KCNJ12: Difference between revisions

Jump to navigation Jump to search
VisualWikitext
m (Robot: Automated text replacement (-{{WikiDoc Cardiology Network Infobox}} +, -<references /> +{{reflist|2}}, -{{reflist}} +{{reflist|2}}))
 
m (Bot: HTTP→HTTPS)
 
Line 1: Line 1:
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{Infobox_gene}}
{{PBB_Controls
'''ATP-sensitive inward rectifier potassium channel 12''' is a [[protein]] that in humans is encoded by the ''KCNJ12'' [[gene]].<ref name="pmid7859381">{{cite journal | vauthors = Wible BA, De Biasi M, Majumder K, Taglialatela M, Brown AM | title = Cloning and functional expression of an inwardly rectifying K+ channel from human atrium | journal = Circulation Research | volume = 76 | issue = 3 | pages = 343–50 | date = Mar 1995 | pmid = 7859381 | pmc =  | doi = 10.1161/01.res.76.3.343 }}</ref><ref name="pmid12417321">{{cite journal | vauthors = Kaibara M, Ishihara K, Doi Y, Hayashi H, Ehara T, Taniyama K | title = Identification of human Kir2.2 (KCNJ12) gene encoding functional inward rectifier potassium channel in both mammalian cells and Xenopus oocytes | journal = FEBS Letters | volume = 531 | issue = 2 | pages = 250–4 | date = Nov 2002 | pmid = 12417321 | pmc =  | doi = 10.1016/S0014-5793(02)03512-3 }}</ref><ref name="pmid16382105">{{cite journal | vauthors = Kubo Y, Adelman JP, Clapham DE, Jan LY, Karschin A, Kurachi Y, Lazdunski M, Nichols CG, Seino S, Vandenberg CA | title = International Union of Pharmacology. LIV. Nomenclature and molecular relationships of inwardly rectifying potassium channels | journal = Pharmacological Reviews | volume = 57 | issue = 4 | pages = 509–26 | date = Dec 2005 | pmid = 16382105 | pmc = | doi = 10.1124/pr.57.4.11 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: KCNJ12 potassium inwardly-rectifying channel, subfamily J, member 12| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3768| accessdate = }}</ref>
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}


<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Function ==
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Potassium inwardly-rectifying channel, subfamily J, member 12
| HGNCid = 6258
| Symbol = KCNJ12
| AltSymbols =; IRK2; KCNJN1; Kir2.2; Kir2.2v; hIRK; hIRK1; hkir2.2x; kcnj12x
| OMIM = 602323
| ECnumber = 
| Homologene = 7793
| MGIid = 108495
| GeneAtlas_image1 = PBB_GE_KCNJ12_207110_at_tn.png
| GeneAtlas_image2 = PBB_GE_KCNJ12_208567_s_at_tn.png
| Function = {{GNF_GO|id=GO:0005242 |text = inward rectifier potassium channel activity}} {{GNF_GO|id=GO:0005244 |text = voltage-gated ion channel activity}} {{GNF_GO|id=GO:0008200 |text = ion channel inhibitor activity}} {{GNF_GO|id=GO:0015459 |text = potassium channel regulator activity}} {{GNF_GO|id=GO:0030955 |text = potassium ion binding}}
| Component = {{GNF_GO|id=GO:0005624 |text = membrane fraction}} {{GNF_GO|id=GO:0005887 |text = integral to plasma membrane}} {{GNF_GO|id=GO:0016020 |text = membrane}} {{GNF_GO|id=GO:0016021 |text = integral to membrane}}
| Process = {{GNF_GO|id=GO:0006811 |text = ion transport}} {{GNF_GO|id=GO:0006813 |text = potassium ion transport}} {{GNF_GO|id=GO:0006936 |text = muscle contraction}} {{GNF_GO|id=GO:0008016 |text = regulation of heart contraction}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 3768
    | Hs_Ensembl = ENSG00000184185
    | Hs_RefseqProtein = XP_944668
    | Hs_RefseqmRNA = XM_939575
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 17
    | Hs_GenLoc_start = 21220292
    | Hs_GenLoc_end = 21260983
    | Hs_Uniprot = Q14500
    | Mm_EntrezGene = 16515
    | Mm_Ensembl = ENSMUSG00000042529
    | Mm_RefseqmRNA = NM_010603
    | Mm_RefseqProtein = NP_034733
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 11
    | Mm_GenLoc_start = 60838759
    | Mm_GenLoc_end = 60887324
    | Mm_Uniprot = Q5SU77
  }}
}}
'''Potassium inwardly-rectifying channel, subfamily J, member 12''', also known as '''KCNJ12''' or '''K<sub>ir</sub>2.2''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: KCNJ12 potassium inwardly-rectifying channel, subfamily J, member 12| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3768| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
This gene encodes an [[inward-rectifier potassium ion channel|inwardly rectifying K<sup>+</sup> channel]] that may be blocked by divalent cations. This protein is thought to be one of multiple inwardly rectifying channels that contribute to the cardiac inward rectifier current (IK1). The gene is located within the [[Smith-Magenis syndrome]] region on chromosome 17.<ref name="entrez"/>
{{PBB_Summary
| section_title =
| summary_text = This gene encodes an inwardly rectifying K+ channel which may be blocked by divalent cations. This protein is thought to be one of multiple inwardly rectifying channels which contribute to the cardiac inward rectifier current (IK1). The gene is located within the Smith-Magenis syndrome region on chromosome 17.<ref name="entrez">{{cite web | title = Entrez Gene: KCNJ12 potassium inwardly-rectifying channel, subfamily J, member 12| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3768| accessdate = }}</ref>
}}


==See also==
== Interactions ==
 
KCNJ12 has been shown to [[Protein-protein interaction|interact]] with:
{{div col|colwidth=20em}}
* [[APBA1]],<ref name = pmid15024025/><ref name = pmid14960569/>
* [[CASK]],<ref name = pmid15024025/><ref name = pmid14960569/>
* [[DLG1]],<ref name = pmid15024025/><ref name = pmid14960569/><ref name = "pmid11181181">{{cite journal | vauthors = Leonoudakis D, Mailliard W, Wingerd K, Clegg D, Vandenberg C | title = Inward rectifier potassium channel Kir2.2 is associated with synapse-associated protein SAP97 | journal = Journal of Cell Science | volume = 114 | issue = Pt 5 | pages = 987–98 | date = Mar 2001 | pmid = 11181181 | doi =  }}</ref>
* [[DLG2]],<ref name = pmid15024025/>
* [[DLG3]],<ref name = pmid15024025/>
* [[DLG4]],<ref name = pmid15024025/><ref name = pmid14960569/>
* [[LIN7A]]<ref name = pmid15024025/><ref name = pmid14960569/>
* [[LIN7B]],<ref name = pmid15024025/><ref name = pmid14960569/>  and
* [[LIN7C]].<ref name = "pmid15024025">{{cite journal | vauthors = Leonoudakis D, Conti LR, Anderson S, Radeke CM, McGuire LM, Adams ME, Froehner SC, Yates JR, Vandenberg CA | title = Protein trafficking and anchoring complexes revealed by proteomic analysis of inward rectifier potassium channel (Kir2.x)-associated proteins | journal = The Journal of Biological Chemistry | volume = 279 | issue = 21 | pages = 22331–46 | date = May 2004 | pmid = 15024025 | doi = 10.1074/jbc.M400285200 }}</ref><ref name = "pmid14960569">{{cite journal | vauthors = Leonoudakis D, Conti LR, Radeke CM, McGuire LM, Vandenberg CA | title = A multiprotein trafficking complex composed of SAP97, CASK, Veli, and Mint1 is associated with inward rectifier Kir2 potassium channels | journal = The Journal of Biological Chemistry | volume = 279 | issue = 18 | pages = 19051–63 | date = Apr 2004 | pmid = 14960569 | doi = 10.1074/jbc.M400284200 }}</ref>
{{Div col end}}
 
== See also ==
* [[Inward-rectifier potassium ion channel]]
* [[Inward-rectifier potassium ion channel]]


==References==
== References ==
{{reflist|2}}
{{reflist}}
 
{{-}}
==Further reading==
== Further reading ==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
* {{cite journal | vauthors = Namba N, Inagaki N, Gonoi T, Seino Y, Seino S | title = Kir2.2v: a possible negative regulator of the inwardly rectifying K+ channel Kir2.2 | journal = FEBS Letters | volume = 386 | issue = 2-3 | pages = 211–4 | date = May 1996 | pmid = 8647284 | doi = 10.1016/0014-5793(96)00445-0 }}
| citations =
* {{cite journal | vauthors = Hugnot JP, Pedeutour F, Le Calvez C, Grosgeorge J, Passage E, Fontes M, Lazdunski M | title = The human inward rectifying K+ channel Kir 2.2 (KCNJ12) gene: gene structure, assignment to chromosome 17p11.1, and identification of a simple tandem repeat polymorphism | journal = Genomics | volume = 39 | issue = 1 | pages = 113–6 | date = Jan 1997 | pmid = 9027495 | doi = 10.1006/geno.1996.4450 }}
*{{cite journal | author=Kubo Y, Adelman JP, Clapham DE, ''et al.'' |title=International Union of Pharmacology. LIV. Nomenclature and molecular relationships of inwardly rectifying potassium channels. |journal=Pharmacol. Rev. |volume=57 |issue= 4 |pages= 509-26 |year= 2006 |pmid= 16382105 |doi= 10.1124/pr.57.4.11 }}
* {{cite journal | vauthors = Gallagher PG, Forget BG | title = An alternate promoter directs expression of a truncated, muscle-specific isoform of the human ankyrin 1 gene | journal = The Journal of Biological Chemistry | volume = 273 | issue = 3 | pages = 1339–48 | date = Jan 1998 | pmid = 9430667 | doi = 10.1074/jbc.273.3.1339 }}
*{{cite journal  | author=Mukherjee A, Varma SK, Natarajan K |title=Ankle joint instability in poliomyelitis. |journal=Indian journal of pediatrics |volume=39 |issue= 289 |pages= 37-8 |year= 1972 |pmid= 5024025 |doi=  }}
* {{cite journal | vauthors = Namba N, Mori R, Tanaka H, Kondo I, Narahara K, Seino Y | title = The inwardly rectifying potassium channel subunit Kir2.2v (KCNJN1) maps to 17p11.2-->p11.1 | journal = Cytogenetics and Cell Genetics | volume = 79 | issue = 1-2 | pages = 85–7 | year = 1998 | pmid = 9533018 | doi = 10.1159/000134688 }}
*{{cite journal  | author=Wible BA, De Biasi M, Majumder K, ''et al.'' |title=Cloning and functional expression of an inwardly rectifying K+ channel from human atrium. |journal=Circ. Res. |volume=76 |issue= 3 |pages= 343-50 |year= 1995 |pmid= 7859381 |doi=  }}
* {{cite journal | vauthors = Leonoudakis D, Mailliard W, Wingerd K, Clegg D, Vandenberg C | title = Inward rectifier potassium channel Kir2.2 is associated with synapse-associated protein SAP97 | journal = Journal of Cell Science | volume = 114 | issue = Pt 5 | pages = 987–98 | date = Mar 2001 | pmid = 11181181 | doi =  }}
*{{cite journal  | author=Namba N, Inagaki N, Gonoi T, ''et al.'' |title=Kir2.2v: a possible negative regulator of the inwardly rectifying K+ channel Kir2.2. |journal=FEBS Lett. |volume=386 |issue= 2-3 |pages= 211-4 |year= 1996 |pmid= 8647284 |doi= }}
* {{cite journal | vauthors = Preisig-Müller R, Schlichthörl G, Goerge T, Heinen S, Brüggemann A, Rajan S, Derst C, Veh RW, Daut J | title = Heteromerization of Kir2.x potassium channels contributes to the phenotype of Andersen's syndrome | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 99 | issue = 11 | pages = 7774–9 | date = May 2002 | pmid = 12032359 | pmc = 124349 | doi = 10.1073/pnas.102609499 }}
*{{cite journal | author=Hugnot JP, Pedeutour F, Le Calvez C, ''et al.'' |title=The human inward rectifying K+ channel Kir 2.2 (KCNJ12) gene: gene structure, assignment to chromosome 17p11.1, and identification of a simple tandem repeat polymorphism. |journal=Genomics |volume=39 |issue= 1 |pages= 113-6 |year= 1997 |pmid= 9027495 |doi= 10.1006/geno.1996.4450 }}
* {{cite journal | vauthors = Chen L, Kawano T, Bajic S, Kaziro Y, Itoh H, Art JJ, Nakajima Y, Nakajima S | title = A glutamate residue at the C terminus regulates activity of inward rectifier K+ channels: implication for Andersen's syndrome | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 99 | issue = 12 | pages = 8430–5 | date = Jun 2002 | pmid = 12034888 | pmc = 123084 | doi = 10.1073/pnas.122682899 }}
*{{cite journal | author=Gallagher PG, Forget BG |title=An alternate promoter directs expression of a truncated, muscle-specific isoform of the human ankyrin 1 gene. |journal=J. Biol. Chem. |volume=273 |issue= 3 |pages= 1339-48 |year= 1998 |pmid= 9430667 |doi= }}
* {{cite journal | vauthors = Karkanis T, Li S, Pickering JG, Sims SM | title = Plasticity of KIR channels in human smooth muscle cells from internal thoracic artery | journal = American Journal of Physiology. Heart and Circulatory Physiology | volume = 284 | issue = 6 | pages = H2325-34 | date = Jun 2003 | pmid = 12598232 | doi = 10.1152/ajpheart.00559.2002 }}
*{{cite journal | author=Namba N, Mori R, Tanaka H, ''et al.'' |title=The inwardly rectifying potassium channel subunit Kir2.2v (KCNJN1) maps to 17p11.2-->p11.1. |journal=Cytogenet. Cell Genet. |volume=79 |issue= 1-2 |pages= 85-7 |year= 1998 |pmid= 9533018 |doi= }}
* {{cite journal | vauthors = Stonehouse AH, Grubb BD, Pringle JH, Norman RI, Stanfield PR, Brammar WJ | title = Nuclear immunostaining in rat neuronal cells using two anti-Kir2.2 ion channel polyclonal antibodies | journal = Journal of Molecular Neuroscience | volume = 20 | issue = 2 | pages = 189–94 | date = Apr 2003 | pmid = 12794312 | doi = 10.1385/JMN:20:2:189 }}
*{{cite journal | author=Leonoudakis D, Mailliard W, Wingerd K, ''et al.'' |title=Inward rectifier potassium channel Kir2.2 is associated with synapse-associated protein SAP97. |journal=J. Cell. Sci. |volume=114 |issue= Pt 5 |pages= 987-98 |year= 2001 |pmid= 11181181 |doi=  }}
* {{cite journal | vauthors = Leonoudakis D, Conti LR, Radeke CM, McGuire LM, Vandenberg CA | title = A multiprotein trafficking complex composed of SAP97, CASK, Veli, and Mint1 is associated with inward rectifier Kir2 potassium channels | journal = The Journal of Biological Chemistry | volume = 279 | issue = 18 | pages = 19051–63 | date = Apr 2004 | pmid = 14960569 | doi = 10.1074/jbc.M400284200 }}
*{{cite journal | author=Preisig-Müller R, Schlichthörl G, Goerge T, ''et al.'' |title=Heteromerization of Kir2.x potassium channels contributes to the phenotype of Andersen's syndrome. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 11 |pages= 7774-9 |year= 2002 |pmid= 12032359 |doi= 10.1073/pnas.102609499 }}
* {{cite journal | vauthors = Leonoudakis D, Conti LR, Anderson S, Radeke CM, McGuire LM, Adams ME, Froehner SC, Yates JR, Vandenberg CA | title = Protein trafficking and anchoring complexes revealed by proteomic analysis of inward rectifier potassium channel (Kir2.x)-associated proteins | journal = The Journal of Biological Chemistry | volume = 279 | issue = 21 | pages = 22331–46 | date = May 2004 | pmid = 15024025 | doi = 10.1074/jbc.M400285200 }}
*{{cite journal | author=Chen L, Kawano T, Bajic S, ''et al.'' |title=A glutamate residue at the C terminus regulates activity of inward rectifier K+ channels: implication for Andersen's syndrome. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 12 |pages= 8430-5 |year= 2002 |pmid= 12034888 |doi= 10.1073/pnas.122682899 }}
* {{cite journal | vauthors = Fang Y, Schram G, Romanenko VG, Shi C, Conti L, Vandenberg CA, Davies PF, Nattel S, Levitan I | title = Functional expression of Kir2.x in human aortic endothelial cells: the dominant role of Kir2.2 | journal = American Journal of Physiology. Cell Physiology | volume = 289 | issue = 5 | pages = C1134-44 | date = Nov 2005 | pmid = 15958527 | doi = 10.1152/ajpcell.00077.2005 }}
*{{cite journal  | author=Kaibara M, Ishihara K, Doi Y, ''et al.'' |title=Identification of human Kir2.2 (KCNJ12) gene encoding functional inward rectifier potassium channel in both mammalian cells and Xenopus oocytes. |journal=FEBS Lett. |volume=531 |issue= 2 |pages= 250-4 |year= 2002 |pmid= 12417321 |doi=  }}
* {{cite journal | vauthors = Kiesecker C, Zitron E, Scherer D, Lueck S, Bloehs R, Scholz EP, Pirot M, Kathöfer S, Thomas D, Kreye VA, Kiehn J, Borst MM, Katus HA, Schoels W, Karle CA | title = Regulation of cardiac inwardly rectifying potassium current IK1 and Kir2.x channels by endothelin-1 | journal = Journal of Molecular Medicine | volume = 84 | issue = 1 | pages = 46–56 | date = Jan 2006 | pmid = 16258766 | doi = 10.1007/s00109-005-0707-8 }}
*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal | author=Karkanis T, Li S, Pickering JG, Sims SM |title=Plasticity of KIR channels in human smooth muscle cells from internal thoracic artery. |journal=Am. J. Physiol. Heart Circ. Physiol. |volume=284 |issue= 6 |pages= H2325-34 |year= 2003 |pmid= 12598232 |doi= 10.1152/ajpheart.00559.2002 }}
*{{cite journal | author=Stonehouse AH, Grubb BD, Pringle JH, ''et al.'' |title=Nuclear immunostaining in rat neuronal cells using two anti-Kir2.2 ion channel polyclonal antibodies. |journal=J. Mol. Neurosci. |volume=20 |issue= 2 |pages= 189-94 |year= 2003 |pmid= 12794312 |doi=  }}
*{{cite journal  | author=Ota T, Suzuki Y, Nishikawa T, ''et al.'' |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40-5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
*{{cite journal | author=Leonoudakis D, Conti LR, Radeke CM, ''et al.'' |title=A multiprotein trafficking complex composed of SAP97, CASK, Veli, and Mint1 is associated with inward rectifier Kir2 potassium channels. |journal=J. Biol. Chem. |volume=279 |issue= 18 |pages= 19051-63 |year= 2004 |pmid= 14960569 |doi= 10.1074/jbc.M400284200 }}
*{{cite journal | author=Leonoudakis D, Conti LR, Anderson S, ''et al.'' |title=Protein trafficking and anchoring complexes revealed by proteomic analysis of inward rectifier potassium channel (Kir2.x)-associated proteins. |journal=J. Biol. Chem. |volume=279 |issue= 21 |pages= 22331-46 |year= 2004 |pmid= 15024025 |doi= 10.1074/jbc.M400285200 }}
*{{cite journal | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal  | author=Fang Y, Schram G, Romanenko VG, ''et al.'' |title=Functional expression of Kir2.x in human aortic endothelial cells: the dominant role of Kir2.2. |journal=Am. J. Physiol., Cell Physiol. |volume=289 |issue= 5 |pages= C1134-44 |year= 2005 |pmid= 15958527 |doi= 10.1152/ajpcell.00077.2005 }}
*{{cite journal | author=Kiesecker C, Zitron E, Scherer D, ''et al.'' |title=Regulation of cardiac inwardly rectifying potassium current IK1 and Kir2.x channels by endothelin-1. |journal=J. Mol. Med. |volume=84 |issue= 1 |pages= 46-56 |year= 2006 |pmid= 16258766 |doi= 10.1007/s00109-005-0707-8 }}
}}
{{refend}}
{{refend}}


Line 91: Line 47:
* {{MeshName|Kir2.2+channel}}
* {{MeshName|Kir2.2+channel}}


{{membrane-protein-stub}}
{{NLM content}}
{{NLM content}}
{{Ion channels}}
{{Ion channels|g3}}
 
[[Category:Ion channels]]
[[Category:Ion channels]]
{{WikiDoc Sources}}

Latest revision as of 06:14, 2 September 2017

VALUE_ERROR (nil)
Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

n/a

n/a

Ensembl

n/a

n/a

UniProt

n/a

n/a

RefSeq (mRNA)

n/a

n/a

RefSeq (protein)

n/a

n/a

Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

ATP-sensitive inward rectifier potassium channel 12 is a protein that in humans is encoded by the KCNJ12 gene.[1][2][3][4]

Function

This gene encodes an inwardly rectifying K+ channel that may be blocked by divalent cations. This protein is thought to be one of multiple inwardly rectifying channels that contribute to the cardiac inward rectifier current (IK1). The gene is located within the Smith-Magenis syndrome region on chromosome 17.[4]

Interactions

KCNJ12 has been shown to interact with:

See also

References

  1. ↑ Wible BA, De Biasi M, Majumder K, Taglialatela M, Brown AM (Mar 1995). "Cloning and functional expression of an inwardly rectifying K+ channel from human atrium". Circulation Research. 76 (3): 343–50. doi:10.1161/01.res.76.3.343. PMID 7859381.
  2. ↑ Kaibara M, Ishihara K, Doi Y, Hayashi H, Ehara T, Taniyama K (Nov 2002). "Identification of human Kir2.2 (KCNJ12) gene encoding functional inward rectifier potassium channel in both mammalian cells and Xenopus oocytes". FEBS Letters. 531 (2): 250–4. doi:10.1016/S0014-5793(02)03512-3. PMID 12417321.
  3. ↑ Kubo Y, Adelman JP, Clapham DE, Jan LY, Karschin A, Kurachi Y, Lazdunski M, Nichols CG, Seino S, Vandenberg CA (Dec 2005). "International Union of Pharmacology. LIV. Nomenclature and molecular relationships of inwardly rectifying potassium channels". Pharmacological Reviews. 57 (4): 509–26. doi:10.1124/pr.57.4.11. PMID 16382105.
  4. ↑ 4.0 4.1 "Entrez Gene: KCNJ12 potassium inwardly-rectifying channel, subfamily J, member 12".
  5. ↑ 5.0 5.1 5.2 5.3 5.4 5.5 5.6 5.7 5.8 Leonoudakis D, Conti LR, Anderson S, Radeke CM, McGuire LM, Adams ME, Froehner SC, Yates JR, Vandenberg CA (May 2004). "Protein trafficking and anchoring complexes revealed by proteomic analysis of inward rectifier potassium channel (Kir2.x)-associated proteins". The Journal of Biological Chemistry. 279 (21): 22331–46. doi:10.1074/jbc.M400285200. PMID 15024025.
  6. ↑ 6.0 6.1 6.2 6.3 6.4 6.5 6.6 Leonoudakis D, Conti LR, Radeke CM, McGuire LM, Vandenberg CA (Apr 2004). "A multiprotein trafficking complex composed of SAP97, CASK, Veli, and Mint1 is associated with inward rectifier Kir2 potassium channels". The Journal of Biological Chemistry. 279 (18): 19051–63. doi:10.1074/jbc.M400284200. PMID 14960569.
  7. ↑ Leonoudakis D, Mailliard W, Wingerd K, Clegg D, Vandenberg C (Mar 2001). "Inward rectifier potassium channel Kir2.2 is associated with synapse-associated protein SAP97". Journal of Cell Science. 114 (Pt 5): 987–98. PMID 11181181.

Further reading

  • Namba N, Inagaki N, Gonoi T, Seino Y, Seino S (May 1996). "Kir2.2v: a possible negative regulator of the inwardly rectifying K+ channel Kir2.2". FEBS Letters. 386 (2–3): 211–4. doi:10.1016/0014-5793(96)00445-0. PMID 8647284.
  • Hugnot JP, Pedeutour F, Le Calvez C, Grosgeorge J, Passage E, Fontes M, Lazdunski M (Jan 1997). "The human inward rectifying K+ channel Kir 2.2 (KCNJ12) gene: gene structure, assignment to chromosome 17p11.1, and identification of a simple tandem repeat polymorphism". Genomics. 39 (1): 113–6. doi:10.1006/geno.1996.4450. PMID 9027495.
  • Gallagher PG, Forget BG (Jan 1998). "An alternate promoter directs expression of a truncated, muscle-specific isoform of the human ankyrin 1 gene". The Journal of Biological Chemistry. 273 (3): 1339–48. doi:10.1074/jbc.273.3.1339. PMID 9430667.
  • Namba N, Mori R, Tanaka H, Kondo I, Narahara K, Seino Y (1998). "The inwardly rectifying potassium channel subunit Kir2.2v (KCNJN1) maps to 17p11.2-->p11.1". Cytogenetics and Cell Genetics. 79 (1–2): 85–7. doi:10.1159/000134688. PMID 9533018.
  • Leonoudakis D, Mailliard W, Wingerd K, Clegg D, Vandenberg C (Mar 2001). "Inward rectifier potassium channel Kir2.2 is associated with synapse-associated protein SAP97". Journal of Cell Science. 114 (Pt 5): 987–98. PMID 11181181.
  • Preisig-Müller R, Schlichthörl G, Goerge T, Heinen S, Brüggemann A, Rajan S, Derst C, Veh RW, Daut J (May 2002). "Heteromerization of Kir2.x potassium channels contributes to the phenotype of Andersen's syndrome". Proceedings of the National Academy of Sciences of the United States of America. 99 (11): 7774–9. doi:10.1073/pnas.102609499. PMC 124349. PMID 12032359.
  • Chen L, Kawano T, Bajic S, Kaziro Y, Itoh H, Art JJ, Nakajima Y, Nakajima S (Jun 2002). "A glutamate residue at the C terminus regulates activity of inward rectifier K+ channels: implication for Andersen's syndrome". Proceedings of the National Academy of Sciences of the United States of America. 99 (12): 8430–5. doi:10.1073/pnas.122682899. PMC 123084. PMID 12034888.
  • Karkanis T, Li S, Pickering JG, Sims SM (Jun 2003). "Plasticity of KIR channels in human smooth muscle cells from internal thoracic artery". American Journal of Physiology. Heart and Circulatory Physiology. 284 (6): H2325–34. doi:10.1152/ajpheart.00559.2002. PMID 12598232.
  • Stonehouse AH, Grubb BD, Pringle JH, Norman RI, Stanfield PR, Brammar WJ (Apr 2003). "Nuclear immunostaining in rat neuronal cells using two anti-Kir2.2 ion channel polyclonal antibodies". Journal of Molecular Neuroscience. 20 (2): 189–94. doi:10.1385/JMN:20:2:189. PMID 12794312.
  • Leonoudakis D, Conti LR, Radeke CM, McGuire LM, Vandenberg CA (Apr 2004). "A multiprotein trafficking complex composed of SAP97, CASK, Veli, and Mint1 is associated with inward rectifier Kir2 potassium channels". The Journal of Biological Chemistry. 279 (18): 19051–63. doi:10.1074/jbc.M400284200. PMID 14960569.
  • Leonoudakis D, Conti LR, Anderson S, Radeke CM, McGuire LM, Adams ME, Froehner SC, Yates JR, Vandenberg CA (May 2004). "Protein trafficking and anchoring complexes revealed by proteomic analysis of inward rectifier potassium channel (Kir2.x)-associated proteins". The Journal of Biological Chemistry. 279 (21): 22331–46. doi:10.1074/jbc.M400285200. PMID 15024025.
  • Fang Y, Schram G, Romanenko VG, Shi C, Conti L, Vandenberg CA, Davies PF, Nattel S, Levitan I (Nov 2005). "Functional expression of Kir2.x in human aortic endothelial cells: the dominant role of Kir2.2". American Journal of Physiology. Cell Physiology. 289 (5): C1134–44. doi:10.1152/ajpcell.00077.2005. PMID 15958527.
  • Kiesecker C, Zitron E, Scherer D, Lueck S, Bloehs R, Scholz EP, Pirot M, Kathöfer S, Thomas D, Kreye VA, Kiehn J, Borst MM, Katus HA, Schoels W, Karle CA (Jan 2006). "Regulation of cardiac inwardly rectifying potassium current IK1 and Kir2.x channels by endothelin-1". Journal of Molecular Medicine. 84 (1): 46–56. doi:10.1007/s00109-005-0707-8. PMID 16258766.

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

Retrieved from "https://www.wikidoc.org/index.php?title=KCNJ12&oldid=1417874"