KCNJ4: Difference between revisions

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<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{Infobox_gene}}
{{PBB_Controls
'''Potassium inwardly-rectifying channel, subfamily J, member 4''', also known as '''KCNJ4''' or '''K<sub>ir</sub>2.3''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: KCNJ4 potassium inwardly-rectifying channel, subfamily J, member 4| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3761| accessdate = }}</ref>
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}


<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Function ==
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Potassium inwardly-rectifying channel, subfamily J, member 4
| HGNCid = 6265
| Symbol = KCNJ4
| AltSymbols =; HIR; HIRK2; HRK1; IRK3; Kir2.3; MGC142066; MGC142068
| OMIM = 600504
| ECnumber = 
| Homologene = 3653
| MGIid = 104743
| GeneAtlas_image1 = PBB_GE_KCNJ4_208359_s_at_tn.png
| GeneAtlas_image2 = PBB_GE_KCNJ4_211451_s_at_tn.png
| Function = {{GNF_GO|id=GO:0005242 |text = inward rectifier potassium channel activity}} {{GNF_GO|id=GO:0005244 |text = voltage-gated ion channel activity}} {{GNF_GO|id=GO:0030955 |text = potassium ion binding}}
| Component = {{GNF_GO|id=GO:0005624 |text = membrane fraction}} {{GNF_GO|id=GO:0008076 |text = voltage-gated potassium channel complex}} {{GNF_GO|id=GO:0016020 |text = membrane}} {{GNF_GO|id=GO:0016021 |text = integral to membrane}}
| Process = {{GNF_GO|id=GO:0006811 |text = ion transport}} {{GNF_GO|id=GO:0006813 |text = potassium ion transport}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 3761
    | Hs_Ensembl = ENSG00000168135
    | Hs_RefseqProtein = NP_004972
    | Hs_RefseqmRNA = NM_004981
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 22
    | Hs_GenLoc_start = 37152278
    | Hs_GenLoc_end = 37181149
    | Hs_Uniprot = P48050
    | Mm_EntrezGene = 16520
    | Mm_Ensembl = ENSMUSG00000044216
    | Mm_RefseqmRNA = NM_008427
    | Mm_RefseqProtein = NP_032453
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 15
    | Mm_GenLoc_start = 79310969
    | Mm_GenLoc_end = 79332496
    | Mm_Uniprot = Q8R434
  }}
}}
'''Potassium inwardly-rectifying channel, subfamily J, member 4''', also known as '''KCNJ4''' or K<sub>ir</sub>2.3, is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: KCNJ4 potassium inwardly-rectifying channel, subfamily J, member 4| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3761| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
Several different potassium channels are known to be involved with electrical signaling in the nervous system. One class is activated by depolarization whereas a second class is not. The latter are referred to as inwardly rectifying K+ channels, and they have a greater tendency to allow potassium to flow into the cell rather than out of it. This asymmetry in potassium ion conductance plays a key role in the excitability of muscle cells and neurons. The protein encoded by this gene is an integral membrane protein and member of the inward rectifier potassium channel family. The encoded protein has a small unitary conductance compared to other members of this protein family. Two transcript variants encoding the same protein have been found for this gene.<ref name="entrez"/>
{{PBB_Summary
 
| section_title =
== Interactions ==
| summary_text = Several different potassium channels are known to be involved with electrical signaling in the nervous system. One class is activated by depolarization whereas a second class is not. The latter are referred to as inwardly rectifying K+ channels, and they have a greater tendency to allow potassium to flow into the cell rather than out of it. This asymmetry in potassium ion conductance plays a key role in the excitability of muscle cells and neurons. The protein encoded by this gene is an integral membrane protein and member of the inward rectifier potassium channel family. The encoded protein has a small unitary conductance compared to other members of this protein family. Two transcript variants encoding the same protein have been found for this gene.<ref name="entrez">{{cite web | title = Entrez Gene: KCNJ4 potassium inwardly-rectifying channel, subfamily J, member 4| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3761| accessdate = }}</ref>
 
}}
KCNJ4 has been shown to [[Protein-protein interaction|interact]] with:
* [[CASK]],<ref name = pmid15024025/><ref name = pmid14960569/>
* [[DLG1]]<ref name = pmid15024025/><ref name = pmid14960569/><ref name = pmid11181181>{{cite journal | vauthors = Leonoudakis D, Mailliard W, Wingerd K, Clegg D, Vandenberg C | title = Inward rectifier potassium channel Kir2.2 is associated with synapse-associated protein SAP97 | journal = J. Cell Sci. | volume = 114 | issue = Pt 5 | pages = 987–98 | date = March 2001 | pmid = 11181181 | doi =  }}</ref>
* [[DLG4]],<ref name = pmid14960569/><ref name = pmid10627592>{{cite journal | vauthors = Nehring RB, Wischmeyer E, Döring F, Veh RW, Sheng M, Karschin A | title = Neuronal inwardly rectifying K(+) channels differentially couple to PDZ proteins of the PSD-95/SAP90 family | journal = J. Neurosci. | volume = 20 | issue = 1 | pages = 156–62 | date = January 2000 | pmid = 10627592 | doi =  }}</ref><ref name = pmid11997254>{{cite journal | vauthors = Inanobe A, Fujita A, Ito M, Tomoike H, Inageda K, Kurachi Y | title = Inward rectifier K+ channel Kir2.3 is localized at the postsynaptic membrane of excitatory synapses | journal = Am. J. Physiol., Cell Physiol. | volume = 282 | issue = 6 | pages = C1396-403 | date = June 2002 | pmid = 11997254 | doi = 10.1152/ajpcell.00615.2001 }}</ref>
* [[LIN7B]],<ref name = pmid11742811>{{cite journal | vauthors = Olsen O, Liu H, Wade JB, Merot J, Welling PA | title = Basolateral membrane expression of the Kir 2.3 channel is coordinated by PDZ interaction with Lin-7/CASK complex | journal = Am. J. Physiol., Cell Physiol. | volume = 282 | issue = 1 | pages = C183-95 | date = January 2002 | pmid = 11742811 | doi = 10.1152/ajpcell.00249.2001 }}</ref>  and
* [[LIN7C]].<ref name = pmid15024025>{{cite journal | vauthors = Leonoudakis D, Conti LR, Anderson S, Radeke CM, McGuire LM, Adams ME, Froehner SC, Yates JR, Vandenberg CA | title = Protein trafficking and anchoring complexes revealed by proteomic analysis of inward rectifier potassium channel (Kir2.x)-associated proteins | journal = J. Biol. Chem. | volume = 279 | issue = 21 | pages = 22331–46 | date = May 2004 | pmid = 15024025 | doi = 10.1074/jbc.M400285200 }}</ref><ref name = pmid14960569>{{cite journal | vauthors = Leonoudakis D, Conti LR, Radeke CM, McGuire LM, Vandenberg CA | title = A multiprotein trafficking complex composed of SAP97, CASK, Veli, and Mint1 is associated with inward rectifier Kir2 potassium channels | journal = J. Biol. Chem. | volume = 279 | issue = 18 | pages = 19051–63 | date = April 2004 | pmid = 14960569 | doi = 10.1074/jbc.M400284200 }}</ref>


==See also==
==See also==
Line 59: Line 19:


==References==
==References==
{{reflist|2}}
{{Reflist}}


==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
*{{cite journal | vauthors = Kubo Y, Adelman JP, Clapham DE, Jan LY, Karschin A, Kurachi Y, Lazdunski M, Nichols CG, Seino S, Vandenberg CA | title = International Union of Pharmacology. LIV. Nomenclature and molecular relationships of inwardly rectifying potassium channels. | journal = Pharmacol. Rev. | volume = 57 | issue = 4 | pages = 509–26 | year = 2006 | pmid = 16382105 | doi = 10.1124/pr.57.4.11 }}
| citations =
*{{cite journal | vauthors = Budarf ML, Périer F, Barnoski BL, Bell CJ, Vandenberg CA | title = Assignment of the human hippocampal inward rectifier potassium channel (HIR) gene to 22q13.1. | journal = Genomics | volume = 26 | issue = 3 | pages = 625–9 | year = 1995 | pmid = 7607694 | doi = 10.1016/0888-7543(95)80189-S }}
*{{cite journal | author=Kubo Y, Adelman JP, Clapham DE, ''et al.'' |title=International Union of Pharmacology. LIV. Nomenclature and molecular relationships of inwardly rectifying potassium channels. |journal=Pharmacol. Rev. |volume=57 |issue= 4 |pages= 509-26 |year= 2006 |pmid= 16382105 |doi= 10.1124/pr.57.4.11 }}
*{{cite journal | vauthors = Périer F, Radeke CM, Vandenberg CA | title = Primary structure and characterization of a small-conductance inwardly rectifying potassium channel from human hippocampus. | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 91 | issue = 13 | pages = 6240–4 | year = 1994 | pmid = 8016146 | pmc = 44174 | doi = 10.1073/pnas.91.13.6240 }}
*{{cite journal | author=Budarf ML, Périer F, Barnoski BL, ''et al.'' |title=Assignment of the human hippocampal inward rectifier potassium channel (HIR) gene to 22q13.1. |journal=Genomics |volume=26 |issue= 3 |pages= 625-9 |year= 1995 |pmid= 7607694 |doi= }}
*{{cite journal | vauthors = Tang W, Yang XC | title = Cloning a novel human brain inward rectifier potassium channel and its functional expression in Xenopus oocytes. | journal = FEBS Lett. | volume = 348 | issue = 3 | pages = 239–43 | year = 1994 | pmid = 8034048 | doi = 10.1016/0014-5793(94)00612-1 }}
*{{cite journal | author=Périer F, Radeke CM, Vandenberg CA |title=Primary structure and characterization of a small-conductance inwardly rectifying potassium channel from human hippocampus. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=91 |issue= 13 |pages= 6240-4 |year= 1994 |pmid= 8016146 |doi= }}
*{{cite journal | vauthors = Makhina EN, Kelly AJ, Lopatin AN, Mercer RW, Nichols CG | title = Cloning and expression of a novel human brain inward rectifier potassium channel. | journal = J. Biol. Chem. | volume = 269 | issue = 32 | pages = 20468–74 | year = 1994 | pmid = 8051145 | doi =  }}
*{{cite journal | author=Tang W, Yang XC |title=Cloning a novel human brain inward rectifier potassium channel and its functional expression in Xenopus oocytes. |journal=FEBS Lett. |volume=348 |issue= 3 |pages= 239-43 |year= 1994 |pmid= 8034048 |doi= }}
*{{cite journal | vauthors = Cohen NA, Brenman JE, Snyder SH, Bredt DS | title = Binding of the inward rectifier K+ channel Kir 2.3 to PSD-95 is regulated by protein kinase A phosphorylation. | journal = Neuron | volume = 17 | issue = 4 | pages = 759–67 | year = 1996 | pmid = 8893032 | doi = 10.1016/S0896-6273(00)80207-X }}
*{{cite journal | author=Makhina EN, Kelly AJ, Lopatin AN, ''et al.'' |title=Cloning and expression of a novel human brain inward rectifier potassium channel. |journal=J. Biol. Chem. |volume=269 |issue= 32 |pages= 20468-74 |year= 1994 |pmid= 8051145 |doi=  }}
*{{cite journal | vauthors = Cohen NA, Sha Q, Makhina EN, Lopatin AN, Linder ME, Snyder SH, Nichols CG | title = Inhibition of an inward rectifier potassium channel (Kir2.3) by G-protein betagamma subunits. | journal = J. Biol. Chem. | volume = 271 | issue = 50 | pages = 32301–5 | year = 1997 | pmid = 8943291 | doi = 10.1074/jbc.271.50.32301 }}
*{{cite journal | author=Cohen NA, Brenman JE, Snyder SH, Bredt DS |title=Binding of the inward rectifier K+ channel Kir 2.3 to PSD-95 is regulated by protein kinase A phosphorylation. |journal=Neuron |volume=17 |issue= 4 |pages= 759-67 |year= 1996 |pmid= 8893032 |doi= }}
*{{cite journal | vauthors = Zhu G, Qu Z, Cui N, Jiang C | title = Suppression of Kir2.3 activity by protein kinase C phosphorylation of the channel protein at threonine 53. | journal = J. Biol. Chem. | volume = 274 | issue = 17 | pages = 11643–6 | year = 1999 | pmid = 10206975 | doi = 10.1074/jbc.274.17.11643 }}
*{{cite journal | author=Cohen NA, Sha Q, Makhina EN, ''et al.'' |title=Inhibition of an inward rectifier potassium channel (Kir2.3) by G-protein betagamma subunits. |journal=J. Biol. Chem. |volume=271 |issue= 50 |pages= 32301-5 |year= 1997 |pmid= 8943291 |doi= }}
*{{cite journal | vauthors = Kurschner C, Yuzaki M | title = Neuronal interleukin-16 (NIL-16): a dual function PDZ domain protein. | journal = J. Neurosci. | volume = 19 | issue = 18 | pages = 7770–80 | year = 1999 | pmid = 10479680 | doi =  }}
*{{cite journal | author=Zhu G, Qu Z, Cui N, Jiang C |title=Suppression of Kir2.3 activity by protein kinase C phosphorylation of the channel protein at threonine 53. |journal=J. Biol. Chem. |volume=274 |issue= 17 |pages= 11643-6 |year= 1999 |pmid= 10206975 |doi= }}
*{{cite journal | vauthors = Dunham I, Shimizu N, Roe BA, Chissoe S, Hunt AR, Collins JE, Bruskiewich R, Beare DM, Clamp M, Smink LJ, Ainscough R, Almeida JP, Babbage A, Bagguley C, Bailey J, Barlow K, Bates KN, Beasley O, Bird CP, Blakey S, Bridgeman AM, Buck D, Burgess J, Burrill WD, O'Brien KP | title = The DNA sequence of human chromosome 22. | journal = Nature | volume = 402 | issue = 6761 | pages = 489–95 | year = 1999 | pmid = 10591208 | doi = 10.1038/990031 }}
*{{cite journal | author=Kurschner C, Yuzaki M |title=Neuronal interleukin-16 (NIL-16): a dual function PDZ domain protein. |journal=J. Neurosci. |volume=19 |issue= 18 |pages= 7770-80 |year= 1999 |pmid= 10479680 |doi=  }}
*{{cite journal | vauthors = Nehring RB, Wischmeyer E, Döring F, Veh RW, Sheng M, Karschin A | title = Neuronal inwardly rectifying K(+) channels differentially couple to PDZ proteins of the PSD-95/SAP90 family. | journal = J. Neurosci. | volume = 20 | issue = 1 | pages = 156–62 | year = 2000 | pmid = 10627592 | doi =  }}
*{{cite journal | author=Dunham I, Shimizu N, Roe BA, ''et al.'' |title=The DNA sequence of human chromosome 22. |journal=Nature |volume=402 |issue= 6761 |pages= 489-95 |year= 1999 |pmid= 10591208 |doi= 10.1038/990031 }}
*{{cite journal | vauthors = Leonoudakis D, Mailliard W, Wingerd K, Clegg D, Vandenberg C | title = Inward rectifier potassium channel Kir2.2 is associated with synapse-associated protein SAP97. | journal = J. Cell Sci. | volume = 114 | issue = Pt 5 | pages = 987–98 | year = 2001 | pmid = 11181181 | doi =  }}
*{{cite journal | author=Nehring RB, Wischmeyer E, Döring F, ''et al.'' |title=Neuronal inwardly rectifying K(+) channels differentially couple to PDZ proteins of the PSD-95/SAP90 family. |journal=J. Neurosci. |volume=20 |issue= 1 |pages= 156-62 |year= 2000 |pmid= 10627592 |doi=  }}
*{{cite journal | vauthors = Liu Y, Liu D, Heath L, Meyers DM, Krafte DS, Wagoner PK, Silvia CP, Yu W, Curran ME | title = Direct activation of an inwardly rectifying potassium channel by arachidonic acid. | journal = Mol. Pharmacol. | volume = 59 | issue = 5 | pages = 1061–8 | year = 2001 | pmid = 11306688 | doi =  }}
*{{cite journal | author=Leonoudakis D, Mailliard W, Wingerd K, ''et al.'' |title=Inward rectifier potassium channel Kir2.2 is associated with synapse-associated protein SAP97. |journal=J. Cell. Sci. |volume=114 |issue= Pt 5 |pages= 987-98 |year= 2001 |pmid= 11181181 |doi=  }}
*{{cite journal | vauthors = Perillan PR, Chen M, Potts EA, Simard JM | title = Transforming growth factor-beta 1 regulates Kir2.3 inward rectifier K+ channels via phospholipase C and protein kinase C-delta in reactive astrocytes from adult rat brain. | journal = J. Biol. Chem. | volume = 277 | issue = 3 | pages = 1974–80 | year = 2002 | pmid = 11713246 | doi = 10.1074/jbc.M107984200 }}
*{{cite journal | author=Liu Y, Liu D, Heath L, ''et al.'' |title=Direct activation of an inwardly rectifying potassium channel by arachidonic acid. |journal=Mol. Pharmacol. |volume=59 |issue= 5 |pages= 1061-8 |year= 2001 |pmid= 11306688 |doi=  }}
*{{cite journal | vauthors = Olsen O, Liu H, Wade JB, Merot J, Welling PA | title = Basolateral membrane expression of the Kir 2.3 channel is coordinated by PDZ interaction with Lin-7/CASK complex. | journal = Am. J. Physiol., Cell Physiol. | volume = 282 | issue = 1 | pages = C183–95 | year = 2002 | pmid = 11742811 | doi = 10.1152/ajpcell.00249.2001 }}
*{{cite journal | author=Perillan PR, Chen M, Potts EA, Simard JM |title=Transforming growth factor-beta 1 regulates Kir2.3 inward rectifier K+ channels via phospholipase C and protein kinase C-delta in reactive astrocytes from adult rat brain. |journal=J. Biol. Chem. |volume=277 |issue= 3 |pages= 1974-80 |year= 2002 |pmid= 11713246 |doi= 10.1074/jbc.M107984200 }}
*{{cite journal | vauthors = Inanobe A, Fujita A, Ito M, Tomoike H, Inageda K, Kurachi Y | title = Inward rectifier K+ channel Kir2.3 is localized at the postsynaptic membrane of excitatory synapses. | journal = Am. J. Physiol., Cell Physiol. | volume = 282 | issue = 6 | pages = C1396–403 | year = 2002 | pmid = 11997254 | doi = 10.1152/ajpcell.00615.2001 }}
*{{cite journal | author=Olsen O, Liu H, Wade JB, ''et al.'' |title=Basolateral membrane expression of the Kir 2.3 channel is coordinated by PDZ interaction with Lin-7/CASK complex. |journal=Am. J. Physiol., Cell Physiol. |volume=282 |issue= 1 |pages= C183-95 |year= 2002 |pmid= 11742811 |doi= 10.1152/ajpcell.00249.2001 }}
*{{cite journal | vauthors = Preisig-Müller R, Schlichthörl G, Goerge T, Heinen S, Brüggemann A, Rajan S, Derst C, Veh RW, Daut J | title = Heteromerization of Kir2.x potassium channels contributes to the phenotype of Andersen's syndrome. | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 99 | issue = 11 | pages = 7774–9 | year = 2002 | pmid = 12032359 | pmc = 124349 | doi = 10.1073/pnas.102609499 }}
*{{cite journal | author=Inanobe A, Fujita A, Ito M, ''et al.'' |title=Inward rectifier K+ channel Kir2.3 is localized at the postsynaptic membrane of excitatory synapses. |journal=Am. J. Physiol., Cell Physiol. |volume=282 |issue= 6 |pages= C1396-403 |year= 2002 |pmid= 11997254 |doi= 10.1152/ajpcell.00615.2001 }}
*{{cite journal | vauthors = Strausberg RL, Feingold EA, Grouse LH, Derge JG, Klausner RD, Collins FS, Wagner L, Shenmen CM, Schuler GD, Altschul SF, Zeeberg B, Buetow KH, Schaefer CF, Bhat NK, Hopkins RF, Jordan H, Moore T, Max SI, Wang J, Hsieh F, Diatchenko L, Marusina K, Farmer AA, Rubin GM, Hong L, Stapleton M, Soares MB, Bonaldo MF, Casavant TL, Scheetz TE, Brownstein MJ, Usdin TB, Toshiyuki S, Carninci P, Prange C, Raha SS, Loquellano NA, Peters GJ, Abramson RD, Mullahy SJ, Bosak SA, McEwan PJ, McKernan KJ, Malek JA, Gunaratne PH, Richards S, Worley KC, Hale S, Garcia AM, Gay LJ, Hulyk SW, Villalon DK, Muzny DM, Sodergren EJ, Lu X, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madan A, Young AC, Shevchenko Y, Bouffard GG, Blakesley RW, Touchman JW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Krzywinski MI, Skalska U, Smailus DE, Schnerch A, Schein JE, Jones SJ, Marra MA | title = Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 99 | issue = 26 | pages = 16899–903 | year = 2003 | pmid = 12477932 | pmc = 139241 | doi = 10.1073/pnas.242603899 }}
*{{cite journal | author=Preisig-Müller R, Schlichthörl G, Goerge T, ''et al.'' |title=Heteromerization of Kir2.x potassium channels contributes to the phenotype of Andersen's syndrome. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 11 |pages= 7774-9 |year= 2002 |pmid= 12032359 |doi= 10.1073/pnas.102609499 }}
*{{cite journal | vauthors = Leonoudakis D, Conti LR, Radeke CM, McGuire LM, Vandenberg CA | title = A multiprotein trafficking complex composed of SAP97, CASK, Veli, and Mint1 is associated with inward rectifier Kir2 potassium channels. | journal = J. Biol. Chem. | volume = 279 | issue = 18 | pages = 19051–63 | year = 2004 | pmid = 14960569 | doi = 10.1074/jbc.M400284200 }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal | vauthors = Leonoudakis D, Conti LR, Anderson S, Radeke CM, McGuire LM, Adams ME, Froehner SC, Yates JR, Vandenberg CA | title = Protein trafficking and anchoring complexes revealed by proteomic analysis of inward rectifier potassium channel (Kir2.x)-associated proteins. | journal = J. Biol. Chem. | volume = 279 | issue = 21 | pages = 22331–46 | year = 2004 | pmid = 15024025 | doi = 10.1074/jbc.M400285200 }}
*{{cite journal  | author=Leonoudakis D, Conti LR, Radeke CM, ''et al.'' |title=A multiprotein trafficking complex composed of SAP97, CASK, Veli, and Mint1 is associated with inward rectifier Kir2 potassium channels. |journal=J. Biol. Chem. |volume=279 |issue= 18 |pages= 19051-63 |year= 2004 |pmid= 14960569 |doi= 10.1074/jbc.M400284200 }}
*{{cite journal  | author=Leonoudakis D, Conti LR, Anderson S, ''et al.'' |title=Protein trafficking and anchoring complexes revealed by proteomic analysis of inward rectifier potassium channel (Kir2.x)-associated proteins. |journal=J. Biol. Chem. |volume=279 |issue= 21 |pages= 22331-46 |year= 2004 |pmid= 15024025 |doi= 10.1074/jbc.M400285200 }}
}}
{{refend}}
{{refend}}


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* {{MeshName|KCNJ4+protein,+human}}
* {{MeshName|KCNJ4+protein,+human}}


{{membrane-protein-stub}}
{{NLM content}}
{{NLM content}}
{{Ion channels}}
{{Ion channels|g3}}
[[Category:Ion channels]]
{{WikiDoc Sources}}

Latest revision as of 20:09, 8 November 2017

VALUE_ERROR (nil)
Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

n/a

n/a

Ensembl

n/a

n/a

UniProt

n/a

n/a

RefSeq (mRNA)

n/a

n/a

RefSeq (protein)

n/a

n/a

Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Potassium inwardly-rectifying channel, subfamily J, member 4, also known as KCNJ4 or Kir2.3, is a human gene.[1]

Function

Several different potassium channels are known to be involved with electrical signaling in the nervous system. One class is activated by depolarization whereas a second class is not. The latter are referred to as inwardly rectifying K+ channels, and they have a greater tendency to allow potassium to flow into the cell rather than out of it. This asymmetry in potassium ion conductance plays a key role in the excitability of muscle cells and neurons. The protein encoded by this gene is an integral membrane protein and member of the inward rectifier potassium channel family. The encoded protein has a small unitary conductance compared to other members of this protein family. Two transcript variants encoding the same protein have been found for this gene.[1]

Interactions

KCNJ4 has been shown to interact with:

See also

References

  1. ↑ 1.0 1.1 "Entrez Gene: KCNJ4 potassium inwardly-rectifying channel, subfamily J, member 4".
  2. ↑ 2.0 2.1 2.2 Leonoudakis D, Conti LR, Anderson S, Radeke CM, McGuire LM, Adams ME, Froehner SC, Yates JR, Vandenberg CA (May 2004). "Protein trafficking and anchoring complexes revealed by proteomic analysis of inward rectifier potassium channel (Kir2.x)-associated proteins". J. Biol. Chem. 279 (21): 22331–46. doi:10.1074/jbc.M400285200. PMID 15024025.
  3. ↑ 3.0 3.1 3.2 3.3 Leonoudakis D, Conti LR, Radeke CM, McGuire LM, Vandenberg CA (April 2004). "A multiprotein trafficking complex composed of SAP97, CASK, Veli, and Mint1 is associated with inward rectifier Kir2 potassium channels". J. Biol. Chem. 279 (18): 19051–63. doi:10.1074/jbc.M400284200. PMID 14960569.
  4. ↑ Leonoudakis D, Mailliard W, Wingerd K, Clegg D, Vandenberg C (March 2001). "Inward rectifier potassium channel Kir2.2 is associated with synapse-associated protein SAP97". J. Cell Sci. 114 (Pt 5): 987–98. PMID 11181181.
  5. ↑ Nehring RB, Wischmeyer E, Döring F, Veh RW, Sheng M, Karschin A (January 2000). "Neuronal inwardly rectifying K(+) channels differentially couple to PDZ proteins of the PSD-95/SAP90 family". J. Neurosci. 20 (1): 156–62. PMID 10627592.
  6. ↑ Inanobe A, Fujita A, Ito M, Tomoike H, Inageda K, Kurachi Y (June 2002). "Inward rectifier K+ channel Kir2.3 is localized at the postsynaptic membrane of excitatory synapses". Am. J. Physiol., Cell Physiol. 282 (6): C1396–403. doi:10.1152/ajpcell.00615.2001. PMID 11997254.
  7. ↑ Olsen O, Liu H, Wade JB, Merot J, Welling PA (January 2002). "Basolateral membrane expression of the Kir 2.3 channel is coordinated by PDZ interaction with Lin-7/CASK complex". Am. J. Physiol., Cell Physiol. 282 (1): C183–95. doi:10.1152/ajpcell.00249.2001. PMID 11742811.

Further reading

  • Kubo Y, Adelman JP, Clapham DE, Jan LY, Karschin A, Kurachi Y, Lazdunski M, Nichols CG, Seino S, Vandenberg CA (2006). "International Union of Pharmacology. LIV. Nomenclature and molecular relationships of inwardly rectifying potassium channels". Pharmacol. Rev. 57 (4): 509–26. doi:10.1124/pr.57.4.11. PMID 16382105.
  • Budarf ML, Périer F, Barnoski BL, Bell CJ, Vandenberg CA (1995). "Assignment of the human hippocampal inward rectifier potassium channel (HIR) gene to 22q13.1". Genomics. 26 (3): 625–9. doi:10.1016/0888-7543(95)80189-S. PMID 7607694.
  • Périer F, Radeke CM, Vandenberg CA (1994). "Primary structure and characterization of a small-conductance inwardly rectifying potassium channel from human hippocampus". Proc. Natl. Acad. Sci. U.S.A. 91 (13): 6240–4. doi:10.1073/pnas.91.13.6240. PMC 44174. PMID 8016146.
  • Tang W, Yang XC (1994). "Cloning a novel human brain inward rectifier potassium channel and its functional expression in Xenopus oocytes". FEBS Lett. 348 (3): 239–43. doi:10.1016/0014-5793(94)00612-1. PMID 8034048.
  • Makhina EN, Kelly AJ, Lopatin AN, Mercer RW, Nichols CG (1994). "Cloning and expression of a novel human brain inward rectifier potassium channel". J. Biol. Chem. 269 (32): 20468–74. PMID 8051145.
  • Cohen NA, Brenman JE, Snyder SH, Bredt DS (1996). "Binding of the inward rectifier K+ channel Kir 2.3 to PSD-95 is regulated by protein kinase A phosphorylation". Neuron. 17 (4): 759–67. doi:10.1016/S0896-6273(00)80207-X. PMID 8893032.
  • Cohen NA, Sha Q, Makhina EN, Lopatin AN, Linder ME, Snyder SH, Nichols CG (1997). "Inhibition of an inward rectifier potassium channel (Kir2.3) by G-protein betagamma subunits". J. Biol. Chem. 271 (50): 32301–5. doi:10.1074/jbc.271.50.32301. PMID 8943291.
  • Zhu G, Qu Z, Cui N, Jiang C (1999). "Suppression of Kir2.3 activity by protein kinase C phosphorylation of the channel protein at threonine 53". J. Biol. Chem. 274 (17): 11643–6. doi:10.1074/jbc.274.17.11643. PMID 10206975.
  • Kurschner C, Yuzaki M (1999). "Neuronal interleukin-16 (NIL-16): a dual function PDZ domain protein". J. Neurosci. 19 (18): 7770–80. PMID 10479680.
  • Dunham I, Shimizu N, Roe BA, Chissoe S, Hunt AR, Collins JE, Bruskiewich R, Beare DM, Clamp M, Smink LJ, Ainscough R, Almeida JP, Babbage A, Bagguley C, Bailey J, Barlow K, Bates KN, Beasley O, Bird CP, Blakey S, Bridgeman AM, Buck D, Burgess J, Burrill WD, O'Brien KP (1999). "The DNA sequence of human chromosome 22". Nature. 402 (6761): 489–95. doi:10.1038/990031. PMID 10591208.
  • Nehring RB, Wischmeyer E, Döring F, Veh RW, Sheng M, Karschin A (2000). "Neuronal inwardly rectifying K(+) channels differentially couple to PDZ proteins of the PSD-95/SAP90 family". J. Neurosci. 20 (1): 156–62. PMID 10627592.
  • Leonoudakis D, Mailliard W, Wingerd K, Clegg D, Vandenberg C (2001). "Inward rectifier potassium channel Kir2.2 is associated with synapse-associated protein SAP97". J. Cell Sci. 114 (Pt 5): 987–98. PMID 11181181.
  • Liu Y, Liu D, Heath L, Meyers DM, Krafte DS, Wagoner PK, Silvia CP, Yu W, Curran ME (2001). "Direct activation of an inwardly rectifying potassium channel by arachidonic acid". Mol. Pharmacol. 59 (5): 1061–8. PMID 11306688.
  • Perillan PR, Chen M, Potts EA, Simard JM (2002). "Transforming growth factor-beta 1 regulates Kir2.3 inward rectifier K+ channels via phospholipase C and protein kinase C-delta in reactive astrocytes from adult rat brain". J. Biol. Chem. 277 (3): 1974–80. doi:10.1074/jbc.M107984200. PMID 11713246.
  • Olsen O, Liu H, Wade JB, Merot J, Welling PA (2002). "Basolateral membrane expression of the Kir 2.3 channel is coordinated by PDZ interaction with Lin-7/CASK complex". Am. J. Physiol., Cell Physiol. 282 (1): C183–95. doi:10.1152/ajpcell.00249.2001. PMID 11742811.
  • Inanobe A, Fujita A, Ito M, Tomoike H, Inageda K, Kurachi Y (2002). "Inward rectifier K+ channel Kir2.3 is localized at the postsynaptic membrane of excitatory synapses". Am. J. Physiol., Cell Physiol. 282 (6): C1396–403. doi:10.1152/ajpcell.00615.2001. PMID 11997254.
  • Preisig-Müller R, Schlichthörl G, Goerge T, Heinen S, Brüggemann A, Rajan S, Derst C, Veh RW, Daut J (2002). "Heteromerization of Kir2.x potassium channels contributes to the phenotype of Andersen's syndrome". Proc. Natl. Acad. Sci. U.S.A. 99 (11): 7774–9. doi:10.1073/pnas.102609499. PMC 124349. PMID 12032359.
  • Strausberg RL, Feingold EA, Grouse LH, Derge JG, Klausner RD, Collins FS, Wagner L, Shenmen CM, Schuler GD, Altschul SF, Zeeberg B, Buetow KH, Schaefer CF, Bhat NK, Hopkins RF, Jordan H, Moore T, Max SI, Wang J, Hsieh F, Diatchenko L, Marusina K, Farmer AA, Rubin GM, Hong L, Stapleton M, Soares MB, Bonaldo MF, Casavant TL, Scheetz TE, Brownstein MJ, Usdin TB, Toshiyuki S, Carninci P, Prange C, Raha SS, Loquellano NA, Peters GJ, Abramson RD, Mullahy SJ, Bosak SA, McEwan PJ, McKernan KJ, Malek JA, Gunaratne PH, Richards S, Worley KC, Hale S, Garcia AM, Gay LJ, Hulyk SW, Villalon DK, Muzny DM, Sodergren EJ, Lu X, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madan A, Young AC, Shevchenko Y, Bouffard GG, Blakesley RW, Touchman JW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Krzywinski MI, Skalska U, Smailus DE, Schnerch A, Schein JE, Jones SJ, Marra MA (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Leonoudakis D, Conti LR, Radeke CM, McGuire LM, Vandenberg CA (2004). "A multiprotein trafficking complex composed of SAP97, CASK, Veli, and Mint1 is associated with inward rectifier Kir2 potassium channels". J. Biol. Chem. 279 (18): 19051–63. doi:10.1074/jbc.M400284200. PMID 14960569.
  • Leonoudakis D, Conti LR, Anderson S, Radeke CM, McGuire LM, Adams ME, Froehner SC, Yates JR, Vandenberg CA (2004). "Protein trafficking and anchoring complexes revealed by proteomic analysis of inward rectifier potassium channel (Kir2.x)-associated proteins". J. Biol. Chem. 279 (21): 22331–46. doi:10.1074/jbc.M400285200. PMID 15024025.

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