: AQP9 aquaporin 9".

[1]

@@ Line 1: / Line 1: @@
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+{{Infobox_gene}}
-{{PBB_Controls
+'''Aquaporin-9''' is a [[protein]] that in humans is encoded by the ''AQP9'' [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: AQP9 aquaporin 9| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=366| accessdate = }}</ref>
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-<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
-{{GNF_Protein_box
- | image =
- | image_source =
- | PDB =
- | Name = Aquaporin 9
- | HGNCid = 643
- | Symbol = AQP9
- | AltSymbols =; HsT17287; SSC1
- | OMIM = 602914
- | ECnumber =
- | Homologene = 41405
- | MGIid = 1891066
- | Function = {{GNF_GO|id=GO:0005275 |text = amine transmembrane transporter activity}} {{GNF_GO|id=GO:0005345 |text = purine transmembrane transporter activity}} {{GNF_GO|id=GO:0005350 |text = pyrimidine transmembrane transporter activity}} {{GNF_GO|id=GO:0015166 |text = polyol transmembrane transporter activity}} {{GNF_GO|id=GO:0015250 |text = water channel activity}} {{GNF_GO|id=GO:0015288 |text = porin activity}} {{GNF_GO|id=GO:0046943 |text = carboxylic acid transmembrane transporter activity}}
- | Component = {{GNF_GO|id=GO:0005887 |text = integral to plasma membrane}} {{GNF_GO|id=GO:0016020 |text = membrane}}
- | Process = {{GNF_GO|id=GO:0006833 |text = water transport}} {{GNF_GO|id=GO:0006863 |text = purine transport}} {{GNF_GO|id=GO:0006955 |text = immune response}} {{GNF_GO|id=GO:0006970 |text = response to osmotic stress}} {{GNF_GO|id=GO:0007588 |text = excretion}} {{GNF_GO|id=GO:0008152 |text = metabolic process}} {{GNF_GO|id=GO:0009935 |text = nutrient import}} {{GNF_GO|id=GO:0010033 |text = response to organic substance}} {{GNF_GO|id=GO:0015791 |text = polyol transport}} {{GNF_GO|id=GO:0015837 |text = amine transport}} {{GNF_GO|id=GO:0015855 |text = pyrimidine transport}} {{GNF_GO|id=GO:0030104 |text = water homeostasis}} {{GNF_GO|id=GO:0046689 |text = response to mercury ion}} {{GNF_GO|id=GO:0046942 |text = carboxylic acid transport}}
- | Orthologs = {{GNF_Ortholog_box
-    | Hs_EntrezGene = 366
-    | Hs_Ensembl = ENSG00000103569
-    | Hs_RefseqProtein = NP_066190
-    | Hs_RefseqmRNA = NM_020980
-    | Hs_GenLoc_db =
-    | Hs_GenLoc_chr = 15
-    | Hs_GenLoc_start = 56217771
-    | Hs_GenLoc_end = 56265401
-    | Hs_Uniprot = O43315
-    | Mm_EntrezGene = 64008
-    | Mm_Ensembl = ENSMUSG00000032204
-    | Mm_RefseqmRNA = NM_022026
-    | Mm_RefseqProtein = NP_071309
-    | Mm_GenLoc_db =
-    | Mm_GenLoc_chr = 9
-    | Mm_GenLoc_start = 70909221
-    | Mm_GenLoc_end = 70961849
-    | Mm_Uniprot = Q4FK77
-  }}
-}}
-'''Aquaporin 9''', also known as '''AQP9''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: AQP9 aquaporin 9| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=366| accessdate = }}</ref>
 <!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
 {{PBB_Summary
 | section_title =
-| summary_text = The aquaporins/major intrinsic protein are a family of water-selective membrane channels. Aquaporin 9 has greater sequence similarity with AQP3 and AQP7 and they may be a subfamily. Aquaporin 9 allows passage of a wide variety of noncharged solutes. AQP9 stimulates urea transport and osmotic water permeability; there are contradicting reports about its role in providing glycerol permeability. Aquaporin 9 may also have some role in specialized leukocyte functions such as immunological response and bactericidal activity.<ref name="entrez">{{cite web | title = Entrez Gene: AQP9 aquaporin 9| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=366| accessdate = }}</ref>
+| summary_text = The aquaporins/major intrinsic protein are a family of water-selective membrane channels. Aquaporin 9 has greater sequence similarity with AQP3 and AQP7 and they may be a subfamily. Aquaporin 9 allows passage of a wide variety of noncharged solutes. AQP9 stimulates urea transport and osmotic water permeability; there are contradicting reports about its role in providing glycerol permeability. Aquaporin 9 may also have some role in specialized leukocyte functions such as immunological response and bactericidal activity.<ref name="entrez" />
 }}
@@ Line 57: / Line 12: @@
 ==References==
-{{reflist|2}}
+{{reflist}}
 ==Further reading==
@@ Line 63: / Line 18: @@
 {{PBB_Further_reading
 | citations =
-*{{cite journal  | author=Ishibashi K, Kuwahara M, Gu Y, ''et al.'' |title=Cloning and functional expression of a new aquaporin (AQP9) abundantly expressed in the peripheral leukocytes permeable to water and urea, but not to glycerol. |journal=Biochem. Biophys. Res. Commun. |volume=244 |issue= 1 |pages= 268-74 |year= 1998 |pmid= 9514918 |doi= 10.1006/bbrc.1998.8252 }}
+*{{cite journal  |vauthors=Ishibashi K, Kuwahara M, Gu Y |title=Cloning and functional expression of a new aquaporin (AQP9) abundantly expressed in the peripheral leukocytes permeable to water and urea, but not to glycerol |journal=Biochem. Biophys. Res. Commun. |volume=244 |issue= 1 |pages= 268–74 |year= 1998 |pmid= 9514918 |doi= 10.1006/bbrc.1998.8252 |display-authors=etal}}
-*{{cite journal  | author=Tsukaguchi H, Shayakul C, Berger UV, ''et al.'' |title=Molecular characterization of a broad selectivity neutral solute channel. |journal=J. Biol. Chem. |volume=273 |issue= 38 |pages= 24737-43 |year= 1998 |pmid= 9733774 |doi=  }}
+*{{cite journal  |vauthors=Tsukaguchi H, Shayakul C, Berger UV |title=Molecular characterization of a broad selectivity neutral solute channel |journal=J. Biol. Chem. |volume=273 |issue= 38 |pages= 24737–43 |year= 1998 |pmid= 9733774 |doi=10.1074/jbc.273.38.24737  |display-authors=etal}}
-*{{cite journal  | author=Tsukaguchi H, Weremowicz S, Morton CC, Hediger MA |title=Functional and molecular characterization of the human neutral solute channel aquaporin-9. |journal=Am. J. Physiol. |volume=277 |issue= 5 Pt 2 |pages= F685-96 |year= 1999 |pmid= 10564231 |doi=  }}
+*{{cite journal  |vauthors=Tsukaguchi H, Weremowicz S, Morton CC, Hediger MA |title=Functional and molecular characterization of the human neutral solute channel aquaporin-9 |journal=Am. J. Physiol. |volume=277 |issue= 5 Pt 2 |pages= F685–96 |year= 1999 |pmid= 10564231 |doi=  }}
-*{{cite journal  | author=Pastor-Soler N, Bagnis C, Sabolic I, ''et al.'' |title=Aquaporin 9 expression along the male reproductive tract. |journal=Biol. Reprod. |volume=65 |issue= 2 |pages= 384-93 |year= 2001 |pmid= 11466204 |doi=  }}
+*{{cite journal  |vauthors=Pastor-Soler N, Bagnis C, Sabolic I |title=Aquaporin 9 expression along the male reproductive tract |journal=Biol. Reprod. |volume=65 |issue= 2 |pages= 384–93 |year= 2001 |pmid= 11466204 |doi=10.1095/biolreprod65.2.384  |display-authors=etal}}
-*{{cite journal  | author=Damiano A, Zotta E, Goldstein J, ''et al.'' |title=Water channel proteins AQP3 and AQP9 are present in syncytiotrophoblast of human term placenta. |journal=Placenta |volume=22 |issue= 8-9 |pages= 776-81 |year= 2001 |pmid= 11597198 |doi= 10.1053/plac.2001.0717 }}
+*{{cite journal  |vauthors=Damiano A, Zotta E, Goldstein J |title=Water channel proteins AQP3 and AQP9 are present in syncytiotrophoblast of human term placenta |journal=Placenta |volume=22 |issue= 8–9 |pages= 776–81 |year= 2001 |pmid= 11597198 |doi= 10.1053/plac.2001.0717 |display-authors=etal}}
-*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
+*{{cite journal  |vauthors=Strausberg RL, Feingold EA, Grouse LH |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899  | pmc=139241 |display-authors=etal}}
-*{{cite journal  | author=Okada S, Misaka T, Matsumoto I, ''et al.'' |title=Aquaporin-9 is expressed in a mucus-secreting goblet cell subset in the small intestine. |journal=FEBS Lett. |volume=540 |issue= 1-3 |pages= 157-62 |year= 2003 |pmid= 12681500 |doi=  }}
+*{{cite journal  |vauthors=Okada S, Misaka T, Matsumoto I |title=Aquaporin-9 is expressed in a mucus-secreting goblet cell subset in the small intestine |journal=FEBS Lett. |volume=540 |issue= 1–3 |pages= 157–62 |year= 2003 |pmid= 12681500 |doi=10.1016/S0014-5793(03)00256-4  |display-authors=etal}}
-*{{cite journal  | author=Bhattacharjee H, Carbrey J, Rosen BP, Mukhopadhyay R |title=Drug uptake and pharmacological modulation of drug sensitivity in leukemia by AQP9. |journal=Biochem. Biophys. Res. Commun. |volume=322 |issue= 3 |pages= 836-41 |year= 2004 |pmid= 15336539 |doi= 10.1016/j.bbrc.2004.08.002 }}
+*{{cite journal  |vauthors=Bhattacharjee H, Carbrey J, Rosen BP, Mukhopadhyay R |title=Drug uptake and pharmacological modulation of drug sensitivity in leukemia by AQP9 |journal=Biochem. Biophys. Res. Commun. |volume=322 |issue= 3 |pages= 836–41 |year= 2004 |pmid= 15336539 |doi= 10.1016/j.bbrc.2004.08.002 }}
-*{{cite journal  | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
+*{{cite journal  |vauthors=Gerhard DS, Wagner L, Feingold EA |title=The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504  | pmc=528928 |display-authors=etal}}
-*{{cite journal  | author=Wang S, Chen J, Beall M, ''et al.'' |title=Expression of aquaporin 9 in human chorioamniotic membranes and placenta. |journal=Am. J. Obstet. Gynecol. |volume=191 |issue= 6 |pages= 2160-7 |year= 2005 |pmid= 15592307 |doi= 10.1016/j.ajog.2004.05.089 }}
+*{{cite journal  |vauthors=Wang S, Chen J, Beall M |title=Expression of aquaporin 9 in human chorioamniotic membranes and placenta |journal=Am. J. Obstet. Gynecol. |volume=191 |issue= 6 |pages= 2160–7 |year= 2005 |pmid= 15592307 |doi= 10.1016/j.ajog.2004.05.089 |display-authors=etal}}
-*{{cite journal  | author=Damiano AE, Zotta E, Ibarra C |title=Functional and molecular expression of AQP9 channel and UT-A transporter in normal and preeclamptic human placentas. |journal=Placenta |volume=27 |issue= 11-12 |pages= 1073-81 |year= 2006 |pmid= 16480766 |doi= 10.1016/j.placenta.2005.11.014 }}
+*{{cite journal  |vauthors=Damiano AE, Zotta E, Ibarra C |title=Functional and molecular expression of AQP9 channel and UT-A transporter in normal and preeclamptic human placentas |journal=Placenta |volume=27 |issue= 11–12 |pages= 1073–81 |year= 2006 |pmid= 16480766 |doi= 10.1016/j.placenta.2005.11.014 }}
-*{{cite journal  | author=Olsen JV, Blagoev B, Gnad F, ''et al.'' |title=Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. |journal=Cell |volume=127 |issue= 3 |pages= 635-48 |year= 2006 |pmid= 17081983 |doi= 10.1016/j.cell.2006.09.026 }}
+*{{cite journal  |vauthors=Olsen JV, Blagoev B, Gnad F |title=Global, in vivo, and site-specific phosphorylation dynamics in signaling networks |journal=Cell |volume=127 |issue= 3 |pages= 635–48 |year= 2006 |pmid= 17081983 |doi= 10.1016/j.cell.2006.09.026 |display-authors=etal}}
-*{{cite journal  | author=Loitto VM, Huang C, Sigal YJ, Jacobson K |title=Filopodia are induced by aquaporin-9 expression. |journal=Exp. Cell Res. |volume=313 |issue= 7 |pages= 1295-306 |year= 2007 |pmid= 17346701 |doi= 10.1016/j.yexcr.2007.01.023 }}
+*{{cite journal  |vauthors=Loitto VM, Huang C, Sigal YJ, Jacobson K |title=Filopodia are induced by aquaporin-9 expression |journal=Exp. Cell Res. |volume=313 |issue= 7 |pages= 1295–306 |year= 2007 |pmid= 17346701 |doi= 10.1016/j.yexcr.2007.01.023 }}
-*{{cite journal  | author=Warth A, Mittelbronn M, Hülper P, ''et al.'' |title=Expression of the water channel protein aquaporin-9 in malignant brain tumors. |journal=Appl. Immunohistochem. Mol. Morphol. |volume=15 |issue= 2 |pages= 193-8 |year= 2007 |pmid= 17525633 |doi= 10.1097/01.pai.0000213110.05108.e9 }}
+*{{cite journal  |vauthors=Warth A, Mittelbronn M, Hülper P |title=Expression of the water channel protein aquaporin-9 in malignant brain tumors |journal=Appl. Immunohistochem. Mol. Morphol. |volume=15 |issue= 2 |pages= 193–8 |year= 2007 |pmid= 17525633 |doi= 10.1097/01.pai.0000213110.05108.e9 |display-authors=etal}}
 }}
 {{refend}}
@@ Line 82: / Line 37: @@
 == External links ==
 * {{MeshName|AQP9+protein,+human}}
+* {{UCSC gene info|AQP9}}
 {{membrane-protein-stub}}
 {{NLM content}}
-{{Ion channels}}
+{{Ion channels|g4}}
-{{WikiDoc Sources}}
+<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
+{{PBB_Controls
+| update_page = yes
+| require_manual_inspection = no
+| update_protein_box = yes
+| update_summary = yes
+| update_citations = yes
+}}

AQP9: Difference between revisions

Latest revision as of 18:10, 29 August 2017

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References

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