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<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{Infobox_gene}}
{{PBB_Controls
'''Cullin-7''' is a RING-E3 ligase [[protein]] that in humans is encoded by the ''CUL7'' [[gene]].<ref name="pmid12481031">{{cite journal | vauthors = Dias DC, Dolios G, Wang R, Pan ZQ | title = CUL7: A DOC domain-containing cullin selectively binds Skp1.Fbx29 to form an SCF-like complex | journal = Proc Natl Acad Sci U S A | volume = 99 | issue = 26 | pages = 16601–6 |date=Dec 2002 | pmid = 12481031 | pmc = 139190 | doi = 10.1073/pnas.252646399 }}</ref><ref name="pmid12904573">{{cite journal | vauthors = Arai T, Kasper JS, Skaar JR, Ali SH, Takahashi C, DeCaprio JA | title = Targeted disruption of p185/Cul7 gene results in abnormal vascular morphogenesis | journal = Proc Natl Acad Sci U S A | volume = 100 | issue = 17 | pages = 9855–60 |date=Aug 2003 | pmid = 12904573 | pmc = 187864 | doi = 10.1073/pnas.1733908100 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: CUL7 cullin 7| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9820| accessdate = }}</ref>
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}


<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Clinical significance ==
{{GNF_Protein_box
It is associated with [[3-M syndrome]].
| image = PBB_Protein_CUL7_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 2jng.
| PDB = {{PDB2|2jng}}
| Name = Cullin 7
| HGNCid = 21024
| Symbol = CUL7
| AltSymbols =; KIAA0076; dJ20C7.5
| OMIM = 609577
| ECnumber = 
| Homologene = 56683
| MGIid = 1913765
| GeneAtlas_image1 = PBB_GE_CUL7_203558_at_tn.png
| GeneAtlas_image2 = PBB_GE_CUL7_36084_at_tn.png
| Function = {{GNF_GO|id=GO:0005515 |text = protein binding}}
| Component = {{GNF_GO|id=GO:0005680 |text = anaphase-promoting complex}}
| Process = {{GNF_GO|id=GO:0001570 |text = vasculogenesis}} {{GNF_GO|id=GO:0006508 |text = proteolysis}} {{GNF_GO|id=GO:0006512 |text = ubiquitin cycle}} {{GNF_GO|id=GO:0007049 |text = cell cycle}} {{GNF_GO|id=GO:0030071 |text = regulation of mitotic metaphase/anaphase transition}} {{GNF_GO|id=GO:0045601 |text = regulation of endothelial cell differentiation}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 9820
    | Hs_Ensembl = ENSG00000044090
    | Hs_RefseqProtein = NP_055595
    | Hs_RefseqmRNA = NM_014780
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 6
    | Hs_GenLoc_start = 43113336
    | Hs_GenLoc_end = 43129632
    | Hs_Uniprot = Q14999
    | Mm_EntrezGene = 66515
    | Mm_Ensembl = ENSMUSG00000038545
    | Mm_RefseqmRNA = NM_025611
    | Mm_RefseqProtein = NP_079887
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 17
    | Mm_GenLoc_start = 46113529
    | Mm_GenLoc_end = 46127557
    | Mm_Uniprot = Q3U270
  }}
}}
'''Cullin 7''', also known as '''CUL7''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: CUL7 cullin 7| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9820| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
==Interactions==
{{PBB_Summary
CUL7 has been shown to [[Protein-protein interaction|interact]] with [[RBX1]].<ref name=pmid12481031 />
| section_title =  
| summary_text =
}}


==References==
==References==
{{reflist|2}}
{{reflist}}
 
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
*{{cite journal  | vauthors=Kim SS, Shago M, Kaustov L |title=CUL7 is a novel antiapoptotic oncogene. |journal=Cancer Res. |volume=67 |issue= 20 |pages= 9616–22 |year= 2007 |pmid= 17942889 |doi= 10.1158/0008-5472.CAN-07-0644 |display-authors=etal}}
| citations =
*{{cite journal  | vauthors=Jung P, Verdoodt B, Bailey A |title=Induction of cullin 7 by DNA damage attenuates p53 function. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=104 |issue= 27 |pages= 11388–93 |year= 2007 |pmid= 17586686 |doi= 10.1073/pnas.0609467104 | pmc=2040908 |display-authors=etal}}
*{{cite journal  | author=Kim SS, Shago M, Kaustov L, ''et al.'' |title=CUL7 is a novel antiapoptotic oncogene. |journal=Cancer Res. |volume=67 |issue= 20 |pages= 9616-22 |year= 2007 |pmid= 17942889 |doi= 10.1158/0008-5472.CAN-07-0644 }}
*{{cite journal  | vauthors=Skaar JR, Florens L, Tsutsumi T |title=PARC and CUL7 form atypical cullin RING ligase complexes. |journal=Cancer Res. |volume=67 |issue= 5 |pages= 2006–14 |year= 2007 |pmid= 17332328 |doi= 10.1158/0008-5472.CAN-06-3241 |display-authors=etal}}
*{{cite journal  | author=Jung P, Verdoodt B, Bailey A, ''et al.'' |title=Induction of cullin 7 by DNA damage attenuates p53 function. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=104 |issue= 27 |pages= 11388-93 |year= 2007 |pmid= 17586686 |doi= 10.1073/pnas.0609467104 }}
*{{cite journal  | vauthors=Kaustov L, Lukin J, Lemak A |title=The conserved CPH domains of Cul7 and PARC are protein-protein interaction modules that bind the tetramerization domain of p53. |journal=J. Biol. Chem. |volume=282 |issue= 15 |pages= 11300–7 |year= 2007 |pmid= 17298945 |doi= 10.1074/jbc.M611297200 |display-authors=etal}}
*{{cite journal  | author=Skaar JR, Florens L, Tsutsumi T, ''et al.'' |title=PARC and CUL7 form atypical cullin RING ligase complexes. |journal=Cancer Res. |volume=67 |issue= 5 |pages= 2006-14 |year= 2007 |pmid= 17332328 |doi= 10.1158/0008-5472.CAN-06-3241 }}
*{{cite journal  | vauthors=Kasper JS, Arai T, DeCaprio JA |title=A novel p53-binding domain in CUL7. |journal=Biochem. Biophys. Res. Commun. |volume=348 |issue= 1 |pages= 132–8 |year= 2006 |pmid= 16875676 |doi= 10.1016/j.bbrc.2006.07.013 }}
*{{cite journal  | author=Kaustov L, Lukin J, Lemak A, ''et al.'' |title=The conserved CPH domains of Cul7 and PARC are protein-protein interaction modules that bind the tetramerization domain of p53. |journal=J. Biol. Chem. |volume=282 |issue= 15 |pages= 11300-7 |year= 2007 |pmid= 17298945 |doi= 10.1074/jbc.M611297200 }}
*{{cite journal  | vauthors=Andrews P, He YJ, Xiong Y |title=Cytoplasmic localized ubiquitin ligase cullin 7 binds to p53 and promotes cell growth by antagonizing p53 function. |journal=Oncogene |volume=25 |issue= 33 |pages= 4534–48 |year= 2006 |pmid= 16547496 |doi= 10.1038/sj.onc.1209490 }}
*{{cite journal  | author=Kasper JS, Arai T, DeCaprio JA |title=A novel p53-binding domain in CUL7. |journal=Biochem. Biophys. Res. Commun. |volume=348 |issue= 1 |pages= 132-8 |year= 2006 |pmid= 16875676 |doi= 10.1016/j.bbrc.2006.07.013 }}
*{{cite journal  | vauthors=Huber C, Dias-Santagata D, Glaser A |title=Identification of mutations in CUL7 in 3-M syndrome. |journal=Nat. Genet. |volume=37 |issue= 10 |pages= 1119–24 |year= 2005 |pmid= 16142236 |doi= 10.1038/ng1628 |display-authors=etal}}
*{{cite journal  | author=Andrews P, He YJ, Xiong Y |title=Cytoplasmic localized ubiquitin ligase cullin 7 binds to p53 and promotes cell growth by antagonizing p53 function. |journal=Oncogene |volume=25 |issue= 33 |pages= 4534-48 |year= 2006 |pmid= 16547496 |doi= 10.1038/sj.onc.1209490 }}
*{{cite journal  | vauthors=Gerhard DS, Wagner L, Feingold EA |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 |display-authors=etal}}
*{{cite journal  | author=Huber C, Dias-Santagata D, Glaser A, ''et al.'' |title=Identification of mutations in CUL7 in 3-M syndrome. |journal=Nat. Genet. |volume=37 |issue= 10 |pages= 1119-24 |year= 2005 |pmid= 16142236 |doi= 10.1038/ng1628 }}
*{{cite journal  | vauthors=Mungall AJ, Palmer SA, Sims SK |title=The DNA sequence and analysis of human chromosome 6. |journal=Nature |volume=425 |issue= 6960 |pages= 805–11 |year= 2003 |pmid= 14574404 |doi= 10.1038/nature02055 |display-authors=etal}}
*{{cite journal  | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal  | vauthors=Strausberg RL, Feingold EA, Grouse LH |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |display-authors=etal}}
*{{cite journal  | author=Mungall AJ, Palmer SA, Sims SK, ''et al.'' |title=The DNA sequence and analysis of human chromosome 6. |journal=Nature |volume=425 |issue= 6960 |pages= 805-11 |year= 2003 |pmid= 14574404 |doi= 10.1038/nature02055 }}
*{{cite journal  | vauthors=Nakayama M, Kikuno R, Ohara O |title=Protein-protein interactions between large proteins: two-hybrid screening using a functionally classified library composed of long cDNAs. |journal=Genome Res. |volume=12 |issue= 11 |pages= 1773–84 |year= 2003 |pmid= 12421765 |doi= 10.1101/gr.406902 | pmc=187542 }}
*{{cite journal  | author=Arai T, Kasper JS, Skaar JR, ''et al.'' |title=Targeted disruption of p185/Cul7 gene results in abnormal vascular morphogenesis. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=100 |issue= 17 |pages= 9855-60 |year= 2003 |pmid= 12904573 |doi= 10.1073/pnas.1733908100 }}
*{{cite journal  | vauthors=Winston JT, Koepp DM, Zhu C |title=A family of mammalian F-box proteins. |journal=Curr. Biol. |volume=9 |issue= 20 |pages= 1180–2 |year= 1999 |pmid= 10531037 |doi= 10.1016/S0960-9822(00)80021-4 |display-authors=etal}}
*{{cite journal  | author=Dias DC, Dolios G, Wang R, Pan ZQ |title=CUL7: A DOC domain-containing cullin selectively binds Skp1.Fbx29 to form an SCF-like complex. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16601-6 |year= 2003 |pmid= 12481031 |doi= 10.1073/pnas.252646399 }}
*{{cite journal  | vauthors=Nomura N, Nagase T, Miyajima N |title=Prediction of the coding sequences of unidentified human genes. II. The coding sequences of 40 new genes (KIAA0041-KIAA0080) deduced by analysis of cDNA clones from human cell line KG-1. |journal=DNA Res. |volume=1 |issue= 5 |pages= 223–9 |year= 1995 |pmid= 7584044 |doi=10.1093/dnares/1.5.223 |display-authors=etal}}
*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal  | author=Nakayama M, Kikuno R, Ohara O |title=Protein-protein interactions between large proteins: two-hybrid screening using a functionally classified library composed of long cDNAs. |journal=Genome Res. |volume=12 |issue= 11 |pages= 1773-84 |year= 2003 |pmid= 12421765 |doi= 10.1101/gr.406902 }}
*{{cite journal  | author=Winston JT, Koepp DM, Zhu C, ''et al.'' |title=A family of mammalian F-box proteins. |journal=Curr. Biol. |volume=9 |issue= 20 |pages= 1180-2 |year= 1999 |pmid= 10531037 |doi= 10.1016/S0960-9822(00)80021-4 }}
*{{cite journal  | author=Nomura N, Nagase T, Miyajima N, ''et al.'' |title=Prediction of the coding sequences of unidentified human genes. II. The coding sequences of 40 new genes (KIAA0041-KIAA0080) deduced by analysis of cDNA clones from human cell line KG-1. |journal=DNA Res. |volume=1 |issue= 5 |pages= 223-9 |year= 1995 |pmid= 7584044 |doi=  }}
}}
{{refend}}
{{refend}}


{{protein-stub}}
==External links==
{{WikiDoc Sources}}
* [https://www.ncbi.nlm.nih.gov/bookshelf/br.fcgi?book=gene&part=gr_3ms  GeneReviews/NIH/NCBI/UW entry on 3-M syndrome]
* [https://www.ncbi.nlm.nih.gov/omim/273750,609577,610991,612921,273750,609577,610991,612921  OMIM entries entry on 3-M syndrome]
* {{UCSC gene info|CUL7}}
 
{{PDB Gallery|geneid=9820}}
{{Cell cycle proteins}}
 
 
{{gene-6-stub}}

Latest revision as of 10:11, 30 August 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Cullin-7 is a RING-E3 ligase protein that in humans is encoded by the CUL7 gene.[1][2][3]

Clinical significance

It is associated with 3-M syndrome.

Interactions

CUL7 has been shown to interact with RBX1.[1]

References

  1. ↑ 1.0 1.1 Dias DC, Dolios G, Wang R, Pan ZQ (Dec 2002). "CUL7: A DOC domain-containing cullin selectively binds Skp1.Fbx29 to form an SCF-like complex". Proc Natl Acad Sci U S A. 99 (26): 16601–6. doi:10.1073/pnas.252646399. PMC 139190. PMID 12481031.
  2. ↑ Arai T, Kasper JS, Skaar JR, Ali SH, Takahashi C, DeCaprio JA (Aug 2003). "Targeted disruption of p185/Cul7 gene results in abnormal vascular morphogenesis". Proc Natl Acad Sci U S A. 100 (17): 9855–60. doi:10.1073/pnas.1733908100. PMC 187864. PMID 12904573.
  3. ↑ "Entrez Gene: CUL7 cullin 7".

Further reading

External links


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