CACNB1: Difference between revisions

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{{Infobox_gene}}
{{PBB_Controls
'''Voltage-dependent L-type calcium channel subunit beta-1''' is a [[protein]] that in humans is encoded by the ''CACNB1'' [[gene]].<ref name="pmid8381767">{{cite journal | vauthors = Gregg RG, Powers PA, Hogan K | title = Assignment of the human gene for the beta subunit of the voltage-dependent calcium channel (CACNLB1) to chromosome 17 using somatic cell hybrids and linkage mapping | journal = Genomics | volume = 15 | issue = 1 | pages = 185–7 |date=Mar 1993 | pmid = 8381767 | pmc =  | doi = 10.1006/geno.1993.1029 }}</ref><ref name="pmid8395940">{{cite journal | vauthors = Iles DE, Segers B, Sengers RC, Monsieurs K, Heytens L, Halsall PJ, Hopkins PM, Ellis FR, Hall-Curran JL, Stewart AD | title = Genetic mapping of the beta 1- and gamma-subunits of the human skeletal muscle L-type voltage-dependent calcium channel on chromosome 17q and exclusion as candidate genes for malignant hyperthermia susceptibility | journal = Hum Mol Genet | volume = 2 | issue = 7 | pages = 863–8 |date=Oct 1993 | pmid = 8395940 | pmc =  | doi =10.1093/hmg/2.7.863 |display-authors=etal}}</ref><ref name="entrez"/>
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{{GNF_Protein_box
| image = PBB_Protein_CACNB1_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1t0h.
| PDB = {{PDB2|1t0h}}, {{PDB2|1t0j}}
| Name = Calcium channel, voltage-dependent, beta 1 subunit
| HGNCid = 1401
| Symbol = CACNB1
| AltSymbols =; CAB1; CACNLB1; CCHLB1; MGC41896
| OMIM = 114207
| ECnumber =
| Homologene = 20186
| MGIid = 102522
  | GeneAtlas_image1 = PBB_GE_CACNB1_210185_at_tn.png
| GeneAtlas_image2 = PBB_GE_CACNB1_206996_x_at_tn.png
| GeneAtlas_image3 = PBB_GE_CACNB1_210967_x_at_tn.png
| Function = {{GNF_GO|id=GO:0005245 |text = voltage-gated calcium channel activity}} {{GNF_GO|id=GO:0005509 |text = calcium ion binding}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0015270 |text = dihydropyridine-sensitive calcium channel activity}}
| Component = {{GNF_GO|id=GO:0005624 |text = membrane fraction}} {{GNF_GO|id=GO:0005891 |text = voltage-gated calcium channel complex}}
| Process = {{GNF_GO|id=GO:0006811 |text = ion transport}} {{GNF_GO|id=GO:0006816 |text = calcium ion transport}} {{GNF_GO|id=GO:0006936 |text = muscle contraction}}
  | Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 782
    | Hs_Ensembl = ENSG00000067191
    | Hs_RefseqProtein = NP_000714
    | Hs_RefseqmRNA = NM_000723
    | Hs_GenLoc_db =   
    | Hs_GenLoc_chr = 17
    | Hs_GenLoc_start = 34583232
    | Hs_GenLoc_end = 34607427
    | Hs_Uniprot = Q02641
    | Mm_EntrezGene = 12295
    | Mm_Ensembl = ENSMUSG00000020882
    | Mm_RefseqmRNA = XM_978622
    | Mm_RefseqProtein = XP_983716
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 11
    | Mm_GenLoc_start = 97817598
    | Mm_GenLoc_end = 97838732
    | Mm_Uniprot = Q6DD95
  }}
}}
'''Calcium channel, voltage-dependent, beta 1 subunit''', also known as '''CACNB1''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: CACNB1 calcium channel, voltage-dependent, beta 1 subunit| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=782| accessdate = }}</ref>


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{{PBB_Summary
{{PBB_Summary
| section_title =  
| section_title =  
| summary_text = The protein encoded by this gene belongs to the calcium channel beta subunit family. It plays an important role in the calcium channel by modulating G protein inhibition, increasing peak calcium current, controlling the alpha-1 subunit membrane targeting and shifting the voltage dependence of activation and inactivation. Alternative splicing occurs at this locus and three transcript variants encoding three distinct isoforms have been identified.<ref name="entrez">{{cite web | title = Entrez Gene: CACNB1 calcium channel, voltage-dependent, beta 1 subunit| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=782| accessdate = }}</ref>
| summary_text = The protein encoded by this gene belongs to the calcium channel beta subunit family. It plays an important role in the calcium channel by modulating G protein inhibition, increasing peak calcium current, controlling the alpha-1 subunit membrane targeting and shifting the voltage dependence of activation and inactivation. Alternative splicing occurs at this locus and three transcript variants encoding three distinct isoforms have been identified.<ref name="entrez">{{cite web | title = Entrez Gene: CACNB1 calcium channel, voltage-dependent, beta 1 subunit| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=782| accessdate = }}</ref>
}}
}}


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==References==
==References==
{{reflist|2}}
{{reflist}}


==Further reading==
==Further reading==
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{{PBB_Further_reading  
{{PBB_Further_reading  
| citations =  
| citations =  
*{{cite journal  | author=Williams ME, Feldman DH, McCue AF, ''et al.'' |title=Structure and functional expression of alpha 1, alpha 2, and beta subunits of a novel human neuronal calcium channel subtype. |journal=Neuron |volume=8 |issue= 1 |pages= 71-84 |year= 1992 |pmid= 1309651 |doi=  }}
*{{cite journal  | vauthors=Williams ME, Feldman DH, McCue AF |title=Structure and functional expression of alpha 1, alpha 2, and beta subunits of a novel human neuronal calcium channel subtype. |journal=Neuron |volume=8 |issue= 1 |pages= 71–84 |year= 1992 |pmid= 1309651 |doi=10.1016/0896-6273(92)90109-Q |display-authors=etal}}
*{{cite journal  | author=Perez-Reyes E, Castellano A, Kim HS, ''et al.'' |title=Cloning and expression of a cardiac/brain beta subunit of the L-type calcium channel. |journal=J. Biol. Chem. |volume=267 |issue= 3 |pages= 1792-7 |year= 1992 |pmid= 1370480 |doi=  }}
*{{cite journal  | vauthors=Perez-Reyes E, Castellano A, Kim HS |title=Cloning and expression of a cardiac/brain beta subunit of the L-type calcium channel. |journal=J. Biol. Chem. |volume=267 |issue= 3 |pages= 1792–7 |year= 1992 |pmid= 1370480 |doi=  |display-authors=etal}}
*{{cite journal  | author=Powers PA, Liu S, Hogan K, Gregg RG |title=Skeletal muscle and brain isoforms of a beta-subunit of human voltage-dependent calcium channels are encoded by a single gene. |journal=J. Biol. Chem. |volume=267 |issue= 32 |pages= 22967-72 |year= 1992 |pmid= 1385409 |doi=  }}
*{{cite journal  | vauthors=Powers PA, Liu S, Hogan K, Gregg RG |title=Skeletal muscle and brain isoforms of a beta-subunit of human voltage-dependent calcium channels are encoded by a single gene. |journal=J. Biol. Chem. |volume=267 |issue= 32 |pages= 22967–72 |year= 1992 |pmid= 1385409 |doi=  }}
*{{cite journal  | author=Pragnell M, Sakamoto J, Jay SD, Campbell KP |title=Cloning and tissue-specific expression of the brain calcium channel beta-subunit. |journal=FEBS Lett. |volume=291 |issue= 2 |pages= 253-8 |year= 1991 |pmid= 1657644 |doi=  }}
*{{cite journal  | vauthors=Pragnell M, Sakamoto J, Jay SD, Campbell KP |title=Cloning and tissue-specific expression of the brain calcium channel beta-subunit. |journal=FEBS Lett. |volume=291 |issue= 2 |pages= 253–8 |year= 1991 |pmid= 1657644 |doi=10.1016/0014-5793(91)81296-K }}
*{{cite journal  | author=Collin T, Wang JJ, Nargeot J, Schwartz A |title=Molecular cloning of three isoforms of the L-type voltage-dependent calcium channel beta subunit from normal human heart. |journal=Circ. Res. |volume=72 |issue= 6 |pages= 1337-44 |year= 1993 |pmid= 7916667 |doi=  }}
*{{cite journal  | vauthors=Collin T, Wang JJ, Nargeot J, Schwartz A |title=Molecular cloning of three isoforms of the L-type voltage-dependent calcium channel beta subunit from normal human heart. |journal=Circ. Res. |volume=72 |issue= 6 |pages= 1337–44 |year= 1993 |pmid= 7916667 |doi=  10.1161/01.res.72.6.1337}}
*{{cite journal  | author=Gregg RG, Powers PA, Hogan K |title=Assignment of the human gene for the beta subunit of the voltage-dependent calcium channel (CACNLB1) to chromosome 17 using somatic cell hybrids and linkage mapping. |journal=Genomics |volume=15 |issue= 1 |pages= 185-7 |year= 1993 |pmid= 8381767 |doi= 10.1006/geno.1993.1029 }}
*{{cite journal  | vauthors=Fukuda K, Kaneko S, Yada N |title=Cyclic AMP-dependent modulation of N- and Q-type Ca2+ channels expressed in Xenopus oocytes. |journal=Neurosci. Lett. |volume=217 |issue= 1 |pages= 13–6 |year= 1997 |pmid= 8905728 |doi= 10.1016/0304-3940(96)13055-X |display-authors=etal}}
*{{cite journal  | author=Iles DE, Segers B, Sengers RC, ''et al.'' |title=Genetic mapping of the beta 1- and gamma-subunits of the human skeletal muscle L-type voltage-dependent calcium channel on chromosome 17q and exclusion as candidate genes for malignant hyperthermia susceptibility. |journal=Hum. Mol. Genet. |volume=2 |issue= 7 |pages= 863-8 |year= 1993 |pmid= 8395940 |doi=  }}
*{{cite journal  | vauthors=Gregg RG, Messing A, Strube C |title=Absence of the β subunit (cchb1) of the skeletal muscle dihydropyridine receptor alters expression of the α1 subunit and eliminates excitation-contraction coupling |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=93 |issue= 24 |pages= 13961–6 |year= 1997 |pmid= 8943043 |doi=10.1073/pnas.93.24.13961 | pmc=19477  |display-authors=etal}}
*{{cite journal  | author=Fukuda K, Kaneko S, Yada N, ''et al.'' |title=Cyclic AMP-dependent modulation of N- and Q-type Ca2+ channels expressed in Xenopus oocytes. |journal=Neurosci. Lett. |volume=217 |issue= 1 |pages= 13-6 |year= 1997 |pmid= 8905728 |doi= }}
*{{cite journal  | vauthors=Brice NL, Dolphin AC |title=Differential plasma membrane targeting of voltage-dependent calcium channel subunits expressed in a polarized epithelial cell line |journal=J. Physiol. |volume=515 ( Pt 3) |issue=  3|pages= 685–94 |year= 1999 |pmid= 10066897 |doi=10.1111/j.1469-7793.1999.685ab.x  | pmc=2269176 }}
*{{cite journal  | author=Gregg RG, Messing A, Strube C, ''et al.'' |title=Absence of the beta subunit (cchb1) of the skeletal muscle dihydropyridine receptor alters expression of the alpha 1 subunit and eliminates excitation-contraction coupling. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=93 |issue= 24 |pages= 13961-6 |year= 1997 |pmid= 8943043 |doi=  }}
*{{cite journal  | vauthors=Lie AA, Blümcke I, Volsen SG |title=Distribution of voltage-dependent calcium channel beta subunits in the hippocampus of patients with temporal lobe epilepsy |journal=Neuroscience |volume=93 |issue= 2 |pages= 449–56 |year= 1999 |pmid= 10465427 |doi=10.1016/S0306-4522(99)00162-1 |display-authors=etal}}
*{{cite journal  | author=Brice NL, Dolphin AC |title=Differential plasma membrane targeting of voltage-dependent calcium channel subunits expressed in a polarized epithelial cell line. |journal=J. Physiol. (Lond.) |volume=515 ( Pt 3) |issue=  |pages= 685-94 |year= 1999 |pmid= 10066897 |doi=  }}
*{{cite journal  | vauthors=Hogan K, Greg RG, Powers PA |title=Structure and alternative splicing of the gene encoding the human beta1 subunit of voltage dependent calcium channels |journal=Neurosci. Lett. |volume=277 |issue= 2 |pages= 111–4 |year= 2000 |pmid= 10624822 |doi=10.1016/S0304-3940(99)00851-4 }}
*{{cite journal  | author=Lie AA, Blümcke I, Volsen SG, ''et al.'' |title=Distribution of voltage-dependent calcium channel beta subunits in the hippocampus of patients with temporal lobe epilepsy. |journal=Neuroscience |volume=93 |issue= 2 |pages= 449-56 |year= 1999 |pmid= 10465427 |doi=  }}
*{{cite journal  | vauthors=Strausberg RL, Feingold EA, Grouse LH |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |display-authors=etal}}
*{{cite journal  | author=Hogan K, Greg RG, Powers PA |title=Structure and alternative splicing of the gene encoding the human beta1 subunit of voltage dependent calcium channels. |journal=Neurosci. Lett. |volume=277 |issue= 2 |pages= 111-4 |year= 2000 |pmid= 10624822 |doi=  }}
*{{cite journal  | vauthors=Finlin BS, Crump SM, Satin J, Andres DA |title=Regulation of voltage-gated calcium channel activity by the Rem and Rad GTPases |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=100 |issue= 24 |pages= 14469–74 |year= 2004 |pmid= 14623965 |doi= 10.1073/pnas.2437756100 | pmc=283615 }}
*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal  | vauthors=Navarro-Lérida I, Martínez Moreno M, Roncal F |title=Proteomic identification of brain proteins that interact with dynein light chain LC8 |journal=Proteomics |volume=4 |issue= 2 |pages= 339–46 |year= 2004 |pmid= 14760703 |doi= 10.1002/pmic.200300528 |display-authors=etal}}
*{{cite journal  | author=Finlin BS, Crump SM, Satin J, Andres DA |title=Regulation of voltage-gated calcium channel activity by the Rem and Rad GTPases. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=100 |issue= 24 |pages= 14469-74 |year= 2004 |pmid= 14623965 |doi= 10.1073/pnas.2437756100 }}
*{{cite journal  | vauthors=Foell JD, Balijepalli RC, Delisle BP |title=Molecular heterogeneity of calcium channel beta-subunits in canine and human heart: evidence for differential subcellular localization |journal=Physiol. Genomics |volume=17 |issue= 2 |pages= 183–200 |year= 2004 |pmid= 14762176 |doi= 10.1152/physiolgenomics.00207.2003 |display-authors=etal}}
*{{cite journal  | author=Navarro-Lérida I, Martínez Moreno M, Roncal F, ''et al.'' |title=Proteomic identification of brain proteins that interact with dynein light chain LC8. |journal=Proteomics |volume=4 |issue= 2 |pages= 339-46 |year= 2004 |pmid= 14760703 |doi= 10.1002/pmic.200300528 }}
*{{cite journal  | vauthors=Lim J, Hao T, Shaw C |title=A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration |journal=Cell |volume=125 |issue= 4 |pages= 801–14 |year= 2006 |pmid= 16713569 |doi= 10.1016/j.cell.2006.03.032 |display-authors=etal}}
*{{cite journal  | author=Foell JD, Balijepalli RC, Delisle BP, ''et al.'' |title=Molecular heterogeneity of calcium channel beta-subunits in canine and human heart: evidence for differential subcellular localization. |journal=Physiol. Genomics |volume=17 |issue= 2 |pages= 183-200 |year= 2004 |pmid= 14762176 |doi= 10.1152/physiolgenomics.00207.2003 }}
*{{cite journal  | vauthors=Olsen JV, Blagoev B, Gnad F |title=Global, in vivo, and site-specific phosphorylation dynamics in signaling networks |journal=Cell |volume=127 |issue= 3 |pages= 635–48 |year= 2006 |pmid= 17081983 |doi= 10.1016/j.cell.2006.09.026 |display-authors=etal}}
*{{cite journal  | author=Lim J, Hao T, Shaw C, ''et al.'' |title=A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration. |journal=Cell |volume=125 |issue= 4 |pages= 801-14 |year= 2006 |pmid= 16713569 |doi= 10.1016/j.cell.2006.03.032 }}
*{{cite journal  | author=Olsen JV, Blagoev B, Gnad F, ''et al.'' |title=Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. |journal=Cell |volume=127 |issue= 3 |pages= 635-48 |year= 2006 |pmid= 17081983 |doi= 10.1016/j.cell.2006.09.026 }}
}}
}}
{{refend}}
{{refend}}
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== External links ==
== External links ==
* {{MeshName|CACNB1+protein,+human}}
* {{MeshName|CACNB1+protein,+human}}
* {{UCSC gene info|CACNB1}}
{{PDB Gallery|geneid=782}}
{{Ion channels|g1}}


{{membrane-protein-stub}}
{{NLM content}}
{{NLM content}}
{{Ion channels}}
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[[Category:Ion channels]]
[[Category:Ion channels]]
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{{membrane-protein-stub}}

Latest revision as of 09:08, 30 August 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

n/a

n/a

Ensembl

n/a

n/a

UniProt

n/a

n/a

RefSeq (mRNA)

n/a

n/a

RefSeq (protein)

n/a

n/a

Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Voltage-dependent L-type calcium channel subunit beta-1 is a protein that in humans is encoded by the CACNB1 gene.[1][2][3]

The protein encoded by this gene belongs to the calcium channel beta subunit family. It plays an important role in the calcium channel by modulating G protein inhibition, increasing peak calcium current, controlling the alpha-1 subunit membrane targeting and shifting the voltage dependence of activation and inactivation. Alternative splicing occurs at this locus and three transcript variants encoding three distinct isoforms have been identified.[3]

See also

References

  1. ↑ Gregg RG, Powers PA, Hogan K (Mar 1993). "Assignment of the human gene for the beta subunit of the voltage-dependent calcium channel (CACNLB1) to chromosome 17 using somatic cell hybrids and linkage mapping". Genomics. 15 (1): 185–7. doi:10.1006/geno.1993.1029. PMID 8381767.
  2. ↑ Iles DE, Segers B, Sengers RC, Monsieurs K, Heytens L, Halsall PJ, Hopkins PM, Ellis FR, Hall-Curran JL, Stewart AD, et al. (Oct 1993). "Genetic mapping of the beta 1- and gamma-subunits of the human skeletal muscle L-type voltage-dependent calcium channel on chromosome 17q and exclusion as candidate genes for malignant hyperthermia susceptibility". Hum Mol Genet. 2 (7): 863–8. doi:10.1093/hmg/2.7.863. PMID 8395940.
  3. ↑ 3.0 3.1 "Entrez Gene: CACNB1 calcium channel, voltage-dependent, beta 1 subunit".

Further reading

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


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